Latimeria chalumnae (coelacanth): 102353265 Help Entry 102353265         CDS       T02913                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism lcm  Latimeria chalumnae (coelacanth) Pathway lcm04020   Calcium signaling pathway lcm04260   Cardiac muscle contraction lcm04261   Adrenergic signaling in cardiomyocytes lcm04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:lcm00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102353265 (RYR2)    04020 Calcium signaling pathway     102353265 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     102353265 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     102353265 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lcm04040]     102353265 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:lcm04990]     102353265 (RYR2) Ion channels [BR:lcm04040]  Voltage-gated cation channels   Ryanodine receptor    102353265 (RYR2) Domain-containing proteins not elsewhere classified [BR:lcm04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    102353265 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  102353265 NCBI-ProteinID:  XP_014340342 LinkDB All DBs Position Un AA seq 4868 aa AA seqDB search MLANTEEKAEGTAQGGGHRTLLYGHAVLLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQED TTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLW SVAPISSGSEVAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSIHAR SLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMDDKGLLLMDKEKADVKSTAFCFR SSKEKLDFGIRKEVDGMGVPEIKYGDSLSYIQHVDTGLWLTYQSVDAKSVRMGSVQRKAI MHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNKFIRGLDALSKKGKSSNIYLPIESV SLSLQDLIGYFQPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLALECINRLHIYSSAA HFADVAGKEAGEAWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGIL EVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLI CDNLLPGRDLLLQTRLVNHVSSMQPNIFLGISEGSAQYRKWYYELIVDQVEPFVTAEATH LRVGWASTDGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGCIARTVNSPNQHLLKAE DVISCCLDLSAPSISFRINGQPVQGMFENFNTDGLFFPVVSFSAGVKVRFLLGGRHGEFK FLPPHGYAPCFEALLPKEKMRVEHNKEYKQDHSGMRDLLGPTISLTQAAFTPTPVDTSQI VLPPHLERIREKLAENIHELWVMNKIELGWTFGPVRDDNKRQHPCLVEFSKLPEQERNYN LQMSLETLKTLLALGCHVGIADEHAEDKVKKLKLPTKYQLPSEYKPAPMDLSHLKLTSAQ EAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYVLLDERTKKSNKDSLRE AVRTLLGYGYNLEAPDQDHATRSDVCSSTVERFRIFRAEKTYAVKSGKWYFEFEAVTAGD MRVGWTRPGCRPDQELGTDDQAFGFDGFKAQRWHQGNEHFGRSWQPGDVVGCMVDVNEST MMFTLNGEVLLDDSGSELAFKDFEVGDGLIPVCSLGLSQIGRMNFGKDVSTLKYFTICGL QEGFEPFAVNMNRDITMWLSKRLPQFIPVPPNHEHIEVLRIDGTIESSPCLKVIQKSFGS QNSYLDIAFYRLSMPIECAEVFSRSTGGSLPSASFFSPKTDLEDYDADSDFEVLMKTAHG HLTSNGQEKEREIAKPEFNNHKDYTQEKPSRLKQRFMLKRTKPDYNTGHPSARLSEDVLA DDRDDYDHLMQTSTYYYSVRIFPGQEPTNVWVGWVTADFHQYDMAFDLEKVKTVTVTLGD EKGKVHESIKRSNCYMVWAGESMSPGQGRNNNGLEIGCLVDTATGLLTFTANGKELSTYY QVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSERKNPVPQCPPRLHVQFL TPVLWSRVPNQFLKVDVSRVNERHGWLVQCAEPLQFMSLHISEENRSLDILELTEQEDLL KFHYHTLRLYSAVCALGNNRVAHALCSHVDESQLLYAIKNKYMPGLLRTGYYDLLIDIHL STYATARLMMNNEFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMRFSSPSFICI NGECFQYSPEFTLEVLKAKTIEMLTEAVQEGSLHVRDPVGGSTEFLFVPLIKLFYTLLIM GVFHNGDLKHILQLIEPSVFSEDSGQEEDEVAEKDASKAEVAAAVSDEEPVPKEGLLQMK LPEPVKLQMCHLLQYLCDCQVRHRIEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAAL TAKKTKEFRSPPQEQINMLLNFKDEKQECPCPDEIQDHLLDFHEDLMKHCGIELDEERAN EGDSDSTIRGRLLNLMEKVAHLKKKEMEKPMEKETKKPTTLQQLISETMVRWTQESVIED SELVRAMFVLLHRQYDGTGGLVRALPKTYTINAVSVEDTINLLASLGQIRSLLSVRMGKE EEKLMIHGLGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGELKEITFPKMVANCC RFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALAL REPDLEKVVQYLAGCGLQSCPMLISKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENA NVVVRLLIRRPECFGPALRGEGGNGLLAAMQEAINIAEDPAKDGPSPTSGSSRTLDLEEE EDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPLEDLEGVIS IPFQMPTLAKDGTVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLR AAASLDTAALSATDMALALNRYLCTAVLPLLTKCAPLFAGTEPHASLIDSLLHTVYRLSK GCSLTKAQRDAIEECLLAICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERC WKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALP PEYMESNYVTMMVKQCSVDAEGNFNPQPVDTTNINVPEKLDYFINKYAEHSHEKWSMEKF ANGWVYGEASNEATKVHQLLKPYKMLSEKEKEVYRWPIKETLKTMLAWEWTIDRAREGDA IYFHNRTRRISQSSQVSIDTAHGYSPRPIDMSNVTLSRDLHAMAEMLAENYHNIWAKKKK LELEAKGGGNHPLLVPYDTLTAKEKSRDREKAQDILKFFQINGYAISRGLKDLELDTPSI EKRFAYSFLQQLITYVDEAQEYILEFDGGTRGKGERFPHEQEIKFFAKVVLPLIDQYFKN HRLYFLSTASRPLSSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGTDASSIVNCLHILG QTLDARTVMKTGLESVKMALRAFFDNSAEDLEKTMENLKQGQFTHTRTQPKGVTQIINYT TVALLPVLSSLFEHIGQHQFGEDLILDDVQVSCYRILCSLYGLGTSKSIYVERQRPALGE CLAAFASAFPVPFLETQLNKYSSHSIYNTKTTRDRTALNLPARVEEAGPNIPSLETLMEE IMELAESGIRYTQMPHVMEVILPMLCSYMSHWWEHGPENNPEKAETCCTALTSEHMNTLL GNILKIIHNNLGIDEGAWMKRLAVFSQPIISKAKPQLLKTHFLPLMEKLKKKAAMVVADE EHLRAEGRGDMSETELLILDEFTILVRDLYAFYPLLIRFVDYNRAKWLKEPSPEAEELFR MVADVFIFWAKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKASVSDQERKKMKRKGD RYSLQTSLIVAALKRLLPVGLNICAPGDQELISLAKNRFSMKDTEDEVRDTIRNNLHLQG KLEDPAIRWQMALYKDLPNRTEDTSDPERTVERVLDMANVLFHLEQVEHPQRSKKAVWHK LLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLARPGE EPVEEDEGTKRLDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEE EVKSFEEKEMEKQNLLYQQARLHDRGAAEMVLQMISASKGEMGPMVAATLKLGIAILNGG NSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVITH ERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQE SISDFYWYYSGKDVIDEQGQRNFSKAIKVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDA VVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDML VESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSET EFLLSCAETDENEMLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELAE SVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEK EKMELFVNFCEDTIFEMQLAAQISESDTSERSTSKDDNEKDRFEEQDPKMGFFTITTIRS ALVALRYNVMILMKLLSMKSLKKQVKKMKKMTMKDMVMALVSSYWCLLVGLLHFTFSVFR GFFRIMYSTFLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEGDESEQKNTNTSLLSEDL TDLTAASDEGDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSAPSVPTLFPEFRRRFQ GEKIKEDEREDKEESKSETEKAEGEDGEKQENAKEEKSKQKYRQHHTQKSGEPEVQESAF WKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSAIIEEKEIPFGGRGD ENHRWNSMGVGSHRIITVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVI FKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGE FYGRDRISELLGMDKAALDFSDAQEKKKSKKDSSLSAVLNSIDVKYQIWKLGVVFTDNSF LYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVY LYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEY EIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFD TVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFR KQYEDQLN NT seq 14607 nt NT seq  +upstreamnt  +downstreamnt atgctggcgaacaccgaggagaaagcagaagggactgcacaaggtggtggacatcggacc cttctttatggacatgcagtattactcaggcattcctacagtggaatgtatctttgctgt ttatctacttcccgatcctcaacagataagttggcatttgatgttggcttgcaggaagac acaacgggcgaggcatgttggtggactatacaccctgcctcaaaacagcgatcagaagga gaaaaggtacgggtaggagatgacctcattctagtcagtgtttcttcagagaggtacctg catttatcatatgggaatggcagtttgcatgtagatgctgcattccagcaaaccctctgg agtgtagccccgatttcatctggaagtgaagtagcacaaggttatctaattggaggggat gtattaaggttgctgcatggtcacatggatgaatgtcttacagtaccttcaggagaacac ggtgaagagcagcgcagaactgtccattatgagggtggggcggtttccattcatgcgcgt tccctttggaggctggaaactctcagagttgcatggagtggaagccacattagatgggga caacctttcaggctaagacacgtcacaacgggaaagtatttaagtctcatggacgacaaa ggccttcttcttatggataaagagaaagctgatgtgaagtccacagcattctgcttccga tcttcaaaggaaaagttggactttggaataaggaaagaagtggatggaatgggagttcct gagataaagtatggggattcattatcctatatacaacatgtagacacaggactctggctc acctatcagtctgtggatgcaaaatctgtgcgaatgggatctgtacagcgtaaggctata atgcaccatgaaggtcacatggatgatggcttaaccctgtccagatcgcaacatgaggag tctcgaacagctcgtgtcatccgaagtacagtcttcctcttcaataaattcataagagga ctagatgccctcagtaaaaaagggaaatcttcaaatatttacctgccaatagaatcagtt agtctgagtctgcaggacttgattggctacttccagccaccagatgaacatctggaacat gaagacaaacagaacagactgagagctctaaagaatcgccagaatctctttcaggaagag ggtatgattaacttagctcttgagtgcatcaaccgtcttcatatctacagtagtgcagct cattttgctgatgttgctggaaaggaggcaggggaagcctggaagtcaattctgaactcg ctttatgagttactagcggctctaatcagaggtaatcgaaaaaactgtgcccagttttct ggctctttggactggcttatcagcagactggagagattagaagcctcctctggaattctt gaagttttacactgtgttcttgtggaaagtcctgaagctttgaatattatcaaagaaggg catataaaatcaatcatttccctactggataaacatggaaggaaccataaggttctagac gtcttgtgttccctgtgcgtatgtcatggagtagctgtacgttccaaccagcacttaatc tgcgacaatcttctaccaggacgagatctgcttttacagacacgtctcgtcaaccatgtt agcagcatgcagccaaatatattccttggaatcagtgagggatctgctcaatataggaag tggtactatgagctgattgttgaccaagtagaaccttttgtaacagcagaagccacacat cttcgagtaggatgggcttcaactgatggttattcaccctatcctggaggaggagaaggc tggggaggaaatggtgttggtgatgacctttactcttatggatttgatggcctgcattta tggtcaggctgtatagcacggacagtaaattcacccaatcagcacctcctgaaggctgag gacgtcattagttgttgtctggacttaagtgcccccagcatctccttccgtataaacggg cagccggttcaaggcatgtttgagaatttcaacacagatggcctcttcttccctgtcgtc agcttctctgcaggggtaaaagtacgtttcctgcttggaggtcgccatggggagttcaag ttcttgccacctcatgggtatgctccctgctttgaagctctgttaccaaaggagaagatg agagtggaacacaacaaagaatacaaacaggaccacagtggtatgagggatttgctgggt ccaacaatctccctcacacaagcagcctttaccccgacgcctgtagacaccagccagatt gtgctgcctcctcatctggagagaattcgtgaaaaactggctgagaacattcatgagctc tgggttatgaacaaaatcgagcttggttggacatttgggccggtacgagatgacaacaag cgacaacacccgtgcctggtggaattctccaagctgccagagcaggagcgcaattacaat ttacagatgtctctggagacactgaaaaccctgttggctctaggttgccatgtcggaatt gctgacgagcatgccgaagataaggtgaagaaactgaaacttcctacaaagtatcagttg ccgagcgagtacaagcctgctcccatggacctgagccacctgaagttaacgtccgctcag gaggccatggtggacaaacttgctgagaatgctcacaacgtgtgggccagggaccgcatc aggcagggctggacgtatggcatccaacaggatgtcaaaaataggagaaatcctcgtctc gttccctatgttcttcttgatgaaaggactaaaaagtccaataaggacagtcttcgtgag gcagtacggacgctcttggggtatggatataaccttgaggcccctgaccaagatcacgct accagatcagatgtttgcagcagtacagttgaaagattccgtatcttccgggctgagaag acatatgcagtaaagagtggaaaatggtactttgagtttgaagcagttacagctggagac atgcgggtgggctggacaagacctggttgccgtcctgatcaggagttgggcactgatgat caagcctttgggtttgatggcttcaaggcacagcgttggcatcagggtaatgaacatttt gggcgctcatggcagccaggggatgtggtgggatgtatggtagatgtgaatgaaagtacc atgatgttcactttgaatggagaagtcttacttgatgactctggttctgagttagcattc aaggactttgaagttggtgatgggttaattcctgtatgcagtcttggcttatctcagatt ggcaggatgaactttggaaaagatgtcagcaccctgaaatacttcaccatctgtgggctt caggaaggctttgagccctttgctgtcaacatgaatagggatattaccatgtggttaagc aaaagacttccccagtttattcctgttcctccaaaccatgagcatattgaggtattgaga atagatggaaccatagaaagttcaccctgcttaaaagtcattcaaaagtcatttggctct cagaatagctatttggacatagcattctatcgtctaagcatgcccattgaatgtgctgaa gtgttctcaagatcgactgggggtagtttgccaagtgccagctttttctctcccaagact gatcttgaggattatgatgcagattctgattttgaagtgctaatgaagacggcgcatggt cacctaacatcgaatgggcaagaaaaagagagagagattgctaaaccagaattcaacaac cataaggattacactcaagaaaaaccctcccgcctgaaacaaaggtttatgttaaagagg acaaagcctgactacaacactggccacccttctgctcggctctcagaggatgtgctggca gatgacagggatgattatgaccatctaatgcaaacatcaacttactattactctgtgagg atctttcctggacaggagcccactaatgtttgggttggttgggtcacagctgactttcat cagtatgacatggcctttgacttggaaaaagttaagacagttacagttacactgggggat gagaaaggaaaggttcatgaaagtatcaaacgcagtaactgctacatggtgtgggcagga gaaagcatgagccctggacaaggacgcaacaacaatggactagagatcggctgcctggta gatacagctactggcttgctgactttcactgcaaatggcaaagagctgagcacctactat caggttgaaccaagcactaaactgtttcctgcagtttttgcccaggctaccagccccaat gttttccagtttgaactgggacggataaagaatgtaatgccactttcagctgggctgttt aaaagtgagaggaaaaatcctgtcccccaatgccctcctaggcttcatgtccagtttctc accccagtgctttggagcagagtgccaaaccagtttctgaaggtggatgtatctcgtgtg aatgaacgtcatggctggctagtacagtgtgctgagcctttacagttcatgtctctacac atttctgaggagaacagatcgctggatattctggagctgacagagcaagaagacctgctc aagtttcactaccataccctccggctttactcggctgtttgtgctctgggaaacaaccga gtggctcatgctctgtgtagccatgtggatgaatcccagctcttgtatgctattaaaaac aagtacatgccaggcttgttacggacaggctattatgatttacttattgacatccatctt agcacgtatgccactgcgaggttgatgatgaataacgaattcattgttcccatgacggaa gagaccaagagcatcactttgtttcctgatgaaaacaaaaaacatgggctccctgggata ggcctcagcacctccttgaggcctagaatgcgcttttcttcacctagctttatatgcatc aatggagagtgcttccagtacagccctgaatttacacttgaagtcctcaaagctaaaact attgagatgttgacagaagcagtacaggaaggcagccttcatgtgagggaccctgttgga ggcagcactgagttcctttttgttccacttatcaaacttttttacactctgctgataatg ggcgttttccacaatggggacctgaagcacatcctgcagctcattgagccaagtgtcttt tcagaagattcaggacaagaagaagatgaggtagctgagaaggatgcaagtaaagctgag gtggcagctgcagtaagtgacgaagagcctgtccccaaagaaggacttctccaaatgaag cttccagagcctgtgaaacttcagatgtgccacctgcttcagtatctctgtgactgccag gtccgccacaggattgaggccattgtggcattctctgatgactttgtagccaaacttcag gaaaaccagcggttccgatacaatgaagtgatgcaagcgttaaacatgtctgcagcactg actgcgaagaagacaaaggaattccgttctcctccccaggagcagattaacatgctgctg aatttcaaagatgaaaaacaagagtgtccatgtcctgatgaaatacaggatcatctttta gacttccatgaggatctcatgaaacactgtggaattgaactcgatgaagagcgggctaat gaaggtgatagtgattctacaataaggggtcgtctgctaaacctgatggaaaaagttgca catttgaagaagaaggagatggagaagcccatggagaaggagaccaaaaaacctactact ctgcaacagttaatctcggagaccatggtgcgttggacccaagagtcagtgattgaagac tccgagctggtcagagctatgtttgttttgctgcacaggcagtatgatggcactggaggc ttggtccgtgctctaccaaagacgtacaccataaacgctgtgtcagtggaagacaccata aacctgttggcttcgctggggcagatccgctcactgctgagtgtcagaatggggaaagag gaagagaagctaatgatccatggacttggaaacataatgaataataaagtgttctaccaa catcccaaccttatgagggccttagggatgcatgaaacagtgatggaagtcatggtgaat gtgcttggaggaggagaattaaaggagataacttttcctaagatggtggccaactgttgt cgattcctgtgttacttttgccgtataagcaggcagaatcagaaagccatgtttgatcac ctaagctatttgctggaaaacagcagtgttggacttgcatctccttccatgcgaggttca acccctcttgatgttgcagctgcctcagtgatggataataatgagcttgccctagctttg cgcgagcctgacctggaaaaagttgtgcagtatttagcaggatgtggcttgcagagttgt cccatgttgatttccaagggatatccagacattggatggaatccagttgagggagaacgg tatttggattttcttcgctttgctgtcttctgtaatggtgaaagtgttgaagaaaatgcc aatgtcgtggtgaggttgctcattcgtcgccctgagtgctttggtccagctctgagagga gaaggggggaatggattactggctgccatgcaggaagctataaacattgcagaagatcca gcaaaagatggaccctcaccaaccagtggatccagtagaaccctagatttagaagaggag gaagatgacactattcacatggggaatgccatcatgacattttatgctgctttaattgac cttttgggacgatgtgctcctgaaatgcacttgatccatgccgggaaaggagaagctatt aggatcagagccatcctccgttctctgattccattagaggatttggagggagtaattagc attcctttccagatgcccacactcgctaaagatggtacagtggtggagccagacatgtca gcagggttttgtcctgatcataaggcagccatggtcctgttcctagatagggtgtatggg attgaggatcaagattttctgctccatctcctggaggttggctttctgccagatctccgt gctgctgcttccttggatacggcagccctgagtgctacagacatggccctggctctgaac cgctacctctgcactgcagtcctgcctttgctcacaaagtgcgctccactctttgctgga accgagcctcatgcatctctcatagactccctacttcacactgtgtacaggctatccaaa ggctgctcccttaccaaagcacagagggatgcaatagaggagtgcttacttgctatctgc ggtcaactgaggccttccatgatgcagcatttattgaggagactggtgtttgatgttccc ctgctaaacgaacatgcaaaaatgcccctcaagttgctgactaaccattatgaaagatgc tggaagtattactgtctcccaggaggatggggaaactttggagctgcttcagaagaagaa ctccatttgtcgagaaaattattctggggaatatttgatgccctatctcagaagaaatat gagcaggagttgtttaagctggctttgccatgcctgagtgcagttgcaggggccttgcct ccagaatacatggagtccaactacgttaccatgatggtgaaacagtgttcggtggatgct gaggggaatttcaacccacaacctgttgatacaacaaatataaatgttccagaaaagctg gattactttatcaataaatatgctgaacattctcatgaaaagtggtctatggaaaagttt gctaatggatgggtttatggtgaagcatccaatgaggctacaaaggttcaccaactttta aaaccatataaaatgctttcagaaaaggaaaaggaagtatatcgttggcccataaaggag accttaaaaacaatgctggcttgggaatggacaattgatagagcaagagaaggggacgcc atttatttccacaatcgaacacgccgcatatcacagtcaagtcaggtttctatagatact gcccatggttacagtccccgaccaatcgacatgagcaatgttacgctgtccagagacctg catgcaatggcagagatgctggcagagaattaccataatatctgggctaagaagaaaaaa ctggaactagaagctaaaggaggaggtaaccaccctcttctggtgccatatgatacgcta acagccaaagaaaaatccagggacagagaaaaagctcaagatatactgaagttctttcag attaatggatatgcaatttcaaggggtttaaaagaccttgagctagatacaccatccatt gagaaacgatttgcctacagttttcttcagcagctcattacatatgttgatgaggcacag gagtacatcttggaatttgatggtggcactagaggcaaaggggaacggtttccacatgag caagaaattaagttctttgcaaaggtggttcttccattaattgatcagtatttcaaaaac caccgcctttactttctgtctacagcaagtcggcctctcagcagtggagggcatgcatcc aataaggagaaagaaatggtaacaagcctgttctgcaaacttggagttcttgtcagacat aggatatcactgtttggtactgatgcatcttcaatcgtcaactgtcttcatatactgggt cagacactggatgcaaggactgtcatgaagactggcttggagtcagtaaagatggcactg agggcattttttgacaattctgcagaggaccttgagaagacaatggaaaacctgaagcaa ggccagtttactcacaccaggactcagccaaaaggggtgacacagataattaattacact acagtggctcttctgccagtcttatcttcattgtttgaacacattggacagcatcagttt ggggaagatttaatattggatgatgtgcaggtctcttgctatagaatactctgcagcttg tatggtctgggcactagtaaaagtatttatgttgaaaggcaacgccctgctttaggagaa tgtctggctgcctttgctagtgcttttccagtgcctttcctagaaacacaactgaataag tacagctctcactctatctacaacaccaaaacaacaagagacagaacagccctcaatttg ccagccagggtagaagaggcaggaccaaacatcccgtcccttgagacactgatggaagag attatggagttggcagaatctggtattcggtatacacaaatgccgcatgtaatggaagtg atattgcccatgctgtgcagctacatgtcacattggtgggaacacggaccagaaaataac cctgagaaggcagaaacgtgttgcactgccctcacgtcggagcacatgaatacactgctg ggcaacatactgaagattatacacaacaacctaggcattgacgagggagcgtggatgaaa agattagcagtattttcacagccaatcataagtaaagctaagccgcagctattgaagacc cattttcttcctcttatggagaagctgaagaagaaagcagcgatggttgtggcagatgaa gagcacttacgagctgagggcagaggagatatgtcagaaacggagctactcatcctagat gaattcaccatcctggtccgagacctctatgccttctacccactgctcattcgatttgta gactataacagggcaaaatggctaaaggaacccagtcctgaggcagaagagctgttccgc atggttgctgatgttttcattttttgggcaaaatctcataattttaagcgggaagaacag aattttgtggtgcaaaatgaaatcaacaacatgtctttcctgattacagacacaaagtca aagatgtcaaaggcttcagtttctgatcaggaacggaagaagatgaagcgaaagggagac cgatattctttacagacatctcttattgtagctgcgttgaaaagactgctgcctgttggg ttaaacatatgtgcacctggagatcaagagctcatttcattggctaagaacaggtttagt atgaaggatacagaggatgaagtcagagatactatccgcaataacctccacctgcagggc aaattagaggatcctgccattaggtggcagatggcactttacaaagacctaccaaacagg actgaagacacttcggatccagaaagaacagtggagcgtgtacttgatatggctaatgtc ctattccacttagagcaggttgagcatccccagcggtccaagaaggctgtgtggcataaa ctactatcaaagcaaagaaaaagagcagtggtggcttgtttcaggatggcaccattatac aacttgccaaggcaccgagctgtcaatctgtttcttcaaggttatgaaaaatcttggatt gagacagaagagcattattttgaggacaagctaattgaggacttggcaagacctggggaa gaaccagtagaagaagatgaaggaaccaagcgactagatccgcttcatcagctcattttg ctgtttagtcgaactgccctcacagagaaatgtaaacttgaagaagactttctctatatg gcgtatgctgatattatggcaaagagttgccatgatgaagaggacgatgacggtgaggaa gaagtcaaaagttttgaagaaaaagaaatggaaaagcagaacctcctctatcagcaagcc aggcttcatgaccgtggtgctgctgagatggttctacagatgatcagtgccagcaaaggc gagatgggtccaatggttgccgccaccctaaaacttggaattgccattttaaatggaggg aactcaacagttcagcagaaaatgcttgactatctcaaggacaagaaggatgtgggcttc tttcaaagtcttgctggtctcatgcagtcttgcagtgttcttgacctaaatgcatttgaa cgtcagaacaaagcagaaggtcttggcatggtgacagaagagggatcagtcatcactcat gagcgtggagaaaaggtgatgcaggacgatgagttcacctgtgaccttttccgcttcctc cagctgctctgtgagggacataactcagattttcagaactatctacgaactcaaacgggc aacaataccacagtgaatataatcatctcaactgtggactacctactgagggttcaggaa tcaattagtgatttttactggtattattcggggaaggatgtcattgatgagcaagggcag cgtaatttttccaaggcaattaaagtggcaaaacaagttttcaacactctcacagagtat attcagggtccatgcacagggaatcagcagagcctggcacacagcaggctgtgggatgca gtagttgggttccttcatgtctttgcccatatgcaaatgaagttgtcacaggactccagt cagattgaattattgaaagaattaatggatcttcagaaggatatggttgtcatgctgctt tccatgctggaaggcaatgttgtgaatggaactattggcaagcagatggttgacatgtta gttgagtcctccaacaatgtggaaatgatcctaaaattctttgacatgttccttaaactg aaggacttaacctcttctgatgcatttaaggagtatgatcctgatggtaaaggtgtcatc tcaaaaagggactttcataaggctatggagagtcacaagcactatacacaatcagaaaca gagttccttctctcttgtgcagagacagatgaaaatgaaatgctggactatgaagagttt gtggaaagatttcatgaacctgccaaagacattggcttcaatgttgctgttttgctaacc aatctttcagagcacatgcctcatgatacaaggctgcagacattcctcgagcttgcagag agtgtgcttaattattttcagccatacttaggcaggatagaaatcatgggcagtgccaag cgcattgagagggtatactttgagattagtgaatctagccggactcagtgggaaaagcct caggtaaaagagtccaagaggcagtttatctttgatgtagtgaatgaaggaggggaaaaa gaaaaaatggaactctttgtcaacttctgtgaggacactatctttgaaatgcagcttgct gctcagatctctgagtcagatacaagtgagaggtctacaagcaaagatgacaatgagaaa gatagatttgaggaacaagaccccaaaatgggcttttttaccatcacaacaattagatca gctctggttgccctaaggtacaatgtaatgatcctcatgaagctgcttagtatgaaaagc cttaagaagcaagtgaagaaaatgaagaaaatgaccatgaaggacatggtgatggctttg gtttcttcttattggtgccttttagtgggactcttgcattttacgtttagtgtattccgt ggattttttcgcatcatgtatagcacatttcttggtggaagccttgtggaaggagctaaa aaaatcaaagtggctgagctattagccaatatgccagacccaacccaggatgaggttcgt ggtgaaggtgatgaaagtgagcaaaaaaatacaaatacctccttgctttctgaagattta acagacttgacagcagcctcagatgaaggggacttgctttcagatatctttggcttagat ctaaaacgtgagggaggtcagtataagttgattccacacaacccaaatgctggtctcagt gatttaatgagtgccccctcagtacctacactgtttcctgagtttcgacgaagattccag ggtgaaaagatcaaagaagatgaaagagaagacaaagaagaaagcaaatcagaaacagaa aaagcagagggggaagatggtgaaaagcaggaaaatgctaaagaagaaaaaagcaagcag aaatataggcagcatcacacacagaaatcaggggagccagaagtacaagaatctgctttc tggaagaaaattattgcctatcaacaaaaactgcttaactattttgcacgtaatttctac aacatgaggatgttggctctttttgttgcctttgcaatcaactttattcttctattctac aaggtctccacttcagcgataatagaagagaaagaaataccttttggagggcgtggagat gaaaaccataggtggaatagcatgggtgttggctcacatagaattattactgtgcactat gtcctggaggaaagcagtggttatatggaaccaactttgaggattcttgctattctccac actgtgatctcctttttctgcatcattggatattattgtctgaaagtccctttggttatt tttaagcgtgagaaagaagtggcaagaaagctggagtttgatggactctatattacagag cagccatcagaagatgacataaagggacagtgggataggcttgtcatcaatacccagtca tttcctaacaactactgggacaagtttgttaagcgaaaggtaatggataaatatggtgaa ttctatggccgagacagaatcagcgagttacttggaatggataaggctgctctagatttc agtgatgcacaagaaaagaaaaagtccaagaaagacagctccctgtcagctgtgctgaat tccattgatgtcaagtaccagatttggaaactaggagtggtttttacagacaattccttc ctgtacttggcctggtacatgacaatgtctgttttgggacattacaacaacttcttcttt gctgctcatctgttggatattgccatgggatttaagacattacgaaccattctgtcttct gtgacccataatggcaaacagctggtgttaactgtgggattgctggctgttgtggtttac ctgtacactgtggtggcttttaatttcttccgcaagttctataacaagagtgaagatgga gataccccagacatgaagtgtgatgacatgctaacctgctacatgtttcacatgtacgtt ggtgtccgtgctggaggaggcattggcgatgaaattgaggacccagctggtgatgagtat gagatctatcgaattatatttgatattactttcttcttctttgtaattgtcatcctgcta gctattattcaaggtttaattattgatgcttttggtgaactaagagaccagcaagagcaa gttaaagaagatatggagaccaaatgcttcatctgtggaattgggaatgattactttgat actgtaccccatgggtttgaaactcacacactgcaggagcacaatttagccaattatctg ttcttcctgatgtatcttattaataaggatgaaactgagcacacaggacaggaatcttat gtctggaagatgtaccaagagcgctgttgggagttttttccagctggagactgtttccgc aaacagtatgaagaccaactcaactga

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