KEGG   Lutra lutra (Eurasian river otter): 125089755
Entry
125089755         CDS       T08100                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
llv  Lutra lutra (Eurasian river otter)
Pathway
llv00562  Inositol phosphate metabolism
llv01100  Metabolic pathways
llv01521  EGFR tyrosine kinase inhibitor resistance
llv04012  ErbB signaling pathway
llv04014  Ras signaling pathway
llv04020  Calcium signaling pathway
llv04062  Chemokine signaling pathway
llv04064  NF-kappa B signaling pathway
llv04066  HIF-1 signaling pathway
llv04070  Phosphatidylinositol signaling system
llv04072  Phospholipase D signaling pathway
llv04360  Axon guidance
llv04370  VEGF signaling pathway
llv04380  Osteoclast differentiation
llv04611  Platelet activation
llv04613  Neutrophil extracellular trap formation
llv04625  C-type lectin receptor signaling pathway
llv04650  Natural killer cell mediated cytotoxicity
llv04662  B cell receptor signaling pathway
llv04664  Fc epsilon RI signaling pathway
llv04666  Fc gamma R-mediated phagocytosis
llv04670  Leukocyte transendothelial migration
llv04722  Neurotrophin signaling pathway
llv04750  Inflammatory mediator regulation of TRP channels
llv04919  Thyroid hormone signaling pathway
llv04933  AGE-RAGE signaling pathway in diabetic complications
llv04935  Growth hormone synthesis, secretion and action
llv05167  Kaposi sarcoma-associated herpesvirus infection
llv05169  Epstein-Barr virus infection
llv05170  Human immunodeficiency virus 1 infection
llv05171  Coronavirus disease - COVID-19
llv05200  Pathways in cancer
llv05205  Proteoglycans in cancer
llv05206  MicroRNAs in cancer
llv05214  Glioma
llv05223  Non-small cell lung cancer
llv05225  Hepatocellular carcinoma
Module
llv_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:llv00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    125089755
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    125089755
   04014 Ras signaling pathway
    125089755
   04370 VEGF signaling pathway
    125089755
   04064 NF-kappa B signaling pathway
    125089755
   04066 HIF-1 signaling pathway
    125089755
   04020 Calcium signaling pathway
    125089755
   04070 Phosphatidylinositol signaling system
    125089755
   04072 Phospholipase D signaling pathway
    125089755
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    125089755
   04613 Neutrophil extracellular trap formation
    125089755
   04625 C-type lectin receptor signaling pathway
    125089755
   04650 Natural killer cell mediated cytotoxicity
    125089755
   04662 B cell receptor signaling pathway
    125089755
   04664 Fc epsilon RI signaling pathway
    125089755
   04666 Fc gamma R-mediated phagocytosis
    125089755
   04670 Leukocyte transendothelial migration
    125089755
   04062 Chemokine signaling pathway
    125089755
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    125089755
   04919 Thyroid hormone signaling pathway
    125089755
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    125089755
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    125089755
  09158 Development and regeneration
   04360 Axon guidance
    125089755
   04380 Osteoclast differentiation
    125089755
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125089755
   05206 MicroRNAs in cancer
    125089755
   05205 Proteoglycans in cancer
    125089755
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    125089755
   05214 Glioma
    125089755
   05223 Non-small cell lung cancer
    125089755
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    125089755
   05171 Coronavirus disease - COVID-19
    125089755
   05167 Kaposi sarcoma-associated herpesvirus infection
    125089755
   05169 Epstein-Barr virus infection
    125089755
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    125089755
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125089755
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:llv04131]
    125089755
Enzymes [BR:llv01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     125089755
Membrane trafficking [BR:llv04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    125089755
 Endocytosis
  Macropinocytosis
   Phospholipase C
    125089755
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH SH3_9 EF-hand_PLCG1 PH_12 SH2_1 SH3_2 PH_14 GDPD EF-hand_like
Other DBs
NCBI-GeneID: 125089755
NCBI-ProteinID: XP_047568144
LinkDB
Position
17:complement(6241360..6382664)
AA seq 1265 aa
MIAPANVDTLPEHEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKVVHQKKDCCFTIFYGTQFVLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDQLLTKPTEASADQLPSPSQLREKFIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDIPPTELHFGEEWFHKKVEKR
TSAERLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYF
LTDNVMFTSIYDLIQHYRETHLRCTEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGRHFVLGTSAYFESLVELVSYY
EKHALYRRMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEISPSMPQRTVKALYDY
KAKRNDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGRNQKQFVFILEPKKQGDPPVEFATDKVEELFEWF
QSIREITWKMDTKENSMKYWEKNQSIAIELSDLVVYCKPTSKAKDNLENPDFREIRSFVE
TKADSVVRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRAEQYDPMPPESQRKILMTLSVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMQPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SRFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgattgccccggccaacgtggacaccctccccgaacacgagaagagtcagatcaagagg
gcgctggagctgggcacagtgatgacggtgttcagcttccgcaagtccaccccagagcgg
aggaccgtccaagtcatcatggagacccgccaggtggcctggagcaagaccgccgacaag
atcgagggtttcttggatatcatggaaatcaaggaaatccgccccgggaagaactccaag
gattttgagcgtgcaaaggttgtgcatcagaagaaagactgctgcttcaccatcttttac
gggacccagttcgtcctcagcaccctcagcctggcagctgactctaaggaggatgcgact
aagtggctctcgggcttgaaaatcttacaccaggaagcgatgagcgcatctacacccacc
atcattgagagctggctgagaaagcagatctattcagtggatcaaaccagaagaaacagc
atcagcctccgagagttaaagaccatcttacccctggtcaacttcaaagtgagcagtgcc
aagttcctcaaagataagtttgtggaaattggcgcacacaaagatgaactcagctttgag
cagttccacctgttctataaaaaacttatgtttgagcagcaaaagtcgattcttgatgaa
ttcaaaaaagattcttctgtgttcatcttgggcaacaccgaccggccggacgcctctgct
gtttacctgcacgacttccagcgctttctcttacacgagcagcaggagctttgggctcag
gatctgaacaaagtccgagagcggatgactaagttcatcgatgacaccatgagggagact
gccgagcccttcttgtttgtcgatgagttcctcacgtacctcttttcgcgggagaacagc
atctgggatgagaagtacgacgtggtggacatgcaggacatgaacaaccccttgtcccat
tactggatttcctcttcgcataacacgtacctcaccggtgaccagctgcggagtgagtcg
tccacagaagcctacatccgctgcctgcgggcgggctgccgctgcattgagctggactgc
tgggatgggcccgacgggaagcccatcatctaccatggctggacacggaccaccaagatc
aagtttgatgacgtcgtgcaggccatcaaagaccatgcctttgtcacctccagcttccca
gtgatcctgtccatcgaggagcactgttgcgtggagcagcagcgccacatggcccgggtg
ttcaaggaggtgtttggcgaccagctgctgacgaagcccacggaggccagcgctgaccag
ctgccctcacccagccagctgcgggagaagttcatcatcaagcataagaagctgggcccc
cggggcgacgtggatgtcaacatggaggacaagaaggatgagcacaagcaacagggtgaa
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgtgccatcgctgat
gccaagctgtcgttcagcgacgacattgaacagacggcagaagaggagctgcctcaggat
ataccccccacagagctgcattttggggaggagtggttccacaagaaggtggagaagagg
acgagtgctgagaggctgctgcaggagtactgtgcggagacggggggcaaagacgggacc
ttcctggtgcgagagagcaagaccttccccaacgactacaccctgtccttctggcggtcc
ggccgggtccagcactgccggatccgttccaccatggagggtgggaccatgaagtacttc
ctgaccgacaatgtcatgttcaccagcatctatgacctcatccagcattaccgcgagaca
cacctgcgctgcaccgagttcgagctccggctcaccgaccccgtgcccaaccccaacccc
cacgagtcaaagccgtggtactacgacgggctgagccgcggggaagcggaggacatgcta
atgagggttccccgggacggggccttcctcatccggaggcgagaaggcaccgactcgtac
gccatcaccttcagggccaggggcaaggtcaagcactgccgcatccaccgggacggccgg
cacttcgtgctggggacctcggcctacttcgagagcctcgtggagctcgtgagctactac
gagaagcacgcgctgtaccggaggatgcggctgcgctaccccgtgacgccggagctcctg
gagcgctacaacatggaaagagacataaactccctttacgacgtcagcagaatgtatgtg
gatcccagtgaaatcagtccctccatgcctcagagaacggtgaaagctctgtatgactac
aaagccaagcggaacgatgagttgagcttctgccgtggagccctcattcacaacgtctcc
aaggagccctggggctggtggaaaggggactatggaaccagaatccagcagtacttcccg
tccaactacgtcgaggacatttccacagccgacgtggaggagctggagaagcagattatt
gaggacaatccgttagggtctctctgtcgggggatattggatctcaacacctataacgtg
gtgaaagcgccccaggggaggaaccagaagcagttcgtgttcatcctggagcccaagaag
caaggcgaccccccggtggagtttgccacggacaaggtggaggagctcttcgagtggttt
cagagtatccgggagatcacgtggaagatggacaccaaggagaacagcatgaagtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtcgtctactgcaagccaacc
agcaaggccaaggacaatctcgaaaaccccgacttccgagaaatccgctcctttgtggag
acgaaggcggacagtgtcgtcaggcagaaacccgtcgacctcctgaagtacaaccagaag
ggcctgactcgagtttaccccaagggacagagggtggactcctccaactacgaccccttt
cgcctctggctgtgcggctcccagatggtggctctcaatttccagactccagataagtac
atgcagatgaaccacgccttgttctcactcaacggtcgcaccggctacgtcctccagcct
gagagcatgagggctgagcagtatgacccgatgcctcccgagtcccagagaaagatcttg
atgactctgtcggtcaaggttctcggggctcgccatctccccaaacttggacgaagtatt
gcgtgtccctttgtggaggtggaaatttgtggagcggagtatgacaacaacaagtttaag
acaacagttgtgaatgacaatggcctcagccctatttgggctccaacacaggaaaaagtg
acctttgaaatttatgaccccaacctggcgtttctgcgttttgtcgtctacgaggaagat
atgttcagtgatcccaacttccttgcccatgccacttaccccatcaaaggaatcaaatcg
ggattcagatctgttcctctgaagaacgggtacagtgaagacatcgagctggcttccctc
ctggttttctgtgagatgcagccagtcctggagagtgaagaggagctctactcctcctgc
cgccagctgcggaggcgacaagaagagctaaacaatcagctctttctgtacgacacacac
cagaacttgcgcaatgccaaccgggacgccctcgttaaagagttcaatgtcaacgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttgagagagaagagagtcagcaac
agcaggttttactcctag

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