Lemur catta (Ring-tailed lemur): 123649468 Help Entry 123649468         CDS       T08326                                  Symbol SOS2 Name (RefSeq) son of sevenless homolog 2   KO K03099   son of sevenless Organism lcat  Lemur catta (Ring-tailed lemur) Pathway lcat01521   EGFR tyrosine kinase inhibitor resistance lcat01522   Endocrine resistance lcat04010   MAPK signaling pathway lcat04012   ErbB signaling pathway lcat04014   Ras signaling pathway lcat04062   Chemokine signaling pathway lcat04068   FoxO signaling pathway lcat04072   Phospholipase D signaling pathway lcat04150   mTOR signaling pathway lcat04151   PI3K-Akt signaling pathway lcat04510   Focal adhesion lcat04540   Gap junction lcat04630   JAK-STAT signaling pathway lcat04650   Natural killer cell mediated cytotoxicity lcat04660   T cell receptor signaling pathway lcat04662   B cell receptor signaling pathway lcat04664   Fc epsilon RI signaling pathway lcat04714   Thermogenesis lcat04722   Neurotrophin signaling pathway lcat04810   Regulation of actin cytoskeleton lcat04910   Insulin signaling pathway lcat04912   GnRH signaling pathway lcat04915   Estrogen signaling pathway lcat04917   Prolactin signaling pathway lcat04926   Relaxin signaling pathway lcat04935   Growth hormone synthesis, secretion and action lcat05034   Alcoholism lcat05160   Hepatitis C lcat05161   Hepatitis B lcat05163   Human cytomegalovirus infection lcat05165   Human papillomavirus infection lcat05200   Pathways in cancer lcat05205   Proteoglycans in cancer lcat05206   MicroRNAs in cancer lcat05207   Chemical carcinogenesis - receptor activation lcat05208   Chemical carcinogenesis - reactive oxygen species lcat05210   Colorectal cancer lcat05211   Renal cell carcinoma lcat05213   Endometrial cancer lcat05214   Glioma lcat05215   Prostate cancer lcat05220   Chronic myeloid leukemia lcat05221   Acute myeloid leukemia lcat05223   Non-small cell lung cancer lcat05224   Breast cancer lcat05225   Hepatocellular carcinoma lcat05226   Gastric cancer lcat05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:lcat00001]  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     123649468 (SOS2)    04630 JAK-STAT signaling pathway     123649468 (SOS2)    04068 FoxO signaling pathway     123649468 (SOS2)    04072 Phospholipase D signaling pathway     123649468 (SOS2)    04151 PI3K-Akt signaling pathway     123649468 (SOS2)    04150 mTOR signaling pathway     123649468 (SOS2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     123649468 (SOS2)    04660 T cell receptor signaling pathway     123649468 (SOS2)    04662 B cell receptor signaling pathway     123649468 (SOS2)    04664 Fc epsilon RI signaling pathway     123649468 (SOS2)    04062 Chemokine signaling pathway     123649468 (SOS2)   09152 Endocrine system    04915 Estrogen signaling pathway     123649468 (SOS2)    04917 Prolactin signaling pathway     123649468 (SOS2)    04926 Relaxin signaling pathway     123649468 (SOS2)    04935 Growth hormone synthesis, secretion and action     123649468 (SOS2)   09156 Nervous system    04722 Neurotrophin signaling pathway     123649468 (SOS2)   09159 Environmental adaptation    04714 Thermogenesis     123649468 (SOS2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     123649468 (SOS2)    05206 MicroRNAs in cancer     123649468 (SOS2)    05205 Proteoglycans in cancer     123649468 (SOS2)    05207 Chemical carcinogenesis - receptor activation     123649468 (SOS2)    05208 Chemical carcinogenesis - reactive oxygen species     123649468 (SOS2)    05231 Choline metabolism in cancer     123649468 (SOS2)   09162 Cancer: specific types    05210 Colorectal cancer     123649468 (SOS2)    05225 Hepatocellular carcinoma     123649468 (SOS2)    05226 Gastric cancer     123649468 (SOS2)    05214 Glioma     123649468 (SOS2)    05221 Acute myeloid leukemia     123649468 (SOS2)    05220 Chronic myeloid leukemia     123649468 (SOS2)    05211 Renal cell carcinoma     123649468 (SOS2)    05215 Prostate cancer     123649468 (SOS2)    05213 Endometrial cancer     123649468 (SOS2)    05224 Breast cancer     123649468 (SOS2)    05223 Non-small cell lung cancer     123649468 (SOS2)   09172 Infectious disease: viral    05161 Hepatitis B     123649468 (SOS2)    05160 Hepatitis C     123649468 (SOS2)    05163 Human cytomegalovirus infection     123649468 (SOS2)    05165 Human papillomavirus infection     123649468 (SOS2)   09165 Substance dependence    05034 Alcoholism     123649468 (SOS2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     123649468 (SOS2)    01522 Endocrine resistance     123649468 (SOS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH IQ_SEC7_PH PH_19 RHG20_PH PH_13 Motif Other DBs NCBI-GeneID:  123649468 NCBI-ProteinID:  XP_045423600 LinkDB All DBs Position 1:44839336..44919820 Genome browser AA seq 1332 aa AA seqDB search MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLC MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD IGLVSLCEDEPSSSGELNYYDLVRSEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI EKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI LSPEFNEHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA CSEEQEDRECLNQAITALLNLQGSMDRIYRQYSPRRRPGDPVCPFYNRQLRSKHLAIKKM NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPG YSSAEYRLKEKFVMRKIQICDKEDTCEYKHAFELVSKDENSIIFAAKSAEEKNNWMAALI SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLA IEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPI EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILD EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR KVAEITGEIQQYQNQPYCLRIEPEIRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCK QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTV SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGNLHKLS DEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPL HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPMGHLHRDPDWFRDVSTCPNSPS TPPSTPSPRVPRRCYVLSSSHNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLY RLPLLENAETPQ NT seq 3999 nt NT seq  +upstreamnt  +downstreamnt atgcagcaggcgccgcagccttacgagttcttcagcgaggagaacagtccgaaatggcgg ggactgctggtctcggccctgcggaaggttcaggagcaagtacatcccactctctcagct aatgaagagtctctatattatattgaagagctgatttttcagctgcttaataaattatgc atggcccaacccaggactgttcaggatgtggaggaacgagttcaaaagacctttcctcac ccaattgataaatgggctattgctgatgcacaatctgccatagagaaacgaaaaagaaga aatcctcttttactgcctgtggacaagatccatccttcattgaaggaggttttggggtac aaagtggactaccatgtgtccctatatattgtggctgtactagagtatatctcagctgat attttgaaattggctggtaattatgtttttaatatccgacattatgaaatatctcagcag gacattaaagtatcaatgtgtgcagataaggttttgatggacatgtttgatcaagatgac ataggtttggtttctctctgtgaagatgaacctagttcttcaggtgaattaaactactat gaccttgtcagaagtgaaattgcagaagaaagacagtatctgcgggaactgaatatgatc ataaaagtgtttcgagaagcctttctttctgacagaaaactgtttaaaccttctgatatt gaaaagatttttagtaacatttcagatatacatgaattgactgtgaaacttttaggtttg attgaagacacagttgaaatgactgatgaaagcagtcctcatccgttagctggcagctgt tttgaagatttagcagaagaacaagcatttgatccgtatgaaacattatcacaggacatt ctttcaccagagtttaatgaacatttcagtaaactgatggccagacctgcagttgctcta cattttcagtccattgctgatggttttaaagaggcagttcgttatgtccttccacgcctt atgctggtgccagtgtatcattgttggcactattttgaattattaaagcaattgaaagca tgtagtgaagagcaagaagacagagagtgtttgaaccaagctattactgctctcctgaat ctccaaggtagcatggaccgaatttacaggcagtattcacctagacgtcgacctggggat cctgtttgccctttttataatcgtcaattaagaagcaagcacctggctatcaaaaaaatg aatgaaattcagaaaaacatagatggatgggaaggcaaagatattggacagtgttgtaat gaattcattatggaaggaccattgacaagaattggtgctaaacatgaacggcacattttt ctctttgatggcttaatgatcagttgtaaacctaatcatgggcagacccgacttccaggt tacagtagtgcagaatacagattaaaagaaaaatttgtcatgaggaaaatacaaatctgt gataaagaagatacttgtgagtacaaacatgcttttgaattagtatccaaagatgaaaac agcataatatttgctgctaaatctgctgaagagaaaaacaattggatggcagcccttatt tctcttcattatcgtagtactctagatcgaatgctagattcagtattactgaaagaagaa aatgagcagccgctgagattaccaagtccagaggtgtatcgttttgtagtaaaagactct gaggaaaacattgtttttgaagacaacttgcaaagtcgaagtggaatccccattattaaa ggaggaactgtggtgaaattaattgaaaggttaacatatcatatgtatgcagatcccaat tttgttcgtacttttcttaccacatatcgttcgttttgtaaaccacaggaattgctaagc ttactgattgaacgatttgaaattccagagccagaacccactgaagcagacaaattggca atagagaaaggagagcagcccatcagtgcagaccttaaaagatttcgcaaggaatatgtc caaccagtacaacttaggatcttaaatgtgtttcggcactgggttgaacaccatttttat gactttgaaagagatttggaattacttgaaagactagaatccttcatttcaagtgtaaga gggaaagctatgaagaaatgggtagaatcaattgctaagatcatcaagaggaagaaacaa gctcaggcaaatggaataagccataatattacctttgaaagtccccctccaccaattgaa tggcatatcagcagaccaggacagtttgaaacatttgatctcatgacactgcatccaata gaaatcgcgcgtcagctaacacttttggaatctgatctctacaggaaagttcaaccatct gaacttgtagggagtgtgtggaccaaagaagataaagaaataaattctccaaatttatta aaaatgattcgtcataccacaaatctcacgctctggtttgaaaaatgcattgtggaagca gaaaattttgaagaacgggtggcagtactgagtagaattatagaaattctgcaagttttt caagatttgaataatttcaatggtgtattggagatagtcagtgcagtaaattccgtgtca gtatacagactagaccatacctttgaggcattgcaagaaagaaaacggagaattttggat gaagctgtggaactgagtcaagatcactttaaaaaatacttagtaaaacttaagtcaatt aatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaagactgaagaa ggaaataatgattttttaaaaaagaaagggaaagatttgatcaatttcagtaagaggagg aaagtggctgaaattactggagaaattcagcagtatcagaatcagccttactgtttacgg atagaaccagaaataaggagattctttgaaaaccttaaccctatgggaagtgcatctgaa aaagagtttacagattatttgttcaataaatcactagaaatcgaaccccgaaactgcaaa cagccacctcgatttcctaggaagtcaactttctccctaaaatctcctggaataaggcct aacacaggccgacatggctctacctcaggtactttacgaggtcatccaacgccattagaa agagaaccatgtaaaataagctttagtcggattgctgaaactgagctggaatcaacagtg tcagcaccaacctctccaaatacaccatctactccaccagtatctgcttcttcagacctt agtgtgtttttagatgtggatctcaacagttcgtgtggcagcaatagcatctttgctcca gtgctcttgccacattcaaagtctttcttcagttcgtgtggtaatttacataaactaagt gatgagccactgattcctcctcctcttcctcctcgaaaaaagtttgatcatgatgcttcg aattccaagggaaatatgaaatctgatgatgaccctcctgctattccaccgagacagcct cctcctccaaaagtaaaacccagagttcctgttcctactggtgcatttgatgggcctctg catagtccacctccaccacctccaagagatcctcttcctgatactcctccaccggttccc cttcgtcctccagaacactttataaattgtccatttaatcttcagccacctccaatggga catcttcacagagatccagactggttcagagatgttagtacgtgtccaaactcgccaagc actcctcctagcacaccctctccaagggtaccacgacgatgctatgtgctcagttctagt cataataatcttgctcatcctccagctccccctgttccaccaaggcagaattcaagccct cacctaccaaaactgccaccaaagacttacaaacgggagctttcgcaccccccattgtat agactgcctttgctagaaaatgcagaaactcctcaatga

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