Lemur catta (Ring-tailed lemur): 123633033
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Entry
123633033 CDS
T08326
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
lcat
Lemur catta (Ring-tailed lemur)
Pathway
lcat00310
Lysine degradation
lcat01100
Metabolic pathways
lcat05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
lcat00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
123633033 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
123633033 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
lcat03036
]
123633033 (DOT1L)
Enzymes [BR:
lcat01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
123633033 (DOT1L)
Chromosome and associated proteins [BR:
lcat03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
123633033 (DOT1L)
HMT complexes
Dot1-containing complex
123633033 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
Motif
Other DBs
NCBI-GeneID:
123633033
NCBI-ProteinID:
XP_045399911
LinkDB
All DBs
Position
1:107869093..107921661
Genome browser
AA seq
1734 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHVLQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNATTPTKVT
ESKAAGLTDAPVDSGAEEDKAGAAPVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTA
NPERRPKKSQTALDLLHTQTASQTASPSPQDAYRSPHSPFYQLPPSVQRPSPNPLLGAPT
PPALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFSHCQAQK
EEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSQLRSQSLQLL
KARCEELKLDWATLSLEKLLKEKQALRTQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCLPPDDALSTHLRGKGTLGRELEADPGRLHLELDCAKFSLPRFSNMSPELSMNGHATSY
ELCSALSRPSSKQNTPQYLASPLDQEVVPCTPSHGSRPRLEKLSGLAVPDYTRLSPAKIV
LRRHLSQDHAASSRAAASELHPRAEHAKENGLPYQSPSTSSSLKLSPQDPRPPSPGALQL
AGEKSSEKGLKERAYGSSGEAITSLPISIPLSTVQPSKLPVSIPLASVVLPSRAERVRST
PSPVLQPRDSASTLEKQIGANAHGAVSKSLALAPTGFSYAGSVAISGALAGSPAPLGPGA
EPATFEDSSGSGSIFAAVGSRSSTPQHPPLLAQPRSSHPASPAHQLSTSPRLGGATQGPL
PDASKGDLPSDAGFSDPESEAKRRIVFTISAGMGSTKQSPSSKHSPLSAGTRGDCGQSHG
QDSRKRGRRKRASAGTPSLSTGVSPKRRALPPVAGLFTQPSGSPLNLNSMVSNINQPLEI
TAISSPENSLKNSPIPYQDHDQPPVLKKERPLGQTNGAHYSPLTSDEEPGSEDEPSSARI
ERKIATISLESKSPPKTLENGGSLAGRKLTPASEPVNSSKWKSTFSPISDISLAKSADSP
LQAGSALSQNSLFAFRPALEEPVATDAKLAAHPRKGFSSTLAGADTLSPSTNPSHGFAFS
GGLAAELNLHSFSDGASLTHKGPEALGSPLSFPSQRGKEAAEANPFLGKRQLDGLSGLKA
EGAKGKEAGEGSLALCVPGEKVPPPLGIKASKGRDRELDLKNGHNLFISAAAVPPGGLLS
GPGLAPAASSAGGAAPAAQTHRPFLGAFTPGPQFTLGPVSLQANLSSVAGSSVLQSLFSS
VPAAAGLVHVSSAATRLTNSHAMGNFSGVTGGTVGGVFNHAVPSASAHPFGARVGRGAVC
GSATLGPSPLQPAASASASSFQAPASVEPRPPPPPPPPPLPLPLHLGRPPAGPPTLHAPP
NAALPPPPTLLAANPEPVLLQSLASIPPNRAFLPSASAASLQPANASLSAKLASLPHKGA
RPSFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSGVKPR
NT seq
5205 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctcgagctgagactcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacatcatgatgctgctcacgagatcatcgagacc
atccgatgggtctgtgaagaaatcccggatctcaagctcgccatggagaactacgtgttg
atagactatgacaccaaaagcttcgagagcatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccatcagctgtggaagggcaccacccagcccatgaagctgaacacg
cggccctccaacgggctcctgcggcatgtcctgcagcaggtctacaaccactcggtgact
gaccccgagaagctcaacaactacgagcccttctcacccgaggtatatggggagacgtcc
ttcgacctggtggcccagatgattgacgagatcaagatgaccgaggatgacctattcgtg
gacttggggagtggtgtgggccaggtcgtactccaggtcgctgcagctaccaactgcaag
catcactatggcgtcgagaaagcggacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacattggagaga
ggcgacttcctctcagaagagtggagagagcgcatcgccaatacgagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggttcgcaaatatg
aaggaaggtggcaggatcgtgtcctcgaagccctttgcacctctaaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgcccctgaag
ggctccgtgtcgtggacagggaagccagtctcctactacttgcacactattgaccggacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgggagaataagagcaacgcgaccacacccaccaaggtgacc
gagagcaaggcggccggcctcacggacgcccccgtggattccggtgctgaggaagacaaa
gccggagcagcccccgtcaagaagccgtccccctccaaggcccgaaagaagaagctgaac
aagaaggggcggaagatggctggccgcaagcgcgggcgccccaagaagatgagcactgca
aaccccgagcgaaggcccaagaagagccaaactgcactggatctcctgcacacgcagacc
gcgtcccagacagcatccccctcgccccaggatgcctacaggtcacctcatagccccttc
taccagctacctccgagcgtgcagcggccttcccccaacccgctgctgggggcgcccacc
ccgcctgcgctgcagaagctgctagagtccttcaagattcagtacctgcagttcttggca
tatacaaagacccctcagtacaaggccaacctgcagcagctgctggaccaggagaaggag
aagaacacccagctgctgggcacggcgcagcagcttttcagccactgccaggcgcagaag
gaggagatcaggaggcttttccagcagaaactggatgagctgggagtgaaggccctgacc
tataacgacctgatccaggcgcagaaggagatctctgcgcacaaccagcagctgcgggag
cagtcggagcagctggaaaaggacaatagccagctccgcagccagagcctgcagctgctc
aaggcccggtgtgaggagctaaagctggactgggccacactgtccctggagaagctgctg
aaggagaaacaggccctgcggacccagatctcggagaagcagcggcactgcctggagctg
cagatcagcatcgtggagctggagaagagccagcggcagcaggagcttctgcagctcaag
tcctgcttgccacccgatgatgccctgtccacgcacctgcgtgggaaaggcaccctgggc
cgcgagctggaggctgaccccggcaggctgcaccttgagctggactgcgccaagttctcg
ctgccccgcttcagcaacatgagcccggaactctccatgaacggccatgccaccagctat
gagctctgcagcgccttgagccggccctcatctaagcagaacactccccagtacctggcc
tctcccctggaccaggaggtggtgccctgcacgcccagccatggcagccggccacggctg
gagaagctgtctggcctggctgtgcctgactacactaggctctccccggccaagatcgtg
ctgcggcggcacctgagccaggaccatgcagcgtccagcagggcggccgccagcgagctg
cacccgcgagctgagcacgccaaggagaacggccttccctaccagagccccagtacctcc
agcagcctgaagctgagccctcaggaccctcgtcccccgtctcccggggccttgcagctc
gccggggagaagagcagcgagaagggtctgaaggagcgtgcctatggcagcagcggggag
gccatcaccagcctgcccatcagcatcccactgagcacggtgcagcccagcaagctgccc
gtcagcatcccgctggccagcgtggtgctgcccagccgcgcagagagagtgaggagcacc
ccgagccccgtgctgcagccccgagactccgcgtctacacttgaaaagcagatcggtgct
aatgcccacggtgctgtgagcaagagccttgccctggcccctacaggcttctcctatgcg
ggctcggtggccatcagtggggccctggccggcagccctgccccactgggcccaggagcc
gagccggccaccttcgaggactcctctggctcggggagcatctttgctgctgtggggtcc
cgcagctcgacgccgcagcacccacccttgctggcgcaaccccgcagctcccacccagcc
tctcccgcccaccagctctccaccagcccccgactgggtggggccacccagggccccctc
cccgatgccagcaagggggacctgccctctgacgctggcttctcggatccggagagcgaa
gccaagcggaggattgtcttcacgatttccgccggcatgggcagcaccaagcagtcgcct
tccagcaagcacagccctctgagtgcgggcacccgcggggactgcgggcagagccacggg
caggacagccggaagcggggccggaggaagcgagcgtcggctgggacccctagcctgagc
acaggcgtgtcccccaagcgccgggccttgccacctgtggctggcctcttcacgcagccg
tcggggtcccccctcaacctcaactccatggtcagtaacatcaaccaacccttggagatc
acggccatctcgtccccggagaactccctgaagaactcccccatcccctaccaggaccac
gaccagcctcccgtgctcaaaaaggagcggcccctgggccagaccaacggagcacactac
tccccactgacctcagacgaggagcccggctcggaggacgagcccagcagcgcccgaatt
gagagaaaaattgcaacgatttctttagaaagcaagtctcccccgaaaaccctggagaat
ggtggcagcttggcgggaaggaagctgacgcccgcaagcgagcctgtcaacagcagcaag
tggaaatccaccttctcacccatctccgacattagcctggccaagtctgcggacagcccg
ctacaggccggctccgccctgagccagaactccctgttcgcgttccggcccgccctagag
gagcctgtcgccaccgacgccaagctcgccgctcaccccaggaaaggcttttccagcacc
ctggccggggctgacacactcagcccaagcaccaacccctcgcatggctttgcctttagc
gggggcctggccgcggaactcaacttacacagcttcagcgacggtgcttctctcacccac
aagggccccgaggctctgggctccccgctgagcttcccctcgcagcggggcaaggaggct
gcggaggccaaccccttccttggcaagaggcagctggacggcctatctggcctgaaggcc
gagggcgccaaaggcaaggaggcgggcgagggcagcctggccctgtgcgtgcctggggag
aaggtgcccccaccattgggcatcaaggccagcaagggccgggaccgcgagcttgacctc
aagaatggccacaatctcttcatctccgcagcagccgtgcctcccgggggcctcctcagc
ggcccaggcctggcccccgcggcatcctctgcaggcggtgcggcccccgccgctcagact
caccggcccttcctgggcgccttcaccccgggcccacagttcacactggggcccgtgtcc
ctgcaggccaacctcagctcggtggccggctcatctgtgctccagtccttgttcagctcg
gtgccggccgctgcgggcctggtccacgtgtcctccgccgccactagactgaccaattcg
cacgccatgggcaacttctccggggtgacaggcggaacagttggaggtgtctttaaccac
gcggtgccttccgcctctgctcatccgtttggagcccgtgtcggccgcggggccgtgtgt
ggcagcgccacgctgggcccgagcccattacagccggcggccagcgcctcggcctcttcc
tttcaggccccggcctcggtcgagcctcggccgccccctccgcctccgcctcccccgctc
cctctgcctctgcacctgggccggccccctgcggggccacccaccctccacgcaccccct
aacgccgccttgcctcctccccccacgctgctggccgctaaccccgagcccgtgcttctg
cagagccttgcgtccatcccacctaaccgcgctttcttgccctccgcctctgccgcctcc
ctgcagcctgctaacgcctctttgtctgccaagctggcctccctcccacacaagggcgcc
cgcccctccttcacggtgcaccaccagcccctgcctcggctggccctggcgcaggccgcg
cctgggatcccgcaggccagcgccacagggccatcggctgtgtgggtttcccttggcatg
ccgcctccttatgccgcgcacctttcgggggttaagccgcgataa
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