KEGG   Lutra lutra (Eurasian river otter): 125080939
Entry
125080939         CDS       T08100                                 
Name
(RefSeq) hepatocyte growth factor receptor isoform X1
  KO
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Organism
llv  Lutra lutra (Eurasian river otter)
Pathway
llv01521  EGFR tyrosine kinase inhibitor resistance
llv04010  MAPK signaling pathway
llv04014  Ras signaling pathway
llv04015  Rap1 signaling pathway
llv04020  Calcium signaling pathway
llv04151  PI3K-Akt signaling pathway
llv04360  Axon guidance
llv04510  Focal adhesion
llv04520  Adherens junction
llv05100  Bacterial invasion of epithelial cells
llv05144  Malaria
llv05200  Pathways in cancer
llv05202  Transcriptional misregulation in cancer
llv05205  Proteoglycans in cancer
llv05206  MicroRNAs in cancer
llv05208  Chemical carcinogenesis - reactive oxygen species
llv05211  Renal cell carcinoma
llv05218  Melanoma
llv05223  Non-small cell lung cancer
llv05225  Hepatocellular carcinoma
llv05226  Gastric cancer
llv05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:llv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125080939
   04014 Ras signaling pathway
    125080939
   04015 Rap1 signaling pathway
    125080939
   04020 Calcium signaling pathway
    125080939
   04151 PI3K-Akt signaling pathway
    125080939
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    125080939
   04520 Adherens junction
    125080939
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    125080939
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125080939
   05202 Transcriptional misregulation in cancer
    125080939
   05206 MicroRNAs in cancer
    125080939
   05205 Proteoglycans in cancer
    125080939
   05208 Chemical carcinogenesis - reactive oxygen species
    125080939
   05230 Central carbon metabolism in cancer
    125080939
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    125080939
   05226 Gastric cancer
    125080939
   05218 Melanoma
    125080939
   05211 Renal cell carcinoma
    125080939
   05223 Non-small cell lung cancer
    125080939
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    125080939
  09174 Infectious disease: parasitic
   05144 Malaria
    125080939
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125080939
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:llv01001]
    125080939
Enzymes [BR:llv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     125080939
Protein kinases [BR:llv01001]
 Receptor tyrosine kinases (RTK)
  MET family
   125080939
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr TIG Pkinase Sema PSI Kinase-like Pkinase_fungal Linker_histone PepSY_TM
Other DBs
NCBI-GeneID: 125080939
NCBI-ProteinID: XP_047551128
LinkDB
Position
11:75281006..75396928
AA seq 1382 aa
MRAPAVLAPGILVLLFTLVQKSCGECKEALVKSEMNVNMKYQLPNFTAETPIQNVVLHKH
HIYLGAVNYIYVLNDKDLQKVAEYKTGPVLEHPDCSPCQDCSHKANLSGAVWKDNINMAL
LIDIYYDDQLISCGSVQRGTCQRHVLPHSNTADIQSEVHCMYSPQADEEPGQCPDCVVSA
LGTKVLISEKTRFINFFVGNTINSSYHPDHSLHSISVRRLKETQDGFKFLTDQSYIDVLP
EFRDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECI
LTEKRRKRSTREEVFNILQAAYVSKPGAHLAKQIGANLNDDILYGVFARSQPDSAEPMNR
SAVCAFPIKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRSDEYRTE
FTTALQRVDLFMGQFNQVLLTSISTFIKGELTIANLGTSEGRFMQVVVSRSGSSTPHVNF
RLDSHPVSPEAIVEHPLNQNGYTLVVTGKKITKIPLNGLGCDHFQSCSQCLSAPPFVQCG
WCHDKCVQLEECPTGTWTQEICLPTIYEVFPTSAPLEGGTMLTICGWDFGFRRNNKFDLK
KTKVLLGNESCTLTLSESTTNMLKCTVGPAVNEHFNISIIIANGRGTAQYSKFSYVDPII
TSISPSYGPKTGGTLLTLNGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPAQTTPTE
FPIKLKIDLANREMNSFSYQEDPIVYAIHPTKSFISGGSTITAIGKNLHSVSVLRMGINV
HEARRNFTVACQHRSNSEIICCTTPSLQQLSLQLPLKTKAFFMLDGIHSKYFDLIYVHNP
VFKPFEKPVMISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCETIYSDSEAVLCKVPND
LLKLNNELNIEWKQAVSSTILGKVIVQPDQNFTGLIVGVISISLIVLLLLGLFLWLKRRK
QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNG
SCRQVQYPLTDLSPMLTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVH
FNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV
LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK
FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQK
FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC
WHPKAELRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSQDNIDGEG
DT
NT seq 4149 nt   +upstreamnt  +downstreamnt
atgagggcccctgctgtgcttgcacctggcatccttgtacttctgtttaccttggtgcag
aagagctgtggggagtgcaaagaggcactagtaaagtctgagatgaatgtgaacatgaag
taccagcttcccaactttactgcagaaacacccatccagaatgttgttttacacaagcat
catatttacctcggtgcagttaactatatttacgttttaaatgacaaagaccttcagaag
gttgctgagtacaagactgggcccgtgctggaacacccagattgttccccatgtcaggac
tgcagccacaaagccaatttatcaggcgctgtttggaaagataacatcaacatggctcta
cttattgacatatactatgatgaccagctcattagttgtggcagtgtccagagagggacc
tgccagcgacatgtccttccacatagcaatactgctgatatacagtcggaagtccattgc
atgtactccccacaggcagatgaagagcctggccaatgccctgactgtgtggtgagtgcc
ctgggaaccaaagtcctgatatctgaaaagactcggttcatcaacttcttcgtgggcaat
accataaattcctcgtaccatccagatcattcattgcattcaatatcagtgagaaggcta
aaggaaacgcaagatggtttcaagtttttgacagaccaatcttatattgatgttctacct
gagttcagagattcctaccctattaaatatgtccatgcctttgaaagcaatcattttatt
tactttttgaccgtccaacgagaaactctagatgctcaaacttttcacacaagaataatc
aggttctgttctgtagactctggattgcattcctacatggaaatgcctctggagtgtatt
ctcacagaaaaaagaaggaagagatccacaagggaagaagtctttaatattctccaagct
gcatatgtcagtaagcctggggcccacctcgctaagcaaataggtgccaacctgaatgat
gacattctctatggagtgtttgcacgaagccagccagattcagctgaaccaatgaatcgc
tctgctgtctgtgcattccctatcaaatatgtcaatgaattcttcaacaagatcgtcaac
aaaaacaacgtgagatgtcttcaacatttttatggacccaaccacgaacactgctttaat
aggacacttttgagaaattcatccggctgtgaagtgcgcagtgatgaatatcgaacggag
tttaccacagctttgcagcgtgttgacttattcatgggccaattcaaccaagtcctctta
acatctatatctaccttcattaaaggagaactcaccattgctaatcttgggacgtcagag
ggtcgcttcatgcaggttgtggtttctcgatcaggatcatcaacccctcatgtgaatttt
cgcctagattcccaccctgtgtctcctgaagccattgtggagcacccattaaaccaaaat
ggctacacactggttgtcactgggaagaagattaccaagatcccactgaatggcttaggc
tgtgatcatttccagtcctgcagtcagtgtctctccgcgcctccctttgtgcagtgcggc
tggtgccacgataaatgtgtgcagttggaggaatgccccactggaacatggactcaggag
atctgtctgcctacaatctatgaggttttcccaactagcgcacccttggaaggagggaca
atgctgaccatatgtggctgggacttcggattcaggaggaataataaatttgatttaaag
aaaaccaaagttctccttggaaatgagagctgcaccttgaccttaagtgagagcacaaca
aatatgctgaaatgcacagttggtcctgcagtaaatgagcatttcaatatatccataatt
attgcaaatggtcgagggacagcacaatacagtaaattttcctatgtggatcctataata
acaagtatttctccaagttacggtcctaagactggtggcaccttgctaactttaaatgga
aagtacctgaacagtgggaattctagacacatttcaattggtggaaaaacatgtacttta
aaaagtgtgtcagatagtattctcgaatgttataccccagctcaaaccactccaactgag
tttcctattaaattgaaaattgacttagccaaccgagagatgaacagcttcagttaccaa
gaagaccccattgtctatgcaattcatccaaccaaatcttttattagtggtgggagcaca
ataacagctattggaaaaaacttgcattcagttagtgtcctgaggatgggaataaatgta
catgaagcaagaaggaactttacagtggcatgtcaacatcgctctaattcagagataatc
tgctgtacaactccttcactgcaacagctgagtctgcagctccctctgaaaaccaaagcc
tttttcatgttagatgggatccattccaaatactttgatctcatttatgtacataatcct
gtgtttaagccttttgaaaagccagtgatgatctcaataggcaatgaaaatgtactggaa
attaagggaaatgatattgaccctgaagcagttaaaggtgaagtgttaaaagttggaaat
aagagctgtgagaccatatactcagattctgaagctgttttatgcaaggtccccaatgac
ctgctgaagttgaacaacgagctaaatatagagtggaagcaagcagtttcttcaaccatc
cttggaaaagtaattgttcaaccagatcagaatttcacaggattgattgttggtgttatc
tcaatatcattaatagtcttattattacttgggcttttcctgtggctgaaaaggagaaag
caaattaaagatctgggcagtgaattagttcgctatgatgcaagagtacacactcctcat
ttggataggcttgtaagtgcccgaagtgtaagcccaactacagaaatggtttcaaatgaa
tctgtagactaccgagctacttttccagaagatcagtttcctaactcatcccagaatgga
tcatgcagacaagtacagtatcctctgacggacctgtcccctatgcttactagtggggac
tctgatatatccagtccattactgcaaaatactgtccacattgacctcagtgctctaaat
ccagaactggtccaggcagtccagcacgtagtaattgggccgagtagcctgattgtgcat
ttcaatgaagtcataggaagaggacattttgggtgtgtataccacgggactttgttggac
aatgatgacaagaaaattcactgtgctgtgaaatccttgaatcgaatcactgacataggc
gaagtttcccagtttctgactgagggaatcatcatgaaagactttagtcatccaaatgtt
ctttcactcttgggaatctgccttcgaagtgaggggtctccactggtggtcctaccatac
atgaaacatggagatcttcgaaatttcattagaaatgaaactcataacccaactgtaaaa
gatcttattggctttggtcttcaagtagccaaaggcatgaaatatcttgcaagcaaaaag
tttgtccacagagacttggctgcaagaaactgtatgctggatgaaaaattcactgtcaag
gttgctgattttggccttgccagagacatgtatgataaagaatactatagcgtacacaac
aaaacaggtgccaagctgcccgtgaagtggatggctttagaaagtctgcaaactcagaag
tttaccaccaagtcagatgtgtggtcctttggcgtgctcctctgggaactgatgacaaga
ggagcaccaccttatcctgatgtcaatacctttgatataacagtttacttgttgcaaggc
agaaggctcctacaacccgaatactgcccagatcccttatatgaagtgatgctcaaatgc
tggcaccctaaagctgagctgcgcccatctttttctgaactggtctccaggatatcagca
atattctctactttcattggggagcactacgtccatgtgaacgctacctatgtgaatgtc
aaatgtgttgctccatacccttccctgttgtcttcacaagataacattgatggcgagggg
gacacatga

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