Lates calcarifer (barramundi perch): 108876764 Help Entry 108876764         CDS       T04895                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism lcf  Lates calcarifer (barramundi perch) Pathway lcf04020   Calcium signaling pathway lcf04260   Cardiac muscle contraction lcf04261   Adrenergic signaling in cardiomyocytes lcf04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:lcf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108876764 (ryr2a)    04020 Calcium signaling pathway     108876764 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     108876764 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     108876764 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lcf04040]     108876764 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:lcf04990]     108876764 (ryr2a) Ion channels [BR:lcf04040]  Voltage-gated cation channels   Ryanodine receptor    108876764 (ryr2a) Domain-containing proteins not elsewhere classified [BR:lcf04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    108876764 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  108876764 NCBI-ProteinID:  XP_018521997 UniProt:  A0AAJ7LFC4 LinkDB All DBs Position Unknown AA seq 4968 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCSATIHKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLASTEDKADGTAQGGGHRTLLYGHAVLLRHSYSGMYLCC LSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECLTVPSGEH GDEQRRTVHYEGGAVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKYLSLIEDK SLLLMDKEKADVKSTAFCFRSSKEKLDPGVKKEMDGMGVPDIKYGDSVCYIQHVDTCLWL TYQTVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNTFIRG LDTLRKKGKSSTLDLPIDSVSLSLEDLIGYFQPPGDHLEHEDKQNRLRALKNRQNLFQEE GMISLVLECIDRLHVYSSAAHFAEAVGREAGEAWSSILNSLYQLLAALIRGNRKNCAQFS GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLINHVSSMRPNIFLGVSDGSAQYRR WYYELIVDQALPFVTAEATHLRVGWASTSGYAPYPSGGEGWGGNGVGDDLYSYGFDGLHL WSGCIARTVSSPNQHLLRSEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSDGLFFPVA SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPREKLKLEASQDQTAARDLLGPTVT LSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRDDNKRQHP CLVEFCKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKVKSMKLSPTYELSSGY KPAPLDLSHIKLTSTQEAMVDKLAENAHNVWARDRIHQGWTYGIQQDVKNRRNPRLVPYT LLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAAQSDLNNMSAERFRIFRAEKTYCV NAGKWYFELEVLTAGEIRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGNEHFGRAW QTGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFEAGEGFIPVCSLGVCQVGRMN FGKDVSTLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPDHQHIEVTRIDGT VESCPCLKVTQRSFGSQNSYTDITFYRLSMPIECVESFSRSQPNGSLFSPKRELEDFETV SDFEVLMKSSHGHTGPNGPERDEFNNHKDYNQEKPSKLKQRFMLKRNKPDNSCPSSARLS EEVMADDRDDYEFLVQASIHYYSVRIFPGQEPSSVWVGWVTSDFHQYDPGFELHKVRTVT VTLGDEKGKVHESIKRSNCYMVWAGESSSPGQGRNNNGLEIGCLVDTTNGLLTFTANGKE LSTYYQVEPSTKLFPAVFAKATSPNVFQFELGRIKNVMPLSAGLFKSERKNPVPQCPPRL HVQFLTPVLWSRVPNHFLKVSTSRVNDRHGWLVQCNEPLQFMSLHVPEENRSVDILELSE QKDLLKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLQAIENKYMPGLLRAGYYDLL IDIHLSSYATARLMMNNEYIVPMTDETKSITLFPDEKKKHGLPGIGLSTSLRPRMHFSSP SFVCGTGSLYCNNGSSGSGDCFQYSPEFPLDILKVKTIEMLTEAVREGSMHVRDPIGGST EFLFVPLIKLFYTMLIMGVFQNGDLKNILRLIEPSVFSERPGQEEIHMELEMVKEVVAEG GREDGPRNMPKEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDFVACLQDN QRFRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDEKQECPCPDYIREQLLDF HEDLMRHCGIELDEDRRIDGDSDFTIRGRLISLVEKVAYLKKKMAILPKEKKDKKPSTLQ QLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTINSVSIEDTINL LAALGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVL SGGDSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTP LDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLVRKGYPDIGWNPVEGERYL DFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEEAIKISQDSSR DGPSPTSESSKALSDMLEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAI RIRAILRSLIPIEDLVGVISIPFSMPSLAKDGMVVEPDMSAGFCPDHKAAMVLFLDRVYG IEDQNFLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTAVLPLLTKCAPLFAG TEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQHLLRRLVFDVP LLNEHTKMPLKLLTNHYERCWKYYCLAGGWGNFGAASDEELHLSRKLFWGIFDALSYKQY DQELFKLALPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPADTTNVTVPEKL DYFITRYAEHNHEKWCIEKFSNGWSYGEQICEISKNHPLLKPYKGLSEKDKESYCWSVRE SLKTMLSWGWSIDRIREGDPASLHNKSRRISQASQLSFEGAPAFSPRPIDMSNVTLSRDM QSMAELLAENYHNIWARKKKIELEAKGGGNHPLLVPYDTLTAKEKSKDREKAQDILKFLQ INGYTVSRGVKSQELDTPAIEKRFAYTFLQQLITYVDQAHQHMLEFDLGTRPKGEKIPHE QQIKFFGKVVLPLVDQYFKNHRLYFLSTAIHPISSGGHASNKEKEMVTSLFCKLGVLVRH RISLFGNNATSIVNCLQILGQSLDARTVMKTGLESVKAALRSFFDSAAEDLEKTQENLKL GQFTHSRDQPRGVTQIINYTTFALLPVLSSLFEHIGQNMFGEDLILDDVQVSCYRILNSL YFLGTNKSIYVERQRPALGKCLAAFSAAFPVAFLEPHINKFNSFSIYNSKGTKDRGALGL PGHVWEVCPVIPNLEKSLEEIMELAESGMRYTQMPHVMEVVLPMLCSYMSHWWEHGPESN SDKADSCCTSVTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKPELLKT HFLPLMEKLKKKAAVVLMDEEHSKAEGRGEMSETELLIMDEFTILVRDLYAFYPLLIRFV DYNRARWLKESSPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLITDTKC KMSKGIVSDQERKKMKRKGDRYSMQTSLIVATLKRLLPVGLNICAPGEQELIALAKNRFT QKDTEDEVREIIRNNLHLQGKLEDPAIRWQMALYRDLPNYYEETSDPERTVERVLDIAHV LFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWI EAEEHYFEDKLIEDLAKPGEQEPSEEEEGMKHIDPLHQLIQLFSRTALTEKCKLDEDNLY MAYADIMAKSCHDEEDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKG EMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFE RQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTG NNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLTEY IQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLL SMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVI SKRDFHKAMESHKHYTQSETDFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAVLLT NLSEHMPHDTRLQTFLELADSVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKP QVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAVKEESEREK PDEENTEMGFFSVTTVCMALLALRYNVMLLIKVLSMKSLKKQMKKIKNMTVKDMVTTLVS LYWSVLLGLLHVAFSVARGFCRIFYNTFMGGSLVEGAKTIKVSELLANMPDPTQDEVRGE GDDREKRPSDRSSPKEDLADLAVNTSETELLSDIFGLDLRREGGQYKITPHNPNASLTEL LNSPVPSPNPPAPTTAPPPELRRRHQSKGSSSEEKEATPQTECEPETSEAGHVEEQEKQQ KMKPKIRRHHTSKCDEPDLQESAFLKKIIAYQRKLLNYFARNFYNMRMLALFVAFAINFI LLFYKVSTSSSVADEQEVMYTSSQPESSVQWDPLGGETVETNEDVVDETGEHLKPVTVRF VLEESSGYMEPMLRILAVLHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITE QPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDF SDAHKKRKPRRDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFF AAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDG ELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILL AIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYL FFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14907 nt NT seq  +upstreamnt  +downstreamnt atggccgacggaggagaaggagaggatgaaatccagttcctgcgaactgatgatgaggtg gtcctacagtgctcagctacgattcataaggagcaacagaaactttgtctggctgctgaa ggctttggaaacagactctgcttccttgaatccatctccaactccaagaatgtgcctcca gatctgtccatctgcacttttgtcttggagcagtcactatcagtacgagcccttcaggag atgctggccagcacagaggacaaggctgacgggacggcccagggtggtggtcatcgcacc ttactgtatggacacgctgtcctgctgcgacactcctatagtggaatgtacctatgctgt ctgtcaacctcccgctcatccacagacaaactggcttttgatgtgggattgcaggaagat accacaggcgaggcttgctggtggaccatccatccagcatcaaagcagcgttcagaagga gagaaggttagagtgggagatgatctcatcctggtcagcgtctcctctgaaagatatctg catctgtcctatggcaatggcagtctccatgtagatgcagccttccagcagactctgtgg agcgtggctcccatctgttctggcagtgaagtagcacaaggtttcctgataggaggagac gtccttcgcctccttcacggtcacatggacgagtgtctaactgttccatctggggaacat ggagatgagcagaggaggacagtgcactatgaggggggagcggtgtccagtcatgcccga tccctgtggaggctggagacactgcgggttgtgtggagtgggagtcatatccgctggggt cagccattcagattgagacatgtgaccacagggaagtatctgagtctcatagaagacaaa tctctgctgctgatggacaaagagaaagctgatgtcaagtctactgccttctgcttcaga tcctctaaggaaaagttggaccctggtgtgaagaaggagatggatgggatgggtgttcct gacattaagtatggtgactccgtgtgttacatccaacatgttgacacctgcctttggctc acataccagactgttgatgcaaagtgtgcacgcatggggggagtacagagaaaggccatc atgcaccatgagggccacatggacgacgggctgacgctgtctcggtcacaacatgaagag agtcgcactgccagagtcatccgtagcactgtctttttgttcaataccttcatcaggggt ctggatacactaagaaaaaaggggaagagctccactttagatcttccaatagattcagtc agcctgagtctggaggatctgattggctacttccaaccacctggagatcacctggaacat gaagacaagcagaaccgactgagagctctgaagaaccgtcagaacctctttcaggaggag ggaatgatcagcctggtactggagtgtatcgatcgacttcacgtctacagtagtgcagct cattttgctgaggcagtaggaagagaggcaggagaggcctggagctccatcctcaattca ctctaccaactactggctgcactgatcagaggaaacaggaagaactgtgctcagttttct ggttccttggactggctgatcagtagactcgagcgactagaggcctcttctggtatacta gaggtgcttcactgtgttctggtggagagtcctgaggctctgaacataatcaaagaggga cacatcaagtctattatatctttgctggacaagcatggacgcaaccataaggttctcgat gtgttgtgttcgctgtgtgtatgtcacggtgtagcagtgcgctccaaccagcacctgatt tgtgacaacctgctgccaggaagagatctgttactgcagacccgcctgatcaaccacgta agcagcatgcgtccaaacatcttcctgggcgtcagtgatggctctgctcagtacaggagg tggtactacgagctcattgtggatcaggcattgccgtttgtcacagcagaagccactcac ctcagggtgggctgggccagcaccagtggctacgcaccctacccaagtgggggagagggg tggggaggcaacggggtgggtgatgacctctattcctacggctttgatgggcttcatctt tggtcaggctgcattgcacgaactgtcagctcccccaatcagcatctcttgaggtcagag gacgtagtgagctgttgcctggacctcagtgtgcccagtatctccttcaggatcaacggc cagccagttcagggcatgtttgagaacttcaactctgacggcctcttcttccctgtggcc agcttctcggctggggtcaaggtgcgttttctccttgggggtcgtcatggggagtttaag ttcctccctcctccgggttatgctccttgctatgaggcggtgttgccaagggagaaactg aagctggaggccagtcaggaccagactgctgccagagacctcttggggcccaccgtcacc ttgagccaggcagcattcacccccacacctgttgacaccagccagattgtgctgcctcct cacttggagaggatcagggagaagcttgcagaaaacatccatgaactgtgggtgatgaat aagatagaactgggctggacctacggtgcagtgcgagacgataacaagaggcaacacccc tgtctggtggagttctgcaagcttcctgaacaggaacgaagctacaatctacagatgtct ctggagactctcaaaactctcctggccctgggttgccatgttggcctggcagatgaacac gctgtagaaaaagtcaagagcatgaaactgtcaccaacctacgagttgtccagtggatat aaacctgctcctctggacctgagtcacatcaaactgacctccactcaggaagccatggtg gacaaactagctgagaacgcacataatgtctgggcaagagaccgcatccaccagggctgg acctatggcatccaacaggatgtgaagaatcgtagaaaccctcgtctggtcccctacact ctgctggatgagagaaccaagaaatccaacaaagacagtctgagagaggccgtcaggact ctgttgggatatggatacaacctggaagctcctgatcaggaccatgcagctcagtctgac ctcaacaacatgtctgctgagaggttccgcattttcagagcagagaaaacctactgtgtc aatgctgggaagtggtactttgagctggaggtactgacagcaggagagattagggtgggc tgggccaggccaggatgcctcccggaccaagagctaggatctgatgaccaggcctttgtc tttgatggcttcaaggtccagcgctggcaccagggcaacgagcactttgggcgtgcctgg cagacgggggacgtagtgggctgcatggtggatctgaacgaacacaccatgatgttcaca ctcaacggagaagtgctgctcgatgattctggctctgaactggctttcaaggactttgaa gctggtgaaggttttatcccagtgtgcagtctgggtgtgtgtcaggtggggaggatgaac tttggtaaagatgtcagcactctcaagtacttcaccatctgcggcctgcaggaaggctac gaaccgtttgctgtcaacatgaacagagatgtaaccatgtggctcagcaagaggctgcct cagtttgtacctgtcccccctgaccaccaacacatagaggtgacaaggatagatgggacg gtggagtcgtgtccatgtctaaaggtcacccagaggtcatttggctcacaaaacagttac actgacatcaccttctacagactgagcatgcccatagagtgtgtagagtccttctccaga tcccaacctaatggcagcctcttctcaccaaagagggagttggaggactttgaaacggta tcagactttgaggtcctgatgaagtcgtctcatggccacactggtcccaatggacctgag agagatgaattcaacaaccacaaagattataaccaggagaagccatccaagctcaaacaa cggttcatgttgaagagaaacaaaccagacaacagctgcccctcatcagctcgactgtca gaggaagtgatggctgatgacagagatgactatgaattcctcgtgcaggcctccattcat tactactcagtgcgaatcttccctggccaggagcccagcagtgtgtgggtaggctgggta acctctgacttccatcagtatgaccctgggttcgagctgcacaaagtccgaactgtgact gttaccctgggagacgagaaaggcaaagttcacgagagtataaagcggagtaactgttac atggtgtgggctggagagagcagcagtcctggtcaggggaggaacaataatggcttagag attggctgcctggtcgacacaacaaatggactgctgactttcactgccaacggcaaagaa ctcagcacatattaccaggtggagcccagcactaagctgttccctgcagtctttgccaag gccaccagccccaatgtcttccagtttgaactagggcgaataaagaatgtgatgcctctg tcagctggactgtttaagagtgagaggaagaacccagttcctcagtgtcctcctcggctt catgtccagtttctcactcctgttttatggagtcgtgttcccaaccacttcctcaaggtg tcaacatccagagtgaatgacagacatggctggctggtccagtgtaatgaacctctgcag ttcatgtctctgcatgtacctgaggagaacaggtcggtggatatcctggagctgtcagag cagaaggacttattaaagtttcactaccataccctcagactgtactctgcaatctgtgct ctgggaaacaaccgagtggcacacgccctctgctcccatgtagacgaagcacagcttctg caggctatagagaataagtacatgccagggttgcttcgtgcgggctactacgacctcctt atcgacatccacctgagcagctacgcaacagctcgcctcatgatgaacaatgagtacatt gttcccatgacagacgaaacaaagagcattactctgtttccagatgagaaaaagaaacac ggcctgccaggcatcggcctcagcacctccctcagacccagaatgcacttctcatctccg agcttcgtctgtgggactggatcactgtactgtaacaatggcagcagtggatcaggggac tgtttccagtacagccctgaattccccttagatatactgaaagttaaaaccattgagatg ctgacagaggcggtgagggagggaagcatgcacgtacgggatccaataggaggcagcact gagtttctctttgtccccctcatcaagctcttctacaccatgctcatcatgggagttttc cagaatggagatctgaagaacatcctgcgactgattgaaccatctgtgttctctgaaaga ccaggccaggaggagatacacatggagctggagatggtgaaggaggtcgtggctgaggga ggaagggaggatggaccgaggaacatgccaaaagaaggactgttacagatgaagttgcca gagcctgtaaaactccagatgtgccatgtgctgcagtacctgtgtgactgccaggtgcga catcgtatcgaggcagtggtggccttctctgatgactttgtggcctgtctccaagacaac cagcggttccgctacaatgaggtgatgctggcactcaacatgtctgcagctctcacagcc aagaagacaaaagagtttagatcgcctccacaggaacagatcaacatgttgctgaacttt aaggatgagaagcaggagtgtccctgtcctgactacatccgagaacagctgctcgacttc catgaagatctgatgagacactgtggtatagagttggatgaggacagaaggatagacggt gacagtgacttcaccatccgaggtcgactcatatcgcttgtggagaaagtggcttatcta aagaagaagatggccatcctgccaaaggaaaaaaaagacaagaaacccagtacactacag cagttgatttcagatacaatggttcgctgggctcaggagtccgttattgaggatccagaa ctggtcagagccatgtttgtcctgctgcaccgccagtatgatggcattggaggacaggtg cgggctctgcctaagacgtacactataaactcagtatccatcgaggacaccatcaacctg ttggctgctctaggtcagatcagatctctgctgagtgtccgtatgggaagagaggaggag aaactgatgatccgagggctgggtgatatcatgaacaacaaggtattttatcagcatcct aacctgatgagagctctagggatgcacgagactgtcatggaggtcatggtcaacgtactc agtggaggagactccaaggaaataacctttcctaaaatggtggccaactgttgtcggttt ctctgttatttctgtcgaatcagtcgtcagaaccagaaagccatgtttgaccatctcagc tacctgctggagaacagcagtgttggcctcgcatctccatccatgcgaggctctactcct cttgatgtggctgcagcatcagtcatggataataacgagttggccctggctttgagagag ccagatctggagaaggtggtgcagtacctggctggttgtgggctgcagagctgtgtgatg ctggtacgtaaaggataccctgacattggctggaaccctgtggagggagagcgctacctg gacttcctacgctttgctgtcttctgcaacggtgaaagcgtggaggagaatgctaatgtt gtggtgaggcttctgattcgccgaccagagtgttttggccctgctcttcggggtgaaggt ggtgatgggttgttggcagcgatggaggaagccattaagatctctcaggattcctccagg gatggtccttctccaacatctgagagcagcaaagcactcagtgacatgctggaagaagag gaagatgataccatccacatggggaatgccatcatgaccttctatgctgctctcattgac ctgctgggtcgctgtgctccagagatgcatctgatccatgctggtaaaggtgaagcaatc cgtatcagagccattctaaggtctctcattcccattgaggacctggttggagtcatcagc attccattctccatgcccagcctagctaaagatgggatggtggtggagccagacatgtca gctggtttctgtccagatcataaagcagccatggtgctgttcctggaccgggtctatggt atagaggaccagaacttcctgctccacctcctagaggttggattcttaccagacctgaga gctgctgcctctctggacactgttgctctcagtgccacagacatggccctggccctcaac aggtatctgtgtacagctgtcctgcctctcttgactaaatgtgcaccgctgtttgcgggg acagagccgtttgcctcactgattgactccctcctccacacggtttaccgcctgtccaaa ggctgctgcctcaccaaggcccagagggatgccatagaggagtgtctgttggctgtctgt gggaagctgagaccctccatgatgcagcatctgctgaggaggttggtgtttgacgttccc ctgctaaatgaacacaccaagatgcctctgaagctcttgaccaatcactatgagcgttgt tggaagtattactgcttggctggaggctggggcaactttggagctgcatcagatgaagaa cttcacctctccaggaaactgttctggggaatatttgatgctctgtcttacaagcaatat gaccaggagctgtttaagctggcgttgccttgtctcagtgctgtggcaggagctcttcct ccagactacatggagtctaactacatggccatgatggagaaacagtcatccatggactca gagggaaacttcactccacagcctgcagacactaccaatgtgactgtcccagagaaactg gactatttcataaccagatatgcagagcacaatcatgagaagtggtgtatagaaaagttt tccaatggctggtcatatggggaacagatatgtgaaatcagcaagaaccaccctttactg aaaccatacaaaggcctctctgaaaaggataaagagtcatactgctggtcagtcagagag tctctgaagaccatgctgtcatggggctggagcattgacaggatcagagagggtgacccc gccagcctccataacaagtccaggaggatatcacaggctagccagctgtcatttgaagga gctccagctttcagcccgagacccatcgatatgagcaatgtcacactgtccagagacatg cagtcaatggctgagctgcttgcagagaattatcataatatctgggccaggaaaaagaag atcgagctggaagccaaaggtggaggaaaccatccccttctggttccgtatgatacactg actgccaaagagaaatccaaagacagagaaaaagcacaagacatcctgaagttcctccag atcaatggttacactgtgtccagaggtgtgaagtcacaggagctggacactccagctata gagaaacgatttgcctacaccttcctccagcagctcatcacatacgtagaccaggcccac caacacatgctggagtttgatctaggaacaagaccgaagggagagaagattcctcatgaa cagcagattaagttctttggaaaggttgtgttgccattggtggatcagtactttaaaaac cataggctgtacttcctgtccacagccatccatccaatcagtagtggtggccacgcctcc aacaaagagaaggagatggtgaccagtcttttctgcaaactgggagttcttgtcagacat aggatatccttgtttggtaacaatgccacatccatagtcaactgtctgcagatactggga caaagcctggatgcccggaccgtgatgaagactggtctggagtcagtgaaggcagctcta cggtcattctttgacagtgcagcagaggatctggagaagacacaggagaacctgaagctc ggtcagttcacccacagcagagaccagccacgaggtgtcactcagatcatcaattacacc accttcgctctgctgcctgtcctctcctccctgttcgaacacatcggacagaacatgttt ggagaggacctcatattggatgatgtccaggtctcctgctacagaatcctcaacagcctt tactttctgggaaccaacaaaagcatctatgtagaaagacagcgtccagcattaggaaag tgtcttgctgccttctcagcagccttccctgttgcctttcttgagcctcacatcaataag ttcaacagcttctccatctacaacagcaaaggaactaaagacagaggggctttaggtctt ccggggcacgtttgggaggtttgtcctgttatcccaaacttggagaagtctctggaggag atcatggagttggcagagtctggcatgagatatactcagatgcctcatgtcatggaggtg gtgttacccatgttatgcagctacatgtctcactggtgggaacatggaccagagagcaat tcagacaaagctgacagctgctgcacttctgtgacttcagaacacatgaacactctgctg ggaaacattctcaagatcatctacaacaacctgggaatagatgagggggcctggatgaaa agactggctgttttttctcagccaatcatcagcaaggccaaacctgagctgctcaagacc catttcctgcctctgatggagaaactcaagaaaaaagcagcagttgtgttgatggatgag gaacacagcaaggcggaggggaggggtgagatgtccgagacagagcttctcatcatggat gaattcaccatattggtcagggacctgtacgccttctatcctctcctcatccgatttgta gactacaacagggccagatggctgaaagagtccagtccagaagctgaggagctgttccgc atggtagctgaggttttcatcttctgggccaagtctcataacttcaagagggaagagcag aactttgtggtccagaatgaaatcaacaacatgtccttcctcatcactgataccaagtgt aagatgtcaaagggaatagtttcagaccaggagaggaagaagatgaagaggaagggagat cgatactcgatgcagacgagtctgatcgttgctactctgaagcgtctgctgcctgttgga ctcaacatctgtgcccctggagaacaagagctcatcgcactggccaaaaaccgcttcacc cagaaagatacagaggatgaagtccgagagatcatcaggaacaatctccatttacaaggg aagctggaggacccagctattcgttggcagatggctctgtatagggacctccctaattac tatgaggaaacctctgacccagagaggactgtggagagagtcctggacatcgctcatgtc ctcttccacctagatcaggtggagcaccctcagcgcagcaagaaggctgtctggcacaaa cttctgtccaaacagaggaagagagccgtggtcgcttgcttcaggatggcaccgctttat aacctgcccaggcaccgggctgtcaacctgttcctgcagggctatgagaagtcctggata gaggcagaggaacactactttgaagataaactcatagaggatcttgctaaaccaggtgaa caagagccatccgaagaggaggaagggatgaagcacattgacccactgcatcagctcatt cagctgttcagtagaacagctctcacagagaagtgtaaactggacgaggacaatctttac atggcctatgctgacatcatggctaagagttgccatgatgaagaagatgaagatggagag gaagtaaagagttttgaggagaaggagatggagaagcagaagctgttgtatcagcaggct cggcttcatgaccgaggagctgctgagatggtgcttcaaaccatcagtgctagcaaaggt gagatgggtcccatggtggcctctactctgaagctgggcatagctattctgaatggagga aactctactgtacagcagaaaatgttggattatctgaaagacaagaaggatgtaggtttt tttcagagcctggctggtctgatgcagtcatgcagtgttctagatctgaatgcatttgag aggcagaacaaagcagagggactgggaatggtgacagaggagggatcagtcatcactcat gagcgtggtgagaaggtcatgcaggatgatgagttcacctgtgaccttttccgcttcctg cagctgctctgtgaaggacacaactcagacttccagaactacttaaggacacaaacaggg aacaatacgactgtcaacatcatcatctctactgttgactacctcctcagagtccaggag tctatcagtgatttctactggtattattctgggaaagatgttattgatgaacagggccag aggaatttctctaaggcaataaatgtggccaagcaggttttcaatacactgactgagtac atccagggtccatgcactggcaaccagcagagtttggcccatagccgtctgtgggatgct gtggttggttttctccatgtctttgctcatatgcagatgaaactgtctcaggactccagt cagatcgagttactgaaggaactgatggatctgcagaaagacatggtggtcatgctgctg tcgatgctggagggtaatgtggtgaatgggactattggtaagcagatggtggacatgttg gtggagtcatcaaacaatgtagagatgatcctcaagttctttgacatgttcctcaaactg aaagacctgacctcctcagatgccttcaaggagtatgaccctgacggaaaaggtgtcatc tccaagagggacttccataaggccatggagagccacaaacactacacacagtctgagacg gacttcctgctctcctgtgcagagactgatgagaatgaactcttggactatgaagaattt gtagagcgctttcatgagccagccaaggatattggcttcaatgttgcggttttgctgacc aacctgtccgagcacatgcctcatgacacccggctgcagaccttcttggagctggcagac agcgtcctcaactacttccaaccatacctgggccggattgagatcatgggcagcgctaag cgcatcgagagggtctattttgagatcagcgagtccagtcgaacacagtgggagaaacct caggtcaaagaatccaagcgtcagttcatctttgatgtggtgaatgagggaggagagaag gagaagatggagctgtttgtcaatttctgtgaggacaccatctttgaaatgcagctggca gctcagatgtctgatgctggtgagcgctcagcagtgaaagaggagagtgagcgggagaaa ccagatgaggagaatactgagatgggcttcttctctgttactactgtctgcatggctctg ttagctctgcgatacaacgtcatgctgctgataaaggtgctgtctatgaagagcttgaag aagcagatgaagaagataaagaacatgacagtgaaggacatggtgaccaccctggtgtcc ttatactggtcagtgttgctgggccttctccatgtggcgttcagtgttgctcgaggattt tgcagaatcttctacaacactttcatgggaggaagtctggtggagggggcaaagaccata aaggtgtcagagctgctggccaacatgcctgaccccacccaggatgaggtgaggggtgag ggagatgacagagagaagaggccgtccgaccgcagctcacccaaggaggacctggctgac ctagcagtcaacaccagtgagaccgagctgctgtcagacatctttggtctggacttaaga agggaggggggccagtacaagatcaccccccataaccccaatgccagcctgaccgaactg ctcaactccccagttccctccccaaacccaccagcaccaaccacagcacccccacctgag ctcagacggaggcatcagtcaaagggctcttcctcagaggagaaggaagcaactccacag actgaatgtgaacctgaaacgtcagaggctggacatgtagaggaacaagagaaacaacag aagatgaagccaaaaattagacggcatcacacctcaaagtgtgacgaaccagatctgcag gagtctgcattcttgaagaagatcatcgcctaccagaggaaactgctgaactactttgcc aggaacttctataacatgaggatgttggccctgtttgttgcctttgcaatcaacttcatc ctcttattctataaggtgtcgacatcctcatctgtggctgacgagcaggaagtgatgtac accagcagccaaccagagagcagtgttcagtgggatccattgggtggagaaactgtggag acaaatgaggatgttgtggatgagactggggagcacctgaagcctgtcacagtgcgtttt gtcctggaggagagcagtggatacatggagcccatgctacgcatcctggctgtcctgcac actgtcatctctttcttctgtatcattggatactactgtctcaaggtgccactggtgatc tttaagcgtgagaaggaggtggccaggaagctggaatttgacggcttgtatatcacagaa caaccatctgaagatgacattaaaggacagtgggacagactggtcattaacacacaatct ttccccaacaactactgggataagtttgtgaagaggaaggtgatggataaatatggggag ttttatggccatgaccgaatcagtgagctgctaggaatggacaaagctgcactggacttc agcgatgctcacaaaaagagaaaacccaggagagacagttcactggctgctgtgctgaac tccattgatgtcaagtaccagatctggaagctgggggttgtatttacagacaattccttc ctgtatctggcctggtatatgaccatgtccatcctgggtcactataacaacttcttcttt gctgcccatctcctcgacatcgccatgggttttaagacactgcgtaccatcctgtcctca gtcacacacaatggcaaacagctggtgttaacagttggcctgttagcagtggtggtgtac ctttacacagtagtggccttcaacttcttcaggaagttctacaacaagagtgaagatgga gaactgccagacatgaagtgtgatgacatgctgacatgctacatgtttcacatgtatgtg ggtgtgagagcaggtggagggattggagaccagattgaagacccagcaggtgacgagtat gagatctatcgcatcatctttgacatcaccttcttcttctttgtcattgtaatcctcctg gctatcatccaggggttgatcattgatgcatttggagagctgagggaccagcaggaacaa gtgaaagaagatatggagaccaaatgttttatctgtggaataggaaatgactactttgac acagtgccacatggctttgaaacgcacacactacaggagcacaacttagccaactaccta ttctttgtgatgtatctcatcaacaaagatgaaacagagcacacaggccaggaatcatat gtatggaagatgtaccaggagcgttgctgggagtttttccctgctggtgactgtttccgg aaacagtatgaggatcagctcaactga

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