KEGG   Lutra lutra (Eurasian river otter): 125100627
Entry
125100627         CDS       T08100                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
llv  Lutra lutra (Eurasian river otter)
Pathway
llv00562  Inositol phosphate metabolism
llv01100  Metabolic pathways
llv01521  EGFR tyrosine kinase inhibitor resistance
llv01522  Endocrine resistance
llv01524  Platinum drug resistance
llv04012  ErbB signaling pathway
llv04014  Ras signaling pathway
llv04015  Rap1 signaling pathway
llv04024  cAMP signaling pathway
llv04062  Chemokine signaling pathway
llv04066  HIF-1 signaling pathway
llv04068  FoxO signaling pathway
llv04070  Phosphatidylinositol signaling system
llv04071  Sphingolipid signaling pathway
llv04072  Phospholipase D signaling pathway
llv04081  Hormone signaling
llv04140  Autophagy - animal
llv04150  mTOR signaling pathway
llv04151  PI3K-Akt signaling pathway
llv04152  AMPK signaling pathway
llv04210  Apoptosis
llv04211  Longevity regulating pathway
llv04213  Longevity regulating pathway - multiple species
llv04218  Cellular senescence
llv04360  Axon guidance
llv04370  VEGF signaling pathway
llv04380  Osteoclast differentiation
llv04510  Focal adhesion
llv04517  IgSF CAM signaling
llv04550  Signaling pathways regulating pluripotency of stem cells
llv04611  Platelet activation
llv04613  Neutrophil extracellular trap formation
llv04620  Toll-like receptor signaling pathway
llv04625  C-type lectin receptor signaling pathway
llv04630  JAK-STAT signaling pathway
llv04650  Natural killer cell mediated cytotoxicity
llv04660  T cell receptor signaling pathway
llv04662  B cell receptor signaling pathway
llv04664  Fc epsilon RI signaling pathway
llv04666  Fc gamma R-mediated phagocytosis
llv04668  TNF signaling pathway
llv04670  Leukocyte transendothelial migration
llv04722  Neurotrophin signaling pathway
llv04725  Cholinergic synapse
llv04750  Inflammatory mediator regulation of TRP channels
llv04810  Regulation of actin cytoskeleton
llv04910  Insulin signaling pathway
llv04914  Progesterone-mediated oocyte maturation
llv04915  Estrogen signaling pathway
llv04917  Prolactin signaling pathway
llv04919  Thyroid hormone signaling pathway
llv04923  Regulation of lipolysis in adipocytes
llv04926  Relaxin signaling pathway
llv04929  GnRH secretion
llv04930  Type II diabetes mellitus
llv04931  Insulin resistance
llv04932  Non-alcoholic fatty liver disease
llv04933  AGE-RAGE signaling pathway in diabetic complications
llv04935  Growth hormone synthesis, secretion and action
llv04960  Aldosterone-regulated sodium reabsorption
llv04973  Carbohydrate digestion and absorption
llv05010  Alzheimer disease
llv05017  Spinocerebellar ataxia
llv05020  Prion disease
llv05100  Bacterial invasion of epithelial cells
llv05132  Salmonella infection
llv05135  Yersinia infection
llv05142  Chagas disease
llv05146  Amoebiasis
llv05160  Hepatitis C
llv05161  Hepatitis B
llv05162  Measles
llv05163  Human cytomegalovirus infection
llv05164  Influenza A
llv05165  Human papillomavirus infection
llv05166  Human T-cell leukemia virus 1 infection
llv05167  Kaposi sarcoma-associated herpesvirus infection
llv05168  Herpes simplex virus 1 infection
llv05169  Epstein-Barr virus infection
llv05170  Human immunodeficiency virus 1 infection
llv05171  Coronavirus disease - COVID-19
llv05200  Pathways in cancer
llv05203  Viral carcinogenesis
llv05205  Proteoglycans in cancer
llv05206  MicroRNAs in cancer
llv05207  Chemical carcinogenesis - receptor activation
llv05208  Chemical carcinogenesis - reactive oxygen species
llv05210  Colorectal cancer
llv05211  Renal cell carcinoma
llv05212  Pancreatic cancer
llv05213  Endometrial cancer
llv05214  Glioma
llv05215  Prostate cancer
llv05218  Melanoma
llv05220  Chronic myeloid leukemia
llv05221  Acute myeloid leukemia
llv05222  Small cell lung cancer
llv05223  Non-small cell lung cancer
llv05224  Breast cancer
llv05225  Hepatocellular carcinoma
llv05226  Gastric cancer
llv05230  Central carbon metabolism in cancer
llv05231  Choline metabolism in cancer
llv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
llv05415  Diabetic cardiomyopathy
llv05417  Lipid and atherosclerosis
llv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:llv00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    125100627
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    125100627
   04014 Ras signaling pathway
    125100627
   04015 Rap1 signaling pathway
    125100627
   04370 VEGF signaling pathway
    125100627
   04630 JAK-STAT signaling pathway
    125100627
   04668 TNF signaling pathway
    125100627
   04066 HIF-1 signaling pathway
    125100627
   04068 FoxO signaling pathway
    125100627
   04070 Phosphatidylinositol signaling system
    125100627
   04072 Phospholipase D signaling pathway
    125100627
   04071 Sphingolipid signaling pathway
    125100627
   04024 cAMP signaling pathway
    125100627
   04151 PI3K-Akt signaling pathway
    125100627
   04152 AMPK signaling pathway
    125100627
   04150 mTOR signaling pathway
    125100627
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    125100627
   04517 IgSF CAM signaling
    125100627
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    125100627
  09143 Cell growth and death
   04210 Apoptosis
    125100627
   04218 Cellular senescence
    125100627
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    125100627
   04550 Signaling pathways regulating pluripotency of stem cells
    125100627
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125100627
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    125100627
   04613 Neutrophil extracellular trap formation
    125100627
   04620 Toll-like receptor signaling pathway
    125100627
   04625 C-type lectin receptor signaling pathway
    125100627
   04650 Natural killer cell mediated cytotoxicity
    125100627
   04660 T cell receptor signaling pathway
    125100627
   04662 B cell receptor signaling pathway
    125100627
   04664 Fc epsilon RI signaling pathway
    125100627
   04666 Fc gamma R-mediated phagocytosis
    125100627
   04670 Leukocyte transendothelial migration
    125100627
   04062 Chemokine signaling pathway
    125100627
  09152 Endocrine system
   04910 Insulin signaling pathway
    125100627
   04923 Regulation of lipolysis in adipocytes
    125100627
   04929 GnRH secretion
    125100627
   04915 Estrogen signaling pathway
    125100627
   04914 Progesterone-mediated oocyte maturation
    125100627
   04917 Prolactin signaling pathway
    125100627
   04926 Relaxin signaling pathway
    125100627
   04935 Growth hormone synthesis, secretion and action
    125100627
   04919 Thyroid hormone signaling pathway
    125100627
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    125100627
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    125100627
  09156 Nervous system
   04725 Cholinergic synapse
    125100627
   04722 Neurotrophin signaling pathway
    125100627
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    125100627
  09158 Development and regeneration
   04360 Axon guidance
    125100627
   04380 Osteoclast differentiation
    125100627
  09149 Aging
   04211 Longevity regulating pathway
    125100627
   04213 Longevity regulating pathway - multiple species
    125100627
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125100627
   05206 MicroRNAs in cancer
    125100627
   05205 Proteoglycans in cancer
    125100627
   05207 Chemical carcinogenesis - receptor activation
    125100627
   05208 Chemical carcinogenesis - reactive oxygen species
    125100627
   05203 Viral carcinogenesis
    125100627
   05230 Central carbon metabolism in cancer
    125100627
   05231 Choline metabolism in cancer
    125100627
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125100627
  09162 Cancer: specific types
   05210 Colorectal cancer
    125100627
   05212 Pancreatic cancer
    125100627
   05225 Hepatocellular carcinoma
    125100627
   05226 Gastric cancer
    125100627
   05214 Glioma
    125100627
   05221 Acute myeloid leukemia
    125100627
   05220 Chronic myeloid leukemia
    125100627
   05218 Melanoma
    125100627
   05211 Renal cell carcinoma
    125100627
   05215 Prostate cancer
    125100627
   05213 Endometrial cancer
    125100627
   05224 Breast cancer
    125100627
   05222 Small cell lung cancer
    125100627
   05223 Non-small cell lung cancer
    125100627
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    125100627
   05170 Human immunodeficiency virus 1 infection
    125100627
   05161 Hepatitis B
    125100627
   05160 Hepatitis C
    125100627
   05171 Coronavirus disease - COVID-19
    125100627
   05164 Influenza A
    125100627
   05162 Measles
    125100627
   05168 Herpes simplex virus 1 infection
    125100627
   05163 Human cytomegalovirus infection
    125100627
   05167 Kaposi sarcoma-associated herpesvirus infection
    125100627
   05169 Epstein-Barr virus infection
    125100627
   05165 Human papillomavirus infection
    125100627
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125100627
   05135 Yersinia infection
    125100627
   05100 Bacterial invasion of epithelial cells
    125100627
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    125100627
   05142 Chagas disease
    125100627
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125100627
   05017 Spinocerebellar ataxia
    125100627
   05020 Prion disease
    125100627
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125100627
   05418 Fluid shear stress and atherosclerosis
    125100627
   05415 Diabetic cardiomyopathy
    125100627
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    125100627
   04932 Non-alcoholic fatty liver disease
    125100627
   04931 Insulin resistance
    125100627
   04933 AGE-RAGE signaling pathway in diabetic complications
    125100627
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125100627
   01524 Platinum drug resistance
    125100627
   01522 Endocrine resistance
    125100627
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:llv04131]
    125100627
Enzymes [BR:llv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     125100627
Membrane trafficking [BR:llv04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    125100627
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 125100627
NCBI-ProteinID: XP_047586909
LinkDB
Position
1:103559582..103644276
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaacgggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagagaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataagttagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaaccagaagtatgttgctatcatctgaacaactcaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgagaaatatcctctaagtcagtataagtacataagaagctgtataatgctgggg
aggatgcccaatttgatgctgatggctaaagaaagcctttattcccaactgccaatggac
tgtttcacaatgccttcatattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgcgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctaaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattatacagatactctagtatctggaaaa
atggctctgaatctgtggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaacaccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtcggtg
tctcgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaacgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggctatggag
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttagaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacggtt
agtcagaggtttggccttcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgatatcctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcagatgcgg
cgaccagatttcatggatgctctccaaggttttctatctcctcttaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacgtcaagatatgctaacacttcaaataattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatctccgaatgttaccttatggttgtctgtca
attggtgattgtgtgggacttattgaggtggtgcgaaattctcacacgattatgcagatt
cagtgcaaaggtggcctgaaaggcgctctgcagtttaacagccacacactccaccagtgg
ctcaaagacaagaacaaaggagaaatatatgatgctgccattgacctgttcacacgttca
tgtgctggatattgtgtcgctaccttcattctgggcattggagaccgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagactttggacactttttggatcac
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgctacaaggcttatctggctatccggcagcacgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaaccgaacaagaagctttggaatatttcatg
aaacaaatgaatgacgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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