Lemur catta (Ring-tailed lemur): 123647518
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Entry
123647518 CDS
T08326
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
lcat
Lemur catta (Ring-tailed lemur)
Pathway
lcat00220
Arginine biosynthesis
lcat00330
Arginine and proline metabolism
lcat01100
Metabolic pathways
lcat04020
Calcium signaling pathway
lcat04022
cGMP-PKG signaling pathway
lcat04066
HIF-1 signaling pathway
lcat04071
Sphingolipid signaling pathway
lcat04151
PI3K-Akt signaling pathway
lcat04370
VEGF signaling pathway
lcat04371
Apelin signaling pathway
lcat04611
Platelet activation
lcat04915
Estrogen signaling pathway
lcat04921
Oxytocin signaling pathway
lcat04926
Relaxin signaling pathway
lcat04931
Insulin resistance
lcat04933
AGE-RAGE signaling pathway in diabetic complications
lcat05415
Diabetic cardiomyopathy
lcat05417
Lipid and atherosclerosis
lcat05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
lcat00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
123647518 (NOS3)
00330 Arginine and proline metabolism
123647518 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
123647518 (NOS3)
04371 Apelin signaling pathway
123647518 (NOS3)
04066 HIF-1 signaling pathway
123647518 (NOS3)
04020 Calcium signaling pathway
123647518 (NOS3)
04071 Sphingolipid signaling pathway
123647518 (NOS3)
04022 cGMP-PKG signaling pathway
123647518 (NOS3)
04151 PI3K-Akt signaling pathway
123647518 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
123647518 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
123647518 (NOS3)
04921 Oxytocin signaling pathway
123647518 (NOS3)
04926 Relaxin signaling pathway
123647518 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
123647518 (NOS3)
05418 Fluid shear stress and atherosclerosis
123647518 (NOS3)
05415 Diabetic cardiomyopathy
123647518 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
123647518 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
123647518 (NOS3)
Enzymes [BR:
lcat01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
123647518 (NOS3)
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GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
123647518
NCBI-ProteinID:
XP_045420974
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Position
11:complement(5279219..5297687)
Genome browser
AA seq
1197 aa
AA seq
DB search
MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPVSEPSQAPVSPPLPAAEHSPPLTRPP
EGPKFPRVKNWEVGSIAYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQSRPSPGPAAPEQL
LSQARAFINQYFGSIKRSGSQAHQQRLQEVEAEVAATGTYQLQESELVFGAKQAWRNAPR
CVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRI
WNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWAPGNGRFDVLPLLLQAPDEPPELF
PLPPELVLEVPLEHPTLEWFAALDLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIG
TRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDHHAA
TASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGG
AAKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATVLYGSETGRAQSYAQQLGRLFR
KAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRP
EQHKSYKIRFNSVSCSDPLVSSWRRRRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAF
ARAVDTRLEELGGERLLPLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAARDI
FSPKQSWKRQRYRLSAQVEGLQLLPGLTHVHRRKMFQASVLSVENLQSSKSTRATILVRL
DTRGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGPPPG
WVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLGTLAEEPGEQQELEALSQDPRRYEEW
KWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSVHPGQIHLTVAVLAYR
TQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRG
FWQERLHDIESKGLHPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSREPDS
PKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELEEAG
DVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPALDT
NT seq
3594 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagcgtggcccaggagcccgggccaccctgcggcctggggctgggg
ctgggcctcgggctgtgtggcaagcagggcccagccaccccggtatcagagcccagccag
gccccggtctccccacccctgccggcagccgaacacagccccccgctaacccggcctcca
gaggggcccaagttccctcgagtgaagaactgggaggtggggagcatcgcctacgacacc
ctcagcgcccaggcgcagcaggatgggccctgcacccccagacgctgcctgggctccctc
gtgtttccgcggaagttgcagagccggccctccccgggccctgcagcccctgagcagctg
ctgagtcaggccagggccttcatcaaccagtactttggctccatcaagaggagcggctcc
caggcccaccagcagcggctccaggaggtggaagccgaggtggcagccacaggcacctac
cagctgcaggagagcgagctggtgttcggggccaagcaggcctggcgcaacgctccccgc
tgcgtgggccgcatccagtgggggaagctgcaggtgttcgatgcccgagattgcaggtct
gcccaggaaatgttcacctacatctgcaaccacatcaagtatgccaccaaccggggcaac
cttcgctcggccatcacagtgttcccgcagcgctgcccaggccgaggggacttccggatc
tggaacagccagctggtgcgctacgcaggctacaggcaacaggatggctctgtgcggggg
gacccggccaacgtggagatcaccgagctctgcatccagcacggctgggccccaggaaac
ggccgcttcgatgtgctgcccctgctgctgcaggccccagacgagcccccagaactcttc
cctctgcctcctgagctggtcctcgaggtgcccctggaacaccccacgctggagtggttc
gcggccctggacctgcgctggtatgccctcccggcggtgtccaacatgctgctggaaatt
gggggcctggagttccccgcagcccccttcagtggctggtacatgagcactgagatcggc
acacgcaacctgtgcgaccctcaccgctacaacatcctggaggatgtggccgtctgcatg
gacctggatacccggacaacgtcatccttgtggaaagacaaggcagcggtagaaattaac
ttagccgtgctgcacagttaccagctggccaaagtgaccatcgtggaccaccacgccgcc
acggcctccttcatgaagcacctggagaacgagcagaaggccagggggggctgccctgcc
gactgggcctggatcgtgccccccatctcaggcagcctcactcctgtcttccatcaggag
atggtcaactacttcctgtcccctgccttccgctaccagccagacccctggaaggggggt
gcagccaagggcgccggcatcaccaggaagaagacctttaaggaagtggccaacgcggtg
aagatctccgcctcactcatgggcacagtgatggcgaagcgggtgaaggccacagtcctg
tacggctccgagaccggccgggctcagagttacgcacagcaactagggagactcttccgg
aaggctttcgacccccgggtcctgtgcatggatgagtatgacgtggtatccctcgagcac
gagacgctggtgttggtggtgaccagcacattcgggaacggggatcccccggaaaatgga
gagagcttcgcagcggccctcatggagatgtctggcccctacaacagctcccctcggccg
gagcagcacaagagttacaaaatccgcttcaacagtgtctcctgctcagacccgctggtg
tcctcctggcggcggaggaggaaggagtccagtaacacagacagtgcaggggccctgggc
accctcaggttctgtgtgttcgggctgggctcccgggcatacccccacttctgtgccttt
gctcgtgcggtggacacgcggctggaggagctgggcggggagcgtctgctgccgctgggc
cagggcgacgagctgtgcggccaggaggaggccttccgcggctgggcccaggccgccttc
caggcctcctgtgagactttctgtgttggagaggatgccaaggccgccgcgagagacata
ttcagccccaaacagagctggaagcgccagagataccggctgagtgcccaggttgagggc
ctgcagttactgccaggcctgacccatgtgcacaggcgcaagatgttccaggcttcagtc
ctctcagtggaaaacctgcaaagcagcaagtccacccgggccacaatcctggtgcgcctg
gacaccagaggccaggaggggctgcagtaccagccaggggaccacataggcatctgccca
cccaaccggcctggcctcgtggaggcgctactgagccgtgtagaggacccgccggcaccc
accgagccagtggcagtggagcagctggagaagggcagccctggtggccctcctcccggc
tgggtgcgggacccccggctgcccccgtgcacgctgcgccaggctctcaccttcttcctg
gacatcacctccccacccagccctcaactccttcgactgctcggcaccctcgctgaagag
cccggcgaacagcaggagctggaggccctcagccaggacccccggcgctacgaggaatgg
aagtggttccgctgccccacgctgctggaggtgctggagcagttcccgtccgtggccctg
ccggcgcccctgctcctcacccagctgcctctactccagccccggtactactcggtcagc
tcggcacccagcgtccacccagggcagatccacctcactgtagccgtgctggcctacagg
acccaggatgggctgggccccctgcactatggcgtttgctcaacatggctgagccagctc
aaggctggagaccccgtgccctgcttcatcaggggggctccctccttccggctaccacct
gatcccagcttgccgtgcatcctggtgggcccaggcactggcattgccccgttccgggga
ttctggcaggagcggctgcacgacatcgagagcaaagggctgcatcccgcccccatgact
ttggtgttcggctgccgatgctcccaactcgaccacctctaccgcgacgaggtgcaggac
gcccagcagcgcggggtgtttggccgcgttctcaccgccttctcccgggaacccgacagc
cccaagacctacgtgcaggacatcctgaggaccgagctggctgctgaggtgcaccgcgtg
ctgtgcctcgagcggggccacatgttcgtctgcggcgatgtcaccatggcaaccagcgtc
ctgcagactgtgcagcgaatcctggcgaccgagggcgacatggagctggaagaggccggt
gacgtcatcggcgtgctgcgggatcagcaacgctaccacgaggacattttcgggctcacg
ctgcgcacccaggaggtgacgagccgcatacgcacccagagcttttccttgcaggagcgg
cagctgcggggcgcagtgccctgggcgttcgacccgcccgccctggacacctag
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