Lemur catta (Ring-tailed lemur): 123632875 Help Entry 123632875         CDS       T08326                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism lcat  Lemur catta (Ring-tailed lemur) Pathway lcat04020   Calcium signaling pathway lcat04371   Apelin signaling pathway lcat04713   Circadian entrainment lcat04921   Oxytocin signaling pathway lcat04970   Salivary secretion lcat05010   Alzheimer disease lcat05012   Parkinson disease lcat05020   Prion disease lcat05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:lcat00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     123632875 (RYR3)    04020 Calcium signaling pathway     123632875 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     123632875 (RYR3)   09154 Digestive system    04970 Salivary secretion     123632875 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     123632875 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     123632875 (RYR3)    05012 Parkinson disease     123632875 (RYR3)    05020 Prion disease     123632875 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     123632875 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lcat04040]     123632875 (RYR3) Ion channels [BR:lcat04040]  Voltage-gated cation channels   Ryanodine receptor    123632875 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  123632875 NCBI-ProteinID:  XP_045399605 LinkDB All DBs Position 1:complement(69106888..69445734) Genome browser AA seq 4857 aa AA seqDB search MCLSLGEDEVVLQCIATVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDLCVCNFVLE QSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYLTCLTTSRSQTD KLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSISNGNI QVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTDQNDSQHRRIFY EAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLLLQDRGKS DTKSTAFSFRPSKEIKEKLDSSHKRDIEGMGLPEIKYGDSICFVQHIASGLWVTYKAQDA KTPRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFVSGNNRAAAP VTLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDR LNIYNSVAHFAGIAREESGTAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDR LESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDVLCSLCLCNGVA VRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVDP FLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAVASI NQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMSFSAGVKVRFLM GGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGTTQFLSQASFIP CPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPCLVEFSKL PETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMSNGYKPSPLDLS DVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDERTKK SNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSYAVRSGKWYFEF EVVTGGDMRVGWARPGCRPDIELGADNQAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCM INLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGRMNLGTDASTFK FYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPRDHPHIEVVRIDGTMDSPPCLKV THKTFGSQNSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEILSHTTTQCYYA VRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHESVKRSNCYMVW GGDIVASSQRSSRSNVDLEVGCLVDLAMGMLSFSANGKELGTCYQVEPNTKVFPAVFLQP TSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLWSRMPNSFLKVE TERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQEDLMQFHYHTLRLYSALCAL GNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKERKLMMKNEYII PITSTTRNIRLYPDQSKRHGLPGVGLRTCLKPEFRFSTPCFVTTSEEHQKQSPEIPLETL KTRALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLVGTLLVMGVFDDDDVRQILLLID PSVFGEHGGETEEGTEKEEVTQVEEKAVEAGEKASKEAPVRGLLQTRLPESVKVQMCELL SYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTREFRSPPQ EQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEEDASWMGKLCILM CKIKGPREPEKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVRMMFNLLRRQYD SIGELLQALRKTYTISQVSVSDTINLLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNK VFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYFCRISRQNQKAM FEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGL QSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPA LRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVTEDDEEEEEIVHMGNAIMSFYSAL IDLLGRCAPEMHLIQTGKGEAIRVRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPD MAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALA LNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLA ICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVE EELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQVSV DADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKTQSGWKYGISLDENVKTHP LIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQASQ GNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTL TAKEKFRDREKAQDLFKFLQVNGVIVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQ EFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYA SHKEKEMVASLFCKLAALVRHRISLFGSDSSTMVSCLHILAQTLDTRTVMKSGSELVKAG LRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVAQHQ FGVDLLLSDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLN RYNPLSVFNTKTSRERSILGMPDTVEEMCPDIPQLEELMKEINDLAESGARYMEMPHVIE VVLPMICSYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGDILKIINNNLGIEEASWM KRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADGRGDTQEAELLIL DEFAVLCRDLYAFYPILIRYVDNSRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREE QNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVAALK KMLPIGLNMCTPGDQELISLAKSRYGYRDTDEEVKEHLRNNLHLQEKSDDPAVKWQLNLY KDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFR MAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEETEKQPDP LHQIILHFSRNALTERSKLEDDPLYTSYCSMMAKSCQSGEDEEEEEDKEKTFEEKEMEKQ KTLYQQARLHERGTAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNTGVQQKMLDYLK EKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFT RDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKD IIDESGQHNFSKALAVTKQIFNSLTEYIQGPCVGNQQSLAHSRLWDAVVGFLHVFANMQM KLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKF FDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADEND MFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRI EIMGGAKKIERVYFEITESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDT IFEMQLASQISESDSADRPEEEEEEDASYILEIEGEEEEDKCFESASAFAMACASVKRSV TSFLQKATLKNLRKQYRNVKKMSAKELVKVFFSFFWTLFLGLFQLFFGILGGIFQVLWST VFGGGLVEGAKNIRVTKILGDMPDPTQFGIHEDAVETERAEGTEPGITAELAHFIKGEKA DADMMPDLFGLHPRKEGSLKHGPEVGLGDLSEIIGKDEAPTLESTVRKKRKAQAAEIKAA HEAEGKLDSEKADMEDGEKEDRAKEEEQAEYLWAEVTKRRKRRHGQKVEKPEALTANFFK GLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDVANLWNSFN DEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKVPLVVFKREKEIAR KLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAE LLGLDKNALDFSPIEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSV LGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFR KFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITF FFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTL QEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14574 nt NT seq  +upstreamnt  +downstreamnt atgtgcctgtcattgggggaagatgaagtggtcctccagtgcatcgccaccgttcacaag gagcagaggaagttctgcctggccgctgagggacttggcaatcgcctgtgcttcttggaa cccacttcagaagccaagtatattcctccagatctctgcgtctgcaattttgtgctggag cagtccctctctgtcagagccctgcaggaaatgcttgccaacacaggtgaaaatggaggc gaaggggcagcacaagggggtggccacaggaccctgctgtatggacatgcgattctcctg aggcactccttcagcggaatgtatctaacatgtttgactacatcaagatcccagacggat aaacttgcctttgatgtaggtctacgggaacatgccacaggagaagcctgctggtggact atacatcctgcttccaaacagaggtctgagggagagaaagttcgaattggcgatgatctc atccttgtcagtgtgtcctctgaaagataccttcatctctcaatatcaaacggtaacata caagtggatgcctcctttatgcaaacactctggaatgtacatcctacgtgctcaggaagt agcatcgaagaaggatacctacttggtgggcatgtagtacgtctcttccacggtcatgat gagtgtttgacgataccatctacagaccagaatgattcccagcacaggagaatattctat gaagctgggggagctgggacaagagccaggtctctgtggagagtggaaccccttcggata agctggagtggcagtaacatcagatggggccaggctttccgacttcggcatctgaccaca ggccactacttggccttgacagaggaccagggcctcctgctgcaagaccgggggaagtca gacaccaagtccacagccttctctttccggccgtcaaaggaaatcaaggagaaattggat tccagtcacaagcgagatatcgaaggcatgggccttccagagatcaagtatggagattcc atctgctttgtccagcatatagccagtggtctgtgggtgacgtacaaagcacaagatgcc aagacaccccggctgggacctctgaaaagaaaggtcatactgcatcaggaaggccacatg gatgacgggttaacactgcagagatgccagcgcgaggagtcccaggctgctcggatcatc cggaacaccacagccttgttcagccagtttgtcagtggcaacaatcgcgcagccgcccct gtcaccctgcccatagaagaggtcctgcagaccctgcaggacttgattgcctacttccag cccccagaggaggagatgcagcatgaagacaagcagaacaagctccgctcgctcaaaaac agacagaatcttttcaaggaagagggaatgttggcccttgtcttaaattgcatcgatcgc ttaaatatctacaatagcgtagcacactttgcagggattgccagggaagagagtggtacg gcctggaaagaaattctgaacctcctctacaaattgctggctgctctcattcgtggaaac agaaacaactgtgctcaattctccaataaccttgattggctaatcagtaaattggacaga ctagagtcttcctcaggtatcttggaagttttgcactgcatcttgattgaaagcccagaa gccttaaatctgatagcagagggacacatcaagtccatcatctccctgttggataagcat gggcggaatcacaaggttctagatgtcctgtgctccctatgcctctgcaatggggttgca gtgagagccaaccagaatctgatctgcgacaacttactgccccggagaaacctgctcctg caaacacgactcattaacgatgttaccagtatccggccaaacatcttcctgggagtcgct gagggctcagcccagtataagaagtggtactttgagctgattatcgaccaagtggacccc ttcctaacagcagagcccacacatctgcgggtgggctgggcctcttcctcaggctatgcc ccgtacccaggaggtggagaaggatggggaggcaatggtgttggtgatgacctgtactcc tatggctttgatggacttcacctttggtcagggcggatacccagagccgtggcctccatc aaccagcacctcctgaaatcagatgatgtggtcagctgctgccttgacctcggagtgccc agcatctccttccgcatcaacgggcagccggtgcaggggatgtttgagaacttcaacaca gacgggctcttcttccctgtgatgagcttttcagcaggtgtcaaggtacgtttcctgatg ggtggacgtcatggagaatttaagttcctgcctccctctggctacgccccttgctatgaa gccttacttccaaaagagaaaatgagattggagcctgtcaaagaatataaacgtgatgct gaaggggtcagagatctgctgggcaccacccagttcctctcccaagcctccttcatcccc tgccccatagacaccagtcaggttgttttgccacctcacctagagaagatccgagacaga ctggctgaaaacatccacgagctctggggaatgaataagatagagctcggctggactttc ggcaagatacgagatgacaacaaaagacaacacccttgccttgtggagttttcaaaactc cccgaaactgagaagaattataacttgcaaatgtcaactgaaaccttaaaaaccctcctg gccctggggtgccacattgctcacgtcaatccagctgcagaggaggatctcaagaaggtc aaactgcccaaaaactacatgatgtccaatggctataagccatcccctttggacttgtct gatgtaaagctcttacctcctcaagaaattttagtggataagcttgcagaaaatgcacac aatgtttgggcaaaagacagaataaaacaaggatggacctatggcattcaacaggatttg aagaacaaaaggaatccccgtctggtgccatatgcattactagatgagcgtaccaagaag tcaaacagggacagcctgcgtgaagctgttcgcacatttgttggttacgggtataatatt gagccatcggaccaagaactagctgacccagctgtggagaaagtcagcatagacaagatc cgattcttccgggtagagcggtcgtatgcagtgagatctggaaagtggtattttgagttt gaggtggtgaccggaggagacatgcgggttggctgggccaggccaggctgtcgccctgac atcgagctgggtgctgacaaccaagccttcgtgtttgaaggcagcaggggccagcgttgg catcaagggagtgggtattttgggcgtacctggcagccaggagatgtggttggatgtatg attaacctggatgatgcttcgatgatcttcacactgaatggggagctgctgatcaccaac aaaggctctgaacttgcctttgctgactacgagattgagaatggcttcgtgcctatctgc tctctggggctgtctcagatcggccgcatgaatcttgggacagacgccagtaccttcaag ttttataccatgtgcggcctccaagagggctttgagccttttgctgtcaacatgaaccga gatgttgcaatgtggttcagcaagcgcctcccgacgtttgtcaacgtgcccagagatcac ccgcacatagaggtcgtgaggattgatggcaccatggacagcccgccttgcctcaaggtg acccacaagacgtttggctcacagaacagcaatgccgacatgatctattgccgtctaagc atgcctgtcgagtgccactcctccttcagccacagcccctgtctggacagtgaagctttc cagaagaggaaacagatgcaagaaatactctctcataccacaacacagtgctactacgct gtccgcatctttgccggacaggacccctcctgcgtctgggtcggatgggtgactccagac tatcacttgtacagtgaaaaatttgacctgaataaaaactgcacggtgactgtcaccctg ggggatgaaagaggccgggtccacgaaagtgtgaaacgcagcaactgctacatggtctgg ggtggggacattgtggccagttcccagagatccagtcggagcaacgtggacctggaggtc ggctgtcttgtggatctggcgatgggcatgttgtccttctcagccaatgggaaagaactc ggcacctgctaccaggtggagcccaataccaaagtattcccagcagtcttcctgcagcct acaagtacttctttgtttcagtttgaactgggaaagctgaagaatgcgatgcccctgtcg gcggccatattcaagagtgaagagaagaaccccgtaccgcagtgtccacctcggctggac gtgcagaccatccagcccgtgctctggagccgcatgcccaacagcttcctgaaggtggag acggagcgggtgagcgagcgccacggctgggtggtgcagtgcctggagcccctgcagatg atggcgctccacatccccgaggagaacaggtgtgtggatgtcctggagctctgtgagcag gaggacctgatgcagttccattaccacacgctgcgactctacagcgccttgtgtgccctg ggaaacagccgggtagcctacgccctgtgcagccacgtggacctctcccagctcttctac gccatcgacaacaagtacctccctggcctccttcggtcaggtttctatgacctactcatc agcatccacctggccaatgctaaggagaggaagctgatgatgaagaacgagtacatcatc cccattaccagcacgaccaggaatatccgcctgtacccagaccagtccaagaggcacgga ctgcccggggtgggcctgagaacgtgcctcaagccagagttccggttctccaccccttgc tttgtcacgaccagtgaggagcatcaaaagcagagccccgagatccccttggagaccctc aagacgagggcactgagcatgctgacggaggcagtgcagtgcagcggggcccacatccgc gaccctgttggggggtccgtggagttccagtttgtgcccgtgctgaaactcgttggaacc ctgctggtcatgggggtgtttgatgatgacgacgttcggcagatcctcctcctaatagat ccctctgtgtttggggagcacggtggggagacggaggaggggacagaaaaggaggaagtg acccaggtggaggagaaggcagtggaggctggagagaaggccagcaaggaggctcccgtc agaggcttgttgcagacccgcctaccagagtccgtcaaagtgcagatgtgtgagctcctc agctatctctgtgactgtgagctacaacaccgagtggaggccattgtggcatttggtgac atttatgtctccaagctgcaggcaaatcagaagttccgctacaatgagctcatgcaggcc ctgaacatgtctgcagccttgaccgctcggaagaccagggagttccgttcacccccacag gagcagatcaacatgcttcttaactttcaactgggagagaactgcccctgcccagaggag atccgggaggagttgtacgacttccacgaggaccttctccttcactgtggggttcccctg gaggaagaggaagaagaggaggaggacgcctcctggatgggaaaactgtgcatcttgatg tgtaaaattaaaggcccacgtgagccagaaaaggagcagccgacggaggaggaggagaga tgccctacaacactgaaagagctcatctcgcagacaatgatccgctgggcccaggaggac cagatccaggacgcggagctggtccggatgatgttcaacctcctccggaggcagtacgac agcatcggggagctgctgcaggcgctgcggaagacctacaccatcagccaggtctccgtg agcgacaccatcaacctgctggctgcgctgggccagattcgctccctcctcagtgtcagg atgggcaaggaggaggagctactcatgatcaatgggctgggggatataatgaacaacaag gtgttttaccagcatcccaacctcatgagagtccttggcatgcatgagacggtgatggag gtgatggtgaacgtgttggggacagagaagtctcagattgcttttccaaagatggttgct agctgctgccgcttcctttgctatttttgtcgaattagccggcagaatcagaaggccatg tttgagcatctgagttacctgctggagaatagcagtgttggcctagcctccccgtcgatg aggggatccactccgctggacgtggccgcctcctctgtgatggacaacaacgagttagcg ctgggcttagaggaaccagacctcgagaaggtggtgacctacttggcaggctgtggcctg cagagctgccccatgcttctggccaaaggataccctgacgtcggctggaaccccattgaa ggggaacgctacctgtccttcctgaggtttgctgtcttcgtgaacagtgaaagtgtggaa gaaaacgcaagcgtcgtggtcaagctgcttatcagacgcccagagtgctttggcccagcc ctgcggggcgagggaggaaacggcctcttggcagccatgcagggtgccattaagatctct gagaacccagcgctcgacctcccctctcagggatacaagagggaagtcacggaggatgat gaagaggaagaagaaatcgtgcacatgggcaatgcaattatgtcattttactcggctctt atagatctactgggccgctgtgctcctgaaatgcacctcatccagacaggaaaaggggaa gccatccgtgtcaggtccatcctgcgctccctggtgcccaccgaggacctggttgggatt atcagcatccccttgaagctgccgtccctgaacaaagatgggtcagtcagcgagccagac atggcagccaacttctgccctgaccacaaggcacccatggtgctgttcttggaccgagtt tatggcattaaggatcaaacttttctgctccacttactagaggttggatttttacctgac ttaagagcctctgcctctctagatacagtttccctaagcaccacggaggctgcgcttgca ctgaacaggtacatatgttctgctgtgctcccgctccttacaagatgcgcccctctcttt gccggaacagaacattgcacctctctgatcgattctacgctgcagacaatatacaggctt tccaaaggacgttccctcaccaaagcacagagggacactatagaagaatgtttgcttgcg atttgcaatcacttgaggccttccatgttacagcagctcctgcgacgtcttgtgtttgac gtgccacagctcaatgaatactgcaaaatgcctctcaagcttctgacgaatcactatgaa cagtgctggaagtattactgtctgccttcaggatgggggagctacggcctcgctgtggaa gaagaactgcacctaacagagaagctcttctgggggattttcgactccctctcccataag aaatatgacccagatcttttccgaatggctctgccttgtctcagtgctatagctggggcc ttgccaccagattatttagacaccagaatcacagccacattggagaaacaggtctcggtg gatgcagatggcaactttgaccccaaacctatcaacaccatgaatttttccttgcctgaa aaattggaatacatcgtcaccaagtacgctgagcattcacatgataaatgggcctgtgac aagactcagagcggatggaagtatgggatttccctggatgagaacgtgaaaacccacccc ctgataaggcctttcaagacattaacggaaaaggagaaggaaatttatcgctggcctgcc agagagtccctgaaaaccatgctggctgtgggctggactgtggagaggaccaaagagggg gaagctttggttcaacagcgggaaaatgaaaagcttcgaagcgtgtcccaggccagccag ggcaacagctacagccctgctcccctcgacctctcaaacgttgtgctctccagagagctc cagggcatggtggaggttgtggctgagaactatcacaatatctgggccaagaagaaaaag ctggaactggagagcaaaggtggtggcagtcaccctcttctggtgccatatgacaccttg actgccaaggaaaagttcagggaccgagagaaggcacaggacctgtttaaattcctccaa gtgaatggcgttatagtttctagaggtatgaaggatatggagctggatgcctcctccatg gaaaagagatttgcctataagtttttgaagaagattttgaaatacgttgattctgctcaa gagtttattgcccatttggaagccattgtcagcagtgggaaaactgaaaagtctccccat gaccaggagatcaaattctttgccaaagtcctcctcccactggttgaccaatacttcacc aaccaccgcctctacttcctgtcgtcccctctgaagccccttagcagcagcgggtatgcc tcccataaggagaaagaaatggtggccagcctgttctgcaaacttgctgctctcgttaga cacaggatttccctatttgggagtgattcttccacaatggtgagctgtcttcatatcttg gctcagacgcttgacacaagaactgtcatgaagtcgggctcagagctggtgaaggctggg ttgcgagcattctttgaaaatgctgcggaagacttagagaagacttcggaaaacctgaag cttgggaagtttacccattccaggacgcagattaaaggcgtctcacagaatattaactat accacggtggctctgctccccatcctgacgtccatctttgagcacgtcgctcagcatcag ttcggggtggatctgctcttgagcgacgtgcagatttcatgctaccacatactgtgcagc ctctactcccttgggacgggaaagaacatctatgtcgaaaggcaacgtcctgccctcgga gaatgtctggcctcgctggcagctgccataccagtggcgttcctggagcccacccttaac cgttacaatccactctcggtcttcaacaccaaaacctccagggaaaggtctattctgggg atgccagacacggtggaagagatgtgtcctgacatcccccagctggaagagctgatgaag gaaatcaatgacctggccgagtcaggggcccggtacatggagatgccacacgtcatcgag gtggtcttgcccatgatctgcagctacctgtcctactggtgggagcgggggcccgagaac ctgccccccagcacagggccctgctgtaccaaggtcacctctgaacacctcagtctcatc ctgggcgacattttgaagatcatcaacaacaacctgggcatcgaggaagcctcctggatg aagcgcatcgcagtgtacgcccagccgatcatcagcaaagccaggcctgacctgctgaga agccacttcatcccgactctggagaagctgaagaaaaaggccgtcaagactgtgcaggag gaggagcagctgaaagctgacggcagaggggacacgcaggaggcagagctcctcatcctg gatgagttcgcagtcctctgcagggatctctacgccttctaccccatattgatccgctat gtggacaacagcagatctaactggctcaaaagccctgacgccgattctgaccagctcttc cgcatggtggcagaggtcttcatcctgtggtgtaaatcgcacaacttcaagagggaagag caaaattttgtgattcagaatgaaataaataatttggcatttttgactggagacagcaaa agcaagatgtcaaaagccatgcaagtaaagtctggaggacaggaccaggaacggaagaag acaaagcggaggggagacttgtattccatccagacctccctcatcgtggctgctctcaag aaaatgctgcccattggcttgaatatgtgcaccccaggcgatcaggagctgatctccctg gcgaaatcacgctacggctacagggacacagatgaagaggtcaaggaacatctgcggaat aacttgcacttgcaggaaaagtctgatgacccagctgtaaaatggcaactgaatctctac aaggatgttctgaagagtgaagaaccttctaatccagaaaagacagtagagcgtgtgcag agaatttcagcagctgtcttccacctggagcaggtggagcagcctttgaggtccaagaag gctgtctggcacaaactgttgtcaaagcagcggaaacgggcagtggtggcctgtttcagg atggcccctctctacaacctgcccaggcaccgctctattaacctcttcctccatggctat cagagattttggatagaaacagaggagtattcctttgaagagaaactagttcaggatttg gctaaatctcccaaggtggaagaggaggaagaggaagagacagaaaagcaacctgaccca cttcatcagatcatcctccatttcagccgcaatgcgctcacagagaggagcaaattggaa gatgaccctttgtacacctcctattgcagcatgatggccaagagttgtcaaagtggtgag gatgaagaagaagaggaagacaaggaaaaaacttttgaagaaaaagagatggagaaacag aaaaccctctatcagcaagctcggctgcatgagcgtggcactgccgagatggtccttcag atgataagcgccagcaaaggtgagatgagccccatggtggttgagactctgaagctgggg atcgccattctgaatggaggcaacactggtgtgcagcagaaaatgctggattacctcaag gagaaaaaggatgctggattctttcaaagcctttctggtcttatgcagtcttgcagtgtc cttgatttgaatgcatttgagaggcagaataaagctgaaggcctggggatggtgactgaa gaaggaacgctcattgttcgtgagcgtggtgaaaaagtcctccagaatgacgagttcacg cgtgatctctttagattcctgcagttactttgtgagggacataacagtgactttcagaac ttcctgcggactcagatgggcaacaccaccaccgtgaacatcatcatcagcactgtggac taccttctgcgtctgcaggaatcaatcagtgatttctactggtattattcagggaaggac atcattgatgaatctggacagcacaatttttccaaagctctggcagtcaccaagcagatt ttcaattctcttacagaatacatccagggcccttgtgtcgggaaccagcagagcctggct cacagcaggctgtgggacgcagtggtcggcttcctccatgtgtttgctaacatgcagatg aagctctctcaggattccagtcagatcgagctgctgaaggaactcttggatctccttcag gacatggtggtgatgcttctgtccctcctggaagggaatgtggtaaatggaactattggc aagcagatggttgacacactggtagaatcatctaccaatgtagaaatgatcttgaaattc tttgacatgttcttgaaacttaaagacttaaccagctcagataccttcaaagaatatgac ccagatggtaaagggattatctccaaaaaagaattccagaaggccatggaagggcaaaaa cagtacacacagtcagagattgactttctcctttcgtgtgcagaagctgatgagaatgac atgtttaattacattgattttgtagaccggttccacgagccggccaaggacatagggttc aatgtggcggtgttgttgacaaatctttctgaacacatgcctaatgactctcgcctgaag tgtctgctggacccggcagaaagtgtgctgaattacttcgaaccgtacttaggaaggatc gagatcatgggtggggccaagaaaatcgagcgtgtttattttgagatcactgaatccagt cggactcagtgggagaagccccaggtgaaggaatctaagcgacagttcatttttgatgtc gtcaatgaaggtggggagcaggaaaagatggaactgttcgtgaacttttgtgaggacacg atcttcgagatgcagttagcatctcagatctctgaatccgactcagcggacaggccggag gaggaggaggaggaagatgcttcttacatattagaaattgaaggtgaagaggaggaagac aagtgtttcgagtctgcctcggcatttgccatggcctgtgcctccgtgaaaagaagtgtc accagttttctacagaaggccaccctgaagaatctcaggaagcagtacaggaacgtgaaa aagatgtctgcaaaggagctggtgaaggtgttcttctcttttttctggacgctgttcctg gggctcttccagctgttcttcggcatattgggagggatctttcaggtcctgtggagcaca gtgtttggagggggcctagtagaaggggcaaagaacatcagagtgaccaagatcctgggt gacatgcctgacccaacccaatttggtatccatgaggatgctgtggagacggagagggca gaggggaccgagccggggatcacggctgaactggcccacttcataaagggtgagaaggca gatgcagacatgatgccagacctctttggactgcacccaaggaaagaaggtagcttaaag catgggcccgaagtgggtttgggtgacctctctgaaattattggcaaggatgaagccccc acgttagagagtaccgtacggaagaaaaggaaagcacaggcagcagagataaaagcagca catgaagcagaaggaaaactagactctgagaaggcagacatggaagatggagaaaaagag gacagagccaaagaagaggagcaagctgagtacctgtgggcagaagtgacaaaaaggagg aagcgacggcacggtcagaaggttgagaagccagaagctctcacggccaatttctttaaa gggctggaaatctatcagaccaagctactgcattacctggccaggaatttctacaacctg aggttccttgctctgtttgtagccttcgctatcaacttcatcctgcttttttataaggtc actgaagaacctttagaagaagagacagaggacgttgcgaacctgtggaattcctttaat gatgaggaagaggaggaagcgatggtgttctttgttctgcaggagagcactggatatatg gcacccacgctgcgggccctggccatcatccacacgatcatctctctagtctgtgtggtg ggctactactgcctgaaggtccctttggtggtattcaaaagggaaaaagaaattgccagg aagctggagtttgatggcctgtatatcacagaacaaccatccgaagatgacatcaagggg cagtgggaccgcttggtgatcaacacaccgtcttttcctaataactattgggacaagttt gtaaagagaaaggtgatcaacaagtatggagatctctacggagcggagcgcattgctgaa ctcctgggtttggacaaaaatgcccttgactttagcccaatagaagagaccaaagcagaa gcggcttctctggtgtcatggctaagttccatcgacatgaagtaccatatctggaagctg ggtgttgtttttactgacaactcctttctctaccttgcctggtacacaaccatgtcagtc ctgggccactacaacaacttcttctttgctgctcatctactggatatcgccatgggcttc aagacgctgaggacgatcctgtcttctgtaactcacaatggcaaacagttggttctaacc gtcggtctcctcgctgtggtggtttatctctacacggtggtggccttcaacttcttccgc aagttctacaacaagagtgaagacgacgacgagccggatatgaagtgtgacgacatgatg acgtgttaccttttccacatgtacgtgggtgtgagagcaggaggcggcattggcgatgaa attgaagaccctgctggtgacccttatgaaatgtatcgcatcgtctttgacattaccttt ttcttctttgtcattgtcatcttgctggccatcattcaaggtcttattattgatgctttc ggagagctaagagaccagcaggaacaagtgcgagaagacatggagactaaatgtttcatc tgtgggattggcaatgactacttcgacacgacccctcatggttttgagacacatacatta caagagcacaacttagccaactacttgttttttctgatgtatttgattaataaggatgaa actgagcacacgggtcaggaatcttacgtctggaagatgtaccaagaaaggtgttgggat ttcttcccggccggcgactgctttcgtaaacaatatgaagatcagcttggctaa

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