KEGG   Leopardus geoffroyi (Geoffroy's cat): 123584351
Entry
123584351         CDS       T10761                                 
Symbol
AKT1
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
lgf  Leopardus geoffroyi (Geoffroy's cat)
Pathway
lgf01521  EGFR tyrosine kinase inhibitor resistance
lgf01522  Endocrine resistance
lgf01524  Platinum drug resistance
lgf04010  MAPK signaling pathway
lgf04012  ErbB signaling pathway
lgf04014  Ras signaling pathway
lgf04015  Rap1 signaling pathway
lgf04022  cGMP-PKG signaling pathway
lgf04024  cAMP signaling pathway
lgf04062  Chemokine signaling pathway
lgf04066  HIF-1 signaling pathway
lgf04068  FoxO signaling pathway
lgf04071  Sphingolipid signaling pathway
lgf04072  Phospholipase D signaling pathway
lgf04140  Autophagy - animal
lgf04150  mTOR signaling pathway
lgf04151  PI3K-Akt signaling pathway
lgf04152  AMPK signaling pathway
lgf04210  Apoptosis
lgf04211  Longevity regulating pathway
lgf04213  Longevity regulating pathway - multiple species
lgf04218  Cellular senescence
lgf04261  Adrenergic signaling in cardiomyocytes
lgf04370  VEGF signaling pathway
lgf04371  Apelin signaling pathway
lgf04380  Osteoclast differentiation
lgf04510  Focal adhesion
lgf04517  IgSF CAM signaling
lgf04518  Integrin signaling
lgf04550  Signaling pathways regulating pluripotency of stem cells
lgf04611  Platelet activation
lgf04613  Neutrophil extracellular trap formation
lgf04620  Toll-like receptor signaling pathway
lgf04625  C-type lectin receptor signaling pathway
lgf04630  JAK-STAT signaling pathway
lgf04660  T cell receptor signaling pathway
lgf04662  B cell receptor signaling pathway
lgf04664  Fc epsilon RI signaling pathway
lgf04666  Fc gamma R-mediated phagocytosis
lgf04668  TNF signaling pathway
lgf04722  Neurotrophin signaling pathway
lgf04725  Cholinergic synapse
lgf04728  Dopaminergic synapse
lgf04810  Regulation of actin cytoskeleton
lgf04910  Insulin signaling pathway
lgf04914  Progesterone-mediated oocyte maturation
lgf04915  Estrogen signaling pathway
lgf04917  Prolactin signaling pathway
lgf04919  Thyroid hormone signaling pathway
lgf04920  Adipocytokine signaling pathway
lgf04922  Glucagon signaling pathway
lgf04923  Regulation of lipolysis in adipocytes
lgf04926  Relaxin signaling pathway
lgf04929  GnRH secretion
lgf04931  Insulin resistance
lgf04932  Non-alcoholic fatty liver disease
lgf04933  AGE-RAGE signaling pathway in diabetic complications
lgf04935  Growth hormone synthesis, secretion and action
lgf04936  Alcoholic liver disease
lgf04973  Carbohydrate digestion and absorption
lgf05010  Alzheimer disease
lgf05017  Spinocerebellar ataxia
lgf05132  Salmonella infection
lgf05135  Yersinia infection
lgf05142  Chagas disease
lgf05145  Toxoplasmosis
lgf05152  Tuberculosis
lgf05160  Hepatitis C
lgf05161  Hepatitis B
lgf05162  Measles
lgf05163  Human cytomegalovirus infection
lgf05164  Influenza A
lgf05165  Human papillomavirus infection
lgf05166  Human T-cell leukemia virus 1 infection
lgf05167  Kaposi sarcoma-associated herpesvirus infection
lgf05168  Herpes simplex virus 1 infection
lgf05169  Epstein-Barr virus infection
lgf05170  Human immunodeficiency virus 1 infection
lgf05200  Pathways in cancer
lgf05205  Proteoglycans in cancer
lgf05207  Chemical carcinogenesis - receptor activation
lgf05208  Chemical carcinogenesis - reactive oxygen species
lgf05210  Colorectal cancer
lgf05211  Renal cell carcinoma
lgf05212  Pancreatic cancer
lgf05213  Endometrial cancer
lgf05214  Glioma
lgf05215  Prostate cancer
lgf05218  Melanoma
lgf05220  Chronic myeloid leukemia
lgf05221  Acute myeloid leukemia
lgf05222  Small cell lung cancer
lgf05223  Non-small cell lung cancer
lgf05224  Breast cancer
lgf05225  Hepatocellular carcinoma
lgf05226  Gastric cancer
lgf05230  Central carbon metabolism in cancer
lgf05231  Choline metabolism in cancer
lgf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lgf05415  Diabetic cardiomyopathy
lgf05417  Lipid and atherosclerosis
lgf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lgf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123584351 (AKT1)
   04012 ErbB signaling pathway
    123584351 (AKT1)
   04014 Ras signaling pathway
    123584351 (AKT1)
   04015 Rap1 signaling pathway
    123584351 (AKT1)
   04370 VEGF signaling pathway
    123584351 (AKT1)
   04371 Apelin signaling pathway
    123584351 (AKT1)
   04630 JAK-STAT signaling pathway
    123584351 (AKT1)
   04668 TNF signaling pathway
    123584351 (AKT1)
   04066 HIF-1 signaling pathway
    123584351 (AKT1)
   04068 FoxO signaling pathway
    123584351 (AKT1)
   04072 Phospholipase D signaling pathway
    123584351 (AKT1)
   04071 Sphingolipid signaling pathway
    123584351 (AKT1)
   04024 cAMP signaling pathway
    123584351 (AKT1)
   04022 cGMP-PKG signaling pathway
    123584351 (AKT1)
   04151 PI3K-Akt signaling pathway
    123584351 (AKT1)
   04152 AMPK signaling pathway
    123584351 (AKT1)
   04150 mTOR signaling pathway
    123584351 (AKT1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    123584351 (AKT1)
   04518 Integrin signaling
    123584351 (AKT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    123584351 (AKT1)
  09143 Cell growth and death
   04210 Apoptosis
    123584351 (AKT1)
   04218 Cellular senescence
    123584351 (AKT1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123584351 (AKT1)
   04550 Signaling pathways regulating pluripotency of stem cells
    123584351 (AKT1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123584351 (AKT1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123584351 (AKT1)
   04613 Neutrophil extracellular trap formation
    123584351 (AKT1)
   04620 Toll-like receptor signaling pathway
    123584351 (AKT1)
   04625 C-type lectin receptor signaling pathway
    123584351 (AKT1)
   04660 T cell receptor signaling pathway
    123584351 (AKT1)
   04662 B cell receptor signaling pathway
    123584351 (AKT1)
   04664 Fc epsilon RI signaling pathway
    123584351 (AKT1)
   04666 Fc gamma R-mediated phagocytosis
    123584351 (AKT1)
   04062 Chemokine signaling pathway
    123584351 (AKT1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123584351 (AKT1)
   04922 Glucagon signaling pathway
    123584351 (AKT1)
   04923 Regulation of lipolysis in adipocytes
    123584351 (AKT1)
   04920 Adipocytokine signaling pathway
    123584351 (AKT1)
   04929 GnRH secretion
    123584351 (AKT1)
   04915 Estrogen signaling pathway
    123584351 (AKT1)
   04914 Progesterone-mediated oocyte maturation
    123584351 (AKT1)
   04917 Prolactin signaling pathway
    123584351 (AKT1)
   04926 Relaxin signaling pathway
    123584351 (AKT1)
   04935 Growth hormone synthesis, secretion and action
    123584351 (AKT1)
   04919 Thyroid hormone signaling pathway
    123584351 (AKT1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    123584351 (AKT1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    123584351 (AKT1)
  09156 Nervous system
   04725 Cholinergic synapse
    123584351 (AKT1)
   04728 Dopaminergic synapse
    123584351 (AKT1)
   04722 Neurotrophin signaling pathway
    123584351 (AKT1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    123584351 (AKT1)
  09149 Aging
   04211 Longevity regulating pathway
    123584351 (AKT1)
   04213 Longevity regulating pathway - multiple species
    123584351 (AKT1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123584351 (AKT1)
   05205 Proteoglycans in cancer
    123584351 (AKT1)
   05207 Chemical carcinogenesis - receptor activation
    123584351 (AKT1)
   05208 Chemical carcinogenesis - reactive oxygen species
    123584351 (AKT1)
   05230 Central carbon metabolism in cancer
    123584351 (AKT1)
   05231 Choline metabolism in cancer
    123584351 (AKT1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123584351 (AKT1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123584351 (AKT1)
   05212 Pancreatic cancer
    123584351 (AKT1)
   05225 Hepatocellular carcinoma
    123584351 (AKT1)
   05226 Gastric cancer
    123584351 (AKT1)
   05214 Glioma
    123584351 (AKT1)
   05221 Acute myeloid leukemia
    123584351 (AKT1)
   05220 Chronic myeloid leukemia
    123584351 (AKT1)
   05218 Melanoma
    123584351 (AKT1)
   05211 Renal cell carcinoma
    123584351 (AKT1)
   05215 Prostate cancer
    123584351 (AKT1)
   05213 Endometrial cancer
    123584351 (AKT1)
   05224 Breast cancer
    123584351 (AKT1)
   05222 Small cell lung cancer
    123584351 (AKT1)
   05223 Non-small cell lung cancer
    123584351 (AKT1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123584351 (AKT1)
   05170 Human immunodeficiency virus 1 infection
    123584351 (AKT1)
   05161 Hepatitis B
    123584351 (AKT1)
   05160 Hepatitis C
    123584351 (AKT1)
   05164 Influenza A
    123584351 (AKT1)
   05162 Measles
    123584351 (AKT1)
   05168 Herpes simplex virus 1 infection
    123584351 (AKT1)
   05163 Human cytomegalovirus infection
    123584351 (AKT1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123584351 (AKT1)
   05169 Epstein-Barr virus infection
    123584351 (AKT1)
   05165 Human papillomavirus infection
    123584351 (AKT1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123584351 (AKT1)
   05135 Yersinia infection
    123584351 (AKT1)
   05152 Tuberculosis
    123584351 (AKT1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    123584351 (AKT1)
   05142 Chagas disease
    123584351 (AKT1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123584351 (AKT1)
   05017 Spinocerebellar ataxia
    123584351 (AKT1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123584351 (AKT1)
   05418 Fluid shear stress and atherosclerosis
    123584351 (AKT1)
   05415 Diabetic cardiomyopathy
    123584351 (AKT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    123584351 (AKT1)
   04932 Non-alcoholic fatty liver disease
    123584351 (AKT1)
   04931 Insulin resistance
    123584351 (AKT1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    123584351 (AKT1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123584351 (AKT1)
   01524 Platinum drug resistance
    123584351 (AKT1)
   01522 Endocrine resistance
    123584351 (AKT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lgf01001]
    123584351 (AKT1)
Enzymes [BR:lgf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     123584351 (AKT1)
Protein kinases [BR:lgf01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   123584351 (AKT1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 Seadorna_VP7
Other DBs
NCBI-GeneID: 123584351
NCBI-ProteinID: XP_045308123
LinkDB
Position
B3:complement(146436369..146458114)
AA seq 480 aa
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEEMMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFPEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMLCGRLPFYNQDHEKLFEL
ILMEELRFPRTLSPEAKSLLSGLLKKDPKQRLGGGAEDAKEIMQHRFFASIVWQDVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQGDSVEGEDSERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgaacgacgtggccatcgtgaaggagggttggctgcacaagagaggggaatacatcaag
acctggcggccccggtacttcctcctcaagaacgacggcaccttcatcggctacaaggag
cggccacaggacgtggagcagagagagtccccgctcaacaacttctctgtggcgcagtgt
cagctgatgaagacggagcggcccaggcccaacaccttcatcatccgctgcctgcagtgg
accacggtcatcgagcgcaccttccacgtggagacccccgaggagcgggaggagtggacc
accgccatccagacggtggccgacgggctcaagaggcaggaggaggaaatgatggacttc
cggtcgggctcgcccagcgacaactcgggggccgaggagatggaggtgtccctggccaag
cccaagcaccgcgtgaccatgaacgagttcgagtacctgaagctgctggggaaaggcacg
ttcgggaaggtgatcctggtgaaggagaaggccacgggccgctactacgccatgaagatc
ctcaagaaggaggtcatcgtggccaaggatgaggtggcccacacgctcacagagaaccgc
gttctccagaactctcggcaccctttcctgacggccctgaagtactccttccagacccac
gaccgtctctgcttcgtcatggagtatgccaacgggggcgagctcttcttccacttgtcc
cgggagcgggtcttccccgaggaccgtgcacgcttctacggcgccgagatcgtgtccgcc
ctggactacctgcactccgagaagaacgtggtctaccgtgacctcaagctggagaacctc
atgctggacaaggacgggcacatcaagatcaccgacttcggcctgtgcaaggagggcatc
aaggacggtgccaccatgaagaccttctgtgggacgcccgagtacctggcccccgaggtg
ctggaggacaacgactacggccgcgcggtcgactggtgggggctgggcgtggtcatgtac
gagatgctgtgcggccgcctgcccttctataatcaggaccacgagaagctcttcgagctc
atcctcatggaggagctccgcttcccgcgcacgctcagccccgaggccaagtccctgctg
tcggggctgctcaagaaggaccctaagcagaggctgggagggggcgccgaggacgccaag
gagatcatgcagcaccgctttttcgccagcatcgtgtggcaggacgtgtacgagaagaag
ctcagcccgcccttcaagccccaggtcacctcagagacggacaccaggtattttgatgag
gagttcacggcccagatgatcaccatcacgccccccgaccaaggcgacagcgtggagggc
gaggacagcgagcggaggccccacttcccacagttctcctactccgccagcggcacggcc
tga

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