Lachnospiraceae bacterium JLR.KK008: V1224_00970
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Entry
V1224_00970 CDS
T10585
Symbol
murF
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
lbp Lachnospiraceae bacterium JLR.KK008
Pathway
lbp00300
Lysine biosynthesis
lbp00550
Peptidoglycan biosynthesis
lbp01100
Metabolic pathways
lbp01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
lbp00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
V1224_00970 (murF)
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
V1224_00970 (murF)
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
V1224_00970 (murF)
Enzymes [BR:
lbp01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
V1224_00970 (murF)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
WWR16059
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Position
202138..203532
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AA seq
464 aa
AA seq
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MENMTLERIAKACGGIYKGKEEDRQREVEGVVLDSRLVEKDYCFIATKGERVDGHSFIAD
VFEKGAACVICESLPDGIEGNFIQVADSFQALKEVAEYYRSTLHIPVVGITGSVGKTSTK
ELIASVLAQKYCVLKTEGNYNNEIGVPLTLLRIRREHEIAVLEMGINHFGEMRRLSKMAK
PDTCVITNIGECHLEFLKSRQGILQAKSEIFEYASEESTVYVNGDDDMLRTIERVKHKRP
VRFGLGHQNDYYAEVTEDHGLSGCDVMICRDGGRFLAEIPLPGEHMIRNALAATAIGEQY
GLTEAEIAAGIAAVTPVGGRSNIVTYGSLTLIDDCYNANPVSMRAALDMLSRVSGKTIAV
LGDMGELGENEAQYHREIGAYAVEKKITGLICVGRLARYLYQGACKAKERTMNNTFVLYF
ETLEALLCKLENENLFSYHITALVKASHSMQFSRIIKMLDQKKS
NT seq
1395 nt
NT seq
+upstream
nt +downstream
nt
atggagaatatgacactggagcgtatcgcgaaggcgtgcggcggtatttataagggaaag
gaagaagacagacagagggaagtggaaggcgtagtacttgattcgcgtctggtggaaaaa
gactattgttttatcgccacaaaaggagaacgggtggacggacacagttttattgctgat
gtctttgagaaaggggctgcctgtgtcatctgtgaatcgctcccggacggaatcgaggga
aattttattcaggttgcggattcctttcaggcgctgaaagaggtggcggagtattatcgg
agtacattgcacatccccgtagtcgggatcaccggcagtgtggggaaaacgagtacgaaa
gagctgatagccagtgtgctggcgcaaaaatactgcgtactgaagacggaaggcaactat
aacaatgaaataggggtgccgctgacacttctgcgcattcgcagggaacacgagatcgcc
gtgctggagatgggcatcaatcatttcggagaaatgcgccgactgagtaaaatggcaaaa
cctgacacttgtgtcataacgaatatcggagagtgtcaccttgaatttttgaaatcccgg
caggggattttacaggcaaaatccgaaatttttgagtatgccagtgaagagagcacggta
tatgtcaacggagatgatgatatgctgcggacgatcgagcgggtgaaacataaaaggccg
gtgcggttcggtctggggcatcagaatgattattatgcggaagtgacggaggatcacggg
ctgtcaggctgtgatgtgatgatctgcagagacggcggccgctttttggcagagatccca
ttgcccggggaacatatgatacggaatgcactggctgcaacagcgatcggggaacagtat
gggctgacggaggcagagattgccgccgggatcgccgcggtaacgccagtaggcggccgc
agtaatatcgtcacatacgggagtctgacgctgattgatgactgctacaatgccaatccg
gtatccatgcgggcggcgctcgatatgctcagccgtgtgagcggcaagacgatcgctgtc
ctgggcgacatgggagagcttggtgagaatgaagcacagtatcaccgggaaatcggagcc
tatgcggtggaaaaaaagatcaccggtctgatctgtgtcggcaggctggcgcgttatctg
tatcagggagcctgtaaagcaaaagagaggacaatgaataatacattcgtcctctacttc
gagacattggaagcgctgctttgcaaactggaaaacgaaaatctgttttcctatcatatc
acagcgcttgtcaaggcgtcacacagtatgcagttttccagaattataaagatgctggat
caaaagaaaagctga
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