KEGG   Lutra lutra (Eurasian river otter): 125103018
Entry
125103018         CDS       T08100                                 
Name
(RefSeq) mitogen-activated protein kinase 13
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
llv  Lutra lutra (Eurasian river otter)
Pathway
llv01522  Endocrine resistance
llv04010  MAPK signaling pathway
llv04015  Rap1 signaling pathway
llv04068  FoxO signaling pathway
llv04071  Sphingolipid signaling pathway
llv04114  Oocyte meiosis
llv04148  Efferocytosis
llv04218  Cellular senescence
llv04261  Adrenergic signaling in cardiomyocytes
llv04370  VEGF signaling pathway
llv04380  Osteoclast differentiation
llv04550  Signaling pathways regulating pluripotency of stem cells
llv04611  Platelet activation
llv04613  Neutrophil extracellular trap formation
llv04620  Toll-like receptor signaling pathway
llv04621  NOD-like receptor signaling pathway
llv04622  RIG-I-like receptor signaling pathway
llv04625  C-type lectin receptor signaling pathway
llv04657  IL-17 signaling pathway
llv04658  Th1 and Th2 cell differentiation
llv04659  Th17 cell differentiation
llv04660  T cell receptor signaling pathway
llv04664  Fc epsilon RI signaling pathway
llv04668  TNF signaling pathway
llv04670  Leukocyte transendothelial migration
llv04714  Thermogenesis
llv04722  Neurotrophin signaling pathway
llv04723  Retrograde endocannabinoid signaling
llv04728  Dopaminergic synapse
llv04750  Inflammatory mediator regulation of TRP channels
llv04912  GnRH signaling pathway
llv04914  Progesterone-mediated oocyte maturation
llv04917  Prolactin signaling pathway
llv04926  Relaxin signaling pathway
llv04932  Non-alcoholic fatty liver disease
llv04933  AGE-RAGE signaling pathway in diabetic complications
llv04935  Growth hormone synthesis, secretion and action
llv04936  Alcoholic liver disease
llv05014  Amyotrophic lateral sclerosis
llv05020  Prion disease
llv05022  Pathways of neurodegeneration - multiple diseases
llv05132  Salmonella infection
llv05133  Pertussis
llv05135  Yersinia infection
llv05140  Leishmaniasis
llv05142  Chagas disease
llv05145  Toxoplasmosis
llv05152  Tuberculosis
llv05161  Hepatitis B
llv05163  Human cytomegalovirus infection
llv05167  Kaposi sarcoma-associated herpesvirus infection
llv05169  Epstein-Barr virus infection
llv05170  Human immunodeficiency virus 1 infection
llv05171  Coronavirus disease - COVID-19
llv05205  Proteoglycans in cancer
llv05208  Chemical carcinogenesis - reactive oxygen species
llv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
llv05415  Diabetic cardiomyopathy
llv05417  Lipid and atherosclerosis
llv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:llv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125103018
   04015 Rap1 signaling pathway
    125103018
   04370 VEGF signaling pathway
    125103018
   04668 TNF signaling pathway
    125103018
   04068 FoxO signaling pathway
    125103018
   04071 Sphingolipid signaling pathway
    125103018
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    125103018
  09143 Cell growth and death
   04114 Oocyte meiosis
    125103018
   04218 Cellular senescence
    125103018
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    125103018
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    125103018
   04613 Neutrophil extracellular trap formation
    125103018
   04620 Toll-like receptor signaling pathway
    125103018
   04621 NOD-like receptor signaling pathway
    125103018
   04622 RIG-I-like receptor signaling pathway
    125103018
   04625 C-type lectin receptor signaling pathway
    125103018
   04660 T cell receptor signaling pathway
    125103018
   04658 Th1 and Th2 cell differentiation
    125103018
   04659 Th17 cell differentiation
    125103018
   04657 IL-17 signaling pathway
    125103018
   04664 Fc epsilon RI signaling pathway
    125103018
   04670 Leukocyte transendothelial migration
    125103018
  09152 Endocrine system
   04912 GnRH signaling pathway
    125103018
   04914 Progesterone-mediated oocyte maturation
    125103018
   04917 Prolactin signaling pathway
    125103018
   04926 Relaxin signaling pathway
    125103018
   04935 Growth hormone synthesis, secretion and action
    125103018
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    125103018
  09156 Nervous system
   04728 Dopaminergic synapse
    125103018
   04723 Retrograde endocannabinoid signaling
    125103018
   04722 Neurotrophin signaling pathway
    125103018
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    125103018
  09158 Development and regeneration
   04380 Osteoclast differentiation
    125103018
  09159 Environmental adaptation
   04714 Thermogenesis
    125103018
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    125103018
   05208 Chemical carcinogenesis - reactive oxygen species
    125103018
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125103018
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    125103018
   05161 Hepatitis B
    125103018
   05171 Coronavirus disease - COVID-19
    125103018
   05163 Human cytomegalovirus infection
    125103018
   05167 Kaposi sarcoma-associated herpesvirus infection
    125103018
   05169 Epstein-Barr virus infection
    125103018
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125103018
   05135 Yersinia infection
    125103018
   05133 Pertussis
    125103018
   05152 Tuberculosis
    125103018
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    125103018
   05140 Leishmaniasis
    125103018
   05142 Chagas disease
    125103018
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    125103018
   05020 Prion disease
    125103018
   05022 Pathways of neurodegeneration - multiple diseases
    125103018
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125103018
   05418 Fluid shear stress and atherosclerosis
    125103018
   05415 Diabetic cardiomyopathy
    125103018
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    125103018
   04932 Non-alcoholic fatty liver disease
    125103018
   04933 AGE-RAGE signaling pathway in diabetic complications
    125103018
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    125103018
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:llv01001]
    125103018
Enzymes [BR:llv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     125103018
Protein kinases [BR:llv01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   125103018
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH RIO1 Kdo Kinase-like DUF3231
Other DBs
NCBI-GeneID: 125103018
NCBI-ProteinID: XP_047590704
LinkDB
Position
6:35093540..35101902
AA seq 366 aa
MSFTRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGAVCSAIDKRSGEKVAIKKLSRPF
QSEIFAKRAYRELRLLKHMQHENVIGLLDVFTSASSLRSFHDFYLVMPFMQTDLQKIMGM
EFSEDKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT
GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLSQILKVTG
VPGAEFVQKLNDKAAKSYIQALPQSPKKDFSQLFPRASPQAIDLLEKILELDVDKRLTAS
QALAHPFFEPFRDPEEETEAPQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARRDSRRR
SGMKLQ
NT seq 1101 nt   +upstreamnt  +downstreamnt
atgagcttcacgcggaaaaagggcttctacaagcaggacgtcaacaagactgcctgggag
ctgcccaagacctacgtgtccccgacgcacgtaggcagcggggcgtatggcgccgtgtgc
tctgccatcgacaagcggtcaggggagaaggtggccatcaagaagctgagccggcccttc
cagtccgagatctttgccaagcgggcctaccgagagctgcggctgctgaagcacatgcag
catgagaacgtcatcgggctcctggatgtcttcacctcagcctcctccctgcgcagtttc
catgacttctacctggtgatgcccttcatgcagacggacctgcagaagatcatggggatg
gagttcagtgaggacaagatccagtacctggtgtatcaaatgctcaagggtctcaagtat
atccactcagctggggtcgtgcacagggacctgaagccgggcaacctggccgtgaatgag
gattgcgagctgaagatcttggattttgggctggcccggcatgcggacgccgagatgacg
ggctacgtggtgacccgctggtaccgggcccctgaggtgatcctcagctggatgcactac
aatcagactgtggacatctggtctgtgggctgtatcatggcagagatgctgacggggaaa
actctgttcaaggggaaagattacctggaccagctgtcccagatcctaaaagtgaccgga
gtgccaggggcagagtttgtgcagaagctgaacgacaaagcagccaaatcctacatccag
gccctgccacagagtcccaagaaggatttctctcagctcttcccacgtgccagtccccag
gccatagacctgctggagaagattctggagctggatgtggacaagcgcctgacggcttcg
caggcccttgcccaccccttctttgagcccttccgagaccccgaggaggagacagaggcc
ccgcagccatttgatgattccttagaacatgagaaactcacggtggatgaatggaagcag
cacatctacaaagagatcgtgaacttcagtcccattgcccggagggactcacggcgccgc
agcggcatgaagctgcagtga

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