Lutra lutra (Eurasian river otter): 125094922
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Entry
125094922 CDS
T08100
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
llv
Lutra lutra (Eurasian river otter)
Pathway
llv00230
Purine metabolism
llv00670
One carbon pool by folate
llv01100
Metabolic pathways
llv01523
Antifolate resistance
Module
llv_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
llv00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
125094922
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
125094922
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
125094922
Enzymes [BR:
llv01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
125094922
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
125094922
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
125094922
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
GARS_N
AIRS_C
GARS_C
AIRS
ATP-grasp
ATP-grasp_2
CPSase_L_D2
ATP-grasp_3
ATP-grasp_4
Dala_Dala_lig_C
Sacchrp_dh_NADP
RimK
ATP-grasp_5
Motif
Other DBs
NCBI-GeneID:
125094922
NCBI-ProteinID:
XP_047576578
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All DBs
Position
1:11580415..11614942
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AA seq
1009 aa
AA seq
DB search
MAARVLVIGSGGREHALAWKLAQSNHVKHVLVAPGNAGTSSLEKISNTAISINDHTALAQ
FCKDEKIEFVVVGPEAPLAAGIVGNLTSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIP
TARWRAFTKPEEACSFIMSADFPALVVKASGLAAGKGVIVAKSKEEACRAVQEIMQDKAY
GAAGETVVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDHGPNTGGMGAYCPAP
QVSKDLFLKIKNTILQRTVDGMQQEGMPYTGVLYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWFENCTAVTVVMASKGYPGDYTKGVEITGFPAA
QALGLEVFHAGTALKDGRVVTNGGRVLTVTAIRENLILALEEAKKGLAAIKFEGAIYRKD
IGYRAIAFLQQPRGLTYKESGVDIAAGNMLVKKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQQCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLNTTEAVVAGIARACGKAGCALLGGETAEMPDMYPPGAYDLAGFAVGAMERDQKLP
HLERITEEDVVVGVASSGLHSNGFSLVRKIVAKSSLQYSSPAPEGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHIKAFAHITGGGLLENIPRVLPQKFGVDLDAQTWRVPRIFSWLQKEG
HLSEEEMARTFNCGIGAALVVSKDLAEQILRDIKQHKEEAWVIGKVVACPEGSPRVKVKN
LIETMQINGSVLENGTVKNHFSVQSKKARVAVLVSGTGSNLQALIDSTREPSSCAHIVVV
ISNKAAVAGLDKAERAGIPTRVINHKLYKSRVEFDTAIDQVLEEYSTDIVCLAGFMRILS
GPFVRKWDGKMLNIHPSLLPSFKGSNAHEQALEAGVTVTGCTVHFVAEDVDAGQIILQES
VPVKRGDTVATLSERVKLAEHKIFPAALQLVASGAVRLGENGKICWVTE
NT seq
3030 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgagtacttgtaattggcagcggtggaagggaacacgcactggcctggaaa
cttgcacagtctaatcatgtcaaacatgtgttggttgccccaggaaatgcaggcacttcc
tccttggaaaagatttcaaatactgccatctcgatcaatgaccacacagcccttgctcag
ttctgcaaagatgagaaaattgaattcgtagttgttggaccagaggcacctctggctgct
ggaattgttgggaacctgacgtctgcaggagtccaatgctttggtcccactgcagaagca
gctcagttagagtccagcaagagattcgccaaagagtttatggaccgacatgggatccca
actgcacggtggagagctttcaccaaacctgaagaagcctgcagctttataatgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcggctggaaaaggagtgattgtt
gccaagagcaaagaagaggcctgcagggctgtacaggagatcatgcaggataaagcttat
ggagcagctggagaaacagttgtcattgaagaacttctggaaggagaagaggtgtcttgt
ctgtgcttcactgatggaaggaccgtggcccccatgcccccagcacaagaccataagcga
ttgctggagggagatcacggccccaacacaggggggatgggagcctattgtccagcacct
caggtttctaaggatttgttcctgaaaataaaaaataccattcttcagaggacagtggat
ggcatgcagcaagagggtatgccatacacaggtgttctctatgctggtataatgctgacc
aaggatggcccaaaagttctggagttcaattgccgtttcggtgatccagagtgccaagtg
atcctcccgcttcttaaaagtgatctttatgaagtgattcagtctaccttggatggcctg
ctctgtacatctctgcctgtttggtttgaaaactgcactgcagtaactgtcgtgatggca
agtaaaggctatccgggagattacaccaagggtgtggagataacagggtttcctgcggct
caagctttaggactggaggtgttccacgcaggcactgccctgaaagatggcagagtggtg
actaacgggggtagagtccttacggtcacagcgatcagggaaaatctcatcttggccctt
gaagaagccaaaaaaggactagctgctataaagtttgagggagccatttacaggaaggac
ataggctatcgtgccatagcttttctccagcagcccaggggcctgacttacaaggaatct
ggggtagacattgcagctggaaatatgctggtcaagaaaattaaacctttagcaaaagct
acctccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcaagtggaacagatggtgttggaactaaactg
aagattgcccagcagtgtaacaaacatgataccattggtcaagatctggttgcaatgtgt
gtcaatgacattctggcccaaggggcagagccccttttcttcctcgattacttttcctgt
ggaaaacttgaccttaatacaactgaagctgttgtcgctggaatcgccagagcctgtgga
aaagctggatgtgctctccttggaggtgaaactgcagaaatgcctgacatgtatcctccg
ggagcatatgacctagctggttttgccgttggtgccatggagcgggatcagaaactccct
cacctggaaagaatcactgaagaggatgttgttgttggagtagcttcatctggtcttcat
agcaatggatttagccttgtaaggaaaattgtagcaaaatcttccctccagtactcatct
ccagcacctgaaggctgtggtgatcagaccttaggggacttacttcttactccaaccaga
atctacagccattcactgctacctgtcctacgttcaggacacatcaaggcctttgcccat
attactggtggaggattgctagaaaacatccccagagtccttcctcagaagtttggggtg
gatttagatgcccagacctggagggtccccaggatcttctcatggttacagaaggaagga
cacctctctgaggaagaaatggccagaacatttaactgtgggattggggctgccctcgtg
gtgtcaaaggatctggcagagcagattctgagagatattaagcagcacaaggaagaagct
tgggtgattggcaaggtggtggcatgtcctgaaggttctcctcgtgtgaaagtcaagaat
ttgatagaaaccatgcaaataaatgggtcagtattggaaaatggcaccgtgaaaaatcat
ttctctgtccagtcaaaaaaggcgagagtggctgtcttagtatctggaacaggatcaaac
ctgcaagctctcatagacagtactagggagccaagtagctgtgcgcacattgtcgtcgtc
atctccaacaaagccgcagtggctggcttagataaagcggagagagctggaattcccacc
agagtaattaatcataaattatataaaagtcgggtagaatttgacactgcaattgaccaa
gtccttgaagagtactccacagacatagtctgtcttgcaggattcatgagaattttatct
ggcccctttgtcaggaaatgggatgggaagatgctcaacatccacccatccttgctccca
tcttttaagggttcaaatgcccacgagcaagccctagaagccggcgtcacagtcaccggg
tgtactgtgcactttgtagctgaagatgtagatgctggacagattattttacaagaatct
gtgccagtgaagagaggtgacactgttgcaactctgtctgaaagagtgaaattagcagag
cacaaaatattccctgcagccctccagctggtagccagtggagctgtacggcttggagaa
aatggcaagatttgttgggtcacagagtga
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