Lutra lutra (Eurasian river otter): 125106490 Help Entry 125106490         CDS       T08100                                  Name (RefSeq) adenylate cyclase type 6   KO K08046   adenylate cyclase 6 [EC:4.6.1.1] Organism llv  Lutra lutra (Eurasian river otter) Pathway llv00230   Purine metabolism llv01100   Metabolic pathways llv01522   Endocrine resistance llv04015   Rap1 signaling pathway llv04022   cGMP-PKG signaling pathway llv04024   cAMP signaling pathway llv04062   Chemokine signaling pathway llv04072   Phospholipase D signaling pathway llv04081   Hormone signaling llv04082   Neuroactive ligand signaling llv04114   Oocyte meiosis llv04211   Longevity regulating pathway llv04213   Longevity regulating pathway - multiple species llv04261   Adrenergic signaling in cardiomyocytes llv04270   Vascular smooth muscle contraction llv04371   Apelin signaling pathway llv04540   Gap junction llv04611   Platelet activation llv04713   Circadian entrainment llv04714   Thermogenesis llv04723   Retrograde endocannabinoid signaling llv04724   Glutamatergic synapse llv04725   Cholinergic synapse llv04727   GABAergic synapse llv04742   Taste transduction llv04750   Inflammatory mediator regulation of TRP channels llv04911   Insulin secretion llv04912   GnRH signaling pathway llv04913   Ovarian steroidogenesis llv04914   Progesterone-mediated oocyte maturation llv04915   Estrogen signaling pathway llv04916   Melanogenesis llv04918   Thyroid hormone synthesis llv04921   Oxytocin signaling pathway llv04923   Regulation of lipolysis in adipocytes llv04924   Renin secretion llv04925   Aldosterone synthesis and secretion llv04926   Relaxin signaling pathway llv04927   Cortisol synthesis and secretion llv04928   Parathyroid hormone synthesis, secretion and action llv04934   Cushing syndrome llv04935   Growth hormone synthesis, secretion and action llv04961   Endocrine and other factor-regulated calcium reabsorption llv04962   Vasopressin-regulated water reabsorption llv04970   Salivary secretion llv04971   Gastric acid secretion llv04972   Pancreatic secretion llv04976   Bile secretion llv05032   Morphine addiction llv05163   Human cytomegalovirus infection llv05166   Human T-cell leukemia virus 1 infection llv05200   Pathways in cancer llv05207   Chemical carcinogenesis - receptor activation llv05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:llv00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     125106490  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     125106490    04371 Apelin signaling pathway     125106490    04072 Phospholipase D signaling pathway     125106490    04024 cAMP signaling pathway     125106490    04022 cGMP-PKG signaling pathway     125106490   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     125106490    04081 Hormone signaling     125106490  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     125106490   09144 Cellular community - eukaryotes    04540 Gap junction     125106490  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     125106490    04062 Chemokine signaling pathway     125106490   09152 Endocrine system    04911 Insulin secretion     125106490    04923 Regulation of lipolysis in adipocytes     125106490    04912 GnRH signaling pathway     125106490    04913 Ovarian steroidogenesis     125106490    04915 Estrogen signaling pathway     125106490    04914 Progesterone-mediated oocyte maturation     125106490    04921 Oxytocin signaling pathway     125106490    04926 Relaxin signaling pathway     125106490    04935 Growth hormone synthesis, secretion and action     125106490    04918 Thyroid hormone synthesis     125106490    04928 Parathyroid hormone synthesis, secretion and action     125106490    04916 Melanogenesis     125106490    04924 Renin secretion     125106490    04925 Aldosterone synthesis and secretion     125106490    04927 Cortisol synthesis and secretion     125106490   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     125106490    04270 Vascular smooth muscle contraction     125106490   09154 Digestive system    04970 Salivary secretion     125106490    04971 Gastric acid secretion     125106490    04972 Pancreatic secretion     125106490    04976 Bile secretion     125106490   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     125106490    04961 Endocrine and other factor-regulated calcium reabsorption     125106490   09156 Nervous system    04724 Glutamatergic synapse     125106490    04727 GABAergic synapse     125106490    04725 Cholinergic synapse     125106490    04723 Retrograde endocannabinoid signaling     125106490   09157 Sensory system    04742 Taste transduction     125106490    04750 Inflammatory mediator regulation of TRP channels     125106490   09149 Aging    04211 Longevity regulating pathway     125106490    04213 Longevity regulating pathway - multiple species     125106490   09159 Environmental adaptation    04713 Circadian entrainment     125106490    04714 Thermogenesis     125106490  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     125106490    05207 Chemical carcinogenesis - receptor activation     125106490   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     125106490    05163 Human cytomegalovirus infection     125106490   09165 Substance dependence    05032 Morphine addiction     125106490   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     125106490   09167 Endocrine and metabolic disease    04934 Cushing syndrome     125106490   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     125106490 Enzymes [BR:llv01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      125106490 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom HNOBA TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  125106490 NCBI-ProteinID:  XP_047596542 LinkDB All DBs Position 8:59393886..59415415 Genome browser AA seq 1166 aa AA seqDB search MSWFSGLLVPKVDERKTAWGERNGQKRPRRGTRTGGFCTPRYMSCLREAQPPSPSPAAPP RCPWQDEAFIRRGGPGKSNELGLRAVALGFEDTEATAAVGVADVVPDGSPRRWWSCWRRL AQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTVVLLAFHAAPAPPQPAYVT LLACAATLFVALMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSVGLWCP VFFVYITYTLLPIRMRAAVFSGLGLSTLHLILAWQLNRGDAFLWKQLGANMLLFLCTNVI GICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKK EDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLR IKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHC GVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYL KEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLGPRWAPDRAFSRTKDSKAFRQM GIDDSSKDNRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYS RKVDPRFGAYVACALLVFCFICFIQLLVFPHSTVMLGIYAGTFLLLLITVLTCAVSSCGS LFPKALRHLSRSIVRSRAHSTVVGIFSVLLVFTSAIANMFTCNHTPIRNCAARMLNVTPT DITACHLQQLNYSLGLDAPLCEGTAPTCSFPEYFVGNMLLSLLASSVFLHISSIGKLAMV FILGLIYLVLLLLGPPATIFDNYDLLLSVHGLASSNETFDGPDCPAAGRVALKYMTPVIL LVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLA RERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEE RFRQLEKIKTIGSTYMAASGLNASTYDQAGRSHITALADYAMRLMEQMKHINEHSFNNFQ MKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQ LECRGVVKVKGKGEMTTYFLNGGPPS NT seq 3501 nt NT seq  +upstreamnt  +downstreamnt atgtcgtggtttagtggcctcctggtccccaaagtggatgaacggaaaacagcctggggt gagcgcaatgggcagaagcgtccgcgccgtgggacccggacaggtggcttctgcacgccc cgctacatgagctgcctccgggaggcccagccccccagtcccagccccgctgctccccca cggtgcccctggcaggacgaagccttcatccggaggggtggcccgggcaagagcaatgag ctggggctgcgggcagtggccctgggctttgaggacacagaggcgacggcagcagtgggg gtggccgatgtggtgcccgacgggagccccaggcgttggtggtcgtgctggcggcgtctg gcccaggtgttccagtcgaagcagttccgctcggccaagctggagcgcctgtaccagcgg tacttcttccagatgaaccagagcagcctgacactgctgatggccgtgctggtgctactg acagtggtgctgctggccttccacgcagcgcctgcccccccgcagcctgcctatgtgacc ctgctggcctgcgccgccaccctctttgtggcgcttatggtggtgtgcaaccggcacagc ttccgccaggactccatgtgggtggtgagctacgtggtgctgggcatcctggcagctgtg caggtggggggcgccctggcggctgacccccgcagcccctcggtgggcctctggtgtccc gtgtttttcgtctacatcacctacacgctcctgcccatccgcatgcgggcggctgtcttc agtggcctgggcctctccaccctgcatctgatcttggcctggcaactcaaccgcggggac gccttcctctggaagcagctgggcgccaacatgctgctgttcctctgtaccaacgtcatt ggcatctgcacacactacccggcggaggtgtcccagcgccaggcctttcaggagacccgc ggttatatccaggcccggctgcacctgcagcacgagaaccggcagcaggaacggctgctg ctgtccgtgttgccccagcatgttgccatggagatgaaagaagacatcaacacaaagaaa gaagacatgatgttccacaagatctacatccagaagcatgacaatgtcagcatcctgttt gcggacattgaaggcttcaccagcctggcgtcccagtgcaccgcacaggagctggtcatg accctgaacgagctctttgcccggtttgacaagctggctgcggaaaatcactgcctgagg atcaagatcttaggggactgttactactgtgtgtcggggctgccggaggcccgggcagac catgcccactgctgtgtggagatgggggtggacatgatcgaggccatctcgctggtgcgc gaggtgacaggtgtgaacgtgaacatgcgcgtgggcatccacagcgggcgtgtgcactgt ggtgtcctcggcctgcggaaatggcagttcgacgtgtggtccaacgacgtgacactggcc aaccacatggaagcggggggccgggccggccgcatccacatcacccgggccacgctgcag tacctgaatggggactacgaggtggagccaggccgaggcggtgagcggaacgcctacctc aaggagcagcacatcgagaccttcctcatcctgggagccagccagaaacggaaagaggag aaggccatgctggccaagctgcagcggacgcgggccaactccatggaagggctggggcca cgctgggcacccgaccgcgccttctcccggaccaaggactccaaggctttccgtcagatg ggcattgatgattccagcaaggacaaccggggtgcccaagatgccctgaatcccgaggat gaagtagatgagttcctgggccgtgccatcgacgcccgcagcatcgaccagctacggaag gaccatgtgcgccgcttcctgctcaccttccagagagaggatcttgaaaagaagtactcg cggaaggtggacccccgcttcggagcctacgtggcctgtgccctgttggtcttctgcttc atctgcttcatccagcttctcgtcttcccacactccaccgtgatgcttggtatctatgcc ggtaccttcctgctgttgctgatcactgtgctgacctgtgccgtgtcctcgtgtggctct ctcttccccaaggccctgcgccatctttcccgcagcattgtccgctctcgggcacacagc actgtggttggcatcttttcagtcttgcttgtgttcacctctgccatcgccaacatgttc acctgcaaccacacccccatacggaactgcgcagcccggatgctgaatgtgacacccacc gacatcaccgcctgtcacctgcagcagctcaattactctctgggtctggacgctcccctt tgtgagggcaccgcacccacttgcagcttccctgagtacttcgttgggaacatgctgctg agtctcttggccagctctgtcttcctgcacatcagcagcatcggaaagctggccatggtc tttatcctggggctcatctatttggtgctgcttctgctgggccccccagccaccatcttt gacaactacgacctgctgcttagtgtccatggcttggcttcttccaacgagactttcgat gggccggactgcccagctgccgggagggtggcgctcaagtacatgacccccgtgattctg ctggtgtttgcactggcgctgtatctgcatgcccagcaggtggaatcgactgcccggctg gacttcctctggaaactgcaggcaacaggggagaaggaggagatggaggaactgcaggca tacaaccggaggctgctgcataacattctgcccaaggacgtggctgcccacttcctggcc cgggagcgtcggaacgatgagctctactaccagtcgtgtgaatgtgtggccgtcatgttt gcctccattgccaacttttctgagttctatgtggagctggaggcaaacaatgagggtgtc gagtgcctgcggctgctcaatgagatcattgctgactttgatgagatcatcagcgaggag cgcttccggcagctggagaagatcaagacgatcgggagcacctacatggcggcctcagga ctgaacgccagcacctacgatcaggccggccgctcccacatcactgccttggcagactat gccatgcggctcatggagcagatgaaacacatcaacgagcactccttcaacaatttccag atgaagattgggctgaacatgggcccagttgtggcaggcgtcattggggctcggaagcca cagtatgacatctgggggaacacagtgaatgtctctagccgtatggacagcacgggtgtc cctgaccgaatccaggtgaccacggacttgtaccaggttctagctgccaaaggctaccag ctggagtgtcgaggggtggtcaaggtgaagggcaagggggagatgaccacctacttcctc aatgggggccctcccagttag

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