| Entry |
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| Symbol |
TYK2
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| Name |
(RefSeq) non-receptor tyrosine-protein kinase TYK2 isoform X1
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| KO |
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| Organism |
lcat Lemur catta (Ring-tailed lemur)
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| Pathway |
| lcat04620 | Toll-like receptor signaling pathway |
| lcat04621 | NOD-like receptor signaling pathway |
| lcat05167 | Kaposi sarcoma-associated herpesvirus infection |
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| Brite |
KEGG Orthology (KO) [BR:lcat00001]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
123634210 (TYK2)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
123634210 (TYK2)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
123634210 (TYK2)
04621 NOD-like receptor signaling pathway
123634210 (TYK2)
04658 Th1 and Th2 cell differentiation
123634210 (TYK2)
04659 Th17 cell differentiation
123634210 (TYK2)
09158 Development and regeneration
04380 Osteoclast differentiation
123634210 (TYK2)
09160 Human Diseases
09172 Infectious disease: viral
05161 Hepatitis B
123634210 (TYK2)
05160 Hepatitis C
123634210 (TYK2)
05171 Coronavirus disease - COVID-19
123634210 (TYK2)
05164 Influenza A
123634210 (TYK2)
05162 Measles
123634210 (TYK2)
05168 Herpes simplex virus 1 infection
123634210 (TYK2)
05167 Kaposi sarcoma-associated herpesvirus infection
123634210 (TYK2)
05169 Epstein-Barr virus infection
123634210 (TYK2)
05165 Human papillomavirus infection
123634210 (TYK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
123634210 (TYK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:lcat01001]
123634210 (TYK2)
Enzymes [BR:lcat01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
123634210 (TYK2)
Protein kinases [BR:lcat01001]
Non-receptor tyrosine kinases
JAK family [OT]
123634210 (TYK2)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
1:complement(109945712..109965136)
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| AA seq |
1190 aa
MPLCQRRGSRGSKPDANGAQPVAAMGGLKVLLHWAGPGGGEPWVTFSDSSLTAEEVCIHI
AHKIGITPPCVNLFALFDAQAQVWLPPNHILEISSDTSLVLYFRMRFYFRNWHGMNPQEP
AVYRCGPPGTEASSEQTEQGVQLLDPASFEYLFEQGKHEFVNDVASLWELSNEEEIHHFK
NESLGMAFLHLCHLALHRGVPLEEVAKKISFKDCIPRSFRRQIQQHNVLTRLRLRNVFRK
FIRAFQPGLLSQQLVMVKYLATLERLAPRFGTERLPVCHLRLLAQAEVEPCYTLDSGPSP
ADPSPESAAGPSTHEVLVTGTGGIQWRPIQTEGSSGGGGSSNISGSSGRNPHASLSGKKA
KVHEVGDPPVDRPQEPPWAYFCDFRDITHVVLKERHVSIHRQDNKCLELSLPSRAEALSF
VSLVDGYFRLTADSSHYLCHEVAPPRLVMSIQDGIHGPLLEPFVQAKLRPEDGLYLIHWS
TSHLYRLILTVAQRGQSPGHAQSLHLRKFPIEQRAGAFVLEGWGRSFPSVRELRAALQGC
WLRAGNDSFSLHRCCLPRPGEISNLIVMRGPRASSRQLNLSQLSFHRVGQDKITQLSHLG
QGTRTNVYEGVLQVEGGDPEEGKVDGGDPLVPGGNSGQKLRVVLKVLDPSHHDIALAFYE
TASLMSQVSHVHLAFVHGVCVRGSENIMVTEYVEHGPLDVWLRRERGHVPVAWKVVVAQQ
LASALSYLEDKNLVHGNVCGRNVLLARPGLAEGTSPFIKLSDPGVGLSALTREERVERIP
WMAPECLPGGANSLSTATDKWGFGATLLEICFDGEAPLQGRGPSEKERFYQKQHQLPEPS
CPELATLTSQCLTYEPGQRPSFRTILRDLTRLQPHNLADVVTVNPDSPASDPTVFHKRYL
KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQLRSGWRREIDILRTLYHE
HIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHSVGLAQLLLFAQQICEGMAYLHAQ
HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYCVREDGDSPVFWYAPECLKEGK
FYYASDVWSFGVTVYELLTHCDSSQSPPSKFIELIGHTQGQMTVLRLIELLERGERLPRP
DRCPPEIYLLMKNCWDTEASFRPTFQNLIPILKTVQEKYRSQAPSVFSVC |
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| NT seq |
3573 nt +upstreamnt +downstreamnt
atgcccctgtgccaacggcggggctccaggggcagcaagcccgatgcgaacggagctcag
cctgtggctgccatggggggcctgaaggtgcttttgcactgggctggccctggtggtggg
gagccctgggtcaccttcagtgacagctcgctaaccgctgaggaggtctgcatccatatc
gcacacaaaatcggcataactcctccctgcgtcaatctctttgccctattcgatgcccaa
gctcaagtctggctgcccccaaaccacatcctagagatctccagtgacacaagcctggtg
ctgtatttccgcatgaggttttatttccggaactggcatggcatgaatcctcaggagcca
gctgtgtaccgctgcgggcccccaggcaccgaggcttcctcagaacagacagagcagggg
gtgcaactcctggacccagcctcatttgagtacctctttgagcagggcaagcacgagttt
gtgaatgatgtagcatcactgtgggagctctcaaacgaagaggagatccaccactttaag
aatgagagcctgggcatggcttttctgcacctctgccaccttgccctccaccgcggtgta
cccctggaggaggtggccaagaagatcagcttcaaggactgcatcccacgctccttccgg
aggcagatccagcagcacaacgtgctgacgcggctgcgcctgcgcaatgtcttccgcaag
ttcatccgggcctttcagccgggcctcctctcccagcaattggtcatggtcaaatacctg
gccacactggagcggctggcgcctcgctttggcacagagcgcctgccggtgtgccacctg
aggctgctggcccaggccgaagttgagccctgctacaccctggacagcgggccgtccccc
gcggaccccagccctgagtctgcagctgggccctccacccacgaggtgctggtgacaggc
accggcggcatccagtggcgacctatacaaacggagggctctagtggtggcggtggcagc
agcaacatcagtggcagcagtggcaggaatccccacgccagcctgtctgggaagaaagcc
aaggtgcacgaggtgggggacccaccagtggacaggccgcaagagccaccgtgggcctac
ttctgcgacttccgggacatcacccatgtggtgctcaaagagcgccatgtcagcatccat
cggcaggacaacaagtgcctggaactcagcctgccctcccgggccgaggccctgtccttc
gtgtcactcgtggatggctatttccgcctgacagctgactccagtcactacctgtgccac
gaggtggccccaccacggctggtgatgagcattcaggatggcatccacggccccttgctg
gagccgtttgtgcaggccaagctgcggcccgaggacggcctgtacctcatccactggagc
accagccacctctaccgcctcatcctcacagtggcccagcgtggccagtcacctggccac
gcacagagcctgcacctccgcaagttccccattgagcagcgggctggggccttcgtgctg
gagggctggggccgctccttccccagcgtgcgggagctgcgggccgccttgcagggctgc
tggctgcgggccgggaacgacagcttctctttgcaccgctgctgcctgccacggccggga
gaaatctccaacctcattgtcatgcgggggcctcgggccagcagcaggcagctcaacctc
agtcagctcagcttccaccgtgtcggccaggacaagatcacccagctgtcccacttgggc
cagggcacgaggaccaacgtgtatgagggcgtcctgcaagtggagggtggggaccccgag
gagggcaaagtggacggcggggaccctctcgtgcccggtgggaactctgggcagaagcta
cgagtggtgctcaaagtgctggatcctagtcaccatgacattgccctggccttctacgag
acggccagcctcatgagccaggtgtcccacgtgcatctggcctttgtgcacggcgtctgt
gtgcgcggctctgagaacatcatggtgacggagtacgtggaacatgggcccctagatgtg
tggctgcggcgagagagaggccatgtgcctgtggcctggaaggtggtggtcgcccagcag
ctggccagtgccctcagctacttggaggacaagaacttggttcatggtaacgtgtgtggc
cggaacgtcctgctggcacggccggggctggcagaaggcaccagccccttcatcaagctg
agtgacccaggcgtgggcctgagtgccctcaccagggaggagcgggtggagcggatcccg
tggatggcccctgagtgtctgcccggcggagccaacagcctgagcactgccaccgacaag
tggggctttggtgccaccctcctagagatctgcttcgatggggaagccccccttcagggc
cgaggcccctctgagaaagagcgtttctaccagaagcagcaccagctgccggagccctcg
tgccccgaactggccacactcaccagtcagtgcctgacctacgagccaggccagaggccg
tcattccgcaccatcctgcgcgacctcactcggctgcagccacacaatcttgctgacgtt
gtgactgtgaaccccgactccccggcgtcggaccccacggttttccacaagcgctatttg
aaaaagatccgggatttgggcgagggtcactttggcaaggtcagcttgtactgctacgac
ccgaccaacgacggcactggcgagatggtggccgtgaaagccctcaaggcggactgcggc
ccccagctccgctccggctggaggcgggagatagacatcctgcgcacgctctaccacgag
cacatcgtcaagtacaagggctgctgcgaggaccaaggcgagaagtcggtgcagctcgtc
atggagtatgtgcccctgggcagcctccgagactacctgccccggcacagcgtcgggctg
gcccagctgctgctcttcgcccagcagatctgtgagggcatggcctacctgcacgcgcag
cactacatccaccgagacctcgctgcgcgcaacgtgctgctggacaacgacaggctggtc
aagataggggactttggcctagccaaggcggtgcccgaaggccacgagtactactgcgtg
cgcgaggatggggacagccccgtgttctggtatgccccagaatgcctgaaggagggtaag
ttctactatgcgtctgacgtctggtccttcggggtcaccgtgtatgagctgctaacacac
tgcgactccagccagagccccccctcgaaattcatcgagctcataggccacacccagggc
cagatgacggtgctgagactcatagagctgctggaacgaggggaaaggctgccccggcct
gacagatgtccccccgagatctatcttctcatgaagaactgctgggacacggaagcctcc
ttccgccccaccttccagaacctcatacccatcctcaagacagtccaggagaaataccga
agccaggccccttcggtgttcagtgtgtgctga |
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