Leopardus geoffroyi (Geoffroy's cat): 123587689
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Entry
123587689 CDS
T10761
Symbol
MAPK1
Name
(RefSeq) mitogen-activated protein kinase 1
KO
K04371
mitogen-activated protein kinase 1/3 [EC:
2.7.11.24
]
Organism
lgf Leopardus geoffroyi (Geoffroy's cat)
Pathway
lgf01521
EGFR tyrosine kinase inhibitor resistance
lgf01522
Endocrine resistance
lgf01524
Platinum drug resistance
lgf04010
MAPK signaling pathway
lgf04012
ErbB signaling pathway
lgf04014
Ras signaling pathway
lgf04015
Rap1 signaling pathway
lgf04022
cGMP-PKG signaling pathway
lgf04024
cAMP signaling pathway
lgf04062
Chemokine signaling pathway
lgf04066
HIF-1 signaling pathway
lgf04068
FoxO signaling pathway
lgf04071
Sphingolipid signaling pathway
lgf04072
Phospholipase D signaling pathway
lgf04114
Oocyte meiosis
lgf04140
Autophagy - animal
lgf04148
Efferocytosis
lgf04150
mTOR signaling pathway
lgf04151
PI3K-Akt signaling pathway
lgf04210
Apoptosis
lgf04218
Cellular senescence
lgf04261
Adrenergic signaling in cardiomyocytes
lgf04270
Vascular smooth muscle contraction
lgf04350
TGF-beta signaling pathway
lgf04360
Axon guidance
lgf04370
VEGF signaling pathway
lgf04371
Apelin signaling pathway
lgf04380
Osteoclast differentiation
lgf04510
Focal adhesion
lgf04517
IgSF CAM signaling
lgf04520
Adherens junction
lgf04540
Gap junction
lgf04550
Signaling pathways regulating pluripotency of stem cells
lgf04611
Platelet activation
lgf04613
Neutrophil extracellular trap formation
lgf04620
Toll-like receptor signaling pathway
lgf04621
NOD-like receptor signaling pathway
lgf04625
C-type lectin receptor signaling pathway
lgf04650
Natural killer cell mediated cytotoxicity
lgf04657
IL-17 signaling pathway
lgf04658
Th1 and Th2 cell differentiation
lgf04659
Th17 cell differentiation
lgf04660
T cell receptor signaling pathway
lgf04662
B cell receptor signaling pathway
lgf04664
Fc epsilon RI signaling pathway
lgf04666
Fc gamma R-mediated phagocytosis
lgf04668
TNF signaling pathway
lgf04713
Circadian entrainment
lgf04720
Long-term potentiation
lgf04722
Neurotrophin signaling pathway
lgf04723
Retrograde endocannabinoid signaling
lgf04724
Glutamatergic synapse
lgf04725
Cholinergic synapse
lgf04726
Serotonergic synapse
lgf04730
Long-term depression
lgf04810
Regulation of actin cytoskeleton
lgf04910
Insulin signaling pathway
lgf04912
GnRH signaling pathway
lgf04914
Progesterone-mediated oocyte maturation
lgf04915
Estrogen signaling pathway
lgf04916
Melanogenesis
lgf04917
Prolactin signaling pathway
lgf04919
Thyroid hormone signaling pathway
lgf04921
Oxytocin signaling pathway
lgf04926
Relaxin signaling pathway
lgf04928
Parathyroid hormone synthesis, secretion and action
lgf04929
GnRH secretion
lgf04930
Type II diabetes mellitus
lgf04933
AGE-RAGE signaling pathway in diabetic complications
lgf04934
Cushing syndrome
lgf04935
Growth hormone synthesis, secretion and action
lgf04960
Aldosterone-regulated sodium reabsorption
lgf05010
Alzheimer disease
lgf05020
Prion disease
lgf05022
Pathways of neurodegeneration - multiple diseases
lgf05034
Alcoholism
lgf05132
Salmonella infection
lgf05133
Pertussis
lgf05135
Yersinia infection
lgf05140
Leishmaniasis
lgf05142
Chagas disease
lgf05145
Toxoplasmosis
lgf05152
Tuberculosis
lgf05160
Hepatitis C
lgf05161
Hepatitis B
lgf05163
Human cytomegalovirus infection
lgf05164
Influenza A
lgf05165
Human papillomavirus infection
lgf05166
Human T-cell leukemia virus 1 infection
lgf05167
Kaposi sarcoma-associated herpesvirus infection
lgf05170
Human immunodeficiency virus 1 infection
lgf05171
Coronavirus disease - COVID-19
lgf05200
Pathways in cancer
lgf05203
Viral carcinogenesis
lgf05205
Proteoglycans in cancer
lgf05206
MicroRNAs in cancer
lgf05207
Chemical carcinogenesis - receptor activation
lgf05208
Chemical carcinogenesis - reactive oxygen species
lgf05210
Colorectal cancer
lgf05211
Renal cell carcinoma
lgf05212
Pancreatic cancer
lgf05213
Endometrial cancer
lgf05214
Glioma
lgf05215
Prostate cancer
lgf05216
Thyroid cancer
lgf05218
Melanoma
lgf05219
Bladder cancer
lgf05220
Chronic myeloid leukemia
lgf05221
Acute myeloid leukemia
lgf05223
Non-small cell lung cancer
lgf05224
Breast cancer
lgf05225
Hepatocellular carcinoma
lgf05226
Gastric cancer
lgf05230
Central carbon metabolism in cancer
lgf05231
Choline metabolism in cancer
lgf05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
lgf05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
lgf00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
123587689 (MAPK1)
04012 ErbB signaling pathway
123587689 (MAPK1)
04014 Ras signaling pathway
123587689 (MAPK1)
04015 Rap1 signaling pathway
123587689 (MAPK1)
04350 TGF-beta signaling pathway
123587689 (MAPK1)
04370 VEGF signaling pathway
123587689 (MAPK1)
04371 Apelin signaling pathway
123587689 (MAPK1)
04668 TNF signaling pathway
123587689 (MAPK1)
04066 HIF-1 signaling pathway
123587689 (MAPK1)
04068 FoxO signaling pathway
123587689 (MAPK1)
04072 Phospholipase D signaling pathway
123587689 (MAPK1)
04071 Sphingolipid signaling pathway
123587689 (MAPK1)
04024 cAMP signaling pathway
123587689 (MAPK1)
04022 cGMP-PKG signaling pathway
123587689 (MAPK1)
04151 PI3K-Akt signaling pathway
123587689 (MAPK1)
04150 mTOR signaling pathway
123587689 (MAPK1)
09133 Signaling molecules and interaction
04517 IgSF CAM signaling
123587689 (MAPK1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
123587689 (MAPK1)
04148 Efferocytosis
123587689 (MAPK1)
09143 Cell growth and death
04114 Oocyte meiosis
123587689 (MAPK1)
04210 Apoptosis
123587689 (MAPK1)
04218 Cellular senescence
123587689 (MAPK1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
123587689 (MAPK1)
04520 Adherens junction
123587689 (MAPK1)
04540 Gap junction
123587689 (MAPK1)
04550 Signaling pathways regulating pluripotency of stem cells
123587689 (MAPK1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
123587689 (MAPK1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
123587689 (MAPK1)
04613 Neutrophil extracellular trap formation
123587689 (MAPK1)
04620 Toll-like receptor signaling pathway
123587689 (MAPK1)
04621 NOD-like receptor signaling pathway
123587689 (MAPK1)
04625 C-type lectin receptor signaling pathway
123587689 (MAPK1)
04650 Natural killer cell mediated cytotoxicity
123587689 (MAPK1)
04660 T cell receptor signaling pathway
123587689 (MAPK1)
04658 Th1 and Th2 cell differentiation
123587689 (MAPK1)
04659 Th17 cell differentiation
123587689 (MAPK1)
04657 IL-17 signaling pathway
123587689 (MAPK1)
04662 B cell receptor signaling pathway
123587689 (MAPK1)
04664 Fc epsilon RI signaling pathway
123587689 (MAPK1)
04666 Fc gamma R-mediated phagocytosis
123587689 (MAPK1)
04062 Chemokine signaling pathway
123587689 (MAPK1)
09152 Endocrine system
04910 Insulin signaling pathway
123587689 (MAPK1)
04929 GnRH secretion
123587689 (MAPK1)
04912 GnRH signaling pathway
123587689 (MAPK1)
04915 Estrogen signaling pathway
123587689 (MAPK1)
04914 Progesterone-mediated oocyte maturation
123587689 (MAPK1)
04917 Prolactin signaling pathway
123587689 (MAPK1)
04921 Oxytocin signaling pathway
123587689 (MAPK1)
04926 Relaxin signaling pathway
123587689 (MAPK1)
04935 Growth hormone synthesis, secretion and action
123587689 (MAPK1)
04919 Thyroid hormone signaling pathway
123587689 (MAPK1)
04928 Parathyroid hormone synthesis, secretion and action
123587689 (MAPK1)
04916 Melanogenesis
123587689 (MAPK1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
123587689 (MAPK1)
04270 Vascular smooth muscle contraction
123587689 (MAPK1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
123587689 (MAPK1)
09156 Nervous system
04724 Glutamatergic synapse
123587689 (MAPK1)
04725 Cholinergic synapse
123587689 (MAPK1)
04726 Serotonergic synapse
123587689 (MAPK1)
04720 Long-term potentiation
123587689 (MAPK1)
04730 Long-term depression
123587689 (MAPK1)
04723 Retrograde endocannabinoid signaling
123587689 (MAPK1)
04722 Neurotrophin signaling pathway
123587689 (MAPK1)
09158 Development and regeneration
04360 Axon guidance
123587689 (MAPK1)
04380 Osteoclast differentiation
123587689 (MAPK1)
09159 Environmental adaptation
04713 Circadian entrainment
123587689 (MAPK1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
123587689 (MAPK1)
05206 MicroRNAs in cancer
123587689 (MAPK1)
05205 Proteoglycans in cancer
123587689 (MAPK1)
05207 Chemical carcinogenesis - receptor activation
123587689 (MAPK1)
05208 Chemical carcinogenesis - reactive oxygen species
123587689 (MAPK1)
05203 Viral carcinogenesis
123587689 (MAPK1)
05230 Central carbon metabolism in cancer
123587689 (MAPK1)
05231 Choline metabolism in cancer
123587689 (MAPK1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
123587689 (MAPK1)
09162 Cancer: specific types
05210 Colorectal cancer
123587689 (MAPK1)
05212 Pancreatic cancer
123587689 (MAPK1)
05225 Hepatocellular carcinoma
123587689 (MAPK1)
05226 Gastric cancer
123587689 (MAPK1)
05214 Glioma
123587689 (MAPK1)
05216 Thyroid cancer
123587689 (MAPK1)
05221 Acute myeloid leukemia
123587689 (MAPK1)
05220 Chronic myeloid leukemia
123587689 (MAPK1)
05218 Melanoma
123587689 (MAPK1)
05211 Renal cell carcinoma
123587689 (MAPK1)
05219 Bladder cancer
123587689 (MAPK1)
05215 Prostate cancer
123587689 (MAPK1)
05213 Endometrial cancer
123587689 (MAPK1)
05224 Breast cancer
123587689 (MAPK1)
05223 Non-small cell lung cancer
123587689 (MAPK1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
123587689 (MAPK1)
05170 Human immunodeficiency virus 1 infection
123587689 (MAPK1)
05161 Hepatitis B
123587689 (MAPK1)
05160 Hepatitis C
123587689 (MAPK1)
05171 Coronavirus disease - COVID-19
123587689 (MAPK1)
05164 Influenza A
123587689 (MAPK1)
05163 Human cytomegalovirus infection
123587689 (MAPK1)
05167 Kaposi sarcoma-associated herpesvirus infection
123587689 (MAPK1)
05165 Human papillomavirus infection
123587689 (MAPK1)
09171 Infectious disease: bacterial
05132 Salmonella infection
123587689 (MAPK1)
05135 Yersinia infection
123587689 (MAPK1)
05133 Pertussis
123587689 (MAPK1)
05152 Tuberculosis
123587689 (MAPK1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
123587689 (MAPK1)
05140 Leishmaniasis
123587689 (MAPK1)
05142 Chagas disease
123587689 (MAPK1)
09164 Neurodegenerative disease
05010 Alzheimer disease
123587689 (MAPK1)
05020 Prion disease
123587689 (MAPK1)
05022 Pathways of neurodegeneration - multiple diseases
123587689 (MAPK1)
09165 Substance dependence
05034 Alcoholism
123587689 (MAPK1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
123587689 (MAPK1)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
123587689 (MAPK1)
04933 AGE-RAGE signaling pathway in diabetic complications
123587689 (MAPK1)
04934 Cushing syndrome
123587689 (MAPK1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
123587689 (MAPK1)
01524 Platinum drug resistance
123587689 (MAPK1)
01522 Endocrine resistance
123587689 (MAPK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
lgf01001
]
123587689 (MAPK1)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
lgf03036
]
123587689 (MAPK1)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
lgf04147
]
123587689 (MAPK1)
Enzymes [BR:
lgf01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.24 mitogen-activated protein kinase
123587689 (MAPK1)
Protein kinases [BR:
lgf01001
]
Serine/threonine kinases: CMGC group
MAPK family [OT]
123587689 (MAPK1)
Chromosome and associated proteins [BR:
lgf03036
]
Eukaryotic type
Centromeric chromatin formation proteins
SAC (spindle assembly checkpoint) factors
Protein kinases
123587689 (MAPK1)
Exosome [BR:
lgf04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
123587689 (MAPK1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
APH
STATB_N
Haspin_kinase
FTA2
Kdo
Motif
Other DBs
NCBI-GeneID:
123587689
NCBI-ProteinID:
XP_045313596
LinkDB
All DBs
Position
D3:complement(27932828..28042302)
Genome browser
AA seq
360 aa
AA seq
DB search
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPVAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq
1083 nt
NT seq
+upstream
nt +downstream
nt
atggcggcggcggcggcggcgggcgcgggcccggagatggtccgcgggcaggtgttcgac
gtggggccgcgctacaccaacctctcgtatatcggcgagggcgcctacggcatggtgtgc
tctgcttatgataatgtcaacaaagttcgagtagctatcaagaaaatcagtccttttgag
caccagacctactgccagagaaccctgagggagataaaaatcttactgcgcttcagacat
gagaacatcattggaatcaatgatattattagagcgccaaccatcgagcagatgaaagat
gtatatatagtacaggacctcatggaaacagatctctacaagctcttgaagacacaacac
ctcagcaacgaccatatctgctattttctttaccagatcctcagagggttaaaatatatc
cattcagctaatgtactgcaccgtgacctcaaaccttccaacctgctgctcaacaccacc
tgtgatctcaagatctgtgactttggcttggcccgcgttgcagatccagaccatgatcac
acagggttcctgacggagtacgtagccacacgttggtaccgggctccagaaattatgttg
aattccaagggctataccaagtccattgatatttggtctgtaggctgcattctggcagag
atgctgtccaacaggcccatcttcccggggaagcattatctcgaccagctgaaccacatt
ctgggtattcttggatccccatcacaggaagacctgaattgtataataaatttaaaagct
agaaactacttgctttctcttccacacaaaaataaggtgccatggaacaggctgttccca
aatgctgattccaaagctctggatttactggacaaaatgttgacgttcaaccctcacaag
aggattgaagtagaacaggctctggcccatccatatctggagcagtattacgacccaagt
gatgagcccgtcgctgaggcaccgttcaagttcgacatggagctagacgacctgcccaag
gaaaagctcaaagagctcatcttcgaagagacggccaggttccagccgggatacaggtct
taa
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integrated database retrieval system