Leopardus geoffroyi (Geoffroy's cat): 123607114
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Entry
123607114 CDS
T10761
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial isoform X1
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
lgf Leopardus geoffroyi (Geoffroy's cat)
Pathway
lgf00220
Arginine biosynthesis
lgf00330
Arginine and proline metabolism
lgf01100
Metabolic pathways
lgf04020
Calcium signaling pathway
lgf04022
cGMP-PKG signaling pathway
lgf04066
HIF-1 signaling pathway
lgf04071
Sphingolipid signaling pathway
lgf04151
PI3K-Akt signaling pathway
lgf04370
VEGF signaling pathway
lgf04371
Apelin signaling pathway
lgf04611
Platelet activation
lgf04915
Estrogen signaling pathway
lgf04921
Oxytocin signaling pathway
lgf04926
Relaxin signaling pathway
lgf04931
Insulin resistance
lgf04933
AGE-RAGE signaling pathway in diabetic complications
lgf05415
Diabetic cardiomyopathy
lgf05417
Lipid and atherosclerosis
lgf05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
lgf00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
123607114 (NOS3)
00330 Arginine and proline metabolism
123607114 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
123607114 (NOS3)
04371 Apelin signaling pathway
123607114 (NOS3)
04066 HIF-1 signaling pathway
123607114 (NOS3)
04020 Calcium signaling pathway
123607114 (NOS3)
04071 Sphingolipid signaling pathway
123607114 (NOS3)
04022 cGMP-PKG signaling pathway
123607114 (NOS3)
04151 PI3K-Akt signaling pathway
123607114 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
123607114 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
123607114 (NOS3)
04921 Oxytocin signaling pathway
123607114 (NOS3)
04926 Relaxin signaling pathway
123607114 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
123607114 (NOS3)
05418 Fluid shear stress and atherosclerosis
123607114 (NOS3)
05415 Diabetic cardiomyopathy
123607114 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
123607114 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
123607114 (NOS3)
Enzymes [BR:
lgf01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
123607114 (NOS3)
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GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
123607114
NCBI-ProteinID:
XP_045352119
LinkDB
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Position
A2:163413901..163431801
Genome browser
AA seq
1203 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPTAEPGRAPAPAPPPPPAPDRSSPPLT
KPPEGPKFPRVKNWEVGSITYDTLSAQAQQEGPCTPRRCLGSLVFPRKLQSRPSQDPPPT
EQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEIAAAGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCNSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPP
ELFALPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFHYQPDPW
KGSGSKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHRSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAA
RDIFSAKRSWKRQRYRLSTQAEGLQLLPGLIYVHRRKMFQAAILSVENLQSSKSTRATIL
VRLDTGGQEGLHYQPGDHVGICPPNRPGLVEALLSRVEDPPPPGEPVAVEQLEKGSPGGP
PPSWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEESSEQQELESLSQDPRRY
EEWKWFRCPTLLEALEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP
FRGFWQERLHDIDSKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSRE
PDCPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGPDT
HSP
NT seq
3612 nt
NT seq
+upstream
nt +downstream
nt
atgggcaatttgaagagtgtgggccaggagccggggcctccctgcggcctggggctgggg
ctgggcctgggcctgtgtggcaagcagggcccagcctccccgacagcagagcccggcagg
gcaccggcacccgcacccccacccccacccgcgccagaccgcagcagtcccccgctcacc
aagcccccggaggggcccaagttccctcgtgtgaagaactgggaggtggggagcatcact
tacgacaccctgagtgcccaggcacagcaggaggggccctgcacccctagacgctgcctg
ggctccctggtttttccacggaaactgcagagccggccctcccaggacccaccacccact
gagcagctgctgagccaggccagggacttcatcaaccagtactacagctccatcaagagg
agtggctcccaggcccatgagcagaggcttcaggaggtggaagccgagatagcagccgca
ggcacataccagcttcgggagagcgagctggtgttcggggctaagcaggcttggagaaat
gcaccccgctgcgtgggccggatccagtgggggaagctgcaggtgtttgatgcccgggat
tgcaactctgcccaggagatgttcacctacatctgcaaccacatcaagtacgccaccaac
cggggcaacctccgctcggccatcacagtgttcccccagcgcgccccaggccgcggagac
ttccgaatctggaacagccaactggtgcgctacgcggggtacaggcagcaggatggctcc
gtgcggggggacccagccaacgtggagatcactgagctctgcatccagcacggctggacc
ccgggaaacggccgctttgacgtactgcccctactgctccaggccccagatgagcccccg
gaactctttgccctgccccccgagctggtcctcgaggtgcccctggagcaccccacgctg
gagtggtttgcggccctgggcctgcgctggtacgccctcccggcggtgagcaacatgctg
ctggaaattggggggctggagttccccgcggcccctttcagcggctggtacatgagcact
gagatcggcacgcggaacctgtgtgacccgcaccgatacaacatcctggaggatgtggcc
gtctgcatggacttggatacccggaccacctcatccctgtggaaagacaaggcagccgtg
gaaatcaacttggccgtgctgcacagttaccagctggccaaagtgaccatcgtggaccac
catgctgccacggcctccttcatgaagcacctggagaatgagcagaaggctagggggggc
tgccctgccgactgggcctggatcgtgccccccatctccggcagcctcacccctgtgttc
catcaggagatggtcaactatgtcctgtcccctgccttccactatcagccagacccgtgg
aagggaagtgggtccaagggtgccggcatcaccaggaagaagacctttaaggaagtggcc
aatgcggtgaagatctctgcctcactcatgggcaccgtgatggcaaagcgagtaaaggca
acaatcctgtatggctccgagaccggccgggcccagagctatgcacagcagctggggaga
ctcttccggaaggctttcgatccccgggtcctgtgcatggatgagtatgatgtcgtgtcc
ctcgagcatgagacgctagtgctggtcgtgaccagcacattcgggaatggtgatccccca
gagaatggagagagttttgcggcagccctgatggaaatgtctggtccctacaacagctcc
cctcggccagaacaacacaggagttacaaaatccgcttcaacagtgtctcctgctcagac
ccgctggtgtcctcctggaggcggaagagaaaggagtccagtaacacagacagtgcaggg
gcactgggtaccctcaggttctgtgtgttcgggctgggctcccgggcgtacccccacttc
tgtgcctttgcccgtgcggtggacacacggctggaggagctgggtggcgaacggctgctg
cagctgggccagggagatgagctgtgtggccaggaggaggccttccgtggctgggcccag
gccgccttccaggcctcctgtgagacgttctgcgtgggagaggacgccaaggctgccgcc
agggacatattcagcgccaaacggagctggaagcgccaaagataccggctcagcacccag
gcggagggcctccagctgctgccaggcctgatctatgtgcacaggaggaagatgttccag
gctgctatcctctcggtcgaaaacctgcagagcagcaagtccacccgggccacgatcctg
gtgcgcctggacaccggaggccaggaggggctgcactaccagccgggggaccacgtaggc
atctgcccgcccaaccgcccaggcctcgtggaggcgctgctgagccgtgtggaggaccca
cctccgccaggagagcccgtggccgtggagcagctggagaagggcagccctggtggccca
ccccccagctgggttcgggacccccggctgcccccctgcacgctgcgccaggctctcacc
ttcttcctggacatcacctccccgcccagccctcaactccttcgactgctcagcaccctg
gcggaagagtccagtgaacagcaggagctggagagcctcagccaggacccccggcgctac
gaggaatggaagtggttccggtgccccacgctgctggaggcgctggaacagttcccgtcc
gtggcgctgcctgcccccctgctcctcacccagctgcccctgctccagccccggtactac
tccgtcagctcggcgcccagcgcccacccgggagagattcacctcacggtggccgtgctg
gcgtacaggacccaggatggactgggccccctgcactatggagtctgctccacatggctg
agccagctgaaggccggagatcccgtaccttgcttcatcaggggggctccctccttccgg
ctgccgcctgatcccagcttgccctgcatcctagtgggccctggcacaggtattgccccc
ttccggggattttggcaggagcggctgcacgacattgacagcaaagggctgcagccggcc
cccatgaccttggtgttcggctgccgatgctcccagctcgaccacctctaccgcgacgag
gtgcaggatgcccagcagcgcggggtttttggacgcgtcctgaccgccttctctcgggag
cccgactgccctaagacctacgtgcaggacatcctgcggacggagctggcggctgaggtg
caccgcgtgctgtgcctcgagcggggccacatgtttgtgtgcggcgacgtcaccatggca
accagcgtcctgcagacggtgcagcgaatcctagcgacggagggcgacatggagctggac
gaggccggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggacattttc
gggctcacactgcgcacccaggaggtgactagccgcatacgcacccagagcttttccctg
caggagcggcatctgcgcggcgcagtgccctgggcgttcgaccctcccggcccagacacc
cacagtccctga
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