Entry |
|
Symbol |
PLCB2
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
|
KO |
|
Organism |
lcat Lemur catta (Ring-tailed lemur)
|
Pathway |
lcat04070 | Phosphatidylinositol signaling system |
lcat04261 | Adrenergic signaling in cardiomyocytes |
lcat04613 | Neutrophil extracellular trap formation |
lcat04621 | NOD-like receptor signaling pathway |
lcat04723 | Retrograde endocannabinoid signaling |
lcat04750 | Inflammatory mediator regulation of TRP channels |
lcat04925 | Aldosterone synthesis and secretion |
lcat04928 | Parathyroid hormone synthesis, secretion and action |
lcat04933 | AGE-RAGE signaling pathway in diabetic complications |
lcat04935 | Growth hormone synthesis, secretion and action |
lcat04961 | Endocrine and other factor-regulated calcium reabsorption |
lcat04973 | Carbohydrate digestion and absorption |
lcat05022 | Pathways of neurodegeneration - multiple diseases |
|
Module |
lcat_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:lcat00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
123624366 (PLCB2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
123624366 (PLCB2)
04310 Wnt signaling pathway
123624366 (PLCB2)
04070 Phosphatidylinositol signaling system
123624366 (PLCB2)
04072 Phospholipase D signaling pathway
123624366 (PLCB2)
04071 Sphingolipid signaling pathway
123624366 (PLCB2)
04022 cGMP-PKG signaling pathway
123624366 (PLCB2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
123624366 (PLCB2)
04081 Hormone signaling
123624366 (PLCB2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
123624366 (PLCB2)
04613 Neutrophil extracellular trap formation
123624366 (PLCB2)
04062 Chemokine signaling pathway
123624366 (PLCB2)
09152 Endocrine system
04911 Insulin secretion
123624366 (PLCB2)
04922 Glucagon signaling pathway
123624366 (PLCB2)
04929 GnRH secretion
123624366 (PLCB2)
04915 Estrogen signaling pathway
123624366 (PLCB2)
04921 Oxytocin signaling pathway
123624366 (PLCB2)
04926 Relaxin signaling pathway
123624366 (PLCB2)
04935 Growth hormone synthesis, secretion and action
123624366 (PLCB2)
04918 Thyroid hormone synthesis
123624366 (PLCB2)
04919 Thyroid hormone signaling pathway
123624366 (PLCB2)
04928 Parathyroid hormone synthesis, secretion and action
123624366 (PLCB2)
04924 Renin secretion
123624366 (PLCB2)
04925 Aldosterone synthesis and secretion
123624366 (PLCB2)
04927 Cortisol synthesis and secretion
123624366 (PLCB2)
09154 Digestive system
04970 Salivary secretion
123624366 (PLCB2)
04971 Gastric acid secretion
123624366 (PLCB2)
04972 Pancreatic secretion
123624366 (PLCB2)
04973 Carbohydrate digestion and absorption
123624366 (PLCB2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
123624366 (PLCB2)
09156 Nervous system
04724 Glutamatergic synapse
123624366 (PLCB2)
04725 Cholinergic synapse
123624366 (PLCB2)
04728 Dopaminergic synapse
123624366 (PLCB2)
04726 Serotonergic synapse
123624366 (PLCB2)
04720 Long-term potentiation
123624366 (PLCB2)
04730 Long-term depression
123624366 (PLCB2)
04723 Retrograde endocannabinoid signaling
123624366 (PLCB2)
09157 Sensory system
04742 Taste transduction
123624366 (PLCB2)
04750 Inflammatory mediator regulation of TRP channels
123624366 (PLCB2)
09159 Environmental adaptation
04713 Circadian entrainment
123624366 (PLCB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
123624366 (PLCB2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
123624366 (PLCB2)
09174 Infectious disease: parasitic
05146 Amoebiasis
123624366 (PLCB2)
05142 Chagas disease
123624366 (PLCB2)
05143 African trypanosomiasis
123624366 (PLCB2)
09164 Neurodegenerative disease
05010 Alzheimer disease
123624366 (PLCB2)
05016 Huntington disease
123624366 (PLCB2)
05017 Spinocerebellar ataxia
123624366 (PLCB2)
05022 Pathways of neurodegeneration - multiple diseases
123624366 (PLCB2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
123624366 (PLCB2)
05415 Diabetic cardiomyopathy
123624366 (PLCB2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
123624366 (PLCB2)
04934 Cushing syndrome
123624366 (PLCB2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:lcat04131]
123624366 (PLCB2)
Enzymes [BR:lcat01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
123624366 (PLCB2)
Membrane trafficking [BR:lcat04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
123624366 (PLCB2)
Endocytosis
Macropinocytosis
Phospholipase C
123624366 (PLCB2)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
1:complement(75069827..75089121)
|
AA seq |
1190 aa
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKIPKSQKLRGVFDMDFPENTFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKFWAEDVLALAKHPLTANAPRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYYINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTIFGDMLLTEPLEKFPLEPGLPLPSPQDLRGKILIKNKKNQFSGPESPSKEPGGE
AEGSCAPNTAAGEDTVWAGEEGPELEEKEVEEEEEESGSLDEEEIKKMQSDEGTAGLEAT
AYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKSSVQFVDYNKRQMS
RIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFM
RRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTK
LSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLC
LHSESNMPLTMPALFVFLEMKDYVPDTWADLTVALTNPIKFFSAHDKKSVKLKEAMGGPP
EKPFPLGSPLASQANAASAPRSNGSAAPAAGARAREEATKEVAEPRTASLEELREQKGVV
KLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPLGPGGGGCGGYRRLGPGKGSRKK
RILPGEESAGAAPPAEGPEGADARVRELRDRLELELLRQGEEQYESVLKRKEQHAAEQMA
KMMALATEKQAAELKSLKEASEMDTKEMKKKLEAKRLERIQAMTKVTTDKMAQERLKREI
NNSHIQEVVQVIKQMTENLERHQEKLEEKQVACLEQIREMEKQFQQEALAEYEARMKGLE
AEVKESVRACLRTCFPCEAEDKPEKTCEASGELCEQQPLTAKANVQDSRL |
NT seq |
3573 nt +upstreamnt +downstreamnt
atgtctcttctcaatcctgtcctgctgccccccaaggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaacgacagtcgcctcccccgttattctccgtgtg
gatcctaagggctattacttatactggacgtatcagagcaaggagatggagtttctggac
atcaccagcatccgggacacccgctttggaaaatttgccaagatacccaagagccagaag
ctccggggtgtcttcgacatggactttcctgaaaacaccttcctgctgaagacactcaca
gtggtgtccggccccgacatggtggacctcaccttccacaacttcgtctcctacaaggag
aacgtgggcaagttctgggctgaggatgtactggccctggccaagcacccgctgacggcc
aacgcgccccgcagcaccttcctggacaagatcctagtgaagctcaagatgcagctcagc
cctgaaggcaagattcccgtgaagaattttttccagatgtttcctgctgaccgcaagagg
gtggaagctgctctcagtgcctgccacctcccaaaaggcaagaatgacgccatcaatcct
gaggacttcccagaacctgtctacaagagcttcctcatgagcctctgtcctcggccagaa
atagatgagatcttcacctcctaccatgctaaggccaaaccctacatgactaaggagcac
ctgaccaaattcatcaaccagaaacagcgggactcacggcttaactccctgctgttcccg
ccagcacgtcctgaccaggtgcagggcctcatcgacaagtatgagcccagtggcatcaac
gtgcagaggggccagctgtcacctgagggcatggtctggtttctctgtgggccagagaac
agcgtactggcccaggacaagctgctgctccaccacgacatgacacagccactcaaccat
tactacatcaactcctcgcacaacacctacctgacagccggccagttctcaggcctttcc
tcggccgagatgtaccgccaggtgctgctgtctggctgccgatgtgtggagctagactgc
tggaaggggaagcccccggacgaggagcccattatcacccacggcttcactatgaccaca
gacatcttcttcaaggaagcaattgaggcgattgcagaaagtgcctttaagacctccccc
tatcctgtcatcctgtcatttgaaaaccatgtggactcaccccgccaacaggctaagatg
gccgagtactgccggacgatctttggggatatgctgctcacagagcccctggaaaagttc
ccactggaaccaggcctccccctgcccagcccccaggatctcaggggcaagatcctcatc
aagaacaagaagaatcagttttctggccctgaatcccccagcaaggagcctggcggggag
gctgagggcagctgcgctcccaacaccgctgctggcgaggacaccgtgtgggctggtgag
gaagggcctgagctggaggagaaggaggtggaagaggaggaggaggagtcaggaagcctg
gatgaagaggagataaagaagatgcagtcagatgagggcaccgcaggcctggaggcgacg
gcttacgaggagatgtccagcctggtcaattacatccagcccacgaaattcatctccttc
gagttctctgcccagaagaatcggagttacgtcatctcctccttcacggagctcaaggct
tatgacctgctctccaagtcctcagtgcagtttgtggactacaacaagcgccagatgagc
cgcatttaccccaagggaacccgcatggactcctccaactatatgccccagatgttctgg
aatgctggatgccagatggttgccctcaacttccagacgatggacctgcccatgcagcag
aacatggcgctgtttgagttcaatgggcagagtggctacctcctcaagcatgagttcatg
cgccggccggacaagcagttcaatcccttctcagtggaccgcatcgacgtggtggtagcc
accaccctttccatcacggtgatctctgggcagttcctgtcagaacgcagtgtgcgcacc
tacgtggaagtggagctgtttggccttcctggggaccccaagaggcgctatcgtaccaag
ctgtcacccagtaccaactctatcaatcctgtctggaaggaggagccctttgtcttcgag
aagatcttgatgcctgagctggcctccctcagggtggctgtgatggaggaaggcaacaag
tttctaggacatcgcatcatccccattaatgccctaaattctgggtaccaccatctgtgc
ctgcacagcgagagcaacatgcccctcactatgcctgcgctcttcgtcttcctggagatg
aaggactatgtacctgacacctgggcagatctcaccgtggccctcaccaaccccatcaag
ttcttcagtgcccatgacaagaagtctgtgaagctcaaggaggccatgggaggtccgcct
gagaagcccttcccactcgggagtccactcgccagccaggccaatgcggcatcggcccca
aggagcaacgggtcagcagcccccgctgccggggccagagccagggaggaggccacgaaa
gaagtcgcggagccgaggaccgccagcctggaggagctccgggagcagaagggcgtcgtg
aagctgcagcggcggcacgagaaggagctgcgggagctggagcggcgcggcgcgcggcgc
tgggaggagctgctgcagcggggcgcggcgcagctggcggagctcgggccgctgggcccc
gggggcggtggctgcggcggataccgcaggctcggccccggcaagggctcccgcaagaag
agaatcctgcccggggaggagagcgcaggggcagcgccgccggcagagggccccgagggc
gcggacgcgcgcgtgcgggagctgagggacaggctggagctggagctgctgcggcagggc
gaggagcagtacgagagcgtcctgaagcgcaaggagcagcacgcggctgagcaaatggcc
aagatgatggcgctggccaccgagaaacaggccgcagagctgaagtccctcaaggaggcc
tcggagatggacaccaaggagatgaagaaaaagctggaggccaagaggctggagcggatc
caggctatgaccaaagtcaccacagacaagatggcccaggagaggttgaagagagagatt
aataactcccacatccaggaagtggtgcaggtcatcaagcagatgacagagaacctggag
cggcaccaggagaagctggaggagaagcaggtggcctgcttggaacagatccgggagatg
gaaaagcagttccagcaggaggcgctggcagagtacgaggccaggatgaagggtctggag
gccgaggtgaaggagtcggtgagggcctgcctcaggacctgcttcccctgcgaggccgag
gacaagcctgagaagacctgcgaggcctctggggagctgtgtgagcagcagccactcaca
gcaaaggccaacgtccaggacagccgcctctga |