KEGG   Lutra lutra (Eurasian river otter): 125086002
Entry
125086002         CDS       T08100                                 
Name
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1S isoform X1
  KO
K04857  voltage-dependent calcium channel L type alpha-1S
Organism
llv  Lutra lutra (Eurasian river otter)
Pathway
llv04010  MAPK signaling pathway
llv04020  Calcium signaling pathway
llv04022  cGMP-PKG signaling pathway
llv04024  cAMP signaling pathway
llv04260  Cardiac muscle contraction
llv04261  Adrenergic signaling in cardiomyocytes
llv04270  Vascular smooth muscle contraction
llv04723  Retrograde endocannabinoid signaling
llv04725  Cholinergic synapse
llv04726  Serotonergic synapse
llv04727  GABAergic synapse
llv04911  Insulin secretion
llv04912  GnRH signaling pathway
llv04921  Oxytocin signaling pathway
llv04924  Renin secretion
llv04925  Aldosterone synthesis and secretion
llv04927  Cortisol synthesis and secretion
llv04929  GnRH secretion
llv04934  Cushing syndrome
llv04935  Growth hormone synthesis, secretion and action
llv05010  Alzheimer disease
llv05020  Prion disease
llv05022  Pathways of neurodegeneration - multiple diseases
llv05207  Chemical carcinogenesis - receptor activation
llv05410  Hypertrophic cardiomyopathy
llv05412  Arrhythmogenic right ventricular cardiomyopathy
llv05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:llv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125086002
   04020 Calcium signaling pathway
    125086002
   04024 cAMP signaling pathway
    125086002
   04022 cGMP-PKG signaling pathway
    125086002
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    125086002
   04929 GnRH secretion
    125086002
   04912 GnRH signaling pathway
    125086002
   04921 Oxytocin signaling pathway
    125086002
   04935 Growth hormone synthesis, secretion and action
    125086002
   04924 Renin secretion
    125086002
   04925 Aldosterone synthesis and secretion
    125086002
   04927 Cortisol synthesis and secretion
    125086002
  09153 Circulatory system
   04260 Cardiac muscle contraction
    125086002
   04261 Adrenergic signaling in cardiomyocytes
    125086002
   04270 Vascular smooth muscle contraction
    125086002
  09156 Nervous system
   04727 GABAergic synapse
    125086002
   04725 Cholinergic synapse
    125086002
   04726 Serotonergic synapse
    125086002
   04723 Retrograde endocannabinoid signaling
    125086002
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    125086002
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125086002
   05020 Prion disease
    125086002
   05022 Pathways of neurodegeneration - multiple diseases
    125086002
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    125086002
   05412 Arrhythmogenic right ventricular cardiomyopathy
    125086002
   05414 Dilated cardiomyopathy
    125086002
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    125086002
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:llv04040]
    125086002
Ion channels [BR:llv04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   125086002
SSDB
Motif
Pfam: Ion_trans Ca_chan_IQ GPHH PKD_channel CAC1F_C
Other DBs
NCBI-GeneID: 125086002
NCBI-ProteinID: XP_047560970
LinkDB
Position
15:complement(40592111..40661315)
AA seq 1868 aa
MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLQNPLRKACINIVEWKPFETIILLT
IFANCVALAVYLPMPEDDNNTLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRS
GWNVLDFIIVFLGVFTVILEQVNVIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVP
SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE
KPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW
VNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLE
EDLRGYMSWITQGEVMDVEDLREGKLSLDEGGSDTESLYEIEGLNKIIQFVRHWRQWNRI
FRWKCHDVIKSKVFYWLVILVVALNTLSIASEHHNQPLWLTHLQDVANRVLLALFTIEML
MKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMSPLGISVLRCIRLLRIFKITK
YWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVRRSNFDNF
PQALISVFQVLTGEDWNSMMYNGIMAYGGPSYPGVLVCVYFIILFVCGNYILLNVFLAIA
VDNLAEAESLTSAQKAKAEERKRRKMSKGLLDKSEEEKSVMAKKLEQKPKGEGIPTTAKL
KIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPVSPRPRPLAELQLKEKAVPIPEASSFF
IFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVRNQILGYFDIAFT
SVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISVVKILRVLR
VLRPLRAINRAKGLKHVVQCVFVAVRTIGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDL
SKMTEKECRGYYYVYKDGDPTQMELRPRQWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLL
YQAIDSYKEDMGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCE
LDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHY
NQSEEMNHISDILNVAFTIIFTLEMVLKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILS
EIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTF
IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLFRCA
TGEAWQEILLACSYGKLCDPESDYGPGEEYTCGTNFAYYYFISFYMLCAFLIINLFVAVI
MDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCP
HRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKR
TSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDIIQIQAGLR
TIEEEAAPEIRRTISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP
VMANQRPLQFAEIEMEELESPVFLEDFPQDPHTNPLAHANTNNANANIAYGNSNHSNSLH
YEREFPEETETPAARGGAFGQPRRVLGPHSKSCVEKLKEQLTQREMPRSQASPAPSQRAS
TEPPLPEERRRHSPGSLPEQASHSSRTKHSSSQCQTPATAQLIQEALVRGGLDTLAVDAN
FVMATGQALADACQMAPEDMEVAATELLKRQESPEGLTMARGRWSLRSSLGSLDQHQGSQ
ETLIPPRL
NT seq 5607 nt   +upstreamnt  +downstreamnt
atggagccgtcctcaccccaggatgagggcctgaggaagaaacagcccaagaagccggtt
ccggagattctgccaaggccaccccgggccttgttctgcttgaccctccagaaccccctg
aggaaggcctgcatcaacatcgtggaatggaaaccctttgagaccatcatcttgctcacc
atctttgccaactgtgtggcgctggctgtgtacctgcccatgccagaagatgacaacaac
actctgaaccttggcctggagaaactggagtatttcttcctcattgttttctcgattgaa
gccgccatgaagatcattgcctatggcttcctattccatcaggatgcctacctgcgcagt
ggctggaacgtgctagacttcatcattgtcttcctgggggttttcaccgtgattctggaa
caggttaacgtcatccaaagcaacacagccccgatgagcagcaaaggggctggtctggat
gtcaaggccctgagagccttccgcgtgctcagacccctccggctggtgtccggggtgccg
agcctgcaggtggtcctcaattccatcttcaaggccatgctgcccctgttccacatcgcc
ctgctcgtcctcttcatggtcatcatctatgccatcatcgggctggagctcttcaaaggc
aagatgcataagacctgctacttcattgggacagatatcgtggccacagtggagaacgag
aagccctcaccctgcgccaggacgggatcggggcgcccgtgcaccatcaacggcagcgag
tgtcggggcggctggccagggcccaaccacggcatcacccacttcgacaacttcggcttc
tccatgctcaccgtgtaccagtgcatcaccatggagggctggaccgacgttctctactgg
gtcaatgatgccatcgggaacgagtggccctggatctattttgtcaccctcattctgctg
ggatccttcttcattctcaacctggtgctgggtgtcctgagcggggaattcaccaaggag
cgggagaaggccaagtccaggggaaccttccaaaagctccgggagaagcagcagctggag
gaggacctgcggggctacatgagctggatcacgcagggcgaggtcatggatgttgaggac
ttgagagaagggaagttgtctttggatgaaggaggctctgacacagagagcttgtatgaa
atcgagggcttgaacaaaatcattcagtttgttcgccactggaggcagtggaaccgcatc
tttcgctggaagtgccatgacgtgatcaagtccaaagtcttctactggctggtgatcctg
gtcgttgccctcaacaccctgtcaattgcctctgagcaccacaaccagcctctgtggctg
acccacttgcaagatgtagccaaccgcgtgctgctggccctcttcaccatcgagatgctg
atgaagatgtatgggctgggtctgcgccagtacttcatgtccatcttcaaccgcttcgac
tgcttcgtcgtgtgcagcggcatcctggagatcctgctggtggaatcgggcgccatgagc
cccctgggcatctccgtgctgcgctgtatccgcctcctcaggatcttcaagatcaccaag
tactggacgtctctgagcaacctggtggcgtccctgctcaactccatccgctccatcgcc
tcactgctgctgctgctcttcctcttcatcatcatcttcgcgttgctgggcatgcagctc
ttcgggggaaggtacgacttcgaggacacggaggttcggcgcagcaacttcgacaacttt
ccgcaggccctcatcagcgtcttccaggtcctgaccggtgaagactggaactccatgatg
tacaatgggatcatggcctacggcggaccgtcctaccccggggtgctcgtgtgtgtttat
ttcatcatccttttcgtctgtggcaattatatcctgctcaatgtcttcctggccatcgct
gtggacaatctggctgaggcggagagcctgacttctgcccagaaggccaaggctgaggag
agaaagcgcagaaagatgtccaagggtctcctagacaagtcagaggaggagaagtcagtg
atggccaagaagctggaacagaaacccaagggcgagggcatccctaccaccgccaagctg
aaaatcgatgagtttgaatctaacgtcaatgaagtaaaggatccttacccttcggctgac
ttcccaggcgatgatgaagaagatgagcctgagatccccgtgagcccccgaccacggccc
ctggctgagctgcagctgaaagagaaggcggtgcccattccagaagccagctccttcttc
atcttcagccccaccaacaagatccgtgtcctgtgtcaccgcattgtcaatgccacctgg
ttcaccaacttcatcctgctcttcatcctgctcagcagtgccgccctggccgccgaggac
cccatccgggccgagtctgtgaggaatcagatccttgggtattttgacattgcattcacc
tctgtcttcactgtggagattgtcctcaagatgacgacctatggtgccttcctgcacaag
ggctccttctgccgcaactacttcaacatcctggacctgctggtggtggccgtgtccctc
atctccatgggacttgagtccagtgccatctccgtggtgaaaatcctgagggtgctgagg
gtgctccgacccctccgggccatcaacagagccaaagggctgaagcatgtggtgcagtgc
gtgtttgtggccgtccgcaccatcgggaatatcgtcctggtcaccacgctcctgcagttc
atgttcgcctgcatcggcgtccagctcttcaaggggaagttcttcagctgcaatgactta
tccaagatgacagagaaggagtgcaggggctattactatgtgtacaaggacggggacccc
acgcagatggagctgcgcccacgccagtgggtacacagtgatttccacttcgacaacgtg
ctctcggccatgatgtcactcttcacagtctccacctttgagggatggcctcagctactt
taccaggccatagactcatacaaggaggacatgggccccatctacaacaacagagtggag
atggccatcttcttcatcatctacatcatcctcattgccttcttcatgatgaacatcttt
gtgggcttcgtcattgtcaccttccaggagcagggagagactgagtacaagaactgtgag
ctggacaagaaccagcgccagtgtgtgcagtacgccctgaaggcccgcccgctgaggtgc
tatatccccaagaacccgtaccagtatcaagtgtggtatgtcgtcacctcgtcctacttc
gagtatctgatgtttgccctcatcatgctcaacaccatctgcttgggcatgcagcactac
aaccagtcggaggagatgaaccacatctcagacatcctcaatgtggccttcaccatcatc
ttcaccctagagatggtcctcaagctcatggcgttcaaggccaggggctattttggtgac
ccctggaatgtgtttgacttcttgattgtcatcggcagcatcatcgacgtcatcctcagt
gaaattgacactttcctggcctccagcggaggactgtattgcctgggtggaggctgcggg
aacgttgacccggacgagagcgcccgtatctccagtgccttctttcgcctgttccgggtc
atgaggctgatcaagctgctgagccgggcggagggagttcgcactctgctgtggaccttc
atcaagtccttccaggcccttccctacgtggccctcctcatcgtcatgctcttcttcatc
tacgcggtcatcggcatgcagatgtttggtaagatcgccatggtggacgggacccagata
aaccgtaacaacaacttccagaccttcccgcaagctgtgctgctgctcttcaggtgtgca
acgggtgaggcatggcaggagatcctgttggcctgcagctacggcaagttgtgtgacccc
gagtcagattatggcccgggtgaggagtacacgtgtggcaccaacttcgcctactactac
ttcatcagcttctacatgctctgtgccttcctgatcatcaacctctttgttgctgtcatc
atggacaactttgactaccttacacgggactggtccattctgggccctcatcacctggat
gagttcaaggccatttgggcagagtatgacccagaggctaagggcagaatcaaacacctg
gatgtggtgaccctgttgagacggatccagccccctctgggcttcgggaagttctgtccc
caccgggtggcctgtaagcggctggtgggcatgaacatgcccttgaacagcgatggcacg
gtcaccttcaacgccaccctcttcgccctggtccgcacggcactcaagatcaagacggaa
ggtaactttgagcaggccaatgaggagctgagggccatcatcaagaagatctggaagaga
accagcatgaagctcctggaccaggtcattcctccaataggagatgatgaggtgactgtg
gggaagttttacgccacgtttctgatccaggagcacttccgcaagttcatgaagcgccag
gaagagtattatgggtatcggcccaagaaggacatcatacagatccaggctggactgcgg
accattgaggaagaggccgccccagagatccgccgtaccatctcaggagacctgacggca
gaagaggaactggagagagccatggtggaggctgcgatggaggaagggatattccggagg
actggaggcctctttggacaggtggacaacttcctggaaaggaccaactccctgccccct
gtcatggccaaccagagaccgctccagtttgctgagatagagatggaagaactggaatca
cctgtcttcttggaggatttccctcaagatccacacaccaaccctctggctcatgccaat
accaacaatgccaatgccaacattgcctatggcaacagcaaccatagcaacagcctccac
tatgaaagggagttccctgaagagacagagacgcctgctgccagaggaggagcttttggt
caaccccgaagggtcctgggaccccacagcaaatcctgtgtggaaaagctaaaagaacag
ctgacccagagagaaatgcccagatcccaagcatctcctgccccttcccagcgtgccagc
accgagcctcccctgcctgaggagaggaggaggcacagcccagggtctctgcccgagcaa
gcatcccacagcagtaggaccaagcacagtagttcccagtgccagactccagcgacagcc
cagctgattcaagaggctctggttcgaggcggcctagacaccttggcggttgatgctaac
tttgtcatggcgaccggccaggccctggcagacgcctgccagatggcaccagaggacatg
gaggtggcagccacggaactgctgaaaagacaagagtccccagagggcctgaccatggcc
cggggacgctggagcctcaggtcctcgctgggcagccttgaccagcatcagggctcccag
gagaccctgatcccccccaggctgtga

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