KEGG   Leopardus geoffroyi (Geoffroy's cat): 123577697
Entry
123577697         CDS       T10761                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
lgf  Leopardus geoffroyi (Geoffroy's cat)
Pathway
lgf00562  Inositol phosphate metabolism
lgf01100  Metabolic pathways
lgf01521  EGFR tyrosine kinase inhibitor resistance
lgf04012  ErbB signaling pathway
lgf04014  Ras signaling pathway
lgf04020  Calcium signaling pathway
lgf04062  Chemokine signaling pathway
lgf04064  NF-kappa B signaling pathway
lgf04066  HIF-1 signaling pathway
lgf04070  Phosphatidylinositol signaling system
lgf04072  Phospholipase D signaling pathway
lgf04360  Axon guidance
lgf04370  VEGF signaling pathway
lgf04380  Osteoclast differentiation
lgf04517  IgSF CAM signaling
lgf04611  Platelet activation
lgf04613  Neutrophil extracellular trap formation
lgf04625  C-type lectin receptor signaling pathway
lgf04650  Natural killer cell mediated cytotoxicity
lgf04662  B cell receptor signaling pathway
lgf04664  Fc epsilon RI signaling pathway
lgf04666  Fc gamma R-mediated phagocytosis
lgf04670  Leukocyte transendothelial migration
lgf04722  Neurotrophin signaling pathway
lgf04750  Inflammatory mediator regulation of TRP channels
lgf04919  Thyroid hormone signaling pathway
lgf04933  AGE-RAGE signaling pathway in diabetic complications
lgf04935  Growth hormone synthesis, secretion and action
lgf05167  Kaposi sarcoma-associated herpesvirus infection
lgf05169  Epstein-Barr virus infection
lgf05170  Human immunodeficiency virus 1 infection
lgf05171  Coronavirus disease - COVID-19
lgf05200  Pathways in cancer
lgf05205  Proteoglycans in cancer
lgf05206  MicroRNAs in cancer
lgf05214  Glioma
lgf05223  Non-small cell lung cancer
lgf05225  Hepatocellular carcinoma
Module
lgf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:lgf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123577697 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    123577697 (PLCG2)
   04014 Ras signaling pathway
    123577697 (PLCG2)
   04370 VEGF signaling pathway
    123577697 (PLCG2)
   04064 NF-kappa B signaling pathway
    123577697 (PLCG2)
   04066 HIF-1 signaling pathway
    123577697 (PLCG2)
   04020 Calcium signaling pathway
    123577697 (PLCG2)
   04070 Phosphatidylinositol signaling system
    123577697 (PLCG2)
   04072 Phospholipase D signaling pathway
    123577697 (PLCG2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    123577697 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123577697 (PLCG2)
   04613 Neutrophil extracellular trap formation
    123577697 (PLCG2)
   04625 C-type lectin receptor signaling pathway
    123577697 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    123577697 (PLCG2)
   04662 B cell receptor signaling pathway
    123577697 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    123577697 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    123577697 (PLCG2)
   04670 Leukocyte transendothelial migration
    123577697 (PLCG2)
   04062 Chemokine signaling pathway
    123577697 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    123577697 (PLCG2)
   04919 Thyroid hormone signaling pathway
    123577697 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    123577697 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123577697 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    123577697 (PLCG2)
   04380 Osteoclast differentiation
    123577697 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123577697 (PLCG2)
   05206 MicroRNAs in cancer
    123577697 (PLCG2)
   05205 Proteoglycans in cancer
    123577697 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    123577697 (PLCG2)
   05214 Glioma
    123577697 (PLCG2)
   05223 Non-small cell lung cancer
    123577697 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    123577697 (PLCG2)
   05171 Coronavirus disease - COVID-19
    123577697 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123577697 (PLCG2)
   05169 Epstein-Barr virus infection
    123577697 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    123577697 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123577697 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lgf04131]
    123577697 (PLCG2)
Enzymes [BR:lgf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     123577697 (PLCG2)
Membrane trafficking [BR:lgf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    123577697 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    123577697 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF_HAND_2_PLCG C2 SH3_1 PH SH3_9 PH_12 EF_HAND_1_PLCG SH2_1 PH_14 SH3_2 GDPD
Other DBs
NCBI-GeneID: 123577697
NCBI-ProteinID: XP_045295811
LinkDB
Position
E2:55263961..55423148
AA seq 1265 aa
MTAMVNMDTLPEYEKSQIKRTLELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAARQKEDCCFTILYGTQFVLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVNSA
KFLKDKFVEIGAHKDELSFEQFHLFYKNLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLLHEQQEVWAQDLNKVRERMTKFIDDTLRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDIQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDIPPTELHFGEEWFHKKVEKR
TNAEKLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIRSVMEGGTMKYF
LTDNIMFTSIYDLIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGQHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRNDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDISSVDVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKMDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPVDLLKYNHKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNQALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMQPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SRFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgaccgccatggtcaacatggacacccttcctgaatatgagaagagtcagatcaagaga
accctggagctgggcacggtgatgaccgtgttcagcttccgcaagtctacccccgagcgg
aggactgtccaggtgatcatggagacgcggcaggtggcctggagcaagacggctgacaag
attgaaggcttcttggatatcatggaaatcaaggaaatccgccccgggaagaactccaag
gattttgagcgcgcgaaggcagcccgccagaaggaggactgctgtttcaccatcttgtat
ggcacccagttcgtcctgagcactctcagtttggcagctgattctaaagaagacgcgact
aagtggctctctggcttgaaaatcttacaccaggaagcgatgagtgcgtctacgcccacc
attattgagagttggctgagaaagcagatttattcagtggatcaaaccagaagaaacagc
atcagcctccgggagctgaagaccatcttgcccctggtcaacttcaaagtgaacagtgcc
aagttcctcaaagataagtttgtggaaatcggcgctcacaaagatgaactcagctttgag
cagttccaccttttctataaaaatcttatgtttgagcagcaaaagtcgattcttgacgaa
ttcaaaaaagattcttccgtgttcatcttgggcaacaccgaccggccggatgcctccgct
gtttacctgcacgacttccagcggtttctcctacacgaacagcaggaggtttgggctcag
gatctgaacaaagtccgcgagcggatgacaaagtttatcgatgacaccctgagggagacc
gccgagcccttcttgtttgttgatgagttcctcacgtacctgttttcgcgggagaacagc
atctgggacgagaagtacgacgtcgtggacatacaggacatgaacaaccccttgtcccat
tactggatctcctcctcacataacacgtacctcaccggtgaccagctgcggagtgagtcg
tccacggaggcatacatccgctgcctgcgcatgggctgtcgctgcatcgagctggactgc
tgggacgggcccgatgggaagcccatcatctaccacggctggacgcggaccaccaagatc
aagtttgatgacgtcgtgcaggccatcaaagaccatgcctttgtcacctcaagcttcccg
gtgatcctgtccatcgaagagcactgctgtgtggagcagcagcgccacatggccagggtg
ttcaaggaggtgtttggcgacctgctgttgacaaagcccacggaggccagtgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgatgtggatgtcaacgtggaagataagaaagatgagcacaagcaacagggtgaa
ctgtacatgtgggattccattgaccagaaatggacccggcactactgtgccatcgctgat
gccaagctgtcgttcagcgatgacattgagcagactgcagaggaggagctgccccaggat
ataccccccacggagctgcattttggggaggagtggttccacaagaaggtggagaagaga
acaaatgccgagaagctgctgcaggaatactgtgccgagacggggggcaaagatgggacc
ttcttggtgcgggagagcaagaccttccccaacgactacaccctgtccttctggcggtcc
ggccgggtccagcactgccggatccgctccgtcatggagggcgggaccatgaagtacttc
ctgactgacaacatcatgttcaccagcatctatgacctcatccagcactaccgtgagacg
cacctgcgctgtgccgagttcgagctccggctcaccgaccccgtgcccaaccccaacccc
cacgagtcaaagccgtggtactatgatggcctgagccgtggggaagcagaggacatgctg
atgagagttccccgggacggggccttcctgatccggaggcgggaaggtaccgactcctac
gccatcaccttcagggccaggggcaaagtaaagcattgccgcatccatcgggacggccag
cactttgtgctggggacctctgcctacttcgagagcctcgtcgagctggtcagttactac
gagaagcacgcgctgtaccggaagatgcggctgcgctatcctgtgacgcctgagctgctg
gagcgctacaatatggaacgagatatcaactccctctatgacgtcagcaggatgtatgtg
gatcccagtgaaatcaacccgtccatgcctcagaggaccgtcaaagctctgtatgactac
aaagccaagcgaaacgatgagctgagcttctgccgtggggccctcattcacaacgtctcc
aaggagccctggggctggtggaaaggagactatgggaccaggattcagcaatacttccca
tccaactacgtcgaggacatttcatcggtcgatgtggaagaactggaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatactggatctcaacacctacaacgtc
gtgaaagccccacaggggaaaaaccagaaggcgttcgtgttcatcctggagcccaagaag
caaggcgaccctccagtggagtttgccacagacagggtcgaggagctctttgagtggttt
cagagcatccgggagatcacgtggaagatggacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtagtctactgcaagccgacc
agcaagaccaaggacaatttagaaaaccccgacttccgagaaatccgctccttcgtggag
acgaaggctgacagtgtcgtcagacagaaacccgtcgacctcctcaaatacaatcacaag
ggcctgacccgtgtttacccgaagggacagagggtggactcctccaactacgaccccttt
cgcctctggctgtgtggctcccagatggtggcactcaatttccagactccagacaagtac
atgcagatgaatcaagccttgttctcactcaacgggcggacaggctacgtcctgcagccc
gagagcatgaggacggagaagtacgaccccatgccgcccgaatcccagcggaagattctg
atgactctgacagtcaaggttctcggggctcgccatctccccaaacttggccgaagcatc
gcatgtccctttgtggaggtggaaatctgcggggctgaatatgacaacaacaagtttaag
accacagttgtgaatgacaatggcctaagccccgtttgggctccaacacaggagaaggtg
acctttgaaatttatgacccaaacctcgcatttctgcgctttgtggtctacgaggaagat
atgttcagtgatcccaactttctcgctcatgccacttaccccatcaaaggaatcaaatca
ggattcagatctgttcctctgaagaacgggtacagtgaagatatcgagctggcttccctc
ctggtgttctgtgagatgcagccagtcctggagagtgaagaggaactctactcctcctgc
cgccagctgcgaaggcggcaggaagagctgaacaaccagctgttcctgtacgacacacac
cagaacctgcgcaatgccaaccgggatgccctcgtgaaagagttcaacgtcaacgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttaagagagaagagagttagcaac
agtaggttttactcatag

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