Leopardus geoffroyi (Geoffroy's cat): 123603937
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Entry
123603937 CDS
T10761
Symbol
ERN1
Name
(RefSeq) serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1
KO
K08852
serine/threonine-protein kinase/endoribonuclease IRE1 [EC:
2.7.11.1
3.1.26.-]
Organism
lgf Leopardus geoffroyi (Geoffroy's cat)
Pathway
lgf04140
Autophagy - animal
lgf04141
Protein processing in endoplasmic reticulum
lgf04210
Apoptosis
lgf04932
Non-alcoholic fatty liver disease
lgf05010
Alzheimer disease
lgf05012
Parkinson disease
lgf05014
Amyotrophic lateral sclerosis
lgf05016
Huntington disease
lgf05017
Spinocerebellar ataxia
lgf05022
Pathways of neurodegeneration - multiple diseases
lgf05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
lgf00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
123603937 (ERN1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
123603937 (ERN1)
09143 Cell growth and death
04210 Apoptosis
123603937 (ERN1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
123603937 (ERN1)
05012 Parkinson disease
123603937 (ERN1)
05014 Amyotrophic lateral sclerosis
123603937 (ERN1)
05016 Huntington disease
123603937 (ERN1)
05017 Spinocerebellar ataxia
123603937 (ERN1)
05022 Pathways of neurodegeneration - multiple diseases
123603937 (ERN1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
123603937 (ERN1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
123603937 (ERN1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
lgf01001
]
123603937 (ERN1)
Enzymes [BR:
lgf01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
123603937 (ERN1)
Protein kinases [BR:
lgf01001
]
Serine/threonine kinases: Other
IRE family
123603937 (ERN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
Ribonuc_2-5A
PK_Tyr_Ser-Thr
Beta-prop_ACSF4
PQQ_2
Pkinase_fungal
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
123603937
NCBI-ProteinID:
XP_045345420
LinkDB
All DBs
Position
E1:complement(46460986..46545901)
Genome browser
AA seq
973 aa
AA seq
DB search
MCLGCGLSNLSVFICEIFGSPSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVL
QVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQ
DIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDY
AASLPEDDGDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMH
INVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHE
GVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLI
GHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVEQTSENAPTAVSQEV
EEKFEHAPAKPEAPVDSVLKDIATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKE
LEKIQLLQQQQLPFHPPGDVAQDAELLDSSGLYSESSGTSSPSTSPRASNHSLHSSGSAS
RAGASPFLEQDDEDEETSMVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPE
CFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIAIELCAATLQEYVEQKDFAHLGLE
PITLLQQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHS
FSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQAN
ILLGAYSLDCLHPEKHEDVIARELIEKMIATDPQKRPSAKHVLKHPFFWSLEKQLQFFQD
VSDRIEKESLDGPIVKQLERGGRAVVKTDWRENITVPLQTDLRKFRTYKGGSVRDLLRAM
RNKKHHYRELPAEVRETLGSLPDDFVRYFTSRFPHLLPHTYRAMEPCSHERLFQPYYFHE
PPELRPPVTPDAL
NT seq
2922 nt
NT seq
+upstream
nt +downstream
nt
atgtgccttggatgcgggctctctaacctcagcgtcttcatctgtgagatttttggaagt
cccagcacagtgacacttcccgaaaccttgttgtttgtgtcaaccctggatggaagcttg
catgctgtcagtaagaggacgggctcaatcaaatggactttaaaagaagatccggttctg
caggttccaacgcatgtggaagagcctgccttcctcccagatcccaatgatggcagcctg
tatacacttgggggcaagaataatgaaggcctgacgaaacttccctttaccatcccagag
ctcgtacaggcatccccatgccgaagttcagatggaattctctacatgggtaaaaagcag
gacatttggtatgttattgatcttctgaccggggagaagcagcagactttgtcatcggcc
tttgcagacagcctctgcccatcaacctctctgctgtatctcgggcgaacagagtacaca
atcaccatgtacgacaccaaaacccgcgagctccggtggaatgccacctacttcgactac
gcggcctcactgccggaggacgacggggactacaagatgtcccactttgtgtccaacggc
gatgggctggtggtgaccgtggacagtgaatctggcgacgtcctgtggatccaaaactac
gcttcccctgtggtggccttttatgtctggcagcgggagggtctgaggaaggtgatgcac
atcaacgtcgcagtggagacgctgcgctatctgaccttcatgtctggggaggtgggccgc
atcaccaagtggaagtacccgttccccaaggagacggaggccaagagcaagctgacgccc
accctgtatgtcgggaaatactctaccagcctgtatgcctccccctccatggtgcacgag
ggggtcgccgttgtgccccggggcagcacacttcctttgctggaaggcccccagactgac
ggggtcaccattggggataaaggggagtgtgtgatcacgcccagcacagacctaaagttt
gaccctgggctcaaagggaagagcaagctcaactacttgaggaactactggcttctgata
ggacaccatgaaacccccctgtctgcgtctaccaagatgctggagagattccccaataat
ctgcccaaacatcgagaaaatgtgattcctgccgattcagagaagaagagctttgaggaa
gttatcaacctggtcgagcagacttcagaaaacgcgcccaccgccgtttcacaggaggtg
gaggagaagttcgagcatgcccccgctaagcccgaggcccccgtggactctgtgctgaag
gacatagccaccatcatcctgagcaccttcctgctcatcggctgggtggccttcatcatc
acctaccccttgagcatgcatcagcagcagcagctccagcaccagcagttccagaaggag
ctagagaaaatccagctcctgcaacagcagcagctgcccttccatccccctggagacgtg
gctcaggatgctgagctcctggactcgtccggcctgtactcagagagctcgggcaccagc
agccccagcacgtcccccagagcctccaaccactcgctccactccagtggctctgcctcc
agggctggtgccagccccttcctggagcaggacgatgaagatgaggaaaccagcatggtg
attgttgggaagatctcattctgtcccaaggacgtgctgggccacggagctgagggcacg
attgtgtaccggggcatgttcgacaaccgcgatgtggccgtcaagaggatcctccccgag
tgtttcagtttcgcggaccgtgaggtccagctgcttcgggaatcagacgagcaccccaac
gtgattcgttacttctgcacggagagggaccggcagttccagtacattgccatcgagctg
tgtgcggccaccctgcaggagtacgtggagcagaaggacttcgcccaccttggcctggag
cccatcaccttgctgcagcagaccacctcaggcctggcccatttgcactccctcaacatt
gttcacagagacctgaagccccacaacattctcctgtctatgcccaacgcacatggcagg
atcaaggccatgatctctgactttggcctctgcaagaagctggctgtgggcaggcacagt
ttcagccgccgctcaggagtgcctggcacagaaggctggatcgctccggagatgctgagc
gaggactgtaaggacaatcccacctacacagtggacatcttctctgcgggctgtgtcttt
tactatgtgatatctgagggcagccacccttttggcaagtccctgcagcggcaggccaac
atcctcctgggcgcctacagcctcgactgcttacacccggagaagcatgaagacgtcatt
gcccgggaattaatagagaagatgatcgcaacggatcctcagaaacgcccctctgcgaag
catgtgctgaagcacccgttcttctggagcctggaaaagcagctccagttcttccaggac
gtgagtgaccgaatagaaaaggaatccctggacggcccgatagtgaagcagctggagcgc
ggcgggagagccgtggtgaagacggactggagagagaacatcaccgtccccctgcagaca
gatctgcgtaaattcagaacctataaaggtggctctgtccgcgaccttctccgagccatg
agaaacaagaagcaccactaccgggagctccccgcggaggtgcgggagacgctgggctct
ctccccgacgactttgtgcgctacttcacgtcccgcttcccccacctcctcccccacacc
taccgggccatggagccctgcagccacgaaaggctcttccagccttactacttccacgag
cccccagagctccggccccccgtgactccagacgccctttga
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