Lemur catta (Ring-tailed lemur): 123625473
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Entry
123625473 CDS
T08326
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
lcat
Lemur catta (Ring-tailed lemur)
Pathway
lcat00562
Inositol phosphate metabolism
lcat01100
Metabolic pathways
lcat01521
EGFR tyrosine kinase inhibitor resistance
lcat04012
ErbB signaling pathway
lcat04014
Ras signaling pathway
lcat04020
Calcium signaling pathway
lcat04062
Chemokine signaling pathway
lcat04064
NF-kappa B signaling pathway
lcat04066
HIF-1 signaling pathway
lcat04070
Phosphatidylinositol signaling system
lcat04072
Phospholipase D signaling pathway
lcat04360
Axon guidance
lcat04370
VEGF signaling pathway
lcat04380
Osteoclast differentiation
lcat04611
Platelet activation
lcat04613
Neutrophil extracellular trap formation
lcat04625
C-type lectin receptor signaling pathway
lcat04650
Natural killer cell mediated cytotoxicity
lcat04662
B cell receptor signaling pathway
lcat04664
Fc epsilon RI signaling pathway
lcat04666
Fc gamma R-mediated phagocytosis
lcat04670
Leukocyte transendothelial migration
lcat04722
Neurotrophin signaling pathway
lcat04750
Inflammatory mediator regulation of TRP channels
lcat04919
Thyroid hormone signaling pathway
lcat04933
AGE-RAGE signaling pathway in diabetic complications
lcat04935
Growth hormone synthesis, secretion and action
lcat05167
Kaposi sarcoma-associated herpesvirus infection
lcat05169
Epstein-Barr virus infection
lcat05170
Human immunodeficiency virus 1 infection
lcat05171
Coronavirus disease - COVID-19
lcat05200
Pathways in cancer
lcat05205
Proteoglycans in cancer
lcat05206
MicroRNAs in cancer
lcat05214
Glioma
lcat05223
Non-small cell lung cancer
lcat05225
Hepatocellular carcinoma
Module
lcat_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
lcat00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
123625473 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
123625473 (PLCG2)
04014 Ras signaling pathway
123625473 (PLCG2)
04370 VEGF signaling pathway
123625473 (PLCG2)
04064 NF-kappa B signaling pathway
123625473 (PLCG2)
04066 HIF-1 signaling pathway
123625473 (PLCG2)
04020 Calcium signaling pathway
123625473 (PLCG2)
04070 Phosphatidylinositol signaling system
123625473 (PLCG2)
04072 Phospholipase D signaling pathway
123625473 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
123625473 (PLCG2)
04613 Neutrophil extracellular trap formation
123625473 (PLCG2)
04625 C-type lectin receptor signaling pathway
123625473 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
123625473 (PLCG2)
04662 B cell receptor signaling pathway
123625473 (PLCG2)
04664 Fc epsilon RI signaling pathway
123625473 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
123625473 (PLCG2)
04670 Leukocyte transendothelial migration
123625473 (PLCG2)
04062 Chemokine signaling pathway
123625473 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
123625473 (PLCG2)
04919 Thyroid hormone signaling pathway
123625473 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
123625473 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
123625473 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
123625473 (PLCG2)
04380 Osteoclast differentiation
123625473 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
123625473 (PLCG2)
05206 MicroRNAs in cancer
123625473 (PLCG2)
05205 Proteoglycans in cancer
123625473 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
123625473 (PLCG2)
05214 Glioma
123625473 (PLCG2)
05223 Non-small cell lung cancer
123625473 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
123625473 (PLCG2)
05171 Coronavirus disease - COVID-19
123625473 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
123625473 (PLCG2)
05169 Epstein-Barr virus infection
123625473 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
123625473 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
123625473 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
lcat04131
]
123625473 (PLCG2)
Enzymes [BR:
lcat01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
123625473 (PLCG2)
Membrane trafficking [BR:
lcat04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
123625473 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
123625473 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
SH3_1
C2
SH3_9
PH
PH_12
SH2_1
EF-hand_PLCG1
SH3_2
PH_14
Adhesin_E
GDPD
Motif
Other DBs
NCBI-GeneID:
123625473
NCBI-ProteinID:
XP_045389994
LinkDB
All DBs
Position
20:complement(12933096..13064333)
Genome browser
AA seq
1265 aa
AA seq
DB search
MTTMVNMDALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
KWLSGLKILHQEAMNASTPTMIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKLSSA
KFLKDKFVEMGAHKDELSFEQFHLFYKNLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQNMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCVELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPLILSIEEHCSVEQQRHMAKT
FKEVFGDLLLVKPTEVSADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAVADAKLSFSDDIEQTVEEEAPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCTETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYY
LTDNLTFSSIYDLIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAEDML
MRIPRDGAFLIRRRDGSDSFAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVNYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKQSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEEMEKQII
EDNPLGSLCRGILDLNTYNVVKAPHGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIVRQKPLDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTETYHPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALIKEFNVNENQLQLYQEKCSRRLREKRVSN
SKFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgaccaccatggtcaacatggatgcccttccagaatatgagaagagtcagatcaagaga
gccctggagctggggacagtgatgaccgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaggaaatccgcccagggaagaattccaaa
gactttgagcgtgcgaaagccgtccgccagaaggaagactgctgcttcaccatcctgtac
ggcactcagttcgtcctcagcacgctcagcttggcagctgactctaaagaagatgcagtt
aagtggctctctggcttgaaaatcttacaccaagaagcgatgaatgcatccacacccacc
atgatcgagagttggctgagaaagcagatttattctgtggatcaaacgagaagaaacagc
atcagcctccgagagttgaagaccatcttgcccctggtcaacttcaaactgagcagcgcc
aagttcctcaaagataagtttgtggaaatgggtgcacacaaagatgagctcagctttgaa
cagttccatctcttctataaaaaccttatgtttgaacagcaaaaatcgattctcgatgaa
ttcaaaaaggattcctcggtgttcatcctggggaacactgaccggcctgatgcctctgcc
gtttacctgcacgacttccagaggtttctcttacatgaacagcaggagctctgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcatcgacgacacgatgcgggaaacc
gcggagcctttcttgttcgtggacgagttcctcacctatctgttttcacgagaaaacagc
atctgggacgagaagtacgacgtggtggacatgcagaacatgaacaaccccctgtcccat
tactggatctcctcgtcccataacacgtacctcacaggggaccagctgcggagcgagtcg
tccccggaggcgtacatccgctgtctgcgcatgggctgtcgctgcgtcgagctggactgc
tgggacgggcccgacgggaagcctgtcatctaccacggctggacgcggaccaccaagatc
aagtttgatgatgttgtgcaggccatcaaagaccatgcctttgtcacctccagcttcccg
ctgatcctgtccatcgaggagcactgcagcgtggagcagcagcgccacatggccaagacc
ttcaaggaggtgttcggcgacctgctgctggtgaagcccacggaggtcagtgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcaacgtggaggacaagaaggatgaacacaagcaacagggcgaa
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgcgccgtcgccgat
gccaagctgtccttcagtgacgacattgaacagactgtggaggaggaggcgccccaggat
ataccccccacagagctgcattttggggagaaatggttccacaagaaggtcgagaagagg
acgagtgccgagaagttgctgcaggaatactgcaccgagacggggggcaaggacggcacc
ttcttggtgcgggagagcgagaccttccccaacgactacaccctgtccttctggcgctcg
ggccgggtccagcactgccggatccgctccaccatggagggcgggaccatgaagtactac
ctgactgacaacctcaccttctccagcatctacgacctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcaccgaccccgtgcccaaccccaacccc
cacgagtccaagccgtggtactacgacaggctgagccgaggagaagcagaggacatgctg
atgcgaattccccgggacggagccttcctgatccggaggcgggacggcagcgactccttc
gccatcaccttcagggctcggggcaaggtgaagcactgccgcatcaaccgggacggccgg
cacttcgtgctgggcacctccgcctattttgagagccttgtggagctcgtcaattactac
gagaagcacgccctctaccgaaagatgaggctgcgctaccccgtgacccccgagctcctg
gagcgctacaacatggaaagagatataaactccctctatgatgtcagcagaatgtacgtg
gatccgagtgaaatcaacccttccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcaaagcgatgagctgagcttctgccgtggcgccctcatccacaatgtctcc
aaggagcccgggggctggtggaagggagattacgggaccaggatccagcagtacttcccg
tccaattacgttgaggacatttccaccgctgacgtggaggagatggaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagccccacacgggaaaaaccagaagccattcgtcttcatcctggagcccaagaag
cagggtgaccctccggtggagtttgccacagacagggtggaagagctctttgagtggttt
cagagcatccgggagatcacctggaagatcgacaccaaggagaacaacatgaagtactgg
gagaagaaccaatccatcgccatcgagctctctgacctggtcgtctactgcaaaccaacc
agcaaaaccaaggataacttagaaaatcctgacttccgagaaatccgttcctttgtggag
acgaaggctgacagcatcgtcagacagaagcccctcgatctcttgaagtacaatcaaaag
ggcctgacccgtgtctaccccaagggacaaagagttgactcttcgaactacgatcccttc
cgcctctggctgtgtggctcccagatggtggcgctcaatttccagactgcagataagtac
atgcagatgaatcatgcgttgttttctctcaacgggcggacgggctatgtcctgcagccc
gagagcatgaggacagagacgtaccacccgatgccacccgagtcccagaggaaaatcctg
atgactctgactgtcaaggtcctcggtgcccgccatctccccaaacttgggcgaagtatt
gcttgtccctttgtcgaggtggaaatatgcggagccgagtatgacaacaacaagtttaag
acaacagtcgtgaatgataatggcctcagccctgtctgggctccaacacaggagaaggtg
acatttgagatttacgacccaaacctggcatttctacgctttgtggtttacgaggaagat
atgttcagtgaccccaactttcttgctcatgccacgtaccccattaaaggaatcaaatca
ggatttaggtctgtccctctgaagaatgggtacagtgaggacatcgagctcgcttccctc
ctggttttctgcgagatgcggccagtcctggagagcgaggaggaactctactcttcctgt
cgccagctgcggaggcggcaagaagaactgaacaaccagctctttctgtatgacacacac
cagaacttgcgcaacgccaaccgggacgccctcattaaagagttcaatgtcaacgagaac
cagctccagctctaccaggagaagtgcagccggaggttaagagagaagagagtcagcaac
agcaagttttactcatag
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