Lemur catta (Ring-tailed lemur): 123646429
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Entry
123646429 CDS
T08326
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
lcat
Lemur catta (Ring-tailed lemur)
Pathway
lcat00790
Folate biosynthesis
lcat01100
Metabolic pathways
lcat01240
Biosynthesis of cofactors
lcat01523
Antifolate resistance
lcat04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
lcat00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
123646429 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
123646429 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
123646429 (FPGS)
Enzymes [BR:
lcat01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
123646429 (FPGS)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
123646429
NCBI-ProteinID:
XP_045419311
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Position
10:complement(7702888..7721200)
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AA seq
588 aa
AA seq
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MSQAASHLRAALSLAAVSARGATTRGAARRRLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDQLNIIHVTGTKGKGSTCAFTECILRN
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRVYHRLEETKDSSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTLEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPPLEALEEGGPPLMLGLEGE
HQRSNAALALQLAHSWLQQQDHQGTGELKASRPSLLWQLPLAPTFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTSSSVQACVRWFRQALQGRQRLSAGPEVRVLLFNSTGDRD
SAALLKLLQPCQFDYAVFCPNLTEVSSTGSAADQQNFTVTLDQVLLRCLEHQQHWNRLDE
EQASPDLWSTPSLEPGGPASLRLVPHPPHSCSASSLVFSCISHALQWISQGRDPVFQPPR
PPRGLFAHPVAASGASVLQEAVAIHVLVTGSLHLVGGVLKLLEPSLSQ
NT seq
1767 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcaggcggcgagccacctgcgcgcggctctgtccctggcagcggtttctgcgcgc
ggcgcaacgacccggggcgcggcgaggcggaggttgagcgcgtggccggtgccgcaggag
cccagcatggagtatcaggatgcggtgcgcatgctcaacaccctgcagaccaatgctggc
tacctggaacaggtgaagcgccaacggggcgacccccagacacagcttgaagccatggag
ctgtacctggcacggagtgggttgcaggtggaggacttggaccagctgaacatcatccat
gtcactgggaccaaggggaagggctccacgtgtgccttcactgaatgtatcctccgaaac
tatggcctgaagactggattctttagctctccccacctggtgcaggtgcgcgagcggatc
cgcatcaacgggcagcccatcagccccgagctcttcaccaagtacttctggcgcgtctac
caccggctggaggagactaaggacagcagctgtgtctccatgcccccctacttccgcttc
ctcacgctcatggccttccacgtcttcctccaagagaaggtggacctggcagtggtggaa
gtgggcattggcggggcttatgactgcaccaacatcatcaggaagcctgtggtgtgtgga
gtctcctctcttggcatcgaccacaccagccttctgggggacacgttggagaagatcgca
tggcagaaagggggcatctttaagcaaggtgtccctgcctttactgtgctccagcccgaa
ggtcccctggcagtgctgcgggatcgagcacagcagatctcatgtcctctctacctgtgc
ccaccgctggaagccctggaggaaggggggccaccactgatgctgggcctggagggagaa
caccagcggtccaatgctgccttggccttgcagctggcccacagctggctgcagcagcag
gaccaccagggcactggggagctgaaggcgtccaggccgagcctcctgtggcagctgccc
ctggcaccgacgttccagcccacatcccacatgcggctcgggcttcggaacacggaatgg
ccgggccggacgcaggtgctgcggcgcgggcccctcacctggtacctggacggcgcgcac
acctccagcagcgtgcaggcctgcgtgcgctggttccgccaggcgctgcagggccgccag
aggctgagcgcggggccagaggtgcgtgtcttgctgttcaactccactggggaccgggac
tccgcggccctgctgaagctgctgcagccctgccagtttgactatgcagtcttctgcccc
aacctgacagaggtgtcatccacaggcagtgcagcagaccagcagaacttcacagtgaca
ctggaccaggtgctgctccgctgcctcgaacaccaacagcactggaaccgcctggatgag
gagcaggccagcccggacctctggagcacccccagcctggagcctggtgggccggcgtct
ctgcggctggtgcctcacccgccccacagctgcagcgccagctccctcgtcttcagctgc
atctcccacgccttgcagtggatcagccagggccgggaccctgtctttcagccaccccgt
cccccaaggggcctctttgcccaccctgtggcagctagcggggccagtgtactccaagag
gctgttgccattcacgtgctggtcacgggcagcctgcacctggtgggtggtgtcttgaag
ctgctggaaccctccttgtcccagtag
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