Lactobacillus helveticus R0052: R0052_01450
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Entry
R0052_01450 CDS
T02217
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
lhr
Lactobacillus helveticus R0052
Pathway
lhr00300
Lysine biosynthesis
lhr00550
Peptidoglycan biosynthesis
lhr01100
Metabolic pathways
lhr01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
lhr00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
R0052_01450
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
R0052_01450
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
R0052_01450
Enzymes [BR:
lhr01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
R0052_01450
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
RecA-like_ORC2
Motif
Other DBs
NCBI-ProteinID:
AFR21302
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Position
261272..262639
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AA seq
455 aa
AA seq
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MKMQMAEIAKALNTTCEGDDKTVITSVAFDSRNITTGGLFVPLEGERDGHDFVAGAISNG
ASATLWKKGHPNKPENITVIEVDNPLTAMQDLARYYLRKVNPTVVGITGSNGKTTTKDMI
AAVLSKRFNVHKTQANFNNEIGVPMTILEMKPNTEILVLEMGMDRPGQLHHLSELTHPDV
AVITMIGEAHIEFFGSRDKIADAKMEITDFLREDGEFIYNGDEPLLQERAKKLDQAKATF
GFRDEDTVHATGFKSYMHHATFTINDSEQKFSIPMIGKHNVSNAMAAISVGHHFGESDEE
IASSLSNFKPTANRMEWEKGDAGEAIMSDVYNSNPTAVRAVVTSFGQVEVKDGGRRIAVL
GDMLELGEKSPELHAGLSDTLDPQIINEVYLYGSEMKNLYDALQDKYEPENLHYYTQDQM
DHMINDLKNDIKPDDIIVLKGSHGMHLENVLARLR
NT seq
1368 nt
NT seq
+upstream
nt +downstream
nt
atgaaaatgcaaatggctgaaattgccaaggctttaaatactacttgtgaaggcgacgac
aaaactgttattacttctgttgcctttgactccagaaatataacaactggtggtttgttt
gtaccgcttgagggtgaacgtgatggacatgatttcgtagcgggtgctattagtaatggt
gcttctgctactttgtggaaaaagggccatccaaataagcctgaaaatatcacagtaatt
gaagtagataatcctcttactgctatgcaagatttagcgcgttattatttgcgcaaggtt
aatccaactgtagtaggcattaccggttctaatggtaagactactactaaggatatgatt
gctgcagttttatctaagcgttttaacgtacataagacacaagctaactttaataatgaa
attggtgtaccaatgaccattctcgaaatgaaaccaaatactgaaattttggtacttgaa
atgggtatggatagaccaggtcaattacatcatttgagtgaattgactcatccagatgta
gctgtcattactatgatcggtgaagctcatattgagttctttggtagccgtgacaagatt
gctgatgctaagatggaaatcacagactttttgcgtgaagatggtgaattcatttataat
ggtgatgaaccattgttgcaagaacgtgctaagaagcttgatcaagctaaagctacattt
ggcttcagagatgaagatacagttcatgcaactggattcaagagctacatgcatcatgcc
acttttacaattaatgattcagagcaaaagttctcaattcccatgattggtaagcataat
gtttctaatgcaatggcagcaattagtgtaggtcatcactttggtgaaagtgatgaggaa
attgcttcatcattgtctaactttaagccaactgctaaccgaatggaatgggaaaaaggc
gacgctggcgaagctattatgagtgatgtttacaactcaaatccaactgctgttagagcg
gttgttactagttttggtcaagttgaagttaaagatggtggtcgcagaatcgctgtactt
ggcgacatgttggaattaggtgaaaaatcacctgaacttcatgccggattaagcgatact
ttggatccacaaatcatcaatgaagtgtacttgtacggctctgaaatgaagaatttgtat
gatgctttgcaggataaatacgagccagagaatttacattattatactcaagatcaaatg
gatcatatgattaatgatcttaaaaatgacattaagccggacgacattatcgtattaaag
ggttcacacgggatgcaccttgaaaatgtcttagcccgactaagatag
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