Leopardus geoffroyi (Geoffroy's cat): 123576415 Help Entry 123576415         CDS       T10761                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism lgf  Leopardus geoffroyi (Geoffroy's cat) Pathway lgf04020   Calcium signaling pathway lgf04024   cAMP signaling pathway lgf04260   Cardiac muscle contraction lgf04261   Adrenergic signaling in cardiomyocytes lgf04371   Apelin signaling pathway lgf04713   Circadian entrainment lgf04911   Insulin secretion lgf04921   Oxytocin signaling pathway lgf04972   Pancreatic secretion lgf05020   Prion disease lgf05022   Pathways of neurodegeneration - multiple diseases lgf05410   Hypertrophic cardiomyopathy lgf05412   Arrhythmogenic right ventricular cardiomyopathy lgf05414   Dilated cardiomyopathy lgf05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:lgf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     123576415 (RYR2)    04020 Calcium signaling pathway     123576415 (RYR2)    04024 cAMP signaling pathway     123576415 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     123576415 (RYR2)    04921 Oxytocin signaling pathway     123576415 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     123576415 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     123576415 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     123576415 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     123576415 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     123576415 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     123576415 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     123576415 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     123576415 (RYR2)    05414 Dilated cardiomyopathy     123576415 (RYR2)    05415 Diabetic cardiomyopathy     123576415 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lgf04040]     123576415 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:lgf04990]     123576415 (RYR2) Ion channels [BR:lgf04040]  Voltage-gated cation channels   Ryanodine receptor    123576415 (RYR2) Domain-containing proteins not elsewhere classified [BR:lgf04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    123576415 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 PI3_PI4_kinase Motif Other DBs NCBI-GeneID:  123576415 NCBI-ProteinID:  XP_045293184 LinkDB All DBs Position D2:complement(11171135..11933441) Genome browser AA seq 4986 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREGGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGAQNSTADIMFYRLSMPIECAEVFSKTVAG GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAAFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNDCYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEED TEALEKEPSMEDSKPEGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQAEKPVESGSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLETEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRVERTREGDSMALYNRSRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRSKAEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRTF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNV YSIYNTKSSRERAALNLPTDVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSTQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTSMHRRYYSLVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEEEGTKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQ RSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGGNST VQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSASHFESH RLQTGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRV QESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLW DAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVD MLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQS ETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLEL AESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGG EKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKEKPEEQGPRMGFFSIVTV KSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTMKDMVTAAFSSYWSIFMSLLHFVASV SRGFFRIICSLLLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDGEEGDRRPMEAALPSE DLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQE QKVKEEEKEEKEESKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFW KKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKEPPTRSSSGN AKVSSLDSGSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFK REKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFY GRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLY LAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLY TVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEI YRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTV PHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQ YEDQLN NT seq 14961 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggacgagatccagttcctgcgaactgacgatgaagtg gtcctgcagtgcaccgcaaccatccacaaagaacaacagaaactgtgcttggcagcggaa gggtttggcaacagactttgcttcctggagtctacttcgaattccaagaatgttccccca gacctctccatctgcacttttgtgctggaacagtctctctctgtccgggccctacaggag atgctggctaacacagtggagaaatcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggtcatcgaacactcctgtacggacatgccatattg ctacgccattcctatagtggcatgtatctgtgctgtctgtccacctcccggtcttcaact gataaactggcctttgacgttggcttgcaagaggacacaacaggtgaggcttgttggtgg actattcatcctgcctccaagcagaggtcggaaggagaaaaggtgcgcgttggagatgac ctcatcttagtcagtgtgtcctctgagaggtacctgcatttgtcttacggcaatggcagc ttacacgtggatgccgctttccagcagactctctggagcgtggccccaatcagctcagga agtgaagccgcccaagggtatctaattggtggtgacgtcctccggttgctgcacggacac atggatgaatgcctcactgtcccttcaggagaacacggtgaagagcagcggagaactgtt cactatgaaggcggtgctgtatctgtccatgcacgttccctgtggagactagagacacta agagttgcgtggagtggaagccacataagatggggccagcccttccgactacgccatgtc acaacaggaaagtacttgagtctcatggaagacaaaaaccttctactcatggacaaagaa aaggctgatgtaaagtcaacagcatttaccttccgatcttccaaggaaaaattggatgta ggggtgagaaaagaagtcgatggcatgggaacatcagaaataaaatatggagactcagta tgctatattcaacatataaatacaggcctgtggcttacttaccagtctgtggatgtgaaa tcagtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggtcacatggat gacggcttaaatctctctagatctcagcatgaagaatcacggaccgcacgagtcatccgg agcactgtcttccttttcaatagatttataaggggccttgatgcgctcagcaaaaaagtg aaggcttccacagtagacctccctatagaatctgtgagtctgagtctgcaggacctgatt ggttacttccatccccccgacgagcacttagagcatgaagacaaacagaacagattacgg gctctaaagaaccgtcagaatctcttccaggaagagggcatgatcaacctcgtgctcgag tgcatcgacaggctgcatgtctatagcagtgcggcgcatttcgcggacgtggcggggaga gaaggaggcgaggcttggaagtcaattctgaattctctctatgagttgctagcggctcta attagaggaaatcgtaaaaactgtgcccaattttctggctccctggactggttgatcagc cgattggaaagactggaagcttcttctggtattcttgaagttttgcactgtgtgttagta gaaagtccagaagccctaaatattatcaaagaaggacacattaaatccataatctccctt ttagacaagcatggaagaaaccacaaggttctggacgtcttgtgctctctctgcgtctgc catggagtagcggtccgttccaaccagcatctcatctgtgacaatctgctgccgggaaga gatctacttctgcagacacgtcttgtaaaccacgttagcagcatgagacccaatattttt ctgggcgtcagtgaagggtccgcccagtataagaagtggtactatgagctgatggtggac cacacagagccgttcgtgaccgccgaagccactcacctgagggtgggctgggcgtccacc gaagggtactctccctaccctggaggcggtgaggagtggggtggcaatggagttggagat gatctcttttcctacggatttgatggccttcacctctggtcaggttgtattgcacgtact gtaagctcaccgaatcaacatctcttgagaaccgacgatgtcatcagttgctgtttagat ctgagcgccccaagcatctcattccgaattaacgggcaacctgttcaaggaatgtttgag aatttcaacatcgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctgcttggggggagacatggagaatttaaattccttcctccacctggctatgct ccttgttatgaagctgttctcccaaaagagaagttgaaagtggaacacagcagagaatac aagcaagaaagaacttacacccgagacctgctgggccccacggtttccctgacgcaggcc gccttcacaccaatccccgtggataccagccagattgtgttacctcctcacctggagaga ataagagaaaaactggcagagaatatccatgaactctgggttatgaataaaattgaactt ggctggcagtatggtccggttagagatgacaataagagacagcatccgtgtctggtggag ttctccaagctaccggagcaggaacgcaattacaatttgcagatgtcacttgagaccctg aagactttgttggcattaggatgtcatgtgggaatagcagatgaacatgctgaagaaaag gtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgccccg atggacctgagcttcattaaactcacgccgtctcaggaagcgatggtggacaagttggcg gagaacgctcacaacgtgtgggcccgggatcgaatccggcagggctggacttacggcatc cagcaggatgtaaagaacagaagaaaccctcgcctggttccctacacccttctagatgac cgcaccaagaagtccaacaaggacagcctccgtgaggccgtgcgcacgctgctgggatat ggctaccatctggaggcgccagatcaagatcatgctgcccgagccgaagtgtgtagcggc accggggagaggttccgaatcttccgcgcagagaaaacctatgccgtcaaggcaggaagg tggtattttgaatttgaggctgtcactgctggagacatgagagtcggatggagcaggcca ggttgtcaacctgaccaagagctgggctcagacgaacgtgcctttgcttttgatggcttc aaggcccagcggtggcaccagggcaacgaacactatgggcgctcttggcaagcgggcgat gttgtgggatgcatggtggatatgacggagcacaccatgatgttcacactgaatggcgaa atccttctggatgactcgggctcagaactggcgttcaaggacttcgatgttggtgacgga ttcattcctgtctgtagccttggagtggctcaggtgggcaggatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggttacgaaccgtttgct gtgaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccag gtcccttcaaaccatgagcatatcgaggtgaccagaatagacggcaccatcgacagttct ccgtgtttaaaagtcacccagaagtcctttggcgctcagaacagcactgccgacatcatg ttctatcgcctgagcatgccaatcgagtgtgccgaggttttctccaagacggtggcaggc gggctcccaggcgccggcctctttgggcccaagaatgatctggaggattacgatgcagat tctgactttgaggttctaatgaagacagctcatggccatctggtgccagaccgtgttgac aaagacaaggaagccacaaaaccagagtttaataaccacaaagactatgctcaggaaaag ccctctcgtctgaaacaaagatttttgcttagaagaacaaagccagattatagcacgagc cattctgcaaggctcacggaagatgtccttgcagatgatcgggatgattatgattacttg atgcaaacgtccacgtactattactcagtgagaatctttcccggccaagaacctgctaac gtctgggtgggctggattacatcagatttccatcagtatgatacaggctttgacttggac agagttcgtacagtaaccgttactctaggagatgaaaagggaaaagtacatgaaagcatc aaacgcagcaactgctatatggtgtgcgcgggtgagagcatgagcccagggcaaggacgc aacaataatggcctggagatcgggtgcgtggtggatgctgccagtgggcttctcacattc accgccaacggcaaggagctgagcacctactaccaggtggagccaagtacaaagttattt cctgcagcttttgcccaagctacaagtcccaatgttttccagtttgagctgggaagaatc aagaatgtgatgcctctctccgcgggattattcaagagtgagcacaaaaaccctgtgcca cagtgtcccccgcgtctccacgtgcagtttctgtcccacgtcctgtggagcagaatgccc aaccagttcctgaaggtagatgtgtctcgaataagtgagcgccaaggctggctggtgcag tgtttggatcctctgcagttcatgtctctccatatcccggaggagaacagatctgttgac atactggagctgacagagcaggaggagctgctgaaattccactaccacacgctccggctt tactccgccgtctgcgccctcgggaaccaccgggtggcgcatgcgttgtgcagccacgtg gacgaaccccagctgctctacgccatcgagaacaagtacatgcccggtttgctgcgggcc ggctactatgacctgctgattgacatccacctgagctcctacgccactgccaggctcatg atgaacagtgagttcatcgtgcccatgacggaggagaccaagagcatcaccctcttccct gatgagaacaaaaagcatggcctcccggggattggcctcagcacctccctcaggccacgg atacagttttcctcccccagttttgtgagcatcaataacgactgctaccaatacagtcca gagttcccgctggacatcctgaaggccaaaaccattcagatgctgacagaagctgttaaa gagggcagcctgcatgcccgggaccccgtggggggcaccactgaatttctctttgtacct ctcatcaagcttttctatactctgctcatcatggggatcttccacaatgaggacttaaaa cacatcttgcagctgatagagcccagtgtgttcaaggaagccgccactccggaagaagac actgaggctctggagaaagagccctccatggaagactccaagccagaaggagctggagaa gaagaagccaaagggggtaagaggcccaaggaaggactgctccaaatgaaactgcctgag ccagttaaattgcagatgtgtctgctgctccagtacctctgtgactgccaggtccgacac cggatagaagccatcgtggccttttcagatgactttgtagccaagctccaagacaatcag cgcttccgttacaatgaagttatgcaagctttaaacatgtcggccgcgcttactgccagg aagacaaaggaatttcgatccccacctcaggaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaagaaatccgagaccagctcttagattttcac gaagatttgatgacacattgtggaattgagctggatgaagatgggtctcttgatggaaac agtgacttaacaattagaggacgcctgctgtccttggtagaaaaggtgacatacctgaag aagaaacaagccgaaaaaccagttgagagtggctccaagaagtcctccactcttcagcag ttgatttctgagaccatggtccgatgggcgcaagagtctgtcattgaagaccctgaactg gtgagggccatgtttgtgttgctccatcgacagtacgatggcattgggggtctggtccgg gctctgccaaagacctacactataaatggtgtctccgtggaggataccatcaacctgctg gcatctctcggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtattttaccagcaccctaat ctcatgagggcacttgggatgcacgagacggtgatggaggtcatggtgaatgtccttgga ggtggagagtccaaggaaatcacttttcccaagatggtggccaactgttgccgttttctt tgttacttctgtcgtataagtcggcagaatcaaaaagctatgtttgaccatctcagctat ttattggagaacagcagtgttggtcttgcctcaccagcaatgagaggttcaacaccactg gatgtggcagccgcatcagtgatggataataatgaactggccttagctctgcgtgagcca gatttggaaaaggtagttcgatatttggctggttgtggactgcagagttgcccgatgctg gtatctaagggttacccagatattgggtggaatccagttgaaggagagagataccttgac tttctccgatttgctgtcttctgtaatggggagagtgtggaagagaatgctaatgtcgtg gtgaggttgctcatccggaggcccgagtgtttcggtcctgctttgagaggggaaggtggg aacggtcttcttgcagcaatggaagaagccataaaaatagccgaggatccctctcgagat ggtccctcaccaactagcggatccagtaaaacacttgagacagaagaggaggaggatgac actatccacatggggaatgccatcatgacgttttatgcagctttgattgacctcttagga cgctgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccgg tcaattctgagatccctaattccactgggagatttggtgggagtaatcagcattgctttt cagatgccaacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatggcattgaggtt caagatttcctcctccatcttctcgaggttggctttctgcctgatctccgggctgctgct tctttagatacggctgctttgagtgccacagacatggccctggccctcaatcggtacctt tgcacagccgtgttgcctttattaacaagatgtgcccctctttttgcgggcacagaacac cacgcttctctcattgactcgttactgcacactgtgtacagactttcgaagggctgctca cttaccaaagctcagcgggattccatagaagtttgtttgctctctatttgtggccaattg agaccttctatgatgcagcacttgctccggagattagtgtttgatgtcccattattaaat gaacacgcgaagatgcctcttaagttgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaacttcggagctgcctcagaagaagaacttcattta tcaagaaagttgttttggggcatttttgacgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgccgttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaacattacaattcctgagaagttggaatacttc attaacaaatatgctgaacattctcatgacaaatggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcgtctaaagttcagccgttaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaa accatgctggcgtggggttggagggttgagagaacacgggagggagacagcatggccctc tacaaccgttctcgtcgtatttctcagacaagccaggtttctgttgatgcggcgcatggt tatagcccccgagccattgatatgagcaatgtcacactgtccagagacctgcacgctatg gcagaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaaaatggagctg gagtccaaaggaggtggaaaccatcccctgctggtaccctatgatacactgacagccaaa gagaaagccaaggatagggaaaaagcacaggacatcctcaagttcttacagatcaatgga tatgctgtatccaggggattcaaggacctggaattggacacaccttccattgagaaacga tttgcctatagtttccttcagcaactcattcgctatgtggatgaagcccatcagtatatc ctggagtttgatggtggcagcagaagcaaggcggaacattttccttacgagcaagaaatc aagttctttgctaaagttgtgcttcctttaattgatcagtatttcaaaaaccatcgttta tacttcttatctgcagcaagcagacccctctgttctggaggacatgcgtcaaacaaggag aaagaaatggtgacaagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatcaattgtcaactgtctgcatattttgggtcagactttg gatgcaaggaccgtcatgaagactggcctggagagtgttaaaagtgcgctcagaacgttt ctggacaatgcggcggaggacctggagaagacgatggagaatctcaagcagggccagttc acccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggct ctgttgccaatgctgtcatcattatttgagcatattggccagcatcagttcggagaagat ctaatattggaagatgtacaggtgtcatgttatagaattctgactagcttatatgctttg ggaaccagcaaaagtatttatgtggaaaggcaacgctctgcattaggagaatgtcttgct gcttttgctggtgcctttcctgtcgcatttttggaaactcatctcgacaaacataacgtc tactctatctacaataccaagtcatcgcgagaaagagcagctctgaatttgccaactgac gtggaggatgtgtgcccaaatataccgtctttggagaaactcatggaagaaattgtggaa ttagctgagtccggcattcgctacacacagatgccacacgtcatggaagtcatactgccc atgctttgcagctacatgtctcgttggtgggagcacggacctgaaaataatccagaaagg gctgaaatgtgctgtaccgccctgaactccgagcacatgaacacgctcttggggaatata ttgaaaatcatatataataacctgggaattgatgagggagcctggatgaagaggttagca gtattttcacagcccattataaataaagtgaaacctcagctcctgaaaactcatttcttg ccattaatggagaaactcaagaaaaaagcagcgatggtggtgtcggaggaggaccatctg aaggctgaggccaggggggatatgtccgaggcagagcttctcattctcgatgagttcacc actctggccagagatctctatgccttctacccgctcttgattagatttgtggactataac agggcaaagtggctgaaagaacctaacccagaagcagaggaccttttccgcatggtggcc gaagtgtttatctactggtcaaaatcccataatttcaaaagagaagagcagaactttgtg gtacagaatgaaatcaacaatatgtctttccttattacggacaccaagtcaaagatgtca aaggccgctgtctctgatcaggaaaggaagaagatgaagcgcaaaggagatcggtactcc acgcagacctctctcattgtggcagctctgaagcggttactgcccattgggttgaacatc tgtgcccctggggaccaggagctcatcgctctggccaaaaaccgatttagtatgaaagac actgaggatgaagtacgagatataatccgcagtaatattcatttacaaggcaagttggag gatcctgctatcagatggcaaatggctctttacaaagacttaccgaataggactgaagat acatcagacccagagaagaccgtagagagagtattagatatagcaaatgtgctttttcat cttgagcagaaatctacatctatgcaccggagatattacagtctggtggagcacccacag agatcgaagaaagctgtatggcacaaacttctgtccaagcagaggaagagggcagtggtg gcctgcttccgaatggctcctttatataatctgccaaggcaccgggccgttaacctcttt cttcagggatatgaaaagtcttggattgaaacagaagaacactactttgaagataagctg atagaagatttagcaaaacctggagcagaccctccagaggaagaggaaggcacgaagaga gtcgatcccctccatcagctcatccttctgtttagtcgaacagctttaacggagaaatgc aaactggaggaagattttttatatatggcttatgcagatattatggcaaagagttgtcat gatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagtcacaggatcccaa cgcagcaaggaaaaagaaatggagaagcagaagcttctgtaccagcaagccaggctccat gaccgcggggctgctgagatggtgctacagaccatcagtgccagcaaaggtgatactggg ccaatggtagcggcgactttgaaacttggaattgcaatcttaaatggcgggaactccaca gttcagcagaaaatgcttgactatctcaaggagaagaaggacgtgggtttctttcagagc cttgctggcctgatgcagtcgtgcagcgtcctcgacctaaatgcatttgagcggcagaac aaagctgaaggacttggaatggtcaccgaagaaggatcagcctctcactttgaaagtcac agactgcagactggagaaaaggttctccaagatgacgagttcacgtgtgacctcttccgt ttcctccagctgctttgtgagggacacaactcagattttcaaaattatctgagaactcag actggcaataacacaactgtcaacatcatcatctctaccgtagactacctactcagagtc caggaatccattagtgatttctattggtattactctgggaaagatgttattgatgaacaa ggacaacggaatttctccaaagcaattcaagtagcaaaacaagtctttaacacgctcaca gagtatattcagggtccttgcactgggaatcagcagagcttggcccacagcaggctatgg gacgcagttgtgggcttccttcacgtattcgcccacatgcagatgaagctgtctcaggat tccagtcaaatcgagctattaaaagaattaatggatcttcagaaggatatggtggtcatg ttgctgtccatgctagaaggtaatgttgtcaatggaaccattggcaaacagatggtcgat atgcttgtggagtcttccaacaacgtggagatgattctcaagttttttgacatgttctta aaactaaaggatttgacctcttctgacacatttaaagaatacgaccctgacggcaaggga gtcatttccaagagggacttccataaagcgatggagagccataaacactacacgcaatca gaaaccgagtttcttctgtcctgtgcagagacggatgaaaacgaaaccctggactatgaa gagtttgtcaaaaggtttcacgagcccgcaaaggacatcggcttcaatgtggccgttctt ctgaccaatctttcggagcacatgcccaatgatacgcgactgcagactttcctagagttg gcagagagcgtgctgaattacttccagccttttctgggccgcattgagatcatgggaagt gccaaacgcatcgagagggtgtattttgaaatcagtgagtccagccgaacccagtgggag aagccccaggtcaaggagtccaaaaggcagttcatatttgacgtggtcaacgaaggggga gaaaaggagaaaatggaactttttgtcaacttctgtgaggacactatattcgaaatgcag ctggcagcgcagatctcagagtcggatttgaatgagaggtcagcgaataaagaagagagt gagaaggagaagccggaagagcaggggcccagaatgggtttcttttccatcgtgacggtc aagtcggccctgtttgctctcaggtataatatcttgaccctcatgagaatgctcagcctg aagagcctgaagaaacagatgaaaaaagtgaagaagatgacgatgaaggatatggtcacg gccgccttttcgtcctactggagtattttcatgagcctcctgcactttgtggccagcgtt tccagaggcttcttccgcatcatttgcagcctgctgcttggggggagcctggtagaagga gcaaaaaagatccgagtggcagagctcttagccaacatgccagaccccactcaggatgag gtgagaggggatggagaagagggggacaggaggcccatggaggccgccctgccctcggaa gatctgacagacctgaaggaactgacagaggaaagcgaccttctttcggacatatttggc ttggatttgaagagagaaggaggacagtacaaacttattcctcataatccaaacgctggc ctcagcgatctaatgagcaacccggtccctatccctgatgtgcaagaaaaatttcaggaa cagaaggtgaaagaggaagaaaaggaggagaaagaagaaagcaaatctgaacctgaaaag gccgagggagaagatggagaaaaagaagaaaaagccaaagaagataagggtaaacagaag ttgaggcagctccacacacacagatacggagagccagaagttcccgagtcggcattctgg aagaaaatcatcgcatatcaacagaaacttctaaactattttgctcgcaacttttacaac atgagaatgttagccttattcgtcgcgtttgcaatcaatttcatcttgctcttttataag gtctccacttcttctgtggttgaaggaaaggagccccccactcgcagttcaagtggaaat gccaaagttagcagcctggacagtggctcgcctagaatcatcgcggttcactacgtcctg gaggagagcagcggctacatggagcccacgctgcggatcttagccattcttcacacggtc atttctttcttctgcatcatcggctactactgcttgaaagtcccattggttatttttaag cgagaaaaggaagtagctcgaaaattggaatttgatgggctttatattacagaacagcct tcagaagatgatattaaaggccagtgggatagactcgtaatcaacacacagtcatttccc aacaactactgggacaaatttgttaaaagaaaggttatggataaatatggggagttctat ggccgggacagaatcagcgagctccttggtatggacaaagccgccctagatttcagcgat gcccgggaaaagaagaagccaaagaaagacagctccctgtcagccgtactgaactctatt gatgtgaagtatcagatgtggaaactaggagtcgtcttcacggacaactctttcctctac ctggcctggtatatgactatgtccgttctgggacactataacaactttttttttgctgct catcttcttgacattgctatgggattcaagacactgagaaccatcttgtcatcggtaact cacaatggcaagcagcttgtattaactgttggcttgttagctgttgttgtatacctatat actgttgtggcattcaactttttccgaaaattctacaataaaagtgaagatggtgacaca ccggatatgaaatgtgatgacatgctaacgtgctacatgttccacatgtatgtcggggta cgtgccggagggggtatcggcgatgaaatcgaagacccagcaggcgacgaatatgagatc tatcgaatcatctttgacatcaccttcttcttcttcgtgattgtcattctcttggccata attcaaggtttaattattgatgcttttggagagctaagagaccaacaggagcaagtcaaa gaagacatggagaccaaatgtttcatctgtgggataggcaacgattacttcgacacagtg ccacatggctttgaaacccacactttacaggaacacaacctggccaactacctgtttttt ctgatgtatctcataaacaaagatgaaacagagcacacgggacaggaatcttatgtctgg aagatgtatcaagaaaggtgctgggaattcttcccagcaggggattgtttccggaaacag tatgaagaccagctaaattaa

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