Lemur catta (Ring-tailed lemur): 123643730
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Entry
123643730 CDS
T08326
Symbol
SPEG
Name
(RefSeq) striated muscle preferentially expressed protein kinase isoform X1
KO
K08809
striated muscle-specific serine/threonine protein kinase [EC:
2.7.11.1
]
Organism
lcat
Lemur catta (Ring-tailed lemur)
Brite
KEGG Orthology (KO) [BR:
lcat00001
]
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
lcat01001
]
123643730 (SPEG)
Enzymes [BR:
lcat01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
123643730 (SPEG)
Protein kinases [BR:
lcat01001
]
Serine/threonine kinases: CAMK group
Trio family [OT]
123643730 (SPEG)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
I-set
Pkinase
Ig_3
Ig_2
PK_Tyr_Ser-Thr
ig
SPEG_u2
V-set
Ig_VEGFR-1-like_5th
fn3
Pkinase_fungal
ABC1
Kdo
Kinase-like
Motif
Other DBs
NCBI-GeneID:
123643730
NCBI-ProteinID:
XP_045415367
LinkDB
All DBs
Position
8:complement(16501738..16550763)
Genome browser
AA seq
3244 aa
AA seq
DB search
MKKLWVKKRFQKTGHSRRAFGRLTHVFRSCRKQSYDSETAEDDISDVQGTQRLELRDDGA
FSTPTGGSDTLVGTSLDTPPTSVTGTSEEQVSWWGSGQTVLEQEAGSGGGTRRLPGSPRQ
AQATGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASDLYGSAFSLYRGRALSIHVLQ
LSPGSPPLGGPLRACCLSSCCLFISLHIPVPMWAFFWEEQNLSARQLPGEQERAGEQVSN
REREKRASSVPQSGLRREEPDLQPQLASEAPRRPAPPPPSKSALLPPPSPRVGKRSPPGP
SAQPAATPTSPHRRTQELVLPEDATAEEKRGKKSKSSGPSLAGTAESRPQTPLSEASGRL
SALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSEGG
APWGTPGASQEELRSPPGSVAERRRLFQQKAASLDERTRQRSAASDLELRFAQELGRIRR
STSREELVRSHESLRATLHRAPSPREPGEPPLFPRPSTPKTPRAVSPAAAQPAPPSVAGR
PGEEPGRPRSRGPVGRTELGDGPQQEVRRRDQFPLTRGRAIQECRSPVPPPAADPPEART
KVPPGRKREPPAQAVRFLPWATPGLEGVTVPQTLEKNRAGPEAEKRLRRGPEEDGPWGAW
DRRGTRSQGKGRRARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNVVVAPGADVLLKC
IITANPPPQVSWYKDGSALCSEGRLLVRAEGERHTLLLREARATDAGSYMATATNELGQA
SCAASLAVRPGGSSSPFSSPITSDEEYLSPPEDFPEPGETWPQTPTMKLSPSQNRRSSDT
GSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGG
LCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGE
MALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKL
STAKDELTCSARLTVRPSLAPLFTRLLEDMEVLEGRAAHFDCKISGTPPPSVTWTHFGHP
VEESENLRLRQDGGLYSLHIAHVGSEDEGLYEVSATNTHGQAHCSAQLYVEEPRTAASGP
SSKLEKMPSIPEEPEQGELERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFH
NGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYVTDVVPG
PPDGVPQVVAVTGRMVTLTWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTVLATGLREPG
WVATGLRKGLQHTFRVLTTTVKSSSKPSPASEPVQLLERGPPLDEAPAVLDKPDIVYVVE
GQPASVTVTFNHVEAQVVWRSCRGALLEARAGVYELSQPDDDQYCLRICRVSRRDMGALT
CTARNRHGSQTCSVTLELAEAPRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEV
LLAESSHVSFVYEENECSLVVLSTGAQDGGVYTCTARNLAGEVSCKAELAVHSAQTAMEV
EGVREDEEHRGRRLSDFYDIHQEIGRGAFSYLRRVVERSSSLEFAAKFIPSQAKPKASAW
REARLLARLQHDCVLYFHEAFERRRGLVIVTELCTEELLERMARKPTVCESEIRVYMRQI
LEGIHYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQYGTPEF
VAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEENTFLS
LSREARGFLIKVLVQDQLRPTAKETLEHPWFKTQAKGADVSTDHLKLFLSRRRWQRSQIS
YKCHLVLRPIPELLRAPPERVWVTMPRRAPPSGGLSSSSDSEEEELEELPSVPRPLQPEF
SGSRVSLTDIPTEDEALGTPEAGASTPMDWQEQGRVPSQDQEAPSPQALPSPGQEPPAGP
SPRRGELRRGSSAESALPRAGPREPGRGLHKAASVELPQRRSPSPGATRLARGGLGEGEY
AQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPPETR
GLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLGARKLQESPSLSALSEAQPSSPVRPSI
PKPSAPKSAEPSSTAPSDAPQPPAPQPAQDKAPEPTPQPGRASKPAQSPLALQTPALPLT
PYAQIMQSLQLSGHAQGAQQGPAAPVSEPKPHAAVFARVASPPPGAPEKRLPSAAAPPVL
AEKARVPTVPARPGSSLRSSIENLESEALFEAKFKRSRQSPLSRGLRLLSRSRSEERGPF
RGATEEDGMYRPSPAGTPLELVRRPERSRSVQDLRAVGEPGLVRRLSLSLSQRLRRTPPA
QRHPAWEARGGDGESSEGGSSARGSPVLTVRRRLSSTLERLSSRLQRSGSSEDSGGGSGR
STPLFGRLRRATSEGESLRRLDIPHNQLAAQPGATTPSAESLGSEASGTSGSSAPGESRS
RLRWGLSRLRKDKGLSQPNLSASVQEDLGHQYVRSESDFPPVFHIKLKDQVLLEGEAATL
LCLPAACPAPHISWMKDKQSLRSEPSVIIVSCKDGRQLLSIPRAGKRHAGLYECSATNVL
GSITSSCTVAVARVPGKLAPPEVPQTYQDTALVLWKPGDSLAPCTYTLERRVDGESVWHP
VSSGIPDCYYNVTDLPIGVTVRFRVACANRAGQGPFSNPSEKVLIRGTQDSSALPSAAHQ
EAPVTSGPARAPPPDSPTSLALPPAPAPPAPPLVTLSPSSPPMPPSQALSSLKAVGPPPQ
TPPRKHRGLQAARQAEPTPPSARITPNEPKSFVPDTGIPTPASAPQGVKPAPSSTPLYMV
TSFVSAPPAPEPPAPEPPPEPTKVTVRSLSPAQEVVSTPGSSPRSSPRPESTTLRQGPPQ
KPYTFLEEKARGRFGVVRACRENATGRTFMAKIVPYAAEGKRQVLQEYEVLRMLHHERLM
SLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYVVQLLQGLDYLHGRHVLH
LDIKPDNLLLAPDNSLKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSATD
IWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHP
WSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRRRAEAATRHKVLLRSY
PGGP
NT seq
9735 nt
NT seq
+upstream
nt +downstream
nt
atgaagaagctgtgggtgaagaagcgtttccagaaaaccggccattcccgccgggccttt
ggccgactcacccatgttttccgctcctgcagaaagcaaagttacgactcggagacggct
gaggatgacatcagcgatgtacaggggacccagcgcctggagcttcgggatgacggggcc
ttcagcacccccacggggggctctgacaccctggtgggcacctccctggacacacccccg
acctccgtgacaggcacctcggaggagcaagtgagctggtggggcagcgggcagacggtc
ctggagcaggaagcgggcagtgggggtggcacccgccgcctcccgggcagcccaaggcaa
gcacaggcaaccggggccgggccacggcacctgggggtggagccgctggtgcgggcatct
cgagctaatctggtgggcgcaagctgggggtcagaggatagcctttcggtggccagtgac
ctgtatggcagcgcgttcagtctgtacagaggacgggcgctctcgatccacgtgctccag
ttgtccccaggatccccccccctcgggggccccctccgtgcctgctgtctcagcagctgc
tgccttttcatctctctgcacattcctgttcccatgtgggcctttttctgggaggaacag
aacctttctgcacggcagctcccgggagagcaggagagagcaggggagcaagtgagcaac
cgagagagagagaagagagcgagcagcgtccctcagagcggattgcgcagggaggagccc
gaccttcagcctcagctggccagcgaagccccgcgtcgcccggcccctccaccaccctcc
aaatccgcgctgctccccccaccgtcccctcgggtgggtaagcggtccccgccgggaccc
agcgcccagcccgcggctacccctacatcaccccaccggcgcactcaggagctggtgcta
cccgaggacgccaccgccgaagagaagcgagggaaaaagtccaaatcgtcggggccctcg
ctggcaggcacggcagagtcccgtcctcagacgcccctgagcgaggcttcgggccgcctg
tcggcgctcggccgctcgccgaggctggtgcgcgccggctcccgcatcctggacaagctg
cagttcttcgaggaacgacggcgcagcctggagcgcagcgactcgccgccggcacccctg
cggccctgggtgccactgcgcaaggcccgctctctggagcagcccaagtcggagggcggc
gcgccgtggggcacgcccggggcctcacaggaggagctgcggtcgccgccgggcagcgtg
gccgagcggcgccgcctgttccagcagaaggcggcctcgctggacgagcgcacacggcag
cgcagcgcggcctccgacctcgagctgcgtttcgcccaagagctgggccgcatccgccgc
tccacgtcgcgggaggagctggtgcgctctcacgagtccctgcgcgccacgctgcatcgc
gccccgtcccctcgagagcccggcgagcccccgctcttcccccggccctccacccccaaa
accccgcgggccgtgagccccgccgcagcccagccggcccctccgagcgtcgcggggagg
cctggggaagagccagggaggcccaggagccgtgggccggtgggccggacggagctgggg
gacggcccgcagcaagaggttaggcgtcgagaccagttcccgctgacccggggcagagct
atccaggagtgcaggagccccgtgccaccccccgccgccgatcctccagaagccaggacg
aaagtccccccgggacgaaagcgggagcccccagcgcaggctgtgcgcttcctgccctgg
gccacgccgggcctggagggcgttactgtgccccagaccttggagaagaacagggcgggg
cctgaggccgagaagaggctgcgcagagggccggaggaagacggtccctggggggcctgg
gaccgcagagggactcgcagccagggcaaaggtcgccgggcccggcccacctcccctgag
ctcgagtcttcggatgattcctatgtgtccgctggagaggagcccctggaggcccccgta
tttgagatccctctgcagaatgtggtggtggcaccaggggccgacgtgctgctcaaatgt
atcatcaccgccaatcccccaccgcaagtgtcctggtacaaggatgggtcagcgctgtgc
agcgagggccgcctcctcgtccgggccgagggtgagcggcacaccctgctgctcagggag
gcccgggcgactgacgccgggagctatatggccaccgccaccaacgagctgggccaggcc
agctgtgccgcctcactggccgtgagacctggtggatcctcatcccctttcagcagcccc
atcacctcggacgaggagtacctgagccccccagaggatttcccggagcctggagaaacc
tggccccaaacccccaccatgaagctcagtcccagccagaaccgccgttcttctgacact
ggctccaaggcaccccccaccttcaaggtctcacttatggaccagtcagtaagagaaggc
caagatgtcatcatgagcatccgcgtgcagggggagcccaagcctgtggtctcctggctg
agaaaccgccagccggtgcgcccggaccagcggcgcttcgcagaggaggcggagggcggg
ctgtgccggctgcggatcctggctgccgagcgcggcgacgccggcttctacacgtgcaag
gcggtcaacgagtatggcgctcggcagtgcgaggcccgcctggaggtccgagcacaccct
gaaagccggtccttggccgtgctggcccccctgcaggacgtggacgtgggggccggggag
atggcgctgtttgagtgcctggtggcgggtcccaccgatgtggaggtggactggctgtgc
cgcggccgcctgctgcagcctgcgctgctcaaatgcaagatgcatttcgatggccgcaaa
tgcaagctgctgctcacctctgtgcatgaggacgacagtggtgtctacacctgcaagctc
agcacggctaaagatgagctgacctgcagtgcccggctgaccgtgcggccctcgctggcg
cctctgttcacacggctgctggaagacatggaggtgctggagggccgagctgcccacttc
gactgcaagatcagtggcaccccgcccccctcggttacctggacccactttggccacccc
gtggaggagagcgagaacctgcggctgcggcaggacgggggtctgtactcactgcatatc
gcccacgtgggcagcgaggatgaggggctctacgaggtcagtgccaccaacacccatggc
caggcccactgctcagcccagctctacgtggaggagccccggacagcagcctcaggcccc
agctcgaagctggagaagatgccgtccatccccgaggagccagagcagggcgagctggag
cggctgtccattcctgacttcctgcggccactgcaggacctggaggtgggcctggccaag
gaggccatgctggagtgccaggtgactggcctgccctaccccaccatcagctggttccac
aatggccaccgcatccagagcagtgacgaccggcgcatgacacagtacagggatgtacat
cgcttggtgttccctgctgtggggcctcagcacgccggtgtctacaagagtgtcatcgcc
aacaagcttggcaaagctgcctgctatgcccacctgtacgtcacagatgtggttccaggc
cccccagacggcgtcccgcaggtggtagctgtgactgggaggatggtcacgctcacgtgg
aacccgcccagaagtctggacatggccattgacccggactccctcacgtacacggtgcag
caccaggtgctgggctcggaccagtggacagtgctggccacaggcctgcgggagcctggc
tgggtggccacagggctgcggaaggggctccagcacacgttccgggtcctcaccaccacc
gtcaagagcagcagcaagccctcgcccgcctctgagcccgtgcagctgctggagcgcggc
ccgcccctggatgaggctcctgctgtgctggacaaaccggacatcgtgtatgtggtagag
ggacagcctgccagtgtcactgtcaccttcaaccatgtggaggcccaagtcgtctggagg
agctgccgaggggccctcctagaggcacgggcaggtgtgtacgagctgagccagccggat
gacgaccagtactgccttcggatctgccgggtgagccgccgggacatgggggccctcacc
tgcactgctcgaaaccgccatggctcgcagacctgctcagtcacactggagctggcagag
gcccctcggtttgagtccatcatggaggatgtggaggtgggggccggggaaactgcccgc
tttgctgtggtggttgaggggaagccactgccagacatcatgtggtataaggatgaggtg
ctgctggctgagagcagccatgtgagcttcgtgtatgaggagaatgagtgctccctggtg
gtgctgagcacaggggcccaggatggaggcgtctacacctgcacagcccggaacctggcg
ggcgaggtctcctgcaaagcagaactggctgtgcattcagctcagacagctatggaagtc
gagggggtcagggaggacgaggagcatcgaggaaggagactcagcgacttctatgacatc
caccaggagattggcagaggtgccttctcctacctgcggcgtgtggtggagcggagctcc
agcctggagtttgcggccaagttcatccccagccaggccaagccaaaggcatcagcatgg
cgggaggcccggctgctggcccggctccagcatgattgtgtcctctacttccatgaggcc
ttcgagaggcgccggggactggtcattgtcaccgagctctgcacagaggagctgctggag
cgaatggccaggaaacccaccgtgtgtgagtctgagatccgggtctatatgcggcagata
ctagagggaatacactacctgcaccagagccatgtgctgcacctcgatgtcaagcccgag
aacctgctggtgtgggatggtgcagggggagaagagcaggtgcggatctgcgactttggg
aatgcccaggagctgactccaggagagcctcagtactgccaatatggcacacctgagttt
gtggcgcctgagattgtcaaccagagccctgtgtcgggagtcactgacatctggcccgtg
ggcgtcgttgccttcctctgtctgacaggaatctccccgtttgttggagaaaacgatcgg
acaacattgatgaacatccgaaactacaatgtggcctttgaggagaacacgttcctgagc
ctgagcagggaggcccggggtttcctcatcaaagtgctggtgcaggaccagctgagacct
accgcaaaggagaccctagaacatccttggttcaaaactcaggcaaagggtgcagatgtg
agcacagatcacctaaagctgttcctgtcccggcggaggtggcagcgctcccagatcagc
tacaagtgccacctggtgctgcgccccatccccgagctgctgcgcgcccctccagagcgg
gtgtgggtgaccatgcccagaagagcacccccgagcggagggctctcatcctcctcggat
tctgaagaggaagagcttgaagagctgccctcagtgccccgcccgctgcagcccgagttc
tctggctcccgggtgtccctcaccgacattcccactgaggatgaggccctggggacccca
gaggctggggcttccacccccatggactggcaagaacagggaagggttccctctcaggat
caggaggctcccagccctcaggccctcccctctccaggccaggagcccccagctgggccc
agccccaggcggggagagctccgcaggggcagctctgccgagagcgccctgccccgggcc
gggccgcgggagccgggccggggcctgcacaaggcagcgtctgtggagctgccgcagcgc
cggagccccagcccgggggccacccgcctggcccggggaggcctgggcgagggcgagtac
gcccagaggctgcaggccctgcgacagcggctgctgcggggaggccccgaggatggcaag
gtcagcggcctcaggggccccctgctggagagcctggggggccgtgcccgggacccccgg
atggctcgagctgcctccagcgaggcagcgccccaccaccagcccccacccgagactcgg
ggcctgcaaaagagcagcagcttctcccagggtgaggcggagccccggggccggcaccgc
cgcgctggggcgccccttgagatccccgtggccaggcttggggcccgcaagctacaggag
tctccctccctgtctgccctcagcgaggcccagccgtccagccctgtgcggcccagcatc
cccaaacccagtgcccccaagtctgcggaaccttcttccaccgcaccgagtgatgctccg
cagcccccagctccccagcctgcccaagacaaggccccagagcccacaccgcagccaggg
cgagcctccaagcccgcacagtcccccttggccctgcaaaccccagcgctgcccctcaca
ccctatgcccagattatgcagtcgcttcagctgtcgggccacgcccagggtgcccagcag
ggccctgctgcgcccgtgtcagagcccaagccccacgccgctgtgttcgccagggtggcc
tcaccgcctccgggagccccggagaagcgcctgccctctgcggcggctcccccagtgcta
gctgagaaagcccgggtccccacggtgcccgccaggccgggcagcagcctccgcagcagc
atcgagaacctggagtctgaggccctgtttgaggccaaattcaagcgcagccgccagtcg
cccctgtcgcgggggctgcgattgctgagccgctcgcgctcggaggagcgcggccccttc
cgcggggctacggaggaggacggcatgtaccggcccagccctgcgggaaccccgctggag
ctggtgcgacggcccgagcgctcgcgctctgtgcaggacctcagggcggtcggggagccc
ggcctcgtccgccgcctgtcgctgtcgctgtcccagcggctgcggcggaccccgcccgcg
cagcggcacccagcctgggaggcccgcggcggggacggggagagctcggagggcgggagc
tcagcgcggggctccccggtgctgacggtgcgcaggaggctcagctccacgctggagcgg
ctgtccagccggttgcagcgcagcggcagcagcgaggactcggggggcgggtcgggccgc
agcacgcccctgttcggacggctgcgcagggccacgtcggaaggtgagagtctgcggcgc
ctcgacatcccgcacaaccagctggccgcacagccgggcgccaccactccttccgcggag
tctctgggctctgaggccagcggcacctccggctcctcagctccaggggaaagccgaagc
cggcttcgctggggcctctctcggctgcggaaggacaaggggttatcacaaccaaacctc
tctgccagcgtccaggaggacttgggtcaccagtatgtgcgcagtgagtcagacttcccc
ccagtcttccacatcaaactcaaggaccaggtgctgctggagggagaggcagccacgctg
ctctgcctgccggcggcctgccctgcaccgcacatctcctggatgaaagacaagcagtct
cttcggtcagagccctcggtgatcattgtgtcctgcaaagacgggcggcagctgctgagt
atcccccgggcgggcaagcggcacgccgggctctatgagtgttcagctaccaatgtccta
ggaagcatcaccagctcctgtactgtggctgtggcccgagtcccaggaaagctagctcct
cccgaggtgccccagacctaccaggacacggcgctggtgctgtggaagccgggagacagc
ctggcaccttgcacatacacgctggagcggcgggtggatggggaatctgtctggcaccct
gtgagctcaggcatccccgactgctactacaacgtgaccgacctgccaattggtgtgacc
gtgaggttccgtgtggcctgtgccaaccgtgctgggcaggggcccttcagcaacccttct
gagaaggtcctcatcaggggcactcaagattcttcagctctgccatctgctgctcaccaa
gaggcccctgttacctcagggccagccagggccccacctcctgactctcctacctcactg
gccctgcccccagctcctgctcccccagcccccccgttggtcactctcagcccctcatct
ccccctatgccccccagccaggccttgtcctcactcaaggctgtgggtccaccaccccaa
acccccccacgaaagcacaggggcctgcaggctgcccggcaagcagagcccaccccaccc
agtgcccggatcaccccaaatgagcccaagtcttttgtccctgacactgggatcccaact
ccggcctccgcccctcaaggggttaaaccagcgccttcctctactcccctgtatatggtg
acttcctttgtgtctgcaccccccgcccccgagccccccgcccctgagccccctcctgag
cccaccaaggtgactgtgcggagcctcagcccagcccaggaggtagtcagcacccctggg
agcagtccccgcagctctcccaggccagagagtaccactcttcgacagggtccccctcag
aaaccctacaccttcctggaggagaaggccaggggccgctttggtgttgtgcgagcatgc
cgggagaacgccacagggcgaacgttcatggccaagattgtgccctatgcggctgagggc
aagcggcaagtcctgcaggaatacgaagtgctgcggatgctgcaccatgagcggctcatg
tccctgcacgaggcctacatcaccccccgttaccttgtgctcattgctgagagctgcggc
aaccgggaactcctctgtgggctcagcgacaggttccgatattcagaggatgacgtggcc
acctacgtggtacagctgctacaaggcctggactacctccacggccgccatgtgctacac
ctagacatcaagccggacaacctgctgctggcccctgacaatagcctcaagatcgtggac
ttcggcagtgcccagccctacaaccctcaggccctgcggccccttggccaccgcacgggc
acgctggagttcatggctcctgagatggtgaagggagaacctatcggctctgccacggac
atctggggagccggtgtgctcacctacatcatgctcagtggacgctccccattctatgag
ccagacccccaggaaacagaggctcggattgtagggggccgctttgatgccttccagcta
taccccaatacttcccagagcgccaccctcttcttgcgaaaggtcctctcagtacatccc
tggagccggccctccctgcaggactgcctggcccacccctggctgcaggacgcctacctg
atgaagctgcgccgccagacgctcaccttcaccaccaaccggctcaaggagttcctgggt
gaacagcggcggcggcgggcagaggccgccacccgccacaaggtgctgctgcgctcctac
cctggcggcccctag
DBGET
integrated database retrieval system
