KEGG   Lutra lutra (Eurasian river otter): 125084526
Entry
125084526         CDS       T08100                                 
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
llv  Lutra lutra (Eurasian river otter)
Pathway
llv01522  Endocrine resistance
llv04010  MAPK signaling pathway
llv04012  ErbB signaling pathway
llv04014  Ras signaling pathway
llv04024  cAMP signaling pathway
llv04068  FoxO signaling pathway
llv04071  Sphingolipid signaling pathway
llv04137  Mitophagy - animal
llv04140  Autophagy - animal
llv04141  Protein processing in endoplasmic reticulum
llv04210  Apoptosis
llv04215  Apoptosis - multiple species
llv04217  Necroptosis
llv04310  Wnt signaling pathway
llv04380  Osteoclast differentiation
llv04510  Focal adhesion
llv04517  IgSF CAM signaling
llv04530  Tight junction
llv04620  Toll-like receptor signaling pathway
llv04621  NOD-like receptor signaling pathway
llv04622  RIG-I-like receptor signaling pathway
llv04625  C-type lectin receptor signaling pathway
llv04657  IL-17 signaling pathway
llv04658  Th1 and Th2 cell differentiation
llv04659  Th17 cell differentiation
llv04660  T cell receptor signaling pathway
llv04664  Fc epsilon RI signaling pathway
llv04668  TNF signaling pathway
llv04722  Neurotrophin signaling pathway
llv04723  Retrograde endocannabinoid signaling
llv04728  Dopaminergic synapse
llv04750  Inflammatory mediator regulation of TRP channels
llv04910  Insulin signaling pathway
llv04912  GnRH signaling pathway
llv04914  Progesterone-mediated oocyte maturation
llv04917  Prolactin signaling pathway
llv04920  Adipocytokine signaling pathway
llv04926  Relaxin signaling pathway
llv04930  Type II diabetes mellitus
llv04931  Insulin resistance
llv04932  Non-alcoholic fatty liver disease
llv04933  AGE-RAGE signaling pathway in diabetic complications
llv04935  Growth hormone synthesis, secretion and action
llv04936  Alcoholic liver disease
llv05010  Alzheimer disease
llv05012  Parkinson disease
llv05016  Huntington disease
llv05017  Spinocerebellar ataxia
llv05020  Prion disease
llv05022  Pathways of neurodegeneration - multiple diseases
llv05132  Salmonella infection
llv05133  Pertussis
llv05135  Yersinia infection
llv05142  Chagas disease
llv05145  Toxoplasmosis
llv05152  Tuberculosis
llv05161  Hepatitis B
llv05162  Measles
llv05166  Human T-cell leukemia virus 1 infection
llv05167  Kaposi sarcoma-associated herpesvirus infection
llv05169  Epstein-Barr virus infection
llv05170  Human immunodeficiency virus 1 infection
llv05171  Coronavirus disease - COVID-19
llv05200  Pathways in cancer
llv05208  Chemical carcinogenesis - reactive oxygen species
llv05210  Colorectal cancer
llv05212  Pancreatic cancer
llv05231  Choline metabolism in cancer
llv05415  Diabetic cardiomyopathy
llv05417  Lipid and atherosclerosis
llv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:llv00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    125084526
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125084526
   04012 ErbB signaling pathway
    125084526
   04014 Ras signaling pathway
    125084526
   04310 Wnt signaling pathway
    125084526
   04668 TNF signaling pathway
    125084526
   04068 FoxO signaling pathway
    125084526
   04071 Sphingolipid signaling pathway
    125084526
   04024 cAMP signaling pathway
    125084526
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    125084526
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    125084526
   04137 Mitophagy - animal
    125084526
  09143 Cell growth and death
   04210 Apoptosis
    125084526
   04215 Apoptosis - multiple species
    125084526
   04217 Necroptosis
    125084526
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    125084526
   04530 Tight junction
    125084526
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    125084526
   04621 NOD-like receptor signaling pathway
    125084526
   04622 RIG-I-like receptor signaling pathway
    125084526
   04625 C-type lectin receptor signaling pathway
    125084526
   04660 T cell receptor signaling pathway
    125084526
   04658 Th1 and Th2 cell differentiation
    125084526
   04659 Th17 cell differentiation
    125084526
   04657 IL-17 signaling pathway
    125084526
   04664 Fc epsilon RI signaling pathway
    125084526
  09152 Endocrine system
   04910 Insulin signaling pathway
    125084526
   04920 Adipocytokine signaling pathway
    125084526
   04912 GnRH signaling pathway
    125084526
   04914 Progesterone-mediated oocyte maturation
    125084526
   04917 Prolactin signaling pathway
    125084526
   04926 Relaxin signaling pathway
    125084526
   04935 Growth hormone synthesis, secretion and action
    125084526
  09156 Nervous system
   04728 Dopaminergic synapse
    125084526
   04723 Retrograde endocannabinoid signaling
    125084526
   04722 Neurotrophin signaling pathway
    125084526
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    125084526
  09158 Development and regeneration
   04380 Osteoclast differentiation
    125084526
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125084526
   05208 Chemical carcinogenesis - reactive oxygen species
    125084526
   05231 Choline metabolism in cancer
    125084526
  09162 Cancer: specific types
   05210 Colorectal cancer
    125084526
   05212 Pancreatic cancer
    125084526
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    125084526
   05170 Human immunodeficiency virus 1 infection
    125084526
   05161 Hepatitis B
    125084526
   05171 Coronavirus disease - COVID-19
    125084526
   05162 Measles
    125084526
   05167 Kaposi sarcoma-associated herpesvirus infection
    125084526
   05169 Epstein-Barr virus infection
    125084526
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125084526
   05135 Yersinia infection
    125084526
   05133 Pertussis
    125084526
   05152 Tuberculosis
    125084526
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    125084526
   05142 Chagas disease
    125084526
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125084526
   05012 Parkinson disease
    125084526
   05016 Huntington disease
    125084526
   05017 Spinocerebellar ataxia
    125084526
   05020 Prion disease
    125084526
   05022 Pathways of neurodegeneration - multiple diseases
    125084526
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125084526
   05418 Fluid shear stress and atherosclerosis
    125084526
   05415 Diabetic cardiomyopathy
    125084526
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    125084526
   04936 Alcoholic liver disease
    125084526
   04932 Non-alcoholic fatty liver disease
    125084526
   04931 Insulin resistance
    125084526
   04933 AGE-RAGE signaling pathway in diabetic complications
    125084526
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    125084526
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:llv01001]
    125084526
Enzymes [BR:llv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     125084526
Protein kinases [BR:llv01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   125084526
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH
Other DBs
NCBI-GeneID: 125084526
NCBI-ProteinID: XP_047557894
LinkDB
Position
14:47575061..47683420
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagattctacattt
acagtcttgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaatgttgctatcaagaagctaagccggcca
tttcagaaccagactcatgctaaacgggcttacagagagctagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggaactagatcatgagagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcccagtaatatcgtggtaaaa
tcagactgcactttgaagattcttgattttggactggccaggactgcaggaactagtttt
atgatgacaccttacgtagtgactcgctactacagagcacctgaggtcatcctagggatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgccctgaattcatgaagaaactacagccaacagtaaggacttatgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccccgatgtgcttttc
ccagctgactcggaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgctggtaattgatgcatctaaaaggatttctgtagatgaagctctccagcacccatat
atcaatgtctggtatgatccttctgaagcagaagctccaccaccaaagatacctgacaag
cagttagatgaaagggaacatacaatagaagaatggaaagagttgatatacaaagaagtt
atggacttggaggagagaaccaagaatggagttataaggggacagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcatcatcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctcagatacagacagcagtctagaagcatcagct
ggacctctgggctgctgtagatga

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