Leopardus geoffroyi (Geoffroy's cat): 123589052 Help Entry 123589052         CDS       T10761                                  Symbol TSC2 Name (RefSeq) tuberin isoform X1   KO K07207   tuberous sclerosis 2 Organism lgf  Leopardus geoffroyi (Geoffroy's cat) Pathway lgf04072   Phospholipase D signaling pathway lgf04115   p53 signaling pathway lgf04140   Autophagy - animal lgf04150   mTOR signaling pathway lgf04151   PI3K-Akt signaling pathway lgf04152   AMPK signaling pathway lgf04211   Longevity regulating pathway lgf04218   Cellular senescence lgf04714   Thermogenesis lgf04910   Insulin signaling pathway lgf04919   Thyroid hormone signaling pathway lgf05163   Human cytomegalovirus infection lgf05165   Human papillomavirus infection lgf05168   Herpes simplex virus 1 infection lgf05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:lgf00001]  09130 Environmental Information Processing   09132 Signal transduction    04072 Phospholipase D signaling pathway     123589052 (TSC2)    04151 PI3K-Akt signaling pathway     123589052 (TSC2)    04152 AMPK signaling pathway     123589052 (TSC2)    04150 mTOR signaling pathway     123589052 (TSC2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     123589052 (TSC2)   09143 Cell growth and death    04115 p53 signaling pathway     123589052 (TSC2)    04218 Cellular senescence     123589052 (TSC2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     123589052 (TSC2)    04919 Thyroid hormone signaling pathway     123589052 (TSC2)   09149 Aging    04211 Longevity regulating pathway     123589052 (TSC2)   09159 Environmental adaptation    04714 Thermogenesis     123589052 (TSC2)  09160 Human Diseases   09161 Cancer: overview    05231 Choline metabolism in cancer     123589052 (TSC2)   09172 Infectious disease: viral    05168 Herpes simplex virus 1 infection     123589052 (TSC2)    05163 Human cytomegalovirus infection     123589052 (TSC2)    05165 Human papillomavirus infection     123589052 (TSC2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:lgf01009]     123589052 (TSC2) Protein phosphatases and associated proteins [BR:lgf01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      123589052 (TSC2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Tuberin DUF3384 Rap_GAP HEAT Cnd1 Motif Other DBs NCBI-GeneID:  123589052 NCBI-ProteinID:  XP_045316590 LinkDB All DBs Position E3:complement(40174060..40209087) Genome browser AA seq 1809 aa AA seqDB search MAKPTSKDSGLKEKFRILFGLGTPRPNPRSAEGKQTEFIITAEILRELSVECGLNNRIRV IGQICEVAKTKKFEEHAVEALWKAVEDMLQPERPPEARHAVLALLKAIVQGQGDRLGVLR ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAGFVLQWMDIGLSSEFLLVL VNLVKFNSCYLDEYIASMVHMICLLCVQTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFI VTLCRTVNVKELCEPCWKLMRNLLGTHLGHSAIYNMCRIMEDRAYMEDAPLLRGAVFFVG MALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSVTRLIKKYRRELQAVTWDI LLDIIERLLQQLQSLDSPELRAIVHDLLTTVEELCDQNEFHGSHERYFELVERCADQRPE SSLLNLITYRAQSIHPAKDGWIHNLQLLMERFFRNESRSAVRIKVLDVLSFVLLINRQFY EEELISSVVISQLSHIPEDKDPQVRKLATQLLVDLAEGCHTHHFNSLLDIVEKVMARSLS TPPELEERDVVAYSASLEDVKTAVLGLLVILQTKLYALPASHAVRVYETLVSHLQLHYKH GYTLPIASSIRLQAFDFLLLLRADSLHRLGLPSKDGAVRFSPYCVCDSTEPERGSEKKAG GPLSPPTGPSGPAPAGPAVRLGSLPYSLLFRVLLQCLKQETDWKVLKLVLGKLPESLRFK VLIFTSPCSVDQLSSALCSMLSGPRTLERLRGTPEGFSRTDLHLAVVPVLTALISYHNYL DKARQREMVYCLEQGLIYRCASQCVVALAVCSVEMPDIIIKALPVLVVKLTHISATASMA IPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC RLPFRKDFVPYITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS PPVREFQESSAADAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSMAQADDNLKNLHL ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL LGLDSGELQGSPELSSDPGAHVRQTKEAPAKLESQAGQQVCRGARDRVRSMSGGHGLRVG ALDAPATHCPGAQTTPASTSERASAAAQLPAQEKTSLAAYVPLLTQGWAEILVRRPTGNT SWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKERRDTALYKSLSVPAAGSAKPPPP PRSNTVASFSSLYQTSCQGELHRSISWADSAVVLEEGSPSETDLPGEPTELEDFEATLGP ERRCRRPEAYSRSSSSSSQEEKSFAAEEVAAGGLPIGRAVSAEGARPSAGLSFQPAQPLS KSSSSPELQTLQDTLGDPGDKADVGRLSPEAKARSQSGTLDGAGATWSTPGEESQGRGPA RPEGPLPSGCPRSPGGLRPRGYTISDSAPSRRGKRVERDAFKSRAGASNTEKVPGINPSF VFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSSSELAI LSNEHGSYRYTEFLTGLGKLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHI ATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIITPLDYECN LVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWI ARLRHIKRLRHRVGQIREEAHYPNPSLPLTQTHPPGHAKAPAPAEPMPTYETGQRKRLIS SVDDFTEFV NT seq 5430 nt NT seq  +upstreamnt  +downstreamnt atggccaagccgacaagcaaggattcaggcttgaaggagaagttcaggattctgtttgga ctgggaaccccgcggccaaaccccaggtctgcagagggcaagcagacggagtttatcatc acggcggaaatcctgagagagctgagcgttgaatgtggcctcaacaatcgcatccgggtg atcgggcagatctgtgaagttgcaaaaacgaagaagtttgaagagcatgcagtggaagcg ctctggaaggccgtcgaggacatgctgcagccagagcggccaccggaggcccggcatgcg gtgctggctctgctgaaggccatcgtgcaggggcagggggaccgcttgggcgtcctcagg gccctcttctttaaggtcatcaaggattacccctctaacgaagatctccacgaaagactg gaagttttcaaggccctcacagacaatgggagacacatcacatatttggaagaagaactg gctgggtttgtgctgcagtggatggacatcggcctgtcctcagagttccttctggtgctt gtgaacttggtcaaattcaacagctgttacctggatgaatacatcgcatcaatggtccac atgatctgcctgctgtgtgtccagactgtgtcctctgtggacatagaggtctctctgcag gtgctggacgccgtcgtctgctacaactgtctgccggctgagagcctgcccctgttcatc gtcactctctgtcgtaccgtcaacgtcaaggagctctgtgagccttgctggaagctgatg cgtaatctcctgggcacccacctgggtcacagtgccatctacaacatgtgccgcatcatg gaggacagagcctacatggaagacgccccgctgctgagaggggccgtgttcttcgtgggc atggctctctggggggcgcaccgactctactcgctcaagaactccccgacctccgtgctg ccgtcgttttacgaggccatgacctgtccgaacgaggtggtgtcctatgaaatcgtcctg tctgtcaccagactcatcaagaagtaccggagggagctccaggctgtgacgtgggatatc ctgctggacatcatcgaacgtctgctgcagcagctccagagcctggacagcccggagctc agagccatcgtccatgacctgctgaccacagtggaggagctgtgtgaccagaatgagttc cacggctcgcacgagagatacttcgagctcgtcgagagatgtgcagaccagaggccggag tcgtccctcctaaacttaataacctacagggctcagtccatccatccggcaaaggacggc tggattcacaacctgcagttactgatggagagattcttccggaacgaatcccgcagtgct gtgcgcatcaaggtgctcgacgtcctgtcctttgtgctgctcatcaacaggcagttctat gaggaggagctgatcagctcggtggtcatctctcagctctcccacatcccggaggacaaa gacccccaagtccggaaactggccacccagttgctggtggacctggccgaaggctgtcac acccaccacttcaacagcctgctggacattgtggagaaggtgatggcccgctccctttcc acaccccctgagctggaggaaagagatgtggtggcatattcagcctccttagaggatgtg aagactgccgtcttggggctcctggtgatccttcagaccaagctgtacgccttgcctgcc agccacgcggtgcgtgtgtacgagaccctcgtcagccacctgcagctccactacaagcac ggctataccctgcccatcgccagtagcatccggctgcaggcctttgacttcctgctgctg ctgagggcggactccctgcaccgcctcggcctgcccagcaaggacggggctgtgaggttc agcccctactgcgtctgcgactccacggagccagagagaggctctgagaagaaggccggc ggccccctgtcgcctcccaccgggccgtccggcccagcacctgccggtcccgctgtgcgg cttggctccctgccctactccctgctcttccgggtcctgctgcagtgcttaaagcaggag acggactggaaggtgctgaagcttgttctcggcaagctgcccgagtccctgcgcttcaag gtcctcatcttcacgtccccgtgcagcgtcgaccagctgtcttccgccctctgctccatg ctttcaggtcccagaactctggagcggctccgaggcaccccggaaggtttctccaggaca gacctgcacctggctgtggttcctgtgctgacggcgttaatctcttaccataactatttg gacaaagccagacagcgggagatggtgtactgcctggagcaaggcctgatctaccgctgt gccagccagtgtgtggtggccctggccgtgtgcagcgtcgaaatgcccgacatcatcatc aaggcgctgcctgtcttggtcgtgaagcttacacacatttcggccacagccagcatggcc attccactcctcgaattcctgtcaactctggccaggctgcctcacctctacaggaacttt gccgctgagcagtacgcgagtgtgtttgccatctccctgccgtacaccaacccctccaag tttaatcagtacatcgtgtgcctggcccatcacgtcatagccatgtggttcattagatgc cgtctgccttttcggaaggattttgttccttatatcactaagggcctacgctccaatgtc ctcctgtcttttgacgacaccccggagaaggacagcttcagagcgcggagcaccagtctc aacgagaggcccaagagtttgaggatagccagaccccccaaacaaggcttgaataactcc ccacccgtgagagaattccaggagagctctgcagccgacgccttccggtgccgcagcatc agtgtgtctgaacatgtggtccgcagcaggatccagacgtccctcacgagtgccagcttg gggtctgcggacgagaactcaatggcccaggctgacgacaacttgaaaaatctccacctg gagctcacggagacttgtctggacatgatggccagatacgtgttctccaacttcacggcg gtccccaagaggtcccctgtaggggagttcctcttggctggtggcaggaccaagacctgg ctggttggaaacaagctcgtcactgtgacgacgagcgtggggaccgggacccggtcactg ctgggcttggactcaggagagctgcagggcagcccagagctgagctctgaccccggtgcg cacgtgaggcagacaaaggaggcgcctgccaagttggagtcccaggctgggcagcaggtg tgccgtggggcccgggaccgcgtccgctccatgtctgggggccacggccttcgtgttggt gccttggatgctccagccacccactgcccaggcgcacagaccacaccagccagtacgtcc gagagggcctcggctgccgcccagctcccggcgcaggagaagacgagcctggcggcctac gtacccctgctgacccagggctgggcggagatcttggtccggaggcccacggggaacacc agctggctgatgagcctggagaaccccctcagccccttctcctcggacatcaacaacatg cccctgcaggagctgtccaacgccctcatggccgccgagcgcttcaaggagcgtcgtgac acggccctgtacaagtcactttcggtgccggcggccggctctgccaagccccctccgccc ccacgttctaacacagtggcctctttctcctccctgtaccagaccagttgccaaggagag ctgcacaggagcatttcctgggcagactccgcggtggttctggaggagggaagtcccagc gagactgatttgccaggcgagcccactgagctggaggactttgaggccaccctgggccca gagcggcgctgtcggcgccctgaagcctacagtagatcgtcttccagctccagccaagag gagaagtctttcgccgcagaggaggtggctgccggagggctccccatcgggcgggccgtg tctgccgagggagcccggccctctgcggggctctccttccagcccgcccagcccctcagc aagtctagctcctcgccggagctgcagaccctgcaggatacactcggggaccctggggac aaggccgacgttggccggctgagccccgaggccaaggcccgctcacagtccgggactctg gacggggcaggtgccacctggtcaaccccaggtgaagagagtcagggccggggccctgcg aggcccgagggtcccttgccttctggctgtccccgttcccccggtggcctgcgtcccaga ggctacaccatttcggattcagccccgtcacgcagaggcaagagggtagagcgggacgcc ttcaagagcagagctggggcctccaatactgagaaggtgccaggcatcaaccccagcttc gtgttcctgcagctctaccactctcctttctttggcgacgagtccaacaagccgatcctt ctgcctaatgagtccttcgagcggtcggtgcagctcctcgaccagatcccatcctacgac acacacaagatcgctgtcctgtacgtgggagaaggccagagcagcagcgagctcgccatc ctgtccaacgagcacggctcgtaccggtacacagagttcctgacgggcctgggcaagctc atcgagctcaaggactgccagcccgataaggtgtacctgggcggtctggacgtgtgcggg gaggacggccagttcacctactgctggcacgatgacatcatgcaggctgtcttccatatc gccaccctgatgcccaccaaggacgtggacaagcaccgctgtgacaagaagcgccatctg ggcaacgactttgtgtccattgtctataatgactctggcgaggacttcaaactgggcacc attaaaggccagttcaacttcgtccacgtgatcatcacccccctggactacgagtgcaac ctggtgtccctgcagtgcaggaaggatatggagggcctcgtggacaccagcgtggccaag atcgtgtctgatcgcaacctgcccttcgtggcccgtcagatggctctgcacgccaacatg gcctcccaggtgcaccatagccgctccaaccccacggatatctacccgtccaagtggatc gccaggctccgtcacatcaagcggctgcgccaccgggtagggcagatccgtgaggaagcc cactaccccaaccccagcctgccgctgacgcagacgcaccctccgggccacgccaaggcc ccagccccggctgagcccatgcccacgtacgagacgggccagcggaagcgcctcatctcc tctgtggatgacttcaccgagttcgtgtga

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