Leopardus geoffroyi (Geoffroy's cat): 123605045
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Entry
123605045 CDS
T10761
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
lgf Leopardus geoffroyi (Geoffroy's cat)
Pathway
lgf00310
Lysine degradation
lgf01100
Metabolic pathways
lgf05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
lgf00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
123605045 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
123605045 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
lgf03036
]
123605045 (DOT1L)
Enzymes [BR:
lgf01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
123605045 (DOT1L)
Chromosome and associated proteins [BR:
lgf03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
123605045 (DOT1L)
HMT complexes
Dot1-containing complex
123605045 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
123605045
NCBI-ProteinID:
XP_045347281
LinkDB
All DBs
Position
A2:1385665..1449643
Genome browser
AA seq
1692 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSSTTTPTKVP
EGRAAVAADTPVDSGAEEEKAGTTSIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAA
NPERKPRKSQTALDLLHAPASSQTAAPSPQDAYRSPHSPFYQLPPCVQRHAPDRPLLAAT
PPALQKLLESFKIQYLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLQEDNRELRSQSLQLL
KARCEELKLDWSTLSLENLLKEKQALRSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDALSAHLRGKGALGREPEADPGRLHLDLDCSRFSLPHFSSASPELSMNGHAAGY
ELCGALSRPPSKQNTPQYLASPLDQEVVPCTPSHGSRPRLEKVSGLALPDYTRLSPAKLV
LRRHLSQDHAAGGKTAAGELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPVALQM
TGERGSEKGLKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRST
PSPVPQTRESLSTLEKQMGANAHSAGSKSLAPAPAGFYAGSVAVSPAPLASGADPGTFDE
VPSAGGLFASVGSCGSTPQHPPLLPQPRGSGAASPAHPLCASPRLGGAAQGPLPDANKGD
LPPEAGFSDPEGEAKRRIVFTVSAGGGSTKQSPPSKPSPLPTGSRGDGSQGHGQDSRKRG
RRKRAAAGTPGLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPE
SLKSSPVPYQDSDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSTRIERKIATIS
LESRSPPKTLENGGGLAGRKPTPAGEPANSSKWKATFSPISDLGLAKCADSPLQAGSALS
QNSLFAFRPPLEEPGSADAKLAAHPRKSFPGALSGAGGLSPSSNPPNGFAFSGGLAADLS
LHSFSDGASLPHKVPEAAGLGAPLSFPAPRGKDSAAEPGPFVNKRQLDGTGGPKGREAGE
PGPPACGPPDKASLAHGKPGKGRDREPDLKNGHNLFIAAANVPPGGLLSGPGLATAASSV
VSAAPSAQAHRPFLGTFAPGPQFALGPMSLQANLGSSVLQSLFGSVPAAGLVHVSSAATR
LTNSHAMGSFPSGVAGGAVGGVFNHAVPSASAHPFGASFGSGAACRSATLSLTPLQAVAG
APPPPPPGQPALPAPPPPNAALPPAPALLPANSEPALLQNLASLPANQAFLPASSAASLQ
PANASLSIKLASLPHKAPRPSFTVHHQPLPGLALAQAAPVIPQASSTGPSAVWVSLGMPP
PYAARLAGVKPR
NT seq
5079 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtaggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcacgaaatcatcgagacc
atccggtgggtctgcgaagagatcccggacctcaagctcgctatggagaactacgtttta
atcgactacgacaccaaaagcttcgagagcatgcagaggctctgtgataagtacaaccgc
gccatcgacagcatccaccagctgtggaaggggaccactcagcccatgaaactgaacacc
cggccgtccaacgggctcctgcggcacatcctgcagcaggtgtataaccactcggtgacg
gaccccgagaagctcaacaactacgagcccttctccccggaggtgtacggggagacctcc
tttgacctggttgcgcagatgatcgacgagatcaagatgaccgaggacgacctgtttgtg
gacctgggcagcggagtgggccaggtcgtgctccaggtggccgcggccaccaactgcaaa
catcactacggcgtggagaaagctgacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaaaga
ggcgacttcctctcggaggagtggagagagcggattgccaacacaagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcgaacatg
aaggaaggcggcagaattgtgtcctcgaagccctttgcgcctctgaacttcagaataaac
agcagaaacttgagcgacatcggcaccatcatgcgcgtcgtggagctctcgcccctgaag
ggctctgtgtcctggacggggaagcccgtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggagcaagaggcg
gctcggcgccggcagcagcgagaaaacaagagcagcacgaccactcccaccaaggtgccc
gagggcagggctgccgtggccgcggacacccccgtggactccggtgccgaggaagagaag
gctgggacgacctccatcaaaaagccgtccccctccaaagcccggaagaagaagctgaac
aagaaggggcggaaaatggccggcaggaagcgcgggcgccccaagaagatgagcgctgcc
aaccccgagcgcaagccccggaagagccaaactgcactggacctcctgcacgccccggcc
tcgtcgcagacggcggcgccctcgccacaggatgcgtacaggtcacctcatagccccttc
tatcagctacctccctgcgtgcagcggcacgcccccgaccggccgctgctggcagccacc
ccgcccgcactgcagaagctgctagaatccttcaagattcagtacctgcagttcttggcc
tacaccaagacagcccagtacaaggccagccttcagcagctgctggaccaggagaaggag
aagaacgcccggctgctgggggccgcacagcagctgttcggccactgccaggcccagaaa
gaggagatcaagaggctcttccagcagaaactggatgagctgggggtgaaggcgctgacc
tacaacgacctgattcaggcgcagaaggagatctcggcccataaccagcagctgagggag
cagacagagcagctgcaggaggacaacagggagctgaggagccagagcctgcagctgctc
aaggctcggtgtgaggagttgaaactggactggtccacgctgtcgctggagaacctgctg
aaggagaagcaggccctgaggagccagatctccgagaagcagaggcactgcctggagctg
cagatcagcatcgtggagctggagaagagccagcggcagcaagagctgctgcagctcaag
tcctgcgtgccgcccgacgacgccctgtcggcgcacctgcgcgggaaaggcgccctgggc
cgggagccggaggcggaccccggccggctgcacctcgacctggactgctctaggttctcc
ctgccgcacttcagcagcgccagcccggaactctccatgaacggccacgcggcaggctac
gagctctgcggggcgctgagccggcccccgtccaagcagaacaccccccagtacctggcc
tccccgctggaccaggaggtggtgccctgcacccccagccacggcagccggccgaggctc
gagaaggtgtctggcttggccttgccggactacaccaggctgtccccggccaagctggtg
ctgaggcggcacctcagccaggaccacgcggccggcggcaagacggcggccggggagctg
cacccgcgagccgagcacgccaaggagaacggccttccgtaccagagcccgggcatcgcc
aacggcatcaagctgagccctcaggacccccggccctcatcccccgtggccttacagatg
acaggggagaggggcagcgagaagggtttgaaggagcgtgcctacgccagcagcggggag
gccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcagcccagcaagctgccc
gtcagcatccctctggccagcgtggtgctgcccagccgcgccgagaaagtgagaagcacc
cccagccccgtgccgcagacccgagagtccttgtccacacttgaaaagcagatgggcgct
aatgcgcacagcgccggaagcaaaagtctcgccccagcccctgcaggcttctacgcgggc
tcggtggctgtcagcccagcccccctcgcttccggagcagatcccggcacctttgacgag
gtccccagcgcaggcggtctgtttgccagcgtggggtcctgtggctccaccccgcagcac
ccgcccctgctgccgcagccccgcggctctggcgcagcctcgcccgcccacccgctctgc
gccagcccccgcctgggcggcgccgcccagggtccgctccctgacgccaacaaaggggac
cttcctcccgaggccggcttctcggaccccgagggcgaagccaagcggaggatcgtcttc
accgtctcggccggcgggggcagcaccaagcagtcgcctcccagcaagcccagccctctg
cctacaggcagccgtggggacggcagccagggccacgggcaggacagccgcaagcggggc
agaaggaagcgggcggcagcggggacccccggcctgagctcaggcgtgtcgcccaagcgc
cgggccctgccgtccgtggccggcctcttcacgcagtcttcagggtcccccctgaacctc
aactccatggttagcaacattaaccagcctttggaaatcacggccatttcgtcccctgag
agcctgaagagctcccctgtcccctaccaggacagcgaccagccgcccgtcctcaagaag
gagaagcccctgagccagaccaacggggcccactactccccactgacctcggacgaggag
cagggctccgaggatgagccgggcagcaccagaattgagagaaaaattgcgacaatctcc
ttagaaagcagatctcccccgaaaaccttggaaaacggtggtggcctggctgggaggaag
ccgacccctgccggcgagccagccaacagcagcaagtggaaggctaccttttcgcccatc
tccgacctcggcctggccaagtgcgccgacagcccgctgcaggccggctccgccctgagc
cagaactccctgttcgctttccggcccccactggaggagcccggctcggccgacgccaag
ctggccgcccaccccaggaaaagctttcccggtgccctgtcgggggcaggcgggctgagc
ccaagcagcaaccctcccaacggcttcgccttcagcgggggcctggccgccgacctcagt
ttacacagcttcagtgatggtgcttctctcccccacaaggtccccgaggcggcaggcctg
ggcgcccccctgagctttcccgccccccggggcaaggacagcgctgcagagcctgggccc
tttgtgaacaagaggcagctggacggcacgggcggccccaagggcagggaggcaggcgag
ccgggccccccggcgtgcgggcccccggacaaggcctcgctggcgcacggcaagccgggc
aagggccgggaccgtgagcccgacctgaagaacggccacaacctcttcattgcggccgcc
aacgtgccccctgggggcctcctcagtggcccgggcctcgccacggcggcgtcctcggtg
gtcagcgcggccccctccgcccaggcgcaccgccccttcctgggcacatttgcccctggc
ccgcagttcgccctgggccccatgtcgctgcaggccaacctgggctcgtctgtgctgcag
tccctgtttggctccgtgccggccgccggcctggtgcacgtctcgtccgccgcaaccaga
ctgaccaactcgcacgccatgggcagctttccctccggggtggcaggcggcgcagttgga
ggtgtctttaaccacgcggtgccttccgcctccgctcatccgtttggagccagtttcggc
agcggggctgcgtgtcgcagcgccacgctgagcttaaccccgctgcaggcggtggccggc
gccccgcccccgcccccaccggggcagcctgccctccccgcgccccctccccctaacgcc
gccttgcctcccgcccccgcgctgctcccggctaactctgagcccgcgcttctgcagaac
ctcgcgtccctcccggctaaccaggctttcttacccgcctcctctgccgcctctctgcag
cctgctaacgcctctctgtccatcaagctcgcctccctcccgcacaaggccccccgcccc
tccttcacggtgcaccaccagcccctgcccgggctggccctggcccaggccgcgcccgtg
atcccacaggccagctccacggggccgtccgccgtgtgggtttcccttggcatgccgcct
ccgtatgccgcgcgccttgcgggggttaagccaagataa
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