Lemur catta (Ring-tailed lemur): 123645085
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Entry
123645085 CDS
T08326
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
lcat
Lemur catta (Ring-tailed lemur)
Pathway
lcat00230
Purine metabolism
lcat01100
Metabolic pathways
lcat04927
Cortisol synthesis and secretion
lcat04934
Cushing syndrome
lcat05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
lcat00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
123645085 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
123645085 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
123645085 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
123645085 (PDE8A)
Enzymes [BR:
lcat01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
123645085 (PDE8A)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
PDEase_I
PDE8A_N
PAS_9
PAS
PAS_4
PDE8
PAS_3
DUF5894
PAS_8
Sina_ZnF
HTH_Mga
Motif
Other DBs
NCBI-GeneID:
123645085
NCBI-ProteinID:
XP_045417563
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Position
9:complement(3597881..3732461)
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AA seq
837 aa
AA seq
DB search
MGCAPSTHISEGRAVYQGGEEAAVAPGPAAPPPPSSGRPSLTQGQKMTALRPARAASLAE
SEPRDGSGKKVAVAEVQFGPMRFHQDQLQVLLVFAKEDNQCNGFCRACEKAGFKCTVTRE
AQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSELSENTVIVGVVRRVDREELSV
MPFLAAGFTRRYIENPSIMACYNELLQLEFGEVRSQLKLRACNSIFTALEKSQEAIEITN
EDHIIQYANPAFETTMGYQAGELIGKELGEMPINEKKADLLDTINSCIKIGKEWQGVYYA
KKKNGDNVQQNVKIIPVLGQGGKIRHYVSIIRVCSGNNKAEKISECVQSDTNTDNQTGKH
KDRRKGSLDVRAVASRSGETSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVT
EALDRVLEILRTTELYSPQFDAKDDDPHANDLVGALVSDGLRRLSGNEYVLSTKGSQQVS
SNIITPISLHDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLN
CSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPVDKVAALIA
ATIHDVDHPGRTSSFLCNAGSELAILYNDIAVLESHHAALAFQLTTGDDKCNIFKNMERN
DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLAALEESEETEKNQEAINSMLRTPE
NRTLIKRMLIKCADVSNPCRPLESCIEWAARISEEYFSQTDEEKQQDLPVVMPVFDRNTC
SIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDERKFRSLRPPPE
NT seq
2514 nt
NT seq
+upstream
nt +downstream
nt
atgggttgcgccccgagcacccacatttccgagggccgggcggtgtaccaaggcggcgag
gaggccgcggtcgccccggggcccgcggcgccgccgccgccgtcgtccggccggccgtcc
ctcacacagggccagaagatgaccgccctgcgcccggcccgcgccgccagcctcgcggag
tccgagcctcgcgacggcagcgggaagaaggtagcagtagctgaggtgcaatttggcccc
atgagatttcaccaagatcaacttcaggtacttttagtgtttgccaaagaagataaccaa
tgtaatggattctgcagggcatgtgaaaaagcagggtttaagtgtacagtcaccagggag
gctcaggctgtccttgcctgtttcctggacaaacatcatgacatcatcattatagaccac
agaaatcctcgacagctggatgcagaggcactgtgcaggtctataagatcatcagaactc
tcagaaaacacagttattgttggtgtagtacgcagggtggatagagaagagttgtctgta
atgccctttcttgctgctggattcacaaggaggtatattgaaaaccccagcatcatggct
tgctacaatgaactgctccagctggagtttggagaggtgcggtcacaactgaaactcagg
gcttgtaactcaatattcactgcattagagaaaagtcaagaagcaattgaaataacaaat
gaagaccacattatacagtatgcaaatcctgcatttgaaacaacaatgggctatcaggca
ggtgaattaatagggaaggagttaggagaaatgcctataaatgaaaagaaggctgacttg
ctggatactataaattcatgcatcaagataggcaaggagtggcaaggagtttactatgcc
aaaaagaaaaacggagataatgtacaacaaaatgtgaagataatacctgtccttggacag
ggaggaaaaattagacactatgtgtccattatccgagtgtgcagcggcaacaataaggct
gagaaaatatctgaatgtgttcagtctgacactaatacagataatcagacaggcaaacat
aaagacagaaggaaaggctcactggacgtcagagctgtcgcctcccgatcaggtgaaacg
tccagtcagagacgacactcctccatggcccggatacattccatgacgattgaggcgccc
atcaccaaggtaatcaatattatcaatgctgcccaggaaagcagtcccatgcctgtgaca
gaggccctggaccgtgtgctggaaattctaagaaccactgaattatactcaccacagttc
gatgctaaggatgacgatcctcacgccaatgacctcgttggtgccttagtgtctgatggt
ttgcgaagactatcagggaatgaatatgttctttcaacaaaaggcagtcagcaggtttca
agcaatataatcactcccatctcccttcacgatgtcccaccacggatagctcgggctatg
gaaaatgaggaatactgggactttgatatttttgaactggaggctgccacccacaatagg
cctttgatttatcttggtctcaaaatgtttgctcgctttggaatctgtgaattcttaaac
tgctccgagtcaacgctgagatcatggttacaaattattgaagccaattatcattcttct
aacccctaccacaattctacacattctgctgatgtgcttcacgccactgcctattttctc
tccaaggagagaataaaggaaactttagatccagtggacaaggttgctgcgctcattgca
gccaccattcatgatgtcgatcaccctgggagaaccagctccttcctgtgcaatgctggc
agtgagctcgccattctgtacaatgacattgctgtgctggagagccaccacgcggccttg
gccttccagctgaccactggagatgataaatgcaatatctttaaaaacatggagaggaat
gactatcggacactgcgccaggggattattgacatggtcctagccacagaaatgacaaag
cacttcgaacatgttaacaaattcgtcaacagcatcaacaaacccttggcagcactagaa
gaaagtgaggagactgaaaaaaatcaggaagccataaactctatgctcaggactccagag
aatcggactctaatcaaacgaatgctgattaagtgtgctgatgtgtccaatccctgccga
cccctagagtcctgcatcgagtgggctgcacgcatttcagaagagtatttttctcagact
gatgaggagaagcagcaggacttgcctgtggtgatgccggtttttgacagaaatacctgc
agcatccccaaatcccagatctctttcattgactacttcatcacagacatgtttgatgct
tgggatgccttcgtagacctgcctgatctaatgcagcatcttgacaacaacttcaaatac
tggaaaggactggatgaaaggaagtttcggagcctccgaccacctcccgaatag
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