Leopardus geoffroyi (Geoffroy's cat): 123600715
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Entry
123600715 CDS
T10761
Symbol
BACE1
Name
(RefSeq) beta-secretase 1
KO
K04521
beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:
3.4.23.46
]
Organism
lgf Leopardus geoffroyi (Geoffroy's cat)
Pathway
lgf05010
Alzheimer disease
Brite
KEGG Orthology (KO) [BR:
lgf00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
123600715 (BACE1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
lgf01002
]
123600715 (BACE1)
Enzymes [BR:
lgf01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.23 Aspartic endopeptidases
3.4.23.46 memapsin 2
123600715 (BACE1)
Peptidases and inhibitors [BR:
lgf01002
]
Aspartic peptidases
Family A1: pepsin family
123600715 (BACE1)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Asp
TAXi_C
TAXi_N
Motif
Other DBs
NCBI-GeneID:
123600715
NCBI-ProteinID:
XP_045338912
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All DBs
Position
D1:complement(14963759..14985764)
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AA seq
501 aa
AA seq
DB search
MAQTLPWLLLWMSSGMLPAHCTQPGIRLPLRSGLGGAPLGLRLPRETDEEQEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGASPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTPDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRHQHDDFADDISLLK
NT seq
1506 nt
NT seq
+upstream
nt +downstream
nt
atggcccaaacactgccctggctcctgctgtggatgagctcgggaatgctgcctgcccac
tgcacccagcctggcatccggctgcccctgcgaagcgggctagggggggcccccctgggg
ctgcggctgccccgggagaccgacgaggaacaagaggagcctggccggaggggcagcttt
gtggagatggtggacaacctgaggggcaagtccggtcagggctactacgtggagatgacc
gtgggcagccccccacagacgctcaacatcctggtggacacgggcagcagtaactttgca
gtgggggcttccccccaccctttcctgcaccgctactaccagaggcagctgtccagcacg
taccgggacctccggaagggtgtgtatgtgccctacacccagggcaagtgggagggagag
ctgggcaccgacctggtgagcatcccccacggccccaacgtcactgtgcgtgccaacatc
gctgccatcactgaatcagacaagttcttcatcaatggctccaactgggagggcatcctg
gggctggcctatgctgaaattgccaggcccgatgactccctggagccgttctttgactcc
ctggtaaagcagacccacgttcccaacctcttctccctgcagctctgtggtgccggcttt
cccctcaaccagtcagaagtgctggcctcagttggagggagcatgatcattgggggtatc
gaccactcactgtacacgggcagcctctggtacacacccatccggcgggagtggtactac
gaggtgatcattgtgcgggtggagatcaacgggcaggatctgaagatggactgcaaggag
tacaactacgacaagagcatcgtggacagtggcaccaccaaccttcgtttgcccaagaag
gtgtttgaagccgccgttaaatccatcaaggcagcctcctcgacggagaagtttccggac
gggttttggctgggggagcagctggtgtgctggcaagcaggcaccaccccttggaacatt
ttcccagtcatctccctctacctaatgggtgaggtcaccaatcagtccttccgcatcacc
atccttccacagcaatacctgcggccagtggaagacgtggccacgtcccaagatgactgc
tacaagttcgccatctcacagtcctccacgggcacggttatgggagctgtgatcatggag
ggcttctacgtggtctttgatcgggcccggaaacgaattggctttgcggtcagtgcttgt
cacgtgcatgatgagttcaggacagcagcagtggaaggccctttcgtcaccccagacatg
gaagactgtggctacaacatcccacagacagatgaatcaaccctcatgaccatagcctac
gtcatggctgccatctgcgccctcttcatgctgccactgtgcctcatggtgtgccagtgg
cgctgcctccgctgcctgcgccatcaacatgatgactttgcggacgacatctccctgttg
aagtga
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