Leptosomus discolor (cuckoo roller): 104354889 Help Entry 104354889         CDS       T08399                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism ldi  Leptosomus discolor (cuckoo roller) Pathway ldi04020   Calcium signaling pathway ldi04260   Cardiac muscle contraction ldi04261   Adrenergic signaling in cardiomyocytes ldi04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ldi00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     104354889 (RYR2)    04020 Calcium signaling pathway     104354889 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     104354889 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     104354889 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ldi04040]     104354889 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:ldi04990]     104354889 (RYR2) Ion channels [BR:ldi04040]  Voltage-gated cation channels   Ryanodine receptor    104354889 (RYR2) Domain-containing proteins not elsewhere classified [BR:ldi04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    104354889 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  104354889 NCBI-ProteinID:  XP_009960230 LinkDB All DBs Position Unknown AA seq 4706 aa AA seqDB search TVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQAFRLRHITTGKYLSLLDDNSLLLTD KEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSICFIQHVDTGLWLTYQSAD AKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRSTVFLFNRFIRGLDALSK KAKSSTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLV LECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNRKNCAQFSGSLDWL ISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHGRNHKVLDVLCSLC VCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISEGSAQYRKWYYELM VDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSYGFDGLHLWSGCVA RTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGI KVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREYKQDRSYTRDLLGPTISLS QAAFTPVPVDTSQIILPPHLERIREKLAENIHELWVMNKIELGWQYGPIRDDNKRQHPCL VEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLLSGYKP APMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALL DDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAMRLDMCSGIMEKFRIFRTEKTYAVKA GKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRWHQGNEHFGRSWLA GDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGDGFLPVCSLGPSQVGRMNFG KDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNHEHIEVMRIDGTID SCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAGGLPGSGLFGPKNDLEDYD ADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEKPSRLKQRFMLRRTKPDYS TSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTSFD LDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCLVDAASGLL TFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNP VSQCPPRLHVQFLTHVLWSRVPNQFLKVDVSRISERQGWMIQCLDPLQFMALHIPEENRT IDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHVDESQLLYAIENKYMPGLL RAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKKHGLPGIGLSTSLR PRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQEGSLHVRDPVGGSTEFLF VPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFKEAMSREDEIDFSEKELSSDELKSEEG EEEIRGEQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIVAFSDDFVAKLQEN QRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNDCPCPEEIRDQLLDF HEDLMAHCGIELDEDGTLDGNSDLTIRGRLLYLMEKVAYLKKKQQTEKPIDDDAKTTSTL QQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINSVSVEDTIN LLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNV LGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGST PLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLISKGYPDIGWNPVEGERY LDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIQISEDPT RDGPSPSNGSSKTLEMEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIR IRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFCPDHKAAMVLFLDRVYGI EDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGT EHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQHLLRRLVFDVPL LNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYE QELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNPQPVDTSNITIPEKLE YFINKYAEHSHDRWSMEKFANGWTYGETYSESAKVQPLMKQYKLLSEKEKEIYRWPIKES LKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGYTPRAIDMSNVTLSRDLH AMAEMMAENYHNIWAKKKKMELEAKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQI NGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGVSRGKGEHFPYEQ EIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEKEMVTSLFCKLGVLVRHR ISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRAFLDNAAEDLEKTMENLKQG QFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILEDVQVSCYRILASLY ALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYNTKNARDRAVLNLP TSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVILPMLCSYMSHWWEHGPENNP DKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQLLKTH FLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARDLYAFYPLLIRFVD YNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLISDTKSK MSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSM KDTEDEVRDSIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDSSDPEKTVERVLDIANVL FHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAINLFLQGYDKSWIE SEEHYFEDKLIEDLAKPGEEPPEEDESLKRVDPLHQLILLFSRTALTEKCKLEEDFLYMA YADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQ TISASKGEMGPMVAATLKLXILILCVNYLCLLQKMLDYLKDKKDVGFFQSLAGLMQSCSV LDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQT GNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTE YIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVML LSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGI ISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLL TNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEK PQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEENE KDKPEEQDPRMGFFSLVTMKSALVALKYNLMMLMKMLSMKSLRKQMKKVKKMTMKDMVMA LFSSYWSILVGLLHFACSVVRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEV RGEAEEGERKPTEAALPTEDLTDLRTLSDESDLLSDIFGLDLKREGGQYKLIPHNPNAGL SDLLSTPSLAPMPEVPEKIQEQVKEDEKEEKEETKSEPEKAEGENGEKEEKAKEDKGKQK LRQLHTHRYGEPEVQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYK VSTSAVTEEKEVPVVSAGESTKLNILESDNQRVIAVHYVLEESSGYMEPTLRILAVLHTV ISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFP NNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDNSLSAVLNSI DVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVT HNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGV RAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVK EDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVW KMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14122 nt NT seq  +upstreamnt  +downstreamnt aactgtccattatgaaggtggtgctgtgtcaattcatgctcgttccctttggcgactaga aactctaagagttgcgtggagtggcagccacattagatggggacaggcattcagactaag acatataacaacaggaaaatacttaagtctcctggatgacaacagtcttcttcttacaga caaagagaaagcggatgtaaaatctacggcattctgttttcggtcttccaaggaaaagtt ggacatagggacaagaaaagaggtggatggaatgggagcacctgaaatcaaatacgggga ttcaatatgcttcatacaacatgtagatacaggcttatggctcacctatcagtctgctga tgcgaagtctgtaagaatgggctctgtgcagcggaaggcaataatgcaccatgaaggtca catggatgatggtttaacgttgtccagatctcagaatgaagaatcccgtacagcacgtgt catccgtagtacagtcttccttttcaacaggtttataaggggccttgatgctctcagcaa gaaagctaagtcttccactgtcgatttgcctatcgagtcagtcagtctgagccttcagga cttgattggctactttcacccccctgatgaacatttggagcatgaagacaaacaaaacag gctccgagcactgaagaatcgtcagaacctcttccaggaagagggtatgatcaaccttgt tcttgaatgtattgatcgcttgaatgtatacagcagtgcagctcattttgcagacgtagc tgggaaggaagctggagaagcatggaaatctattttgaattctttgtatgaattactagc ggctctgattcgagggaatcgtaaaaattgtgctcaattttccggatctcttgattggtt gatcagcagattagaaagactggaagcttcttctggaattctagaggttttacactgtgt gttggtggaaagcccagaagctctaaacattattaaggaaggacatattaaatcaatcat ctgccttttggacaaacatggaagaaaccataaggttttggatgttttgtgttctctctg tgtttgtcatggagtagctgtgcggtctaatcaacatctaatctgtgataatctcctgcc aggaagagatctactcttacagacacgtcttgtcaaccatgtgagcagcatgcgacctaa catcttcttggggattagtgaaggctctgcccaatacagaaaatggtactatgaacttat ggtggaccatctggagccctttgtgacagcagaatcaactcatctacgagtgggctgggc ttcaacagagggctactcaccgtatccagggggaggagcagaatggggaggaaatggtgt tggtgatgacttgtattcctatggctttgatggtttgcatctgtggtcaggttgtgtagc acgaacagtaaattctcccaatcaacatctgttaagaactgatgatgttattagctgttg tttggacctgagtgcccccagcatctctttccggataaatggtcagccagttcaaggaat gtttgagaatttcaacatagatggcctcttcttcccagttgtcagcttttctgcaggaat aaaggtacgtttcttgcttggaggtcgccatggagagttcaagttccttcctccacctgg atatgccccttgctttgaagctgtcctaccgaaagagaagctgaaagtggagcatagcag agagtacaagcaggatcgtagctatacaagagacctactaggtcccactatctctctgtc acaagcggctttcacgccagttcctgtagatactagccagatcattttgcctccccactt ggaaaggattagagaaaaattagcagagaacatccatgaactttgggttatgaataagat tgaacttggatggcaatatggaccaattagagacgacaacaagagacaacacccatgctt agtggagttctcaaaattgccggagcaggaaagaaattacaacttgcaaatgtcacttga aacactgaaaaccctactggcattaggctgccatgttggaattgctgatgagcatgctga agaaaaagtgaaaaaaatgaaacttccaaagaactaccagttgttgagtggatataagcc tgctcccatggatctgagttttatcaaactgaccccctctcaagaagctatggtggataa actagcagagaatgctcacaatgtgtgggcaagggaccgtataaggcagggctggacgta tggtattcagcaggacgtgaaaaatcgacgaaatcctcgccttgtaccttatgctctttt ggatgatcggacaaagaagtcaaacaaagacagtcttcgggaagcagtccgcacccttct aggctatggttacaacctggaagctcctgaccaagatcatgcaatgagactggacatgtg cagtggaataatggaaaaatttaggatcttccgcacagaaaagacttacgcagtgaaggc tgggaagtggtactttgagtttgaggcagttactgcaggagacatgagagttggctggac caggccgggttgtctgccagatcaggaactcggctcagatgaagaagcttttgtttttga tggctttaaggcacagcggtggcatcaaggtaatgagcattttggccgctcttggttggc aggagatgttgtgggctgtatggttgacatgaatgagcacactatgatgttcaccttaaa tggtgaaatcctgcttgatgactcaggttcagaacttgcgttcaaggattttgaggttgg tgatggatttctacccgtgtgcagcctgggcccatctcaagtgggaagaatgaactttgg aaaagatgtcagcactctgaaatattttactatctgtggcttacaggaagggtatgaacc ctttgctgttaatacgaacagagatatcacgatttggctgagtaaaaggctccctcagtt tctaccagtgccacaaaatcatgaacatattgaggtgatgagaattgatggcaccataga cagctgcccttgcctgaaggtcacacagaagtcctttggttcacagaacagtaaaacaga cgtcatgttttttcgattaagcatgcccattgaatgtgctgaggtgttctccagatcagc tgcaggagggctaccaggctctggcctttttggcccaaagaatgacctggaggattatga tgctgattctgattttgaggttctgatgaaaactgctcatggtcatctagttcctgaccg gacagaaagagaaaaagatgcaacaaaaccagagttaaacaaccataaagattacgttca agaaaagccttcacgtcttaaacaaagatttatgctcaggaggacaaagccagattatag cacaagtcactctgcacggcttactgaggatgtgctagcagatgatagagatgactatga ttatttgatgcaaacatccacgtactattattcagtgagaatatttcctggtcaagaacc tgctaatgtctgggtgggctggattacatctgactttcaccagtatgacacaagctttga cttggacagagtgcgtactgtcacagttacactgggagatgaaaaagggaaggttcatga gagtataaaacgcagcaactgctatatggtgtgcgcaggagagagtatgagccctggaca aggacgtaataataatggtctggagattggttgcttggttgatgctgccagtggtctgct taccttcacagctaatggcaaggaactaggcacctactatcaggttgaaccgagtacaaa gttatttcctgctgtatttgctcaagctacaagccccaacgttttccagtttgaattggg aagaataaagaatgtaatgccattatctgctggtttattcaaaagtgaacacaaaaaccc agtctctcaatgtcctccacgtctccatgtgcaatttctgactcatgtgctttggagcag agtgccaaaccagttcttgaaggtcgatgtctctcggatcagtgaacgtcaaggctggat gatacagtgcctggatcctttgcagttcatggcccttcatattcccgaagaaaacagaac aattgatattttagagctgacagaacaagaagaattgctgaaatttcactaccataccct ccgattatattcagctgtttgtgctttaggcaacaaccgagtggcccatgccatgtgtag ccatgttgatgaatctcagctcctgtatgctattgagaataaatatatgccaggattatt acgtgcgggatattatgacttacttattgacatccatctcaacacctatgcaactgccag gttaatgatgaataatgaatttatagttccaatgacagatgagaccaagagtattacttt gtttcctgatgaaaacaaaaagcatggcctcccgggtataggacttagcacttcattaag gccaagaatgcaattctcctctccgagttttgtaagcattagcagtgaatgctttcagtt cagtcctgaattccctctggaaatcttaaaggccaaaaccatagagatgctgactgaagc tgttcaggagggcagcctccatgtcagagatccggttggaggttctacagagtttctgtt tgtccctctcatcaagctcttttataccctcctaattatgggaatcttccacaatgggga tctgaaacacatcttgcagttgattgagccccgtgttttcaaagaagcaatgagccggga ggatgaaattgatttctcagagaaggagctgagttcagatgagctcaagtcagaagaagg agaggaagaaatcagaggggagcaagtcccaaaggaaggactccttcagatgaaacttcc agaacctgttaaattacagatgtgtcatctactgcagtacctgtgtgattgccaagtacg acaccgaatagaagccattgtagcattttcagatgattttgtggccaagcttcaagagaa tcaacgcttccggtacaatgaagtgatgcaggccttgaacatgtctgctgccctgacagc tagaaaaacaaaagaatttcgatccccacctcaggagcagattaacatgctgctgaactt taaagatgataaaaatgattgtccttgccctgaagaaattcgggatcaactcctggattt ccatgaagacctaatggcacactgtggaattgaactagatgaagatggaaccttggatgg aaacagtgatttaaccattaggggtcgcctcctataccttatggaaaaagttgcatatct gaagaagaagcagcaaactgagaagccaattgatgatgatgctaagacaacctctactct tcagcagttgatttcagacacaatggtacgctgggcccaggaatcagtgatagaagaccc ggagttagtgagggctatgtttgtattgctgcatcgccaatatgatggtattggtggcct ggttcgagccctaccaaagacctacaccataaatagtgtgtctgtggaagacacaatcaa tcttctggcatcccttggccaaatccgttccttgcttagtgtcagaatgggaaaggagga agagaaacttatgattcgtggattaggagacatcatgaataataaagtattttaccaaca tccaaatctcatgagagctttaggcatgcatgaaactgtcatggaagtgatggtaaatgt gcttggtggaggagaatccaaggaaatcactttcccaaagatggtggcaaactgctgtcg ttttctgtgttatttttgccgcatcagcaggcagaatcaaaaagctatgtttgatcatct tagctatttattggaaaacagcagtgttggccttgcctctccttctatgcgaggatcaac tcctttagatgttgcagcagcctctgtgatggataacaatgaacttgcacttgctttaag ggagcctgatctggagaaggtagttcgctacttggctggatgtggattgcagagttgtcc tttgttgatttctaaaggctacccagacattggatggaacccagtagaaggagagagata tttggattttcttcgttttgctgttttttgcaatggagagagtgtggaggagaatgcgaa tgttgtagtcagactgcttatccgtcgacctgaatgttttggtccagctctaagaggaga aggaggcaatgggctacttgctgccatggaggaagcaatacaaatatcagaagatccaac aagagatggaccatccccaagcaatggatctagtaaaacccttgaaatggaagagcaaga agatgacactattcacatgggaaatgcaatcatgaccttttatgctgctttgattgatct cttaggacgttgtgcccctgaaatgcatctaatccatgctggtaaaggggaagccattag aatcagatcaattctacggtctttgattccactggaagatttggtgggagtaattagtat tcctttccacatgccaaccatagctaaagatggtactgtggtggaacctgacatgtctgc ggggttttgcccagatcacaaggcagccatggttttgttccttgacagggtctatggaat tgaggaccaggattttcttctacaccttcttgaagttggctttctgccagatcttcgtgc tgctgcttctttagatacagctgctttaagtgctacagatatggctttggctctgaatcg atacctttgcacagcagtcttgcctctgttgaccagatgtgctcctctttttgctggcac agagcaccacgcttccctcatcgattccttattacacactgtgtacagactctcaaaggg atgctctcttaccaaagctcagcgagattctattgaagagtgtttgctgtctatctgtgg gcagttgcgaccttccatgatgcagcatctgctgagaagattagtgtttgatgttcctct attaaatgaacatgcaaagatgcctctcaagttgctgacaaatcattatgaaagatgctg gaagtattattgtttgccaggtggatggggtaactttggggctgcctcagaagaagaact tcatttatccagaaagttgttctggggtatttttgatgctttgtctcagaagaaatatga acaagaactattcaaattggctttgccttgcttgagcgcagttgcgggggcgttacctcc agactatatggaatcgaattatgttaatatgatggaaaagcagtcttcaatggattcaga tgggaactttaatcctcaacctgttgatacatcaaacattacaatccctgaaaagctaga atatttcattaacaaatatgcagaacactctcatgacagatggtcgatggaaaagtttgc caatggatggacatacggtgaaacgtattctgaatctgcaaaagtgcaaccattaatgaa acaatataagctactatctgaaaaggagaaagaaatttatcgatggccaatcaaagaatc actaaaaactatgctggcatggggatggcgaattgaaagaacacgagagggagattccat ggcactatataatcggacgcgtcgcatatctcaaaccagccaaatctctgtagatacagc ccatggttacactcctcgagcaattgacatgagcaatgtcaccctctccagagacttaca tgctatggctgagatgatggccgaaaactaccataacatatgggcaaagaaaaagaaaat ggagcttgaagcaaaaggaggaggcaaccatcctctccttgttccctatgatacgctcac agccaaagaaaaagccaaggacagagaaaaagcacaggatattctgaaatttctacagat taatggatatgttgtctccagaggacttaaggacctggaattagacacaccttccattga gaaacgctttgcctacagtttccttcagcaacttataagatatgttgatgaagcccatca gtacattctggagtttgatggtgtcagcagaggcaaaggagagcacttcccgtatgaaca agaaatcaagttttttgccaaagttgtgctccctttgattgatcagtattttaaaaatca tcgcctgtatttcttatctgcagcaagtaggcctctcagcagtggaggccatgcctctaa taaagagaaagaaatggtgacaagcctgttctgcaaacttggagttcttgtcaggcatag gatttcactgtttggaaatgatgcaacatcaatagtgaactgtcttcacatactgggcca gaccttggatgcgaggactgtgatgaaaactggtctggaatctgttaagatggcattgag agcatttttggacaatgctgctgaggatctggagaaaacaatggaaaatctcaagcaagg ccagtttacacacagcagaaaccagccaaagggagttacgcaaatcattaattataccac agttgctctccttccagtgctatcttccttatttgagcatattggacagcaccagtttgg ggaagatttgatattggaagatgttcaggtctcctgttatagaatattggccagtttgta tgctctgggaaccagcaagagtatctacgtagagcggcaacgatcagcactaggggagtg cttggctgctttctcaggtgcctttccagtggcttttttggaaactcatttgaacaaaca taatatctactcaatttacaataccaagaatgcgagagacagagcagttctcaatttgcc tactagtgtagaagaggtttgcccgaatattccttccttggtgaagctgatggaagaaat tgtggaactggcagagtctggtattcgttacacgcaaatgccacatatcatggaagtaat actacctatgctgtgtagttacatgtcacactggtgggagcatgggccagaaaacaaccc tgacaaggctgaaatgtgttgcacagccttgacatcagagcacatgaacactcttttggg taacatattgaaaatcatctataacaaccttggtattgatgaaggagcctggatgaagag attagcagtgttttcccagcccatcataagcaaagcgaaaccacagctcttaaagacaca cttcctgccactgatggataagctaaagaaaaaagcagcagtggttgtatcggatgaaga acatctaagagcagaaggcagaggtgacatgtcggaggctgaactgctcatcctagatga gttcactactttggcacgggacctctatgccttctaccctttgttgattagatttgtgga ctataacagggcaaaatggcttaaagagcccaaccctgaagcagaagaattgttccgcat ggtggctgaggtcttcatttactggtcaaagtctcataatttcaaaagggaagagcagaa ctttgtggtacaaaatgaaatcaacaacatgtctttccttatcagtgacaccaaatctaa gatgtccaaggcagcagtttctgaccaggagaggaagaagatgaagcgaaaaggtgaccg atactctatgcagacctctctcattgtggcagcattaaagagattacttcccattggcct aaacatttgtgctcctggagaccaagagctaattgcactggccaaaaatcgattcagtat gaaagatactgaagatgaagtacgagatagcatccgcagtaatcttcatctccagggcaa gcttgaggatcccgccattaggtggcagatggcactttacaaagatttaccaaacaggac tgaagattcctcagatccagagaagactgtggaaagggtccttgatatagctaatgtact gtttcacctggaacaggttgagcaccctcagcggtccaaaaaagcagtgtggcataagct gctgtctaaacagaggaaaagagcagtagttgcctgctttagaatggcaccattgtataa tctgccaaggcaccgagccatcaatctctttcttcaaggctatgataagtcttggattga atcggaagaacattattttgaagacaaactgatagaagacttagcaaaacctggggagga accaccggaggaagacgaaagccttaaaagagttgatcctttacatcaacttattctgct attcagtcgaacagccttgactgaaaaatgcaaattggaagaagatttcctgtacatggc ttatgctgacattatggcaaagagctgccatgatgaagaagatgatgatggtgaagaaga agtaaagagttttgaagtgacaggatcacaacgcagcaaggaaaaagaaatggaaaagca aaaactcctgtatcagcaagccagactgcatgaccggggtgctgctgagatggttctgca gacaatcagtgctagtaaaggtgagatggggccaatggttgcagctaccctaaagctnna aatattaattttgtgtgtaaattatttgtgtttactgcagaaaatgctagactacctcaa ggataaaaaggatgtgggattctttcagagccttgctggtcttatgcagtcctgtagtgt tcttgacttaaatgcatttgaacgtcagaacaaagcagaaggccttggcatggtgacaga agagggatcaggagaaaaggtgatgcaggatgatgagttcacctgtgacctcttccgctt ccttcaattgctttgtgaaggacataattcagattttcagaattacctgagaactcagac tggtaacaatacaactgttaatattatcatttccactgtggattacttattaagagttca ggaatccattagtgatttctattggtattattctgggaaggatgttattgatgaacaagg acaacgaaacttttccaaagccatccaggttgcaaaacaagttttcaatactcttacaga gtatatccagggaccgtgtactgggaatcagcaaagtctggcacacagcaggctatggga tgctgtagttggttttcttcatgtgtttgcccacatgcagatgaagctgtctcaggattc cagtcaaattgaattgctgaaggaattaatggatcttcagaaggatatggttgtcatgtt gctgtctatgctggaaggtaatgttgtgaatggaactattggcaagcagatggtcgatat gcttgtggaatcgtccaacaatgtggagatgattctgaaattttttgatatgttcttaaa attgaaggatttgacctcctctgatgcattcaaagaatatgaccctgatggtaaagggat aatttcaaagagggattttcacaaggcaatggaaagccataagcattacacacagtctga aactgagtttctgctatcgtgtgctgaaacagatgagaatgagactctggactatgagga gtttgtgaaacgattccatgaacctgccaaagacattggtttcaatgttgctgttctcct gactaacctttcagaacacatgccccatgatacccgcttgcaaacttttcttgaactgtc agagagtgtgctgaattactttcagccttttcttggacgcatagaaatcatgggcagtgc gaagcgcattgaacgagtttattttgaaataagtgagtcaagtcggactcagtgggagaa acctcaggtaaaagagtcaaagagacaatttatatttgatgttgtaaatgaaggcgggga gaaagaaaagatggagctttttgttaatttctgtgaggataccatctttgaaatgcaact ggctgcccagatctccgagtcagatctgaatgaaaggtcagcaaataaagaggagaatga gaaagataagcctgaggaacaggatcctagaatgggtttcttctctctcgtgaccatgaa gtcagcattagtagctctcaagtataatttgatgatgctcatgaaaatgctcagcatgaa gagcctaaggaaacagatgaaaaaagtgaagaaaatgaccatgaaggacatggtcatggc tttattttcttcctattggagcattttggtgggcttactacattttgcttgtagtgttgt ccggggcttctttcgcatcatatgcagtttgctgcttggaggaagcctagtagaaggagc aaagaaaatcaaggtggctgaactgttagcgaatatgccagatcccactcaggatgaggt gcgtggggaagcagaagagggggagaggaagccaacagaagctgcattgcctacagaaga cttgacagatctgagaactttatcagatgaaagtgatctactctcagatatatttggttt ggatttgaaacgagaaggtggacagtataaattgatccctcacaatccaaatgctggttt gagtgatttactgagcactccctccttagctccaatgcctgaggtaccggaaaaaatcca ggagcaggtgaaagaagatgaaaaggaagagaaggaggaaacaaaatctgaacctgaaaa agctgaaggagaaaatggagaaaaagaagagaaagccaaggaagacaaagggaaacagaa attaagacaacttcatactcacagatacggagaaccagaagttcaggaatcagctttctg gaagaaaatcattgcataccaacagaagcttcttaattattttgcacgaaacttttacaa catgaggatgttggcgttgtttgttgcttttgccatcaacttcatcctgcttttctataa ggtgtccacctctgccgtgacagaagaaaaggaagttcctgtggtatctgctggtgaaag taccaagttgaacatcctggaaagtgacaaccagagggttattgcagtgcattatgtcct ggaagaaagcagtggctacatggagcccacgctgcggattttggccgtcctacacacagt catctcattcttctgcatcatagggtattactgtttgaaagttccactggttatttttaa gagagaaaaggaagtggcaaggaaattggaatttgatgggctgtatataactgaacagcc atcagaagatgatattaagggacagtgggatagacttgtaatcaacacacagtcttttcc aaataactattgggacaaatttgtgaaaaggaaggtcatggataaatatggtgagttcta tggccgtgacaggatcagtgagttacttggaatggacaaagctgctctcgattttagtga tgctcgagaaaagaagaaaccaaagaaggataactccttatctgctgtgctaaattccat tgatgttaagtatcagatgtggaaattaggagttgttttcactgataactctttccttta cctagcgtggtacatgaccatgtcagtccttggccattacaacaattttttctttgctgc tcatctccttgacattgcaatgggattcaagacattacgaactatcctgtcatcagtgac ccacaatggcaaacagcttgtcctgacagtgggattactggcagtagtagtatacttgta tacagtggtggcattcaattttttccgcaagttctacaataagagtgaagatggtgatat gccagacatgaagtgtgatgatatgctaacatgctacatgtttcacatgtatgttggagt tcgtgcaggtggaggcattggtgatgaaatagaggatccagcaggagatgaatatgaaat ctatcggattatctttgacatcacttttttcttctttgtgattgtcatcctacttgcaat tattcaaggtttaattattgatgcttttggtgagctaagagatcagcaagagcaagttaa ggaagatatggagacgaagtgctttatctgtggaataggaaatgactactttgatacagt gccccatggctttgaaacacacacactacaggagcacaacttggccaattatttgttttt tctgatgtatcttattaacaaagatgaaacagagcatacaggacaggaatcctatgtatg gaaaatgtatcaagagcgatgctgggagtttttccctgctggtgattgtttccgaaaaca atatgaagaccagctcaactaa

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