Lutra lutra (Eurasian river otter): 125097987 Help Entry 125097987         CDS       T08100                                  Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism llv  Lutra lutra (Eurasian river otter) Pathway llv01521   EGFR tyrosine kinase inhibitor resistance llv04151   PI3K-Akt signaling pathway llv04217   Necroptosis llv04380   Osteoclast differentiation llv04550   Signaling pathways regulating pluripotency of stem cells llv04620   Toll-like receptor signaling pathway llv04621   NOD-like receptor signaling pathway llv04630   JAK-STAT signaling pathway llv04658   Th1 and Th2 cell differentiation llv04659   Th17 cell differentiation llv05140   Leishmaniasis llv05145   Toxoplasmosis llv05152   Tuberculosis llv05160   Hepatitis C llv05161   Hepatitis B llv05162   Measles llv05163   Human cytomegalovirus infection llv05164   Influenza A llv05165   Human papillomavirus infection llv05166   Human T-cell leukemia virus 1 infection llv05167   Kaposi sarcoma-associated herpesvirus infection llv05168   Herpes simplex virus 1 infection llv05169   Epstein-Barr virus infection llv05171   Coronavirus disease - COVID-19 llv05200   Pathways in cancer llv05203   Viral carcinogenesis llv05212   Pancreatic cancer llv05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:llv00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     125097987    04151 PI3K-Akt signaling pathway     125097987  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     125097987   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     125097987  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     125097987    04621 NOD-like receptor signaling pathway     125097987    04658 Th1 and Th2 cell differentiation     125097987    04659 Th17 cell differentiation     125097987   09158 Development and regeneration    04380 Osteoclast differentiation     125097987  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     125097987    05203 Viral carcinogenesis     125097987    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     125097987   09162 Cancer: specific types    05212 Pancreatic cancer     125097987   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     125097987    05161 Hepatitis B     125097987    05160 Hepatitis C     125097987    05171 Coronavirus disease - COVID-19     125097987    05164 Influenza A     125097987    05162 Measles     125097987    05168 Herpes simplex virus 1 infection     125097987    05163 Human cytomegalovirus infection     125097987    05167 Kaposi sarcoma-associated herpesvirus infection     125097987    05169 Epstein-Barr virus infection     125097987    05165 Human papillomavirus infection     125097987   09171 Infectious disease: bacterial    05152 Tuberculosis     125097987   09174 Infectious disease: parasitic    05145 Toxoplasmosis     125097987    05140 Leishmaniasis     125097987   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     125097987  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:llv01001]     125097987 Enzymes [BR:llv01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      125097987 Protein kinases [BR:llv01001]  Non-receptor tyrosine kinases   JAK family [OT]    125097987 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  125097987 NCBI-ProteinID:  XP_047582251 LinkDB All DBs Position 4:143944812..144069464 Genome browser AA seq 1153 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLQLGSGEYTAEEI CIRAAQECCISPLCHNLFALYDENSKLWYAPNRAITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHPNDSGNVLYYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLESKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLIDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGT LVDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSERKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD YSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPLHCPDEVYQLMRKCWEFQPSNRTT FQNLIEGFEALLK NT seq 3462 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagacggaggtgaatctggaggcccctgagccaggagtggaagtgctcttc tatctttctgatagggagcccctccagctgggcagcggagagtacactgcggaggagatc tgcatcagggcggcgcaggaatgctgtatctctccactgtgtcacaacctctttgccctg tatgacgagaacagcaagctctggtatgccccgaatcgcgccatcactgttgacgacaag acatccctccggctccactaccggatgaggttctatttcaccaactggcatgggaccaat gataatgagcagtctgtatggcgacattctccaaagaagcagaaaaatggctatgagaaa aaaaaagtcccagatgcaacccctctccttgatgccagttctttggaatatctgtttgct cagggacagtatgatttggtcaaatgtctggctcccattcgagaccccaagaccgagcaa gatgggcacgatattgagaatgagtgtctgggaatggctgtcctggccatctcccactat gccatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat attccagaaacattgaataaatccatcagacaaaggaaccttctcaccaggatgcggata aataatgttttcaaggatttcctgaaggaatttaacaacaagactatttgtgacagcagt gtatctactcatgacctaaaggtgaagtacttagccaccttggaaacactgacaaaacat tatggcgcagaaatatttgagacttccatgttactgatttcatcagaaaatgagatgaat tggtttcatccgaacgacagtggaaatgttctctactatgaagtgatggtaactggaaat cttggaatccagtggagacagaaaccaaacgttgttcctgttgaaaaggaaaaaaacaaa ctgaaacggaaaaaactggaaagtaaacacaagaaggatgaggaaaaaaacaaaatccgg gaggagtggaacaatttttcttacttccctgaaatcacccacattgtaataaaggagtct gtggtcagcatcaataaacaggacaacaaaaaaatggaactgaagctctcgtcccatgaa gaggccttgtcctttgtgtccctgatagatggctacttccggctcacagcagatgcccat cattacctctgcaccgatgtggctcccccattgatcgtccacaacatacagaatggttgt cacggtccaatctgcacggaatatgccatcaataagttgcggcaagaaggaagcgaggag gggatgtatgtgctgaggtggagctgtaccgactttgacaatatcctcatgacggtcacc tgctttgagaaatctgaggtgctgggtggccagaagcagttcaagaactttcagatcgaa gtgcagaagggccgctatagcctgcacggctcggaccgcagcttccccagcctgggggac ctgatgagccacctcaagaagcagatcctgcgcacggacaacatcagcttcgtgctgaag cgctgctgccagcccaagccccgagagatctccaatctgctggtggctacgaagaaagcc caggagtggcagcctgtctaccccatgagccagctgagttttgaccggatcctcaagaaa gatatcgtgcaaggtgagcatctcgggagaggcacacggacacacatctactccggcacc ctggtggattacaaggatgacgaagggacttccgaagagaagagaataaaagtgatcctc aaagtcttagaccccagccacagggacatttctctggccttctttgaagcagccagcatg atgaggcaggtctcccacaaacatatcgtgtacctctatggtgtctgtgtccgagatgtg gagaatatcatggtggaggagtttgtggaaggggggcccctcgatctcttcatgcaccgg aaaagcgatgtcctcactacaccatggaagttcaaagttgccaaacagctagccagcgcc ctcagttacttggaggacaaagacctggtccacggaaatgtgtgcacgaaaaaccttctc ctggcccgtgagggtattgacagcgagtgtggcccattcatcaagctcagtgaccctggc atccccattactgtgctgtccaggcaagagtgcatagaacgaatcccgtggattgctccc gagtgtgttgaagactccaagaacctgagtgtggctgctgacaaatggagctttggaacc acactctgggaaatctgctacaatggagagatccctctgaaagacaagaccctgatcgag aaagagagattctacgaaagccggtgccggccagtgacgccatcttgtaaggagctggct gacctcatgacacgctgcatgaactatgaccccaaccagagacccttcttccgagccatc atgagagacatcaacaaactagaagagcagaatccagacattgtttctgaaagaaagccg gcaaccgaagtagatcccacacattttgaaaagcggttcttgaagaggatccgtgacttg ggagagggccactttgggaaggttgagctctgcaggtatgatcctgagggggacaatact ggggagcaagtggcggtgaagtccctgaagcccgagagtggaggcaaccacatagctgat ctgaagaaggaaattgaaatcctaaggaacctctatcatgagaacattgtgaaatacaaa ggcatctgtacggaagacggaggaaatggtattaagctcatcatggaatttctgccttca ggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcaatta aaatacgccgttcagatttgtaaggggatggactatttgggttctcggcagtacgttcac cgggacttggcagcaagaaatgtccttgtcgagagtgagcaccaagtgaaaattggagac tttggtttgaccaaagcaatcgaaactgacaaagagtactacaccgtcaaggatgatcgg gacagccctgtgttttggtatgctcccgaatgtttaattcagtgtaaattttacatcgcc tctgatgtctggtcgtttggagtgactctgcatgagttgctcacttactgcgactcagat tacagccccatggcgttgttcctgaaaatgataggcccaactcatggccagatgacagtc acaagacttgtgaatacattaaaagaaggaaaacgtttgccttgtccacttcactgtcca gatgaggtttatcaacttatgagaaaatgctgggagttccaaccatccaatcggacaact tttcagaaccttatcgaaggatttgaagcacttttaaaataa

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