KEGG   Lemur catta (Ring-tailed lemur): 123648419
Entry
123648419         CDS       T08326                                 
Symbol
APC
Name
(RefSeq) adenomatous polyposis coli protein
  KO
K02085  adenomatosis polyposis coli protein
Organism
lcat  Lemur catta (Ring-tailed lemur)
Pathway
lcat04310  Wnt signaling pathway
lcat04390  Hippo signaling pathway
lcat04550  Signaling pathways regulating pluripotency of stem cells
lcat04810  Regulation of actin cytoskeleton
lcat04934  Cushing syndrome
lcat05010  Alzheimer disease
lcat05022  Pathways of neurodegeneration - multiple diseases
lcat05165  Human papillomavirus infection
lcat05200  Pathways in cancer
lcat05206  MicroRNAs in cancer
lcat05210  Colorectal cancer
lcat05213  Endometrial cancer
lcat05217  Basal cell carcinoma
lcat05224  Breast cancer
lcat05225  Hepatocellular carcinoma
lcat05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:lcat00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    123648419 (APC)
   04390 Hippo signaling pathway
    123648419 (APC)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    123648419 (APC)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123648419 (APC)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123648419 (APC)
   05206 MicroRNAs in cancer
    123648419 (APC)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123648419 (APC)
   05225 Hepatocellular carcinoma
    123648419 (APC)
   05226 Gastric cancer
    123648419 (APC)
   05217 Basal cell carcinoma
    123648419 (APC)
   05213 Endometrial cancer
    123648419 (APC)
   05224 Breast cancer
    123648419 (APC)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    123648419 (APC)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123648419 (APC)
   05022 Pathways of neurodegeneration - multiple diseases
    123648419 (APC)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    123648419 (APC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:lcat01009]
    123648419 (APC)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:lcat03036]
    123648419 (APC)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:lcat04812]
    123648419 (APC)
Protein phosphatases and associated proteins [BR:lcat01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     123648419 (APC)
Chromosome and associated proteins [BR:lcat03036]
 Eukaryotic type
  Centrosome formation proteins
   Other centrosome associated proteins
    123648419 (APC)
Cytoskeleton proteins [BR:lcat04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    EB / APC
     123648419 (APC)
SSDB
Motif
Pfam: Arm_APC_u3 APC_basic EB1_binding APC_r APC_u5 APC_rep APC_u14 APC_u15 APC_u9 APC_N_CC SAMP Arm APC_u13 APC_15aa Suppressor_APC ARM_ARMC5 Sec7-like_HUS
Other DBs
NCBI-GeneID: 123648419
NCBI-ProteinID: XP_045422126
LinkDB
Position
12:77898791..78023164
AA seq 2845 aa
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAM
ASSGQIDLLERLKELNLDSNNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPR
RGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQAT
EAERSSQSKHEASSHEAERQNEGQGVAEINMATSGSGQGSTTRMDHETASVLSSSSTHSA
PRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETC
WEWQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQ
VDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCT
ENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENN
CLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAM
GSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS
PKASHRSKQRHKQNLYGDYVFDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGS
LDSSRSEKDRSLERERGIGLGNYHPTTENPGTSAKRGLQISTTAAQIAKVMEEVSAIHTS
QEDRSSGSTTELHCVTEERNALRRSSAAHTHSNTYNFTKPENSNRTCSMPYAKLEYKRSS
NDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGE
LDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRSQSTTYPVYTE
STDDKHLKFQPHFGQQECVSPYRSRGASGSETNRVGSNHGINQNVSQSMCQEDDYEDDKP
TNYSERYSEEEQHEEEERPTNYSIKYNEEKHHVDQPIDYSLKYATDISASQKQSFSFSKS
SSGQSTKTEHISSGSENTSTPSSNSKRQNQLHPSSAQSRSGQTQKATSCKVSSINQETIQ
TYCVEDTPICFSRCSSLSSLSSAEDEIGCDQTTQEADSANTVQIAEIKENSGTRSTEDPV
SEVPAVSQHIRTKSSRLQASGLSSESTRQKAVEFSSGAKSPSKSGAQTPKSPPEHYVQET
PLMFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP
PPPQTVQTKREVPKNKVPPAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGF
SCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEPPEESNENQEKETEKPIDSE
KDLLDDSDDDDIEILEECIISAMPTKSSHKAKKPAQTASKLPPPVARKPSQLPVYKLLPS
QNRIQSQKHVSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEAIRAGAQ
SGEFEKRDTIPTEGRSTDEAQRGKTSSITVPELDDNKTEEGDILAECINSAMPKGKSHKP
FRVKKIMDQVQQASVSSPGTNKNQLDGKKKKPTSPVKPIPQNTEYRAHVRKNADSKNTLS
AERAFSDNKDSKKQNLKNNPKDFNNKLPNNEDRVRGSFTFDSPHHYTPIEGTPYCFSRND
SLSSLDFDDDDVDLSREKAELRKGKENKDSEAKVTSHTELSSSNQQSVNKTQAVTKHPIN
RGQSKPVLQKQSTFPQSSKDIPDRGAATDEKLQNFAIENTPVCFSRNSSLSSLSDIDQEN
NNNKENEPIKETEPPDSQGEPNKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDL
LQECISSAMPKKKKPSRLKGDHEKHSPRNMGGILAEDLTLDLKDIQRPDSEHGLSPDSEN
FDWKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKP
FTSNKGPRILKPGEKSTLETKKIECENKGIKGGKKVYKSLITGKVRSNSEVSSQMKQPLQ
TNMPSISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSV
KSELSPVARQASQIGGSNKGSSRSGSRDSTPSRPAQQPLSRPMQSPGRNSISPGRNGISP
PNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTSLSKNGSSIPRSESAS
KGLNQMNNSNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEE
SASFESLSPSSRPDSPTRSQAQTPVLSPSLPDMPLSTHSSVQAGGWRKLPPNLSPTVEYN
DGRPAKRHDIARSHSESPSRLPINRAGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASS
ESSEKAKSEDEKHVNSISGTKQSKENQVSTKGTWRKIKESEISPTNSTSQTTSSGATNGA
ESKTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKGNPNVKDSK
DNQGKQNVGNGAASVRTTGLENRLNSFIQVDAPDQKGTETKPGQSNPVPASETSESSIAE
RTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDS
KTDSAESSGTQSPKRHSGSYLVTSV
NT seq 8538 nt   +upstreamnt  +downstreamnt
atggctgcagcttcatatgatcagttgttaaagcaagttgaggcactgaagatggagaac
tcaaatcttcgacaagagctagaagataattccaatcatcttacaaaactggaaactgag
gcatctaatatgaaggaagtacttaaacagctacaaggaagtattgaagatgaagctatg
gcttcctctggacagattgacttattagagcgtcttaaagaactcaatttagatagcaat
aacttccctggagtgaaactacggtcaaaaatgtccctacgatcttacggaagccgggaa
ggatctgtatcaagtcgttcaggagagtgcagtcctgttccaatgggttcatttccaaga
agagggtttgtaaatggaagcagagaaagtactggatatttagaagaactcgagaaagag
agatcattgcttcttgctgatcttgacaaagaagaaaaggaaaaagactggtattatgct
caacttcagaatctcactaaaagaatagatagtcttcctttaactgaaaatttttcctta
caaacagatatgaccagaaggcaattggaatatgaagcaagacaaatcagagttgcaatg
gaagaacaactaggtacttgccaggatatggaaaaacgagcacagcgaagaatagccaga
attcaacaaatagagaaggacatacttagaatacgacagcttttgcagtctcaagcaaca
gaagcagagaggtcatctcaaagcaagcatgaagccagctcacatgaagctgagcggcag
aatgaaggtcaaggagtggcagaaatcaacatggcaacttccggtagtggtcagggttca
actacacgaatggaccatgaaacagccagtgttttgagttctagtagcacacactctgca
cctcggagactgacaagtcatctgggaaccaaggtggaaatggtgtattcattgttgtca
atgcttggtactcatgataaggatgatatgtcgcgaactttgctagctatgtctagctcc
caagacagctgtatatccatgcgacagtctggatgtcttcctctactcatccagctttta
catggcaatgacaaagactctgtattgttgggaaattcccggggcagtaaagaggctcgg
gccagggccagtgcagcactccacaacatcattcactcacagcctgatgacaagagaggc
aggcgtgaaatccgagtccttcatcttttggaacagatacgagcttactgtgaaacctgt
tgggagtggcaggaagcccatgaacaaggcatggaccaggacaaaaatccaatgccagct
cctgttgaacatcagatctgtcctgctgtgtgtgttctaatgaaactttcatttgatgaa
gaacatagacatgcaatgaatgaacttgggggactacaggccattgcagagttattgcaa
gtggactgtgaaatgtatgggcttactaatgaccactacagtattacattaagacgatat
gctggaatggctttgacaaacttgactttcggagatgtagccaacaaggctacgctatgc
tctatgaaaggctgcatgagagcacttgtggcccaactaaaatctgaaagtgaagactta
cagcaggttattgcaagtgttttgaggaatttgtcttggcgagcagatgtaaatagtaaa
aagacattgcgggaagttggaagtgtgaaagcattgatggaatgtgctttggaagttaaa
aaggaatcaaccctcaaaagtgtattgagtgccttatggaatttgtcagcacactgcact
gagaataaagctgacatatgtgctgtagatggtgcccttgcatttttggttggcactctc
acttaccggagccagacaaatactttagccattattgaaagtggaggtgggatattacgg
aatgtgtccagcttgatagctacaaatgaggaccacaggcaaatcctaagagagaacaac
tgcctacaaaccttattacaacacttgaaatctcacagtttgacaatagtcagtaatgca
tgcggaactttgtggaatctctcagcaagaaatcctaaagaccaggaagcattatgggac
atgggggcagtcagcatgctcaagaaccttattcattcaaagcacaaaatgattgctatg
ggaagtgctgcagctttgaggaatctcatggcaaatagacctgcaaagtataaggatgcc
aatattatgtcacctggttcaagtttgccatctcttcatgttagaaaacaaaaagcccta
gaagcagaattagatgctcagcatttatcagaaacttttgacaatattgacaatttaagt
cccaaggcatctcatcgtagtaaacagaggcacaaacaaaatctctatggcgactatgtt
tttgacaccaatcgacatgatgataataggtcagacaattttaatactggaaacatgact
gtcctttcaccatatttgaatactacagtattacccagctcctcttcatcaaggggaagt
ttagatagttctcgttctgaaaaagatagaagtttggagagggaacgaggaattggctta
ggcaactaccatccaacaacagaaaatccaggaacctccgcaaaacgaggtttgcagatc
tccaccactgcagcacagattgccaaagtcatggaagaagtatcagccattcatacctcc
caggaagacagaagctctgggtctaccactgagttacattgtgtgacagaggagaggaat
gcactaagaagaagctctgctgcccacacacattcaaacacttataatttcactaagcca
gaaaattcaaataggacatgttctatgccttatgccaaactggaatataagagatcttca
aatgatagtttaaatagtgtcagtagtagtgatggttatggtaaaagaggtcaaatgaaa
ccttcaattgaatcctattctgaagatgatgaaagtaagttttgcagttatggtcaatat
ccagctgacctagcccataaaatacatagtgcaaatcatatggatgataatgatggagaa
ctagatacaccaataaactatagtcttaaatattcagatgagcagttgaactctggaagg
caaagtccttcacagaatgaaagatgggcaagacccaaacacataatagaagatgaaata
aaacaaagtgagcaaagacaatcaaggagtcaaagcacaacttaccctgtatatactgag
agcactgatgataaacacctcaagttccagccacattttggacagcaggaatgtgtttcc
ccatataggtcaaggggagccagtggttcagaaacaaatcgagtgggttctaatcatggg
attaatcaaaatgtaagccagtctatgtgtcaggaagatgactatgaagatgataagcca
accaattatagtgaacgttactctgaggaagagcaacatgaagaagaagagagaccaaca
aattatagcataaaatataatgaagaaaaacatcatgtggatcagcctattgattatagt
ttgaaatatgccacagacatttctgcctcacagaaacagtcattttcattctcaaagagt
tcatctggacaaagcactaaaactgaacatatctcttcaggcagtgagaatacatccaca
ccttcatctaattccaagaggcagaatcagctgcatccaagttcagcccaaagtagaagt
ggtcagactcaaaaagctacctcttgcaaagtttcctctatcaaccaagaaaccatacag
acttactgtgttgaagataccccaatatgtttttcaaggtgtagttcattatcatctttg
tcatcagcggaagatgaaataggatgtgatcagacaacacaggaagcagattctgctaat
actgtgcagatagcagaaataaaagaaaacagtggaaccaggtcaactgaagatcctgtg
agtgaggttccagcagtgtcacagcacattagaaccaaatccagcagactccaggcttct
ggtttatcttcagaatcaaccaggcaaaaagctgttgaattttcttcaggggccaaatcg
ccctccaaaagtggtgctcagacacccaaaagcccaccagagcactatgttcaggagact
ccactcatgtttagcagatgtacttctgtcagttcacttgacagttttgagagtcgttcg
attgccagctctgttcagagtgaaccatgcagtggcatggtcagtggcattataagcccc
agtgacctcccagatagccctggacaaaccatgccaccaagcagaagtaaaacccctcca
cctcctcctcaaacagttcaaaccaagcgagaggtacctaaaaataaagtacctcctgcc
gaaaagcgagagagcggccctaagcaagctgctgtaaacgctgcggttcagagggtccag
gttcttccagatgctgatactttattacattttgccacagaaagtactccagatggattt
tcttgttcatctagcctgagtgctctgagccttgatgagccatttatacaaaaagatgtg
gaattaagaataatgcctccagttcaggaaaatgacaatgggaatgaaacagaatcagaa
ccacctgaggaatcaaatgaaaaccaggaaaaagagacagaaaaacctattgattccgag
aaagatctattagatgattcagatgatgatgatattgaaatactagaagaatgtattatt
tctgccatgccaacaaagtcatcacataaagccaaaaaaccagcccagactgcttcaaaa
ttacctccccctgtggcaaggaaaccaagtcaacttcctgtgtacaaacttctaccatca
caaaacaggatacagtcacaaaagcatgttagttttacaccaggagatgatatgccacga
gtgtattgtgtagaagggacacctataaacttttccacagctacatctctaagtgaccta
acaatagagtctcctccaaatgagttagctgctggagaagctattagagcaggggcacag
tcaggtgagtttgaaaaacgagataccattcctacagaaggcagaagtacagatgaggct
caaagaggaaaaacctcatctataactgtacctgaattggatgacaataaaacagaggaa
ggtgatattcttgcagaatgcattaattctgctatgcccaaaggaaaaagtcacaagcct
ttccgtgtgaaaaagataatggaccaagtccagcaagcatctgtgtcttcacctggaact
aacaaaaatcaattagatggtaagaaaaagaaacctacttcaccagtaaaacctatacca
caaaatactgaatatagggcacatgtaagaaaaaatgcagactcaaaaaatactttaagt
gctgaaagagctttctcagacaacaaagattcaaagaagcagaacttgaaaaataatccc
aaggacttcaataataagctaccaaataatgaagatagagtcagaggaagttttactttt
gattcacctcatcattacacacccattgaaggaactccttactgtttttcacgaaatgat
tctttgagttctctagattttgatgatgatgatgttgacctttccagggaaaaggctgaa
ttaagaaaagggaaagaaaataaggactcagaagctaaagttaccagtcacacagaacta
tcctcctcaaatcaacaatcggttaataagacacaagctgttacaaaacatccaataaat
cgaggtcaatctaaacctgtactgcagaaacaatccacttttcctcagtcatccaaagac
ataccagacagaggagcagcaactgatgaaaaattacagaattttgctattgaaaatact
ccagtttgcttctctcgtaattcgtctctgagttctctcagtgacattgaccaagaaaac
aataataacaaagaaaatgaacctatcaaagagaccgagccccctgactcacagggagaa
ccaaataaacctcaggcatccggttatgctcctaaatcttttcatgttgaagacaccccc
gtttgtttctcaagaaacagttctctcagttctcttagtattgactctgaagatgacctg
ttgcaggaatgtataagttctgcaatgccaaaaaagaaaaagccttcaagactcaagggt
gatcatgaaaaacatagtcccagaaatatgggtggcatattagctgaagatttgacactt
gatttgaaagatatacagagaccagattcagaacatggtttatcccctgattcagaaaat
tttgattggaaagctatccaggaaggtgcaaattccatagtgagtagcttacatcaagct
gctgctgctgcatgtttatctagacaagcttcatctgattcagattccatcctttcactg
aaatcaggcatctctctgggatcaccatttcatcttacacctgatcaagaggaaaaaccc
tttacaagtaataaaggcccacgaattctaaaacctggggagaaaagtacattggaaact
aaaaagatagaatgtgaaaataaaggaatcaaaggaggaaaaaaagtttataaaagtttg
attactggaaaagtacgatctaattcagaagtttcaagccaaatgaagcagccccttcaa
acaaacatgccttcaatctctcgaggtaggacaatgattcatattccaggagttcgaaat
agctcctcaagtacaagtcctgtttctaaaaaaggtccaccccttaagactccagcctcc
aaaagccctagtgaaggtcagacagccaccacttctcccaggggagccaagccatcagtg
aaatcagaattgagtcctgttgccaggcaggcatcccaaataggtgggtcaaataaaggg
tcttctagatcaggatccagagactccactccttcaagacctgcccagcagccattaagt
agacctatgcagtctccaggacgaaactcaatttcccctggtagaaacggaataagtcct
cctaacaaattatctcaactgccaaggacgtcatcccctagtactgcttcaactaagtcc
tcaggttctgggaaaatgtcatatacatctccaggcagacagatgagccaacagaacctt
accaaacaaacaagtttatccaagaatggcagtagtatcccaagaagtgagtctgcctcc
aaaggactaaatcagatgaataatagcaatggagccaataaaaaggtagaactttctaga
atgtcttcaactaaatcaagtggaagtgaatctgatagatcagagagacctgtattagta
cgccagtcaactttcatcaaagaagctccaagcccaaccttaaggagaaaattggaggaa
tctgcttcatttgaatctctgtctccatcttctagaccagattctcccactaggtcccag
gcacaaactccagttttaagtccttcccttcctgatatgcctttatccacacattcatct
gttcaggctggtggatggcgaaaacttccgcctaatctcagccccacggtagagtataat
gatggaagaccagcaaagcgtcatgatatagcccgctcccattctgaaagtccttccaga
cttccaatcaatagggcaggaacctggaaacgtgaacacagcaaacactcatcatccctt
cctcgagtaagcacttggagaagaactggaagttcctcttcaattctttctgcctcctca
gaatccagtgaaaaagcaaaaagtgaagatgaaaaacatgtgaactctatttcaggaacc
aaacaaagtaaagaaaaccaagtatccacaaaaggaacgtggagaaaaataaaagaaagt
gaaatttctcccacaaatagtacttctcagaccacttcctcaggtgctacaaatggtgct
gaatcaaagactctaatttatcaaatggcacctgctgtttctaaaacagaggatgtttgg
gttagaattgaggactgtcccattaacaaccctagatctggaaggtctcccacaggtaat
actcccccagtgattgacagtgtttcagaaaaaggaaatccaaatgttaaagattcaaaa
gataatcagggaaaacaaaatgtgggtaatggcgctgcttccgtgcgcaccacaggtttg
gaaaatcgtctgaactcctttattcaggtggatgccccagaccaaaaaggaactgagaca
aaaccaggacaaagtaatccagtccctgcatcagagaccagtgaaagttccatagcagag
cgcaccccattcagttctagcagctcaagcaaacacagttcacctagtgggactgttgct
gccagagtgactccatttaattacaacccaagccctaggaaaagcagcgcagatagcact
tcagcccggccatctcagatcccaacaccagtgaataacaacacaaagaaacgagactca
aaaactgacagcgcagaatccagtggaactcaaagtcctaagcgccattctgggtcttac
cttgtgacatctgtttga

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