KEGG   Lemur catta (Ring-tailed lemur): 123622057
Entry
123622057         CDS       T08326                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
lcat  Lemur catta (Ring-tailed lemur)
Pathway
lcat00562  Inositol phosphate metabolism
lcat01100  Metabolic pathways
lcat04015  Rap1 signaling pathway
lcat04020  Calcium signaling pathway
lcat04022  cGMP-PKG signaling pathway
lcat04062  Chemokine signaling pathway
lcat04070  Phosphatidylinositol signaling system
lcat04071  Sphingolipid signaling pathway
lcat04072  Phospholipase D signaling pathway
lcat04081  Hormone signaling
lcat04082  Neuroactive ligand signaling
lcat04261  Adrenergic signaling in cardiomyocytes
lcat04270  Vascular smooth muscle contraction
lcat04310  Wnt signaling pathway
lcat04371  Apelin signaling pathway
lcat04540  Gap junction
lcat04611  Platelet activation
lcat04613  Neutrophil extracellular trap formation
lcat04621  NOD-like receptor signaling pathway
lcat04713  Circadian entrainment
lcat04720  Long-term potentiation
lcat04723  Retrograde endocannabinoid signaling
lcat04724  Glutamatergic synapse
lcat04725  Cholinergic synapse
lcat04726  Serotonergic synapse
lcat04728  Dopaminergic synapse
lcat04730  Long-term depression
lcat04742  Taste transduction
lcat04750  Inflammatory mediator regulation of TRP channels
lcat04911  Insulin secretion
lcat04912  GnRH signaling pathway
lcat04915  Estrogen signaling pathway
lcat04916  Melanogenesis
lcat04918  Thyroid hormone synthesis
lcat04919  Thyroid hormone signaling pathway
lcat04921  Oxytocin signaling pathway
lcat04922  Glucagon signaling pathway
lcat04924  Renin secretion
lcat04925  Aldosterone synthesis and secretion
lcat04926  Relaxin signaling pathway
lcat04927  Cortisol synthesis and secretion
lcat04928  Parathyroid hormone synthesis, secretion and action
lcat04929  GnRH secretion
lcat04933  AGE-RAGE signaling pathway in diabetic complications
lcat04934  Cushing syndrome
lcat04935  Growth hormone synthesis, secretion and action
lcat04961  Endocrine and other factor-regulated calcium reabsorption
lcat04970  Salivary secretion
lcat04971  Gastric acid secretion
lcat04972  Pancreatic secretion
lcat04973  Carbohydrate digestion and absorption
lcat05010  Alzheimer disease
lcat05016  Huntington disease
lcat05017  Spinocerebellar ataxia
lcat05022  Pathways of neurodegeneration - multiple diseases
lcat05142  Chagas disease
lcat05143  African trypanosomiasis
lcat05146  Amoebiasis
lcat05163  Human cytomegalovirus infection
lcat05200  Pathways in cancer
lcat05415  Diabetic cardiomyopathy
lcat05417  Lipid and atherosclerosis
Module
lcat_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:lcat00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123622057 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    123622057 (PLCB4)
   04310 Wnt signaling pathway
    123622057 (PLCB4)
   04371 Apelin signaling pathway
    123622057 (PLCB4)
   04020 Calcium signaling pathway
    123622057 (PLCB4)
   04070 Phosphatidylinositol signaling system
    123622057 (PLCB4)
   04072 Phospholipase D signaling pathway
    123622057 (PLCB4)
   04071 Sphingolipid signaling pathway
    123622057 (PLCB4)
   04022 cGMP-PKG signaling pathway
    123622057 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    123622057 (PLCB4)
   04081 Hormone signaling
    123622057 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    123622057 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123622057 (PLCB4)
   04613 Neutrophil extracellular trap formation
    123622057 (PLCB4)
   04621 NOD-like receptor signaling pathway
    123622057 (PLCB4)
   04062 Chemokine signaling pathway
    123622057 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    123622057 (PLCB4)
   04922 Glucagon signaling pathway
    123622057 (PLCB4)
   04929 GnRH secretion
    123622057 (PLCB4)
   04912 GnRH signaling pathway
    123622057 (PLCB4)
   04915 Estrogen signaling pathway
    123622057 (PLCB4)
   04921 Oxytocin signaling pathway
    123622057 (PLCB4)
   04926 Relaxin signaling pathway
    123622057 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    123622057 (PLCB4)
   04918 Thyroid hormone synthesis
    123622057 (PLCB4)
   04919 Thyroid hormone signaling pathway
    123622057 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    123622057 (PLCB4)
   04916 Melanogenesis
    123622057 (PLCB4)
   04924 Renin secretion
    123622057 (PLCB4)
   04925 Aldosterone synthesis and secretion
    123622057 (PLCB4)
   04927 Cortisol synthesis and secretion
    123622057 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    123622057 (PLCB4)
   04270 Vascular smooth muscle contraction
    123622057 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    123622057 (PLCB4)
   04971 Gastric acid secretion
    123622057 (PLCB4)
   04972 Pancreatic secretion
    123622057 (PLCB4)
   04973 Carbohydrate digestion and absorption
    123622057 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    123622057 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    123622057 (PLCB4)
   04725 Cholinergic synapse
    123622057 (PLCB4)
   04728 Dopaminergic synapse
    123622057 (PLCB4)
   04726 Serotonergic synapse
    123622057 (PLCB4)
   04720 Long-term potentiation
    123622057 (PLCB4)
   04730 Long-term depression
    123622057 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    123622057 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    123622057 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    123622057 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    123622057 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123622057 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    123622057 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    123622057 (PLCB4)
   05142 Chagas disease
    123622057 (PLCB4)
   05143 African trypanosomiasis
    123622057 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123622057 (PLCB4)
   05016 Huntington disease
    123622057 (PLCB4)
   05017 Spinocerebellar ataxia
    123622057 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    123622057 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123622057 (PLCB4)
   05415 Diabetic cardiomyopathy
    123622057 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    123622057 (PLCB4)
   04934 Cushing syndrome
    123622057 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lcat04131]
    123622057 (PLCB4)
Enzymes [BR:lcat01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     123622057 (PLCB4)
Membrane trafficking [BR:lcat04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    123622057 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    123622057 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 123622057
NCBI-ProteinID: XP_045384060
LinkDB
Position
17:31929955..32246027
AA seq 1189 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRLGAIPKDPKILAALETVGKSENDLEGRIVCVCSGTDLVNISFTYLVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRSMQIVEMYEPDEDLKKKGLMSSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQILLAGCRCIELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRSLPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGESAAPANILEDDNEEEIECADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLEHENIKKGLVTVEDEQAWMASYKYVGATTNIHPYLSAMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEEAFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGS
NT seq 3570 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgtctcttcaaa
gtggatgaatttggcttctttctgacctggaaaagtgaaggcaaggaaggacaagtgcta
gaatgttccctcatcaacagtattcggttgggagccataccaaaggatcccaaaatcctg
gctgctcttgaaactgtcggaaaatcagaaaatgatctggaagggcggatagtttgtgtc
tgcagtggaacagatctggtgaacattagcttcacctacttggtggctgaaaatccagaa
gtaaccaagcaatgggtggaaggcttgagatcaattatacacaacttcagggccaacaac
gtcagtccaatgacatgcctcaagaaacactggatgaaactggcgttcatgaccaacaca
aatggtaaaattccagttaggagtattactagaacttttgcatcagggaaaacagaaaag
gtgatctttcaagcgttaaaggagttgggtcttcccagtggaaagaatgatgaaattgag
cctgcagcatttacttatgaaaagttctatgaactgacacagaaaatttgtcctcggaca
gatatagaagatctgtttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattc
ccattctatgatgctaaaaggtcaatgcagatcgttgaaatgtatgaacctgatgaagat
ttgaagaaaaaaggcctcatgtcaagtgatgggttttgcagatatctgatgtcagacgaa
aatgccccagtcttcctagatcgcttagaactttaccaagaaatggaccaccctctggct
cactacttcatcagttcttcccataacacctatctcactggccggcagtttggcgggaag
tcgtcagtagaaatgtacagacagattcttctggctggttgcagatgcattgaacttgac
tgttgggatggaaaaggtgaagaccaagaaccaataataactcacggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacgtca
gaataccctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccactcgaaccaggcaggtctttgccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaagttgaaaaaaaacagcttgaagctttgagaagcatg
atggaagctggagaatccgctgcccctgctaacattttagaggatgataatgaagaggag
atagaatgtgctgaccaagaggaggaagctcaccccgaattcaaatttggaaatgaactt
tctgccgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcctcagat
gaccttgaacatgaaaatatcaaaaagggcctggtcacggtagaagatgagcaggcgtgg
atggcatcttataaatacgtaggtgctaccactaatatccatccatatttgtccgcaatg
atcaactatgcacagccggtaaagtttcaaggtttccatgtggctgaagaacgcaatatt
cattataacatgtcttcttttaatgaatcggtcggacttggctacctgaagacacacgcg
attgaatttgtaaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgcgggtaccttctcaaaccggatttcatgaggcggcctgatcgaacatttgat
cccttctctgaaactcctgttgatggggttattgcagccacttgttcagtgcaggtcata
tcaggtcagttcttatcagataagaaaattggcacctatgtagaggtggatatgtatggg
ttgcccaccgacactatacgtaaggagttccgaacacgcatggttatgaacaatggactc
aacccagtttacaacgaagaagcattcgtatttcggaaggtgatcctgcccgacctggct
gtcttgagaatagccgtgtatgatgacaacaacaagctgattggccagaggatcctccca
ctggacgggctccaagcagggtatcgacacatttcccttcgaaatgaaggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatacgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttcaattacggaaaagaga
gcagaccaaatgcgagctatgggcattgaaaccagtgacattgccgacgtgcccagtgat
acttccaagaatgacaagaaaggaaaagccaacactgccaaagcaaatgtgacccctcag
agtagctccgagctcagaccaaccaccacggccgccctggcttctggcgtggaagccaag
aaaggtattgaactcatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctaaattctttaaagaagaagcatgcaaag
gaacacagtaccatgcagaagttacactgcacgcaagttgacaaaattgtggcacagtat
gacaaggagaagtcgacgcatgagaaaatcctagagaaggcaatgaagaagaaaggggga
agtaattgtcttgaaatgaaaaaagaaacagaaattaaaattcagacactgacatcagac
cacaaatctaaggtcaaagagattgtggcacagcacacaaaggaatggtcagaaatgatc
aacacccacagtgcggaggagcaagaaatccgggacctgcacctcagccagcagtgcgag
ctgctgagaaagctgctcatcagcgcacacgagcagcagacccagcagctaaaactgtcc
cacgacagggaaagcaaggaaatgcgggcacaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcgagtcagg
gagttaaacagcagcaatactaaaaagtttctggaagaaagaaagagactcgcaatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctagaattcctagag
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagctga

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