KEGG   Lemur catta (Ring-tailed lemur): 123626609
Entry
123626609         CDS       T08326                                 
Symbol
IKBKB
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
  KO
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
lcat  Lemur catta (Ring-tailed lemur)
Pathway
lcat01523  Antifolate resistance
lcat04010  MAPK signaling pathway
lcat04014  Ras signaling pathway
lcat04062  Chemokine signaling pathway
lcat04064  NF-kappa B signaling pathway
lcat04068  FoxO signaling pathway
lcat04150  mTOR signaling pathway
lcat04151  PI3K-Akt signaling pathway
lcat04210  Apoptosis
lcat04380  Osteoclast differentiation
lcat04620  Toll-like receptor signaling pathway
lcat04621  NOD-like receptor signaling pathway
lcat04622  RIG-I-like receptor signaling pathway
lcat04623  Cytosolic DNA-sensing pathway
lcat04625  C-type lectin receptor signaling pathway
lcat04657  IL-17 signaling pathway
lcat04658  Th1 and Th2 cell differentiation
lcat04659  Th17 cell differentiation
lcat04660  T cell receptor signaling pathway
lcat04662  B cell receptor signaling pathway
lcat04668  TNF signaling pathway
lcat04722  Neurotrophin signaling pathway
lcat04910  Insulin signaling pathway
lcat04920  Adipocytokine signaling pathway
lcat04930  Type II diabetes mellitus
lcat04931  Insulin resistance
lcat04932  Non-alcoholic fatty liver disease
lcat04936  Alcoholic liver disease
lcat05010  Alzheimer disease
lcat05132  Salmonella infection
lcat05135  Yersinia infection
lcat05142  Chagas disease
lcat05145  Toxoplasmosis
lcat05160  Hepatitis C
lcat05161  Hepatitis B
lcat05162  Measles
lcat05163  Human cytomegalovirus infection
lcat05164  Influenza A
lcat05165  Human papillomavirus infection
lcat05166  Human T-cell leukemia virus 1 infection
lcat05167  Kaposi sarcoma-associated herpesvirus infection
lcat05168  Herpes simplex virus 1 infection
lcat05169  Epstein-Barr virus infection
lcat05170  Human immunodeficiency virus 1 infection
lcat05171  Coronavirus disease - COVID-19
lcat05200  Pathways in cancer
lcat05206  MicroRNAs in cancer
lcat05208  Chemical carcinogenesis - reactive oxygen species
lcat05212  Pancreatic cancer
lcat05215  Prostate cancer
lcat05220  Chronic myeloid leukemia
lcat05221  Acute myeloid leukemia
lcat05222  Small cell lung cancer
lcat05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lcat05417  Lipid and atherosclerosis
lcat05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lcat00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123626609 (IKBKB)
   04014 Ras signaling pathway
    123626609 (IKBKB)
   04064 NF-kappa B signaling pathway
    123626609 (IKBKB)
   04668 TNF signaling pathway
    123626609 (IKBKB)
   04068 FoxO signaling pathway
    123626609 (IKBKB)
   04151 PI3K-Akt signaling pathway
    123626609 (IKBKB)
   04150 mTOR signaling pathway
    123626609 (IKBKB)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    123626609 (IKBKB)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    123626609 (IKBKB)
   04621 NOD-like receptor signaling pathway
    123626609 (IKBKB)
   04622 RIG-I-like receptor signaling pathway
    123626609 (IKBKB)
   04623 Cytosolic DNA-sensing pathway
    123626609 (IKBKB)
   04625 C-type lectin receptor signaling pathway
    123626609 (IKBKB)
   04660 T cell receptor signaling pathway
    123626609 (IKBKB)
   04658 Th1 and Th2 cell differentiation
    123626609 (IKBKB)
   04659 Th17 cell differentiation
    123626609 (IKBKB)
   04657 IL-17 signaling pathway
    123626609 (IKBKB)
   04662 B cell receptor signaling pathway
    123626609 (IKBKB)
   04062 Chemokine signaling pathway
    123626609 (IKBKB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123626609 (IKBKB)
   04920 Adipocytokine signaling pathway
    123626609 (IKBKB)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    123626609 (IKBKB)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    123626609 (IKBKB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123626609 (IKBKB)
   05206 MicroRNAs in cancer
    123626609 (IKBKB)
   05208 Chemical carcinogenesis - reactive oxygen species
    123626609 (IKBKB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123626609 (IKBKB)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    123626609 (IKBKB)
   05221 Acute myeloid leukemia
    123626609 (IKBKB)
   05220 Chronic myeloid leukemia
    123626609 (IKBKB)
   05215 Prostate cancer
    123626609 (IKBKB)
   05222 Small cell lung cancer
    123626609 (IKBKB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123626609 (IKBKB)
   05170 Human immunodeficiency virus 1 infection
    123626609 (IKBKB)
   05161 Hepatitis B
    123626609 (IKBKB)
   05160 Hepatitis C
    123626609 (IKBKB)
   05171 Coronavirus disease - COVID-19
    123626609 (IKBKB)
   05164 Influenza A
    123626609 (IKBKB)
   05162 Measles
    123626609 (IKBKB)
   05168 Herpes simplex virus 1 infection
    123626609 (IKBKB)
   05163 Human cytomegalovirus infection
    123626609 (IKBKB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123626609 (IKBKB)
   05169 Epstein-Barr virus infection
    123626609 (IKBKB)
   05165 Human papillomavirus infection
    123626609 (IKBKB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123626609 (IKBKB)
   05135 Yersinia infection
    123626609 (IKBKB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    123626609 (IKBKB)
   05142 Chagas disease
    123626609 (IKBKB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123626609 (IKBKB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123626609 (IKBKB)
   05418 Fluid shear stress and atherosclerosis
    123626609 (IKBKB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    123626609 (IKBKB)
   04936 Alcoholic liver disease
    123626609 (IKBKB)
   04932 Non-alcoholic fatty liver disease
    123626609 (IKBKB)
   04931 Insulin resistance
    123626609 (IKBKB)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    123626609 (IKBKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lcat01001]
    123626609 (IKBKB)
Enzymes [BR:lcat01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     123626609 (IKBKB)
Protein kinases [BR:lcat01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   123626609 (IKBKB)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo ubiquitin YrbL-PhoP_reg APH Glyco_hydro_65m VWA7_N GTSE1_N TPR_MLP1_2
Other DBs
NCBI-GeneID: 123626609
NCBI-ProteinID: XP_045391679
LinkDB
Position
22:complement(5335014..5389768)
AA seq 782 aa
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLSHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
MDIVVSEDLNGTVKFSSSLPYPNNLNGVLAQRLEKWLQLMLMWHPRQRGTDPTYGPNGCF
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
LIPDKPATQCISDSKLNEGRTLDMDLVFLFDNSKTTYETQISPRPQPESVSCILQEPKRN
LSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRSNSSLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKHLVERMMAL
QTDIVDLQRSPMGRKPGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQG
FEKKVRVIYTQLSKTVVCKQKALELLPKVDEVVNLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSHPGQLMSQPSAAPSSLPESAKKSEELVAEAHTLCTQLE
SAMQDTVRGQDQSFTVTAFVDPAIPCPFFLQQKRKEMERQPSVTHNLSIYLGFSSTYFLS
FV
NT seq 2349 nt   +upstreamnt  +downstreamnt
atgagctggtcaccttccctgccaacccagacatgtggggcctgggaaatgaaagaacga
cttgggacagggggatttggaaatgtcatccgatggcacaatcaggaaacaggtgagcag
atcgccatcaagcagtgccggcaggagctcagcccccggaaccgcgagcgctggtgcctg
gagatccagatcatgaggaggctgagccaccccaatgtggtcgccgcccgggatgtcccc
gaggggatgcagaacttggcccccaatgacttgcccctgctggccatggagtactgccaa
ggaggggacctccgaaagtacctgaaccagtttgagaactgctgcggcctgcgggaagga
gccatcctcaccttgctgagtgacattgcctctgcacttagatacctgcatgaaaacaga
atcatccaccgggacctcaagccggagaacatcgttctgcagcaaggagagcagagatta
atacacaaaattattgacctgggatatgccaaggaactggatcagggcagcctgtgtact
tcctttgtggggaccctgcagtacctggccccggagctgctggagcagcagaagtacacg
gtgactgttgactactggagctttggcaccttggccttcgagtgcatcacgggcttccgg
cccttccttcccaactggcagcccgtgcagtggcactcgaaagtccggcagaagagtgag
atggacattgttgttagtgaagacttgaatggaacagtgaagttttcaagctctctacca
taccccaataatcttaatggcgtcctggcgcagcggctggagaagtggctgcagctgatg
ctgatgtggcacccccgacaacggggcacagaccccacgtatgggcccaatggctgcttt
aaggccctagatgacatcttaaacctgaagctggttcatatcttgaacatggtcacgggc
accattcacacctacccagtgacggaggatgagagtctgcagagcttaaaggccagaatc
cagcaggacacggggatcccagaggaggaccaggagctgctgcaggaggcgggtctggct
ttgatcccggacaagccggccacgcagtgcatttcagacagcaagttaaatgagggccgc
acgctggacatggatcttgtttttctctttgacaacagtaaaaccacctacgagactcag
atctccccacggccccagcctgagagtgtcagctgtatccttcaagagcccaagaggaat
ctctctttcttccagctgaggaaggtgtggggccaggtctggcacagcatccagaccctg
aaggaggattgcaaccggctgcagcagggacagcgcgccgccatgatgaatctcctccgg
agcaacagctccctgtccaagatgaagaattccatggcgtccatgtctcagcagctcaag
gccaagctggattttttcaaaaccagcatccagatcgacctggagaagtacagtgagcaa
accgagtttgggatcacttcagataaactgctgctggcctggagggagatggaacaggct
gtggagctgtgtgggcgggagaacgaagtgaagcacctggtggagcggatgatggcgctg
cagactgacatcgtggacttgcagcgcagcccgatgggccggaagcccggggggacgctg
gacgacctagaagagcaagccagagagctgtacaggagactgagggagaaaccacgggac
cagcgcactgatggggacagtcaggagatggtgcggctgctgctgcaggccattcagggc
ttcgagaagaaagtgcgagtgatctacacgcagctcagcaaaaccgtggtctgcaagcag
aaggctctggaattgctgcccaaggtggacgaggtggtgaacttaatgaacgaggatgag
aagaccgttgttcggctccaggagaagcggcagaaggagctctggaacctcctaaagatc
gcctgcagcaaggtccgaggtcctgtcagtggcagcccggacagcatgaatgcttctcga
ctgagtcaccctggtcagctgatgtctcagccctctgcagcccccagcagtttacctgag
tcagccaagaaaagtgaggagctggttgctgaagctcacaccctctgcacccagctagaa
agtgccatgcaagacaccgtgagagggcaggaccagagtttcacggtaacagcctttgtg
gacccggctattccatgtcctttctttctgcagcaaaagaggaaagaaatggaaaggcaa
cccagtgttacccacaatctcagtatatacttgggattttctagcacatattttttatca
tttgtataa

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