KEGG   Lutra lutra (Eurasian river otter): 125108926
Entry
125108926         CDS       T08100                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
llv  Lutra lutra (Eurasian river otter)
Pathway
llv00562  Inositol phosphate metabolism
llv01100  Metabolic pathways
llv04015  Rap1 signaling pathway
llv04020  Calcium signaling pathway
llv04022  cGMP-PKG signaling pathway
llv04062  Chemokine signaling pathway
llv04070  Phosphatidylinositol signaling system
llv04071  Sphingolipid signaling pathway
llv04072  Phospholipase D signaling pathway
llv04081  Hormone signaling
llv04082  Neuroactive ligand signaling
llv04261  Adrenergic signaling in cardiomyocytes
llv04270  Vascular smooth muscle contraction
llv04310  Wnt signaling pathway
llv04371  Apelin signaling pathway
llv04540  Gap junction
llv04611  Platelet activation
llv04613  Neutrophil extracellular trap formation
llv04621  NOD-like receptor signaling pathway
llv04713  Circadian entrainment
llv04720  Long-term potentiation
llv04723  Retrograde endocannabinoid signaling
llv04724  Glutamatergic synapse
llv04725  Cholinergic synapse
llv04726  Serotonergic synapse
llv04728  Dopaminergic synapse
llv04730  Long-term depression
llv04742  Taste transduction
llv04750  Inflammatory mediator regulation of TRP channels
llv04911  Insulin secretion
llv04912  GnRH signaling pathway
llv04915  Estrogen signaling pathway
llv04916  Melanogenesis
llv04918  Thyroid hormone synthesis
llv04919  Thyroid hormone signaling pathway
llv04921  Oxytocin signaling pathway
llv04922  Glucagon signaling pathway
llv04924  Renin secretion
llv04925  Aldosterone synthesis and secretion
llv04926  Relaxin signaling pathway
llv04927  Cortisol synthesis and secretion
llv04928  Parathyroid hormone synthesis, secretion and action
llv04929  GnRH secretion
llv04933  AGE-RAGE signaling pathway in diabetic complications
llv04934  Cushing syndrome
llv04935  Growth hormone synthesis, secretion and action
llv04961  Endocrine and other factor-regulated calcium reabsorption
llv04970  Salivary secretion
llv04971  Gastric acid secretion
llv04972  Pancreatic secretion
llv04973  Carbohydrate digestion and absorption
llv05010  Alzheimer disease
llv05016  Huntington disease
llv05017  Spinocerebellar ataxia
llv05022  Pathways of neurodegeneration - multiple diseases
llv05142  Chagas disease
llv05143  African trypanosomiasis
llv05146  Amoebiasis
llv05163  Human cytomegalovirus infection
llv05200  Pathways in cancer
llv05415  Diabetic cardiomyopathy
llv05417  Lipid and atherosclerosis
Module
llv_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:llv00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    125108926
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    125108926
   04310 Wnt signaling pathway
    125108926
   04371 Apelin signaling pathway
    125108926
   04020 Calcium signaling pathway
    125108926
   04070 Phosphatidylinositol signaling system
    125108926
   04072 Phospholipase D signaling pathway
    125108926
   04071 Sphingolipid signaling pathway
    125108926
   04022 cGMP-PKG signaling pathway
    125108926
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    125108926
   04081 Hormone signaling
    125108926
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    125108926
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    125108926
   04613 Neutrophil extracellular trap formation
    125108926
   04621 NOD-like receptor signaling pathway
    125108926
   04062 Chemokine signaling pathway
    125108926
  09152 Endocrine system
   04911 Insulin secretion
    125108926
   04922 Glucagon signaling pathway
    125108926
   04929 GnRH secretion
    125108926
   04912 GnRH signaling pathway
    125108926
   04915 Estrogen signaling pathway
    125108926
   04921 Oxytocin signaling pathway
    125108926
   04926 Relaxin signaling pathway
    125108926
   04935 Growth hormone synthesis, secretion and action
    125108926
   04918 Thyroid hormone synthesis
    125108926
   04919 Thyroid hormone signaling pathway
    125108926
   04928 Parathyroid hormone synthesis, secretion and action
    125108926
   04916 Melanogenesis
    125108926
   04924 Renin secretion
    125108926
   04925 Aldosterone synthesis and secretion
    125108926
   04927 Cortisol synthesis and secretion
    125108926
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    125108926
   04270 Vascular smooth muscle contraction
    125108926
  09154 Digestive system
   04970 Salivary secretion
    125108926
   04971 Gastric acid secretion
    125108926
   04972 Pancreatic secretion
    125108926
   04973 Carbohydrate digestion and absorption
    125108926
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    125108926
  09156 Nervous system
   04724 Glutamatergic synapse
    125108926
   04725 Cholinergic synapse
    125108926
   04728 Dopaminergic synapse
    125108926
   04726 Serotonergic synapse
    125108926
   04720 Long-term potentiation
    125108926
   04730 Long-term depression
    125108926
   04723 Retrograde endocannabinoid signaling
    125108926
  09157 Sensory system
   04742 Taste transduction
    125108926
   04750 Inflammatory mediator regulation of TRP channels
    125108926
  09159 Environmental adaptation
   04713 Circadian entrainment
    125108926
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125108926
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    125108926
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    125108926
   05142 Chagas disease
    125108926
   05143 African trypanosomiasis
    125108926
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125108926
   05016 Huntington disease
    125108926
   05017 Spinocerebellar ataxia
    125108926
   05022 Pathways of neurodegeneration - multiple diseases
    125108926
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125108926
   05415 Diabetic cardiomyopathy
    125108926
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    125108926
   04934 Cushing syndrome
    125108926
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:llv04131]
    125108926
Enzymes [BR:llv01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     125108926
Membrane trafficking [BR:llv04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    125108926
 Endocytosis
  Macropinocytosis
   Phospholipase C
    125108926
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 125108926
NCBI-ProteinID: XP_047601353
LinkDB
Position
9:complement(108896495..109322624)
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKMS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEVGSRDGPQASNSSV
KLQNSN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gccgtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtgcta
gaatgttccctcatcaacagtattcgattgggagccacgcccaaggatcccaaaatcctg
gctgctctcgaagctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtt
tgcagtggcacagatctggtgaacatcagtttcacatacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggactgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacctgcctcaagaaacactggatgaaattggcgtttatgaccaacacg
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaaa
gtgatctttcaagcactcaaggaattaggtcttcccagtggaaagaatgacgaaattgag
cctgcggcatttacttatgaaaagttctatgaactgacacaaaaaatttgtcctcggaca
gatatagaggatctctttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc
ccattttacgatgctaaaagggcaatgcagatcatcgagatgtatgagcccgatgaagat
ttgaagaaaaaaggcctcatatcaagcgatgggttttgcagatacctgatgtcagatgaa
aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccatcctctggcc
cactacttcatcagttcttcccataacacctatctcacgggccgacagtttggcgggaaa
tcttcagtagaaatgtacagacaggttctcctggctggttgcagatgcgttgaacttgac
tgttgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaaccgcatttgtcacatcc
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcagcagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggcccttaccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataagcggctgaaacctgaggttgaaaaaaaacagctcgaggctttgaaaagcatg
atggaagctggagaatctgctgccccggttagcatcctagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccccgaatacaaatttggaaacgaactt
tctgctgatgacttgggccacaaggaggctgttgcaaatagtgtcaagaaggcttcagat
gaccttgaacatgaaatcaacaaaaagggcctggtgaccgtggaagatgaacaggcatgg
atggcgtcttataaatatgtaggtgctaccactaacatccatccgtatttgtctacaatg
atcaactatgcacaacccgtaaagtttcaaggtttccatgtggctgaagagcgcaatatt
cattataacatgtcttcttttaatgagtccgtcggcctgggctacttgaagacgcacgcc
attgaatttgtgaattataacaaacggcaaatgagccgcatttaccccaagggaggccgg
gtcgattccagtaattacatgcctcagattttctggaatgctggctgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcctgcgggtacctcctcaaaccagatttcatgagacggcccgatcgaacattcgat
cccttctctgaaactcctgtcgatggcgttattgcagccacttgctcagtccaggtcata
tcaggtcagtttttatcagataagaaaattggtacatacgtagaagtggatatgtatggg
ttgcccacagacaccatacgtaaggaattccgaactcgcatggtaatgaacaacggactc
aatccagtttacaatgaagaatcatttgtgttccggaaggtaatcctccctgacctggca
gtcttgagaatagcagtgtatgacgacaacaacaggctcataggccagaggatccttcct
ctggatggcctccaagcaggttatcgacacatttcccttcgaaacgagggaaataaacca
ttatcactgccaaccattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatatcgtagatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagtgat
acttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaacgtcaccccacag
agcagctctgagctcagaccaaccaccacggcggccctggggtctggcgtggaagcaaag
aaaggtatcgaacttatccctcaagtgaggatagaagatttgaagcagatgaaggcttac
ctgaagcacttaaagaaacaacagaaggaactaaattctttaaagaagaagcacgcaaag
gagcacagcacaatgcagaagttgcactgcacacaagttgacaaaatcgtggcacagtac
gacaaagagaagtcgacgcatgagaaaatcctagagaaagcaatgaagaagaaaggggga
agtaattgtctcgaaatgaaaaaagaaactgaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatagtggcccagcacacgaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagaaatccgggacctacacctcagccagcagtgtgag
ctcctgagaaaactactgatcaatgcccatgagcagcaaacccagcagctgaaaatgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaacaaagcagaacgggaaaggcgagtcagg
gagttaaatagcagcaacaccaaaaagtttctggaagaaagaaagagacttgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacaccttgagttcctagag
aaacagaatgagcagctattgaaatcctgccatgcagtgtcccaaacacaaggcgaagga
gatgcagcagatggtgaagttggaagccgagatggaccgcaggccagcaacagtagtgtg
aaactccaaaattcaaactga

DBGET integrated database retrieval system