Lutra lutra (Eurasian river otter): 125080419 Help Entry 125080419         CDS       T08100                                  Name (RefSeq) epidermal growth factor receptor   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism llv  Lutra lutra (Eurasian river otter) Pathway llv01521   EGFR tyrosine kinase inhibitor resistance llv01522   Endocrine resistance llv03272   Virion - Hepatitis viruses llv04010   MAPK signaling pathway llv04012   ErbB signaling pathway llv04014   Ras signaling pathway llv04015   Rap1 signaling pathway llv04020   Calcium signaling pathway llv04066   HIF-1 signaling pathway llv04068   FoxO signaling pathway llv04072   Phospholipase D signaling pathway llv04144   Endocytosis llv04151   PI3K-Akt signaling pathway llv04510   Focal adhesion llv04520   Adherens junction llv04540   Gap junction llv04630   JAK-STAT signaling pathway llv04810   Regulation of actin cytoskeleton llv04912   GnRH signaling pathway llv04915   Estrogen signaling pathway llv04921   Oxytocin signaling pathway llv04926   Relaxin signaling pathway llv04928   Parathyroid hormone synthesis, secretion and action llv04934   Cushing syndrome llv05160   Hepatitis C llv05163   Human cytomegalovirus infection llv05165   Human papillomavirus infection llv05171   Coronavirus disease - COVID-19 llv05200   Pathways in cancer llv05205   Proteoglycans in cancer llv05206   MicroRNAs in cancer llv05207   Chemical carcinogenesis - receptor activation llv05208   Chemical carcinogenesis - reactive oxygen species llv05210   Colorectal cancer llv05212   Pancreatic cancer llv05213   Endometrial cancer llv05214   Glioma llv05215   Prostate cancer llv05218   Melanoma llv05219   Bladder cancer llv05223   Non-small cell lung cancer llv05224   Breast cancer llv05225   Hepatocellular carcinoma llv05226   Gastric cancer llv05230   Central carbon metabolism in cancer llv05231   Choline metabolism in cancer llv05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:llv00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03272 Virion - Hepatitis viruses     125080419  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     125080419    04012 ErbB signaling pathway     125080419    04014 Ras signaling pathway     125080419    04015 Rap1 signaling pathway     125080419    04630 JAK-STAT signaling pathway     125080419    04066 HIF-1 signaling pathway     125080419    04068 FoxO signaling pathway     125080419    04020 Calcium signaling pathway     125080419    04072 Phospholipase D signaling pathway     125080419    04151 PI3K-Akt signaling pathway     125080419  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     125080419   09144 Cellular community - eukaryotes    04510 Focal adhesion     125080419    04520 Adherens junction     125080419    04540 Gap junction     125080419   09142 Cell motility    04810 Regulation of actin cytoskeleton     125080419  09150 Organismal Systems   09152 Endocrine system    04912 GnRH signaling pathway     125080419    04915 Estrogen signaling pathway     125080419    04921 Oxytocin signaling pathway     125080419    04926 Relaxin signaling pathway     125080419    04928 Parathyroid hormone synthesis, secretion and action     125080419  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     125080419    05206 MicroRNAs in cancer     125080419    05205 Proteoglycans in cancer     125080419    05207 Chemical carcinogenesis - receptor activation     125080419    05208 Chemical carcinogenesis - reactive oxygen species     125080419    05230 Central carbon metabolism in cancer     125080419    05231 Choline metabolism in cancer     125080419    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     125080419   09162 Cancer: specific types    05210 Colorectal cancer     125080419    05212 Pancreatic cancer     125080419    05225 Hepatocellular carcinoma     125080419    05226 Gastric cancer     125080419    05214 Glioma     125080419    05218 Melanoma     125080419    05219 Bladder cancer     125080419    05215 Prostate cancer     125080419    05213 Endometrial cancer     125080419    05224 Breast cancer     125080419    05223 Non-small cell lung cancer     125080419   09172 Infectious disease: viral    05160 Hepatitis C     125080419    05171 Coronavirus disease - COVID-19     125080419    05163 Human cytomegalovirus infection     125080419    05165 Human papillomavirus infection     125080419   09167 Endocrine and metabolic disease    04934 Cushing syndrome     125080419   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     125080419    01522 Endocrine resistance     125080419  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:llv01001]     125080419   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:llv04147]     125080419 Enzymes [BR:llv01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      125080419 Protein kinases [BR:llv01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    125080419 Exosome [BR:llv04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    125080419   Exosomal proteins of pancreatic cancer cells    125080419   Exosomal proteins of bladder cancer cells    125080419 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Kinase-like Borrelia_P83 ABC1 Motif Other DBs NCBI-GeneID:  125080419 NCBI-ProteinID:  XP_047550144 LinkDB All DBs Position 11:9573917..9775185 Genome browser AA seq 1207 aa AA seqDB search MRPSGTAGAALLVLLAAHFPASPALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYMQKNYDLSFLKTIQEVAGYVLIALNTVEKIPLENLQIIRGNVLYENTHALS VLSNYGTNKTGLQELPLRNLHEILQGAVRFSNNPVLCNVDSIKWQDIVDDSFVSNMSMDF QNHAGNCQKCDPSCPNGSCWGPGKENCQKLTKIICAQQCSGRCRGRSPSDCCHNQCAAGC TGPRESDCLVCRKFRDETTCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV VTDHGSCVRACNSDSYEVEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFK NCTSISGDLHILPVAFRGDSFTRTLPLDPKELDILKTVKEITGFLLIQAWPENRTDLHAF ENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIISGNKKLCYANTINWKKL FGTSSQKTKIINNKDEKGCKAMGHVCHPLCSSEGCWGPEPKDCVSCRNVSRGKECVEKCN VLEGEPREFVENSECIQCHPECLPQPMNVTCTGRGPDNCVKCAHYIDGPHCVKTCPAGIM GENNTLVWKFADANRVCHLCHSNCTYGCDGPGLEGCTIERHKIPSIAIGIVGGLFLVVMV ALGVGLFLRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY GVTVWELMTFGSKPYDGIPASEISTILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQ QGFFHSPSTSRTPLLSSLSATSNNSTVACIDRNGSCPLKEDSFLQRYSSDPTGTLTEDNI DDTFLPAPEYINQSVPKRPAGSVQNPVYHNQPLNPALGRDAHYQNPHSNAVDNPEYLNTI PPCVTSALGGAGLRAQKGNPQVSLDNPDYQQHFFPKEAKANGVFKGPAAENADYLRVAPP SREFIGA NT seq 3624 nt NT seq  +upstreamnt  +downstreamnt atgcgaccctccgggacggcgggagccgcgctcctggtcctgctggccgcgcacttcccg gcgagtccggcgctggaggagaagaaagtttgccaaggcaccagtaaccggctcacccag ctgggcacttttgaagaccactttctgagccttcagaggatgttcaataactgtgaggtg gtccttgggaatctggaaattacctacatgcaaaagaattatgacctttccttcttaaag accatccaggaagttgccggctatgtcctcattgccctgaacaccgtggagaagattccc ttggaaaacctgcagatcatccgaggaaatgtgctctatgaaaacacgcacgccttgtcc gtcttatccaactacggcacgaacaaaacagggctgcaggagcttcccctgagaaactta cacgaaatcctccaaggcgccgtgcgcttcagcaacaaccctgtcctctgcaacgtggac agcatcaagtggcaggacatcgtggacgacagttttgtaagcaacatgtcgatggacttc cagaaccatgcgggcaattgccaaaagtgtgatccgagctgtcccaatggaagttgttgg ggtccaggaaaggagaattgccagaaattgaccaaaatcatctgtgcccagcagtgttcg gggcgctgccgcggcaggtcccccagcgactgctgtcacaaccagtgtgctgccggctgc acggggccccgagagagcgactgtctggtgtgccgcaagttccgcgacgaaaccacgtgc aaggacacctgcccgccgctcatgctctacaacccaaccacctaccagatggacgtcaac ccagagggaaaatacagctttggcgccacctgcgtgaagaagtgcccccgtaactacgtg gtgaccgaccacggctcgtgtgtccgtgcctgcaactccgacagctacgaggtagaggaa gatggagtccgcaagtgtaagaagtgtgaggggccttgccgcaaagtgtgtaatggaata ggcattggcgaatttaaagatacactttccataaatgctacaaatattaaacacttcaaa aattgcacgtcaatcagcggagatcttcatatcctgcctgtagcgtttagaggtgactcc ttcacgcgtactctgcctctcgatccaaaggaactggacattctaaaaactgtaaaggaa ataacagggtttctgctgattcaggcctggcccgaaaacaggactgacctccatgctttc gagaacctagaaatcatacgtggaagaacaaagcaacatggtcagttttctcttgcagtc gtcggcctggacataacgtccttgggcttacgctccctcaaggagataagtgatggggat gtgatcatctcgggaaacaaaaaattgtgctatgcaaatacaataaactggaaaaaacta tttgggacttcaagtcagaaaaccaaaattataaacaacaaagatgaaaaaggctgcaag gccatgggccacgtctgccatcctttgtgctcctcagagggctgctggggcccagagccg aaagactgtgtgtcctgcagaaacgtcagccggggcaaggaatgtgtggagaagtgcaat gttctggagggggagccaagggagtttgtggagaactccgagtgcatacagtgccacccg gaatgcctgccccagcccatgaatgtaacctgcacgggacggggaccggacaactgcgtc aagtgtgcgcactacatcgacggcccacactgcgtcaagacctgtccggctggcatcatg ggagagaacaacaccctggtctggaagtttgcagacgccaatcgcgtgtgccacctgtgt cattccaactgtacctacggctgtgatgggccaggtcttgaaggctgcacgatagaaagg cacaagatcccatccattgccattgggattgtgggcggcctcttcttggtggtgatggtg gccctcggggtgggcctctttttacgccggcgccatattgtccggaagcgtacccttcgt agactgctgcaagaaagagagcttgttgagcctcttacgcccagcggagaagctcccaac caagctctcttgaggatcttaaaggaaacagaattcaaaaagatcaaggtgctgggctct ggagcatttggcacggtgtacaagggactctggatcccagaaggtgagaaagttaaaatt cccgtggccatcaaggaattaagagaagccacatctccgaaagccaacaaggaaattctt gatgaagcctatgtgatggccagcgtggacaatcctcatgtctgccgcctcctgggcatc tgcctcacctccacggtccagctgatcactcagctcatgccctttggctgcctcctggac tacgtccgcgagcacaaggacaacatcggctcccagtacctgctcaactggtgtgtgcag attgcaaagggcatgaactacctagaggaccggcgcttggtgcaccgtgacctggcagct agaaatgtcctggtgaagacaccacagcacgttaagatcacagattttgggctggccaag ctgcttggtgccgaggagaaagaataccatgcggaaggaggcaaggtgcctatcaagtgg atggctttggaatccattttacaccgaatttatacccaccaaagtgatgtgtggagctac ggcgtcaccgtttgggagttgatgaccttcgggtccaagccttatgatggaatccccgcc agcgagatctccaccatcctggagaaaggagagcgcctcccgcagccacccatatgcacc atcgatgtctacatgatcatggtcaagtgctggatgatagatgctgacagtcgtcccaaa ttccgtgaactgatcattgaattctccaaaatggcccgagacccccagcgctaccttgtc atccagggagatgagagaatgcacttgccgagccctacagactccaatttttaccgcgcg ctgatggacgaagaggacatggaggacgtggtggatgccgatgagtacctcatcccccag cagggcttcttccacagcccctccacgtcccggacccccctcctgagctctctgagcgcc accagcaacaactccaccgtggcttgcattgacagaaacgggagctgtcccctcaaagaa gacagcttcctgcagcggtacagctcagaccccactggcactttgactgaggacaacata gatgacacttttctcccagcacccgagtacataaaccagtccgtccccaagcggccggcg ggttccgtgcagaatcctgtctatcacaatcagcctctaaaccccgctcttggcagagac gctcactaccaaaacccccacagcaacgccgtggacaaccctgagtatctcaacaccatc cctccctgcgtcaccagcgcacttggcggtgccggcctccgggcccagaagggcaacccc caggtcagcctggacaaccccgactaccagcagcacttctttcccaaggaagccaaggcc aacggcgtcttcaagggccctgcggccgaaaacgcagactacctgcgggtagccccgccg agcagggagttcatcggggcatga

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