KEGG   Lutra lutra (Eurasian river otter): 125089561
Entry
125089561         CDS       T08100                                 
Name
(RefSeq) RAC-beta serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
llv  Lutra lutra (Eurasian river otter)
Pathway
llv01521  EGFR tyrosine kinase inhibitor resistance
llv01522  Endocrine resistance
llv01524  Platinum drug resistance
llv04010  MAPK signaling pathway
llv04012  ErbB signaling pathway
llv04014  Ras signaling pathway
llv04015  Rap1 signaling pathway
llv04022  cGMP-PKG signaling pathway
llv04024  cAMP signaling pathway
llv04062  Chemokine signaling pathway
llv04066  HIF-1 signaling pathway
llv04068  FoxO signaling pathway
llv04071  Sphingolipid signaling pathway
llv04072  Phospholipase D signaling pathway
llv04140  Autophagy - animal
llv04150  mTOR signaling pathway
llv04151  PI3K-Akt signaling pathway
llv04152  AMPK signaling pathway
llv04210  Apoptosis
llv04211  Longevity regulating pathway
llv04213  Longevity regulating pathway - multiple species
llv04218  Cellular senescence
llv04261  Adrenergic signaling in cardiomyocytes
llv04370  VEGF signaling pathway
llv04371  Apelin signaling pathway
llv04380  Osteoclast differentiation
llv04510  Focal adhesion
llv04517  IgSF CAM signaling
llv04518  Integrin signaling
llv04550  Signaling pathways regulating pluripotency of stem cells
llv04611  Platelet activation
llv04613  Neutrophil extracellular trap formation
llv04620  Toll-like receptor signaling pathway
llv04625  C-type lectin receptor signaling pathway
llv04630  JAK-STAT signaling pathway
llv04660  T cell receptor signaling pathway
llv04662  B cell receptor signaling pathway
llv04664  Fc epsilon RI signaling pathway
llv04666  Fc gamma R-mediated phagocytosis
llv04668  TNF signaling pathway
llv04722  Neurotrophin signaling pathway
llv04725  Cholinergic synapse
llv04728  Dopaminergic synapse
llv04810  Regulation of actin cytoskeleton
llv04910  Insulin signaling pathway
llv04914  Progesterone-mediated oocyte maturation
llv04915  Estrogen signaling pathway
llv04917  Prolactin signaling pathway
llv04919  Thyroid hormone signaling pathway
llv04920  Adipocytokine signaling pathway
llv04922  Glucagon signaling pathway
llv04923  Regulation of lipolysis in adipocytes
llv04926  Relaxin signaling pathway
llv04929  GnRH secretion
llv04931  Insulin resistance
llv04932  Non-alcoholic fatty liver disease
llv04933  AGE-RAGE signaling pathway in diabetic complications
llv04935  Growth hormone synthesis, secretion and action
llv04936  Alcoholic liver disease
llv04973  Carbohydrate digestion and absorption
llv05010  Alzheimer disease
llv05017  Spinocerebellar ataxia
llv05132  Salmonella infection
llv05135  Yersinia infection
llv05142  Chagas disease
llv05145  Toxoplasmosis
llv05152  Tuberculosis
llv05160  Hepatitis C
llv05161  Hepatitis B
llv05162  Measles
llv05163  Human cytomegalovirus infection
llv05164  Influenza A
llv05165  Human papillomavirus infection
llv05166  Human T-cell leukemia virus 1 infection
llv05167  Kaposi sarcoma-associated herpesvirus infection
llv05168  Herpes simplex virus 1 infection
llv05169  Epstein-Barr virus infection
llv05170  Human immunodeficiency virus 1 infection
llv05200  Pathways in cancer
llv05205  Proteoglycans in cancer
llv05207  Chemical carcinogenesis - receptor activation
llv05208  Chemical carcinogenesis - reactive oxygen species
llv05210  Colorectal cancer
llv05211  Renal cell carcinoma
llv05212  Pancreatic cancer
llv05213  Endometrial cancer
llv05214  Glioma
llv05215  Prostate cancer
llv05218  Melanoma
llv05220  Chronic myeloid leukemia
llv05221  Acute myeloid leukemia
llv05222  Small cell lung cancer
llv05223  Non-small cell lung cancer
llv05224  Breast cancer
llv05225  Hepatocellular carcinoma
llv05226  Gastric cancer
llv05230  Central carbon metabolism in cancer
llv05231  Choline metabolism in cancer
llv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
llv05415  Diabetic cardiomyopathy
llv05417  Lipid and atherosclerosis
llv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:llv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125089561
   04012 ErbB signaling pathway
    125089561
   04014 Ras signaling pathway
    125089561
   04015 Rap1 signaling pathway
    125089561
   04370 VEGF signaling pathway
    125089561
   04371 Apelin signaling pathway
    125089561
   04630 JAK-STAT signaling pathway
    125089561
   04668 TNF signaling pathway
    125089561
   04066 HIF-1 signaling pathway
    125089561
   04068 FoxO signaling pathway
    125089561
   04072 Phospholipase D signaling pathway
    125089561
   04071 Sphingolipid signaling pathway
    125089561
   04024 cAMP signaling pathway
    125089561
   04022 cGMP-PKG signaling pathway
    125089561
   04151 PI3K-Akt signaling pathway
    125089561
   04152 AMPK signaling pathway
    125089561
   04150 mTOR signaling pathway
    125089561
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    125089561
   04518 Integrin signaling
    125089561
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    125089561
  09143 Cell growth and death
   04210 Apoptosis
    125089561
   04218 Cellular senescence
    125089561
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    125089561
   04550 Signaling pathways regulating pluripotency of stem cells
    125089561
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125089561
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    125089561
   04613 Neutrophil extracellular trap formation
    125089561
   04620 Toll-like receptor signaling pathway
    125089561
   04625 C-type lectin receptor signaling pathway
    125089561
   04660 T cell receptor signaling pathway
    125089561
   04662 B cell receptor signaling pathway
    125089561
   04664 Fc epsilon RI signaling pathway
    125089561
   04666 Fc gamma R-mediated phagocytosis
    125089561
   04062 Chemokine signaling pathway
    125089561
  09152 Endocrine system
   04910 Insulin signaling pathway
    125089561
   04922 Glucagon signaling pathway
    125089561
   04923 Regulation of lipolysis in adipocytes
    125089561
   04920 Adipocytokine signaling pathway
    125089561
   04929 GnRH secretion
    125089561
   04915 Estrogen signaling pathway
    125089561
   04914 Progesterone-mediated oocyte maturation
    125089561
   04917 Prolactin signaling pathway
    125089561
   04926 Relaxin signaling pathway
    125089561
   04935 Growth hormone synthesis, secretion and action
    125089561
   04919 Thyroid hormone signaling pathway
    125089561
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    125089561
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    125089561
  09156 Nervous system
   04725 Cholinergic synapse
    125089561
   04728 Dopaminergic synapse
    125089561
   04722 Neurotrophin signaling pathway
    125089561
  09158 Development and regeneration
   04380 Osteoclast differentiation
    125089561
  09149 Aging
   04211 Longevity regulating pathway
    125089561
   04213 Longevity regulating pathway - multiple species
    125089561
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125089561
   05205 Proteoglycans in cancer
    125089561
   05207 Chemical carcinogenesis - receptor activation
    125089561
   05208 Chemical carcinogenesis - reactive oxygen species
    125089561
   05230 Central carbon metabolism in cancer
    125089561
   05231 Choline metabolism in cancer
    125089561
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125089561
  09162 Cancer: specific types
   05210 Colorectal cancer
    125089561
   05212 Pancreatic cancer
    125089561
   05225 Hepatocellular carcinoma
    125089561
   05226 Gastric cancer
    125089561
   05214 Glioma
    125089561
   05221 Acute myeloid leukemia
    125089561
   05220 Chronic myeloid leukemia
    125089561
   05218 Melanoma
    125089561
   05211 Renal cell carcinoma
    125089561
   05215 Prostate cancer
    125089561
   05213 Endometrial cancer
    125089561
   05224 Breast cancer
    125089561
   05222 Small cell lung cancer
    125089561
   05223 Non-small cell lung cancer
    125089561
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    125089561
   05170 Human immunodeficiency virus 1 infection
    125089561
   05161 Hepatitis B
    125089561
   05160 Hepatitis C
    125089561
   05164 Influenza A
    125089561
   05162 Measles
    125089561
   05168 Herpes simplex virus 1 infection
    125089561
   05163 Human cytomegalovirus infection
    125089561
   05167 Kaposi sarcoma-associated herpesvirus infection
    125089561
   05169 Epstein-Barr virus infection
    125089561
   05165 Human papillomavirus infection
    125089561
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125089561
   05135 Yersinia infection
    125089561
   05152 Tuberculosis
    125089561
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    125089561
   05142 Chagas disease
    125089561
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125089561
   05017 Spinocerebellar ataxia
    125089561
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125089561
   05418 Fluid shear stress and atherosclerosis
    125089561
   05415 Diabetic cardiomyopathy
    125089561
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    125089561
   04932 Non-alcoholic fatty liver disease
    125089561
   04931 Insulin resistance
    125089561
   04933 AGE-RAGE signaling pathway in diabetic complications
    125089561
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125089561
   01524 Platinum drug resistance
    125089561
   01522 Endocrine resistance
    125089561
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:llv01001]
    125089561
Enzymes [BR:llv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     125089561
Protein kinases [BR:llv01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   125089561
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Kinase-like PH_20 Seadorna_VP7
Other DBs
NCBI-GeneID: 125089561
NCBI-ProteinID: XP_047567791
LinkDB
Position
17:complement(46797956..46846249)
AA seq 510 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPDAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDPM
DYKCGSPSDPSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKASGRYYAM
KILRKEVIIAKDEVAHTVTESWVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQSFCHPSNLRSLLRSTRGTLTMSLPPSPSQ
SRPRTAMTAWALSNWTSGPTFPSSPTRPASASEQSRPPPLTPLQDAPSAAITALGACLFV
FKLFILPFFVCIPIPHLLTPISSFFSPLPN
NT seq 1533 nt   +upstreamnt  +downstreamnt
atgaacgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaag
acctggaggccccggtacttcctgttgaagagtgacggctccttcatcggctacaaggag
cggcctgatgcccctgaccagaccctgccccccctgaacaacttctctgtcgcagaatgc
cagctgatgaagactgagagaccacggcccaatacctttgtcatacgctgcctgcagtgg
accacggtcattgagaggaccttccatgtagactctccagatgagagggaagagtggatg
cgagccattcagatggttgccaacagcctcaagcagcggggcccaggtgaggaccccatg
gactataagtgtggctcccccagcgacccttctgcggctgaggagatggaagtggcagtt
agcaaggcccgggccaaggtgaccatgaatgacttcgactatctcaaacttctgggcaag
ggcacctttggcaaagtgattctggtgcgagagaaggccagcggccggtactatgccatg
aagatcctgcggaaggaagttatcatcgccaaggatgaagttgcccacacggtcaccgag
agctgggtcctacagaacaccagacacccgttcctcaccgccctgaagtacgccttccag
acccatgaccgcctgtgtttcgtgatggagtacgccaatggcggcgagctgtttttccac
ctgtcccgggagcgcgtcttcacggaggagcgggctcgcttctatggcgcagagatcgtc
tctgcccttgagtatctgcactcgagggacgtggtgtaccgtgacatcaagctggaaaac
ctcatgctggacaaagatggccacatcaagatcacggacttcggcctatgcaaagaaggc
atcagtgacggggccaccatgaaaaccttctgtgggacgcccgagtacctggcacctgag
gtgctggaggacaacgactacggccgcgcggtggactggtgggggctgggcgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaagagatccgcttcccgcgcacgctcagccccgaggccaagtccttg
cttgctgggctgcttaagaaggaccccaagcagagcttctgccacccttcaaacctcagg
tcacttctgaggtcgacacgaggtactttgacgatgagtttaccgcccagtccatcacaa
tcacgcccccggaccgctatgacagcctgggctctctcgaactggaccagcggacccact
ttccccagttctcctactcggccagcatccgcgagtgagcagagccgcccaccgccgctg
acgccgctgcaggacgctccatcggctgccatcaccgccctgggggcttgtctctttgtt
tttaaactttttattttgcctttttttgtttgcatccccatccctcacctgctcaccccc
atttccagttttttcagccctctgccaaactga

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