Labrus mixtus (cuckoo wrasse): 132956005 Help Entry 132956005         CDS       T10666                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism lmix  Labrus mixtus (cuckoo wrasse) Pathway lmix04020   Calcium signaling pathway lmix04260   Cardiac muscle contraction lmix04261   Adrenergic signaling in cardiomyocytes lmix04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:lmix00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     132956005 (ryr2a)    04020 Calcium signaling pathway     132956005 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     132956005 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     132956005 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lmix04040]     132956005 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:lmix04990]     132956005 (ryr2a) Ion channels [BR:lmix04040]  Voltage-gated cation channels   Ryanodine receptor    132956005 (ryr2a) Domain-containing proteins not elsewhere classified [BR:lmix04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    132956005 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 IRK Motif Other DBs NCBI-GeneID:  132956005 NCBI-ProteinID:  XP_060885132 LinkDB All DBs Position 21:15679550..15786175 Genome browser AA seq 4959 aa AA seqDB search MSDGGEGEDEIQFLRTDDEVVLQCSATLHKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEDRNEGTGQGGSHRTLLYGHAVLLRHSYSGMYLCC LSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNSSLHVDAAFQQTLWSVAPICSGSEVAQGYLIGGDVLRILHGHMDECLTVPSGEH GDEQRRTVHYEGGAVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKYLSLIEDK SLQLLDKERADVKSTAFCFRSSKEKLDPGVKKEVDGMGAPDIKYGDSVCYIQHVDTFLWL TYQTVDAKCARMGGVQRRAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNLFIRG LDSLRKKGRGSTPDLPIDSVSLSLEDLIGYFQPPGDHLEHEDKQNRLRALKNRQNLFQEE GMISLVLECIDRLHVYSSAAHFTEAAGREAGDAWSSILNSLYQLLAALIRGNRKNCAQFS GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLSNHVSSMRPNIFLGVSDGSAQYRK WYYELIVDQALPFVTAEATHLRVGWANTNGYAPFPSGGEGWGGNGVGDDLYSYGFDGLHL WSGCIARSVSSPNQHLLRVEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSDGLFFPVA SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPREKLKLEPSQDQTEDRDLLGPTIT LSQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRDDNKRQHP CLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKVKSLKLSQTYELSSGY KPAPLDLSHIKLTSTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKSRRNPRLVPYV LLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAAQCDLSNMSAERFRIFRAEKTYSV NAGKWYFELEVLTAGEMRVGWARPGCLPDHELGSDDQAFVFDGFKVQRWHQGNEHFGRAW QTGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFDAGEGFIPVCSLGVCQVGRMN FGKDVSSLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPNHQHIDVTRIDGT VESCPCLRVTQRSFGSQNSHNDITFYRLSMPIECAESFSRSPHDSLFSPKRELEDFETVS DFEVLMKSPHGPNGPDRDEFNNHKDYNQEKPSKLKQRFMLKKNKPDNSCPTSTRLSEEVM ADDRDEYEFLMHASTHHYSVRIFPGQEPSSVWVGWVTSDFHQYDPGFELHKVRTVTVTLG DEKGKVHESIKRSNCYMVWAGESSSPGQGRNNNGLEIGCLVDTTHGLLTFTANGKELSTY YQVEPSTKLFPAVFAKATSPNVFQFELGRVKNVMPLSAGLFKSERKNPAPQCPPRLHVQF LTPVLWSRVPNHFLKVSASRVNDRHGWLVQCTEPLQFMSLHIPEENRCVDILELSEQSDL LKFHFHTLRLYSAICALGNNRVAHALCSHVDESQLLQAIQNKYMPGLLRAGYYDLLIDIH LSSYATARLMMNNEYIVPMTDETKSITLFPDQDKKHGLPGIGLSTSLRPRMHFTSPCFVC GAVPSHCNHSNNGSASGDCFQYSPEFPLDVLKVKTIEMLTEAVREGSLHVRDPIGGSTEF LFVPLIKLFYTMLIMGVFKNGDLKNILRLIEPSVFCVSGEEQEGVLKEQEGGGRGEEGGR SMPKEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDFVACLQDNQRFRYNE VMLALNMSAALTARKTKEFRSPPQEQINMLLNFKDNKQDCPCPESIRDQLLDFHEDLMRH CGIELDEDRAIGGDGDFTIRGRLMSLVEKVSYLKNKMAALPAEKKHRKPSTLQQLISDTM VRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVQALPKTYTINSVSIEDTITLLAALGQI RSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLSGGDLKE ITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAAS VMDNNELALALREPDLEKVVQYLAGCGLQSCVMLIHKGYPDIGWNPVEGERYLDFLRFAV FCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEDAIKISQDSSRDGPSPSS ESSKTLSDITEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAILR SLIPIEDLVGVISIPFSMPNLGTDGHVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQNFL LHLLEVGFLPDLRAAASLDTVSLSATDMALALNRYLCTAVLPLLTKCAPLFAGTEPFASL IDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQHLLRRLVFDVPLLNEHTK MPLKLLTNHYERCWKYYCLAGGWGNFGAASDEELHLSRKLFWGIFDALSRKRYDQELFKL ALPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPADTAHVCVPEKLDYFISRY AEHIHEKWSIEKFSSGWSFGEQLCELSKSQPLLKPYKGLSEKDKDSYCIPVRESLKTMLS WGWSIDRIREGDPANLHNKSRRISQASQLSFEGTSSFSPRPIDMSNVTLSRDMQSMAELL AENYHNIWARKKKSELEAKGGGNHPLLVPYDTLTAKEKSKDRERAQDILKFLQINGYTVS RGVKSQELDTPAIEKRFAYTFLQQLITYVDQAHQHMMEFDLGTRLKGDKIPHEQQIKFFG KVVLPLVDQYFKYHRLYFLSTAIHPISSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGN NATSIVNCLQILGQSLDARTVMKTCLESVKVALCSFFVSAAEDLERTQENLKLGQFTHSR DQPRGVTQIINYTTFALLPVLSSLFEHVGLHGFGEDLILDDVQVSCYRILNSLYLLGTNK SIYVERQRPALGKCLAAFSAAFPVAFLEPQINKFNSFSIYNNRAHNDTTALGIPEQVEDV CPLVPNLEKSLEEILELAESGMRYNQMPHVMEVVLPMLCSYMSHWWEHGAESHLDRRDTC CTSVTSDHMNSLLGNILKIIYNNLGVDEGTWMKRLAVFSQPIISKAKPELLKTHFLPLMD KLKKKAAVVLLDEEQSRAEGRGEMSETELLIMDQFTVLVRDLYAFYPLLIRFVDYNRARW LKESSPEAEDLFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLITDTKCKMSKGIV SDQERKKMKRKGDRYSMQTSLIVATLKRLLPVGLNTCAPGEHELIALAKNRFNQKDTEEE VREIIKNNLHLQGKLEDPAIRWQMALYRDLPNHPEDSPDPERTVDRVLDIAHVLFHLDQV EHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIEAEEHYF EDKLIEDLAKPGDQEMCEEEEGLKNIDPLHQLIQLFSRTALTEKCKLDEDNLYMAYADIM AKSCHDEEDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGLMVA STLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEG LGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNI IISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQGPCTG NQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNV VNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHK AMESHKHYTQSETDFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMP HDTRLQTFLELADSVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKR QFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAVKEESEREKPDEESPE MGFFSVTTVRMALLALRYNVMMLIKVLSMKSVKKQVKRMKNMTLKDLLTTLMAFYWSFLL ALLHMAFSVARGFCRIFYNSFMGGGLVEGAKTIKVSELLANMPDPTQDEVRGEGEEREKR PSPQEDLADLAVNTSETELLSDIFGLDLRREGGQYKITPHNPNASLTELLNSPVPSPTPQ APPTAPPPELRQRHQSKSPSCEEKEATADTQSEPEKTSEVVEKQEKQEKKEKTIPKVKRL HTSKSDEPDLQESAVLKKIIAYQRKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTS SSVVEQREVVLTSGRLDSSVQWDPLGGEAAEVKEEVLEEAGEVLKPVTVRFVLEESSGYM EPMLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKG QWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDAHKKRKP RRDGSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAM GFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKGEDGELPDMKCDD MLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIID AFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFVMYLINK DETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14880 nt NT seq  +upstreamnt  +downstreamnt atgtctgacggaggagaaggagaggacgagatccagttcctgcggactgatgacgaggtg gtcctgcagtgttcagccactctccataaagagcaacagaaactctgtttggctgctgaa ggtttcgggaacagactctgcttccttgagtccatctccaactccaagaatgttcctcct gatttgtccatctgcaccttcgtgttggagcagtctctgtctgttcgagctctgcaggag atgctggccaacacagaggacaggaacgaggggacggggcagggcggcagccatcgaacc ttactgtacggacatgcagtgctgctgagacactcctacagcgggatgtacctgtgctgt ctctccacctcccgctcgtccactgacaaactggcctttgatgtcggcctgcaggaggac acgacaggcgaggcgtgctggtggactatccatcctgcctcgaagcagcgttcagagggg gagaaggtcagagtgggtgatgatctcatcctggtcagcgtgtcctcagagagatacctg cacctgtcgtatggaaacagctctctgcatgtggacgcagccttccagcagactctgtgg agtgtagctcccatctgttcaggaagcgaggtggctcaaggttacctgatcggaggagac gtcctgcgcatccttcacggtcacatggacgagtgtctgacggttccatcaggagagcac ggagacgagcagaggaggacggtgcactacgagggcggagctgtgtccagtcacgcccgt tctctgtggagactggagactctgagggtggtgtggagtgggagtcacatccgttggggt cagccgttcagactgcgtcatgtgaccacgggaaaatacttgagtctgatagaagataaa tctctgcagctgctggacaaagaacgagcagacgtcaaatctacggccttctgcttcagg tcgtctaaggaaaagttggaccctggtgtgaagaaggaggtggatgggatgggggctcct gacattaaatatggagactctgtgtgttacatccaacacgtggacacctttctgtggctc acctatcagactgtggacgctaagtgtgctcgtatgggcggagtccagagaagggccata atgcatcacgagggccacatggacgatgggctgactctgtctcgctctcaacacgaggag agtcgaactgcacgagtcatcaggagtactgtgtttctgttcaacctgttcatcaggggg ctggactctctgaggaaaaaggggcggggctccactccagatctacccatagattcagtc agtctgagtctggaggatctgattggatacttccaaccacctggagatcacctggagcac gaagacaaacagaaccgcctgagagcgctcaagaaccgccagaaccttttccaggaggag gggatgatcagcctggtgttggagtgtatcgatcgtctccacgtttacagcagtgcggct cattttactgaagctgcaggaagagaagcaggagacgcttggagctccatcctcaactct ctgtaccagctgctggcggctctgatcagaggaaacaggaagaactgtgctcagttctcg ggctcattggattggttaatcagcagactggagcggctggaggcctcctcgggtatccta gaggttcttcactgtgtgctggtggagagtcctgaggctctgaacatcatcaaagaggga cacatcaagtccatcatctctctgctggacaaacacggacgcaaccacaaggtactggac gtgttgtgctctctgtgcgtgtgtcacggcgttgctgttcgctcaaaccaacatctgatc tgtgacaacctgctgccaggaagagacctgctgctgcagaccaggctgagcaaccacgta agcagcatgcgtccaaacatcttcctaggcgtcagcgatggctccgcccagtacaggaag tggtactacgagctgatcgttgatcaggctctgccgttcgtcacagcggaggcgactcac ctgagggtgggctgggccaacacaaacggctacgcccccttccccagcgggggggagggg tgggggggcaatggggtgggagatgacctctactcgtatggctttgatggactccacctg tggtcaggctgcatcgctcgctctgtgagctctcctaaccagcacctcctgagggtggag gacgtggtgagctgctgtctggatctgagcgtgcccagtatctccttcaggatcaacggg cagcccgtgcagggcatgttcgagaacttcaactctgacggactattcttccccgtggcg agcttctctgcaggagtcaaagtgcgtttcctactggggggtcgtcatggagagtttaag ttcctcccccctcctggttacgccccctgctacgaggccgtgttaccccgagagaagcta aagctggagcccagtcaggaccagactgaggacagagacctgcttggacccaccatcacc ctgagccaggcagccttcacccccatacctgtggacaccagccagatcgttcttcctcct cacttggagagaatccgggagaaactggcagaaaacattcatgagctttgggtgatgaat aagattgaactgggctggacctacggagccgtgagagatgataacaagaggcagcacccc tgtctggtggagttctccaaacttcccgagcaggagaggagctacaacctgcagatgtct ctggagacgctcaaaactctgctggctctgggctgccatgttggtctggctgatgaacac gccgtggagaaagtgaagagtctgaagctgtcccaaacctatgagttatccagtggttat aaacctgcacctctggacctgagtcacatcaaactgacctccacccaggaagccatggtg gacaaactggctgagaacgctcacaacgtgtgggctagagaccgcattcggcagggctgg acctacggcatccagcaggatgtgaagagccgtagaaaccctcgtctggtcccctacgtt ctgctggacgagaggaccaagaagtccaacaaagacagtctgagagaggcggtcaggact ctgctgggctacggatacaacctggaagctccagaccaggaccacgcagctcagtgtgac ctcagtaacatgtctgctgagaggttcagaatcttcagagcagagaaaacctacagtgtg aacgcagggaagtggtactttgagctggaggtgttaacagcaggagaaatgagggtgggc tgggccagaccagggtgccttccagaccacgagctgggatctgatgatcaggcctttgtg tttgatggtttcaaggtccagcgctggcaccagggtaacgagcactttgggcgggcatgg cagacgggggatgtggtgggctgcatggtggacctaaacgaacacaccatgatgttcaca ctgaacggagaagtgctgctggatgactctggatctgagctggcattcaaggactttgat gctggtgaaggtttcatcccggtgtgcagtctgggggtatgtcaggtggggaggatgaac tttggaaaagatgtcagctctctgaagtacttcaccatctgcggactgcaggaaggatat gaaccattcgccgtcaacatgaaccgggacgtcaccatgtggctcagcaagaggctgcct cagtttgtacctgtgcccccaaaccaccaacacatagatgtgacgaggatcgacgggacg gtggagtcgtgtccatgtctcagggtcactcagaggtcatttggctctcagaacagtcac aatgacatcaccttctacagactgagcatgcccatagagtgtgcagagtccttctccaga tcgccacatgacagcctcttctctccaaagagggaactggaggactttgagacagtgtca gacttcgaggtcctcatgaagtctcctcatggtcccaacggtcctgacagagacgagttc aacaaccacaaagattataaccaggagaagccctccaaacttaagcagaggttcatgctg aagaaaaacaaacctgacaacagctgtccaacatctacccgtctgtcagaggaggtgatg gctgacgacagagatgaatacgagtttctcatgcatgcatcaacgcaccactactcagtg cggatcttccccggtcaggagcccagcagtgtgtgggtgggctgggtgacctctgacttc catcagtacgaccccggcttcgagctgcacaaagtccgaactgtgactgtgaccctggga gacgagaagggcaaagttcacgagagtataaagcgcagtaactgctacatggtgtgggcc ggagagagcagcagtcctggtcaagggaggaacaacaacggtttggagatcggctgtctg gtcgacacaacacacggtctactgaccttcacggccaacgggaaggaactcagcacatac taccaggtggagcccagcaccaaactgttccctgcagtgtttgccaaagccaccagtccc aatgtgttccagtttgaactgggacgagtcaagaatgtgatgcctttgtcagctggtctg tttaagagcgagaggaagaacccggctcctcagtgtcctcctcgactgcacgtccagttt ctcacaccagtgttatggagtcgagtaccaaaccacttcctcaaggtctcagcgtccaga gtgaacgacagacacggctggctggtccagtgtactgaacctctgcagttcatgtctctg cacatacctgaggagaacaggtgtgtggacatcctggagctgtccgagcagagcgacttg ttaaagtttcacttccacactctcagactgtactctgctatctgtgctctgggaaacaac cgggtcgctcacgctctctgctcacacgtggacgagtcccagctgctgcaggctatccag aacaaatacatgccaggtctgctgcgtgcaggttactacgacctgctgatcgacatccac ctgagcagctacgccacagctcgcctcatgatgaacaacgagtacatcgtccccatgacc gacgagaccaagagcatcaccctgttccccgaccaggacaagaagcacggcctgcccggc atcggcctcagcacctccctcagacccagaatgcacttcacctcgccctgcttcgtctgc ggggccgtgccgtcccactgtaaccatagcaacaacggctcagcatccggagactgtttc cagtacagccccgagttccccttagatgtcctgaaggtgaagactatcgagatgctgacg gaggcggtgagggagggcagcttgcacgtcagagatcctatagggggcagcactgagttc ctgttcgtccccctcattaaactgttctacaccatgctcatcatgggcgtgttcaagaac ggagacctgaagaacatcctgaggctgatcgagccctcagtcttctgtgtgagtggggag gagcaggagggggtgctgaaggagcaggaggggggaggaagaggagaggagggggggagg agcatgcccaaagaaggactgttacagatgaagctacctgagcccgtcaaactacagatg tgccacgtgctgcagtacctgtgtgactgtcaggtgcgtcaccggatcgaggcggtggtc gccttctctgacgactttgtggcctgtctccaagacaaccagcgtttccgctacaacgag gtgatgctcgctctcaacatgtccgcagcgctcaccgccaggaagaccaaagagttcagg tcccctccacaggagcagatcaacatgctgctgaactttaaagacaacaaacaggactgt ccctgtcccgagtccatccgagaccagctgctggacttccacgaggacctcatgagacac tgtggtatagagctggacgaggaccgagcgatcggcggagacggtgacttcaccatcaga ggtcggctcatgtcattggttgagaaggtgtcgtacctgaagaacaagatggccgccctt cctgcagagaagaagcacaggaagcccagtaccttacaacagctgatctcggacacaatg gtccgctgggctcaggagtcggtcatcgaggatccagaactggtcagagccatgtttgtt ttgctgcaccgacagtacgacggcatcggaggacaggtgcaggctctcccaaagacctac accatcaactcggtctccatcgaggacaccatcaccctgctggcggctctgggtcagatc agatctctgctcagcgtccggatgggccgcgaggaggagaagctgatgatccgagggctg ggtgacatcatgaacaacaaggtgttctaccagcaccctaacctgatgagagctctgggg atgcatgagaccgtcatggaggtgatggtgaacgtgctgagtggaggagacttgaaggag atcacgtttcctaagatggtggctaactgctgtcgcttcctgtgttacttctgtcgaatc agccgtcagaaccagaaggccatgtttgatcacctgagttacctgctggagaacagcagt gtgggcctagcctctccctccatgaggggctcgactcccctcgatgtggctgcagcttca gtgatggataataacgagctggctctggctctaagagaacccgacctggagaaggtggtt cagtacctcgcgggctgtgggctgcagagctgtgtgatgctcattcataaaggttaccca gacatcggctggaacccggttgagggagaacgctacctcgacttcctgcgattcgccgtc ttctgcaacggtgagagcgtggaggagaatgctaatgtggtggtgaggctcctgattcgt cggcctgagtgttttggccccgccctccgaggtgaaggtggagatgggctgttagcagcg atggaggacgccatcaagatctcccaggattcctccagagacggaccatcgccgtcgtct gaaagcagcaagaccctcagtgacatcacagaggaagaggaagatgacacaatccacatg gggaacgccatcatgacattctacgctgctctgatcgacctgctaggccgctgtgctcca gagatgcatctgatacatgcagggaaaggtgaagcaatcaggatcagagccatcctgagg tctctgatccccatcgaggacctggtgggagtcatcagcatcccgttctccatgcctaac ctggggacagacggtcacgtggtggagcctgacatgtcagctggtttctgtccggatcat aaagccgccatggttctgttcctggaccgagtgtacggcatcgaggaccagaacttcctg ctccacctgctggaggtcgggttcttacctgacctgagggccgctgcctcgctcgacacg gtgtctctcagtgccacagacatggcgttggctctgaacaggtatctgtgtaccgctgtg ctccctcttctcactaaatgtgctcctctgtttgcggggactgaaccgttcgcctcgctg atcgactccctgctgcacaccgtgtaccgcctgtccaaaggatgctgccttaccaaggcc cagagggacgccatcgaggagtgtctgctcgccgtctgtgggaagctgaggccgtccatg atgcagcatcttctgaggaggctggtgtttgacgtcccgctgctcaacgaacacaccaag atgcctttaaagctgctgaccaatcactacgagcgttgttggaagtattactgtctggct ggaggctgggggaactttggagcagcttcagatgaagagctgcatctgtccaggaaactc ttctgggggatctttgatgctctgtcacgcaagaggtacgatcaggagctgtttaaactc gctctgccgtgtctcagcgccgtggccggagctcttcctccagactacatggagtccaac tacatggccatgatggagaaacagtcgtccatggactccgagggaaacttcaccccccag cctgcagacactgcacatgtttgtgttccagagaaactggattattttatctccagatat gcagaacacatccatgagaagtggagtatagagaagttttccagcggctggtcgtttgga gagcagctctgtgaactctctaagagtcaaccgttactgaaaccttacaaaggcctctct gagaaggataaggattcgtactgcattcctgtcagagagtctctgaagacaatgttatcg tggggctggagcattgacaggatcagagaaggagaccctgcaaacctgcacaacaagtcc aggaggatctcacaggccagccagctgtcgtttgaaggaacttcatctttcagcccgaga ccgatcgacatgagtaacgtcactctgtccagagacatgcagtctatggctgagctgctg gcagagaattatcacaacatttgggcgaggaagaagaaaagtgagctggaggctaaaggc ggaggaaaccatcctctgctggttccttacgacactctgacggctaaagagaaatctaaa gacagagagagagctcaggacatcctcaagttcctgcagatcaacggatacaccgtgtcc agaggggttaagtctcaggagctggacacgcctgccatagagaagcgtttcgcttacacc ttcctgcagcagctcatcacatacgttgaccaggctcaccaacacatgatggagtttgat ttgggaactcgactgaaaggagacaagattcctcatgaacagcagattaaattctttgga aaggtggtcttgccgttggtggatcagtacttcaaataccataggctctacttcctgtcc acagccatccatccaataagcagtggaggccacgcctccaacaaggagaaagagatggtg accagtcttttctgcaaactgggagttctggtcagacacaggatatctttatttggtaac aatgccacctccatagtgaactgtctacagatcctgggtcagagtctggatgccaggacc gtgatgaaaacctgtctggagtcggtgaaggtggctctgtgctcgttcttcgtcagtgca gccgaggatctggagcggactcaggagaacctgaagctgggtcagttcactcacagtcgg gatcagcctcgaggagtcactcagatcataaactacaccacgttcgccctgctgcccgtc ctctcctcgctgttcgaacacgtgggcctgcacggcttcggagaggacctcatactggac gatgttcaggtctcctgctacagaatcttaaacagtctctacctgctgggaaccaacaag agcatctatgtggagagacagcgtccggcgttggggaaatgtttggcagccttctctgca gcatttcctgtcgctttcctcgagccgcaaatcaacaagttcaatagtttctccatttac aacaacagagcgcacaacgacacaacagctctgggtatacctgagcaggtggaggatgtg tgtccgctggtccctaacctggagaagtctctggaggagatcttggagctggcagagtcg ggcatgagatataaccagatgcctcatgtcatggaggtggtgctgcccatgctgtgcagc tacatgtctcactggtgggagcacggagcagagagtcacctggacaggcgtgacacatgc tgcacatcggtcacctctgatcacatgaactccctgctggggaacatcctgaagatcatc tacaacaacctgggcgtcgacgagggcacatggatgaagaggctggctgtattctctcag ccgatcatcagtaaagctaaacctgagctgttaaagactcacttcttgcctctcatggac aaactgaagaagaaggcagcggtggtcctgctggacgaggagcagagtcgggcggaggga cggggggagatgtctgagacggagctcctcatcatggatcagttcactgtgctggtcaga gacctgtacgccttctaccccctgctcatacgattcgtcgactacaacagggctcgctgg ctgaaggagtccagtccagaggccgaggatctgttccgtatggtggccgaggttttcatc ttctgggccaaatctcacaactttaagagggaggagcagaactttgtggtgcagaacgag atcaacaacatgtcgttcctcatcacagacactaagtgtaagatgtcaaagggcatcgtg tcggaccaggagaggaagaagatgaagaggaagggcgatcgatactccatgcagaccagt ctgatcgtggccactctgaaacgtctgcttcctgtcggtctgaacacctgtgcacctgga gaacacgagctcatcgccctcgccaagaacaggttcaaccagaaagacacagaggaggaa gtcagagagatcatcaagaacaacctccatcttcaggggaagctggaggacccggcgatc cgctggcagatggctctgtacagagatctaccaaaccacccggaggactcgcctgatcct gagaggactgtggaccgagtgctggacatcgctcatgtcctctttcacctggaccaggtt gaacaccctcagcgcagtaagaaggccgtgtggcacaaacttctgtccaagcagaggaag agagccgtggtggcctgtttcaggatggctcctctctacaacctgcccaggcaccgtgcc gtgaacctgttcctgcagggctatgagaagtcgtggatcgaggctgaggagcattacttt gaggacaaactgatcgaggacctcgctaaaccaggtgatcaggagatgtgtgaagaagag gaagggctaaagaacattgatcctcttcatcagctcatccagctgttcagcaggacggcc ctgaccgagaagtgtaaactggatgaagataacctgtacatggcgtacgctgacatcatg gcaaagagctgtcatgatgaagaggacgaggatggagaggaagtcaagagctttgaagag aaggagatggagaaacagaagctgttgtatcagcaggctcgtctccacgacagaggagca gcagagatggttcttcagaccatcagcgccagcaaaggtgagatgggtctgatggtggca tccactctaaagctgggcatcgccatcctgaatggaggaaactcgacggtccaacagaaa atgttggactatctgaaggataagaaggacgtgggtttcttccagagtctggctggtctc atgcagtcctgcagtgttctggacctgaatgcgtttgagcgtcagaacaaagcagaaggt ctgggcatggtgaccgaggagggatcagtcatcactcatgagcgtggtgagaaggtcatg caggatgatgagttcacctgtgaccttttccgcttcctgcagctgctgtgtgaaggacac aactcagactttcagaactatctgaggactcagacaggaaacaacacgacggtgaacatc atcatctctacggtggattacctcctcagagtgcaggagtccatcagtgacttttactgg tattactctggtaaagacgtgattgatgagcagggtcagaggaatttctccaaggcgata aatgtggccaaacaggtgttcaacactctgaccgagtacatccagggtccgtgcaccggg aaccagcagagtctggctcacagtcggctgtgggacgctgtggttggctttcttcacgtt ttcgctcacatgcagatgaaactgtctcaggactccagtcagatcgagttactgaaggag ctgatggacctgcagaaggacatggtggtcatgctgctgtccatgctggagggtaacgtg gtgaacgggaccattgggaagcagatggtggacatgttggtggagtcatccaacaacgtg gagatgatcctcaagttcttcgatatgttcctcaaactgaaggacctgacgtcgtccgac gccttcaaggagtacgaccccgacgggaaaggagtcatctccaagagagacttccacaaa gccatggagagccacaaacactacacccaatctgaaaccgacttcctgctgtcctgtgct gagaccgacgagaacgagctgctcgactacgaggagtttgtggagaggtttcatgagccg gccaaggacataggcttcaatgtagcagtcctgctgaccaacctgtcggagcacatgcct catgacacgcggctgcagacgtttctggagctggccgacagcgtcctgaattatttccag ccttacctgggacgcatcgagatcatgggcagtgccaaacgcatcgagagggtttacttt gagatcagcgagtccagccggacgcagtgggagaagcctcaggtgaaggaatccaagcgt cagttcatctttgacgtagtgaacgagggaggcgagaaggagaaaatggagctgtttgtc aacttctgtgaggacaccatctttgagatgcagcttgcagctcagatgtccgacgccgga gagcgctcggccgtcaaagaggagagcgagcgagagaaacccgacgaggagagtcctgag atgggcttcttctccgtcaccaccgtccgtatggctctgttagctctgcgctacaacgtc atgatgttaataaaggttctgtcgatgaagagtgtgaagaagcaggtgaagaggatgaaa aacatgacgctgaaggacctgctgaccaccctgatggcgttctattggtccttcctgcta gcactgctgcacatggcatttagcgtggccagaggtttctgcaggatcttctacaacagc ttcatgggcggggggctggtagagggggccaagaccatcaaggtgtccgaactgctagcc aacatgcccgaccccacgcaggacgaggtaaggggagagggggaggagcgtgagaagaga ccctcccctcaggaggacctggcagacctggcggtgaacaccagcgagacagagctgctg tcggacatctttggtctggacttaaggagggagggggggcaatataagatcaccccccac aaccccaatgccagcctcaccgagctgctcaactcccccgtaccctccccaacaccccaa gccccacccacagcacccccacctgagctcagacagaggcatcagtcgaagagtccttcc tgtgaggagaaagaggcgacagcagacacacaatcggaaccagagaaaacatcagaggtt gtagagaagcaggagaaacaggagaagaaggaaaagacgatacccaaagtaaagagactt cacacttcaaagtctgatgaacccgaccttcaggagtctgctgtcctgaagaagatcatc gcctaccagaggaagctgctgaattactttgccagaaacttctacaacatgaggatgctc gctctgtttgtcgccttcgcaatcaacttcatcctgcttttctataaggtctctacgtct tcctccgtggtggagcagagggaggtggtgttgacgagcggccgtttagacagcagtgtt cagtgggaccctctgggaggagaagcagcggaggtgaaggaggaggtgctggaggaggcg ggggaggtgctgaagccggtcacagtgcgtttcgttctggaggagagcagcggctacatg gagcctatgttacgaatcctcgctatcctgcacactgtcatctccttcttctgcatcatc ggatactactgcctcaaggttccattggtgatctttaagagagaaaaggaagtggcgagg aaactggagtttgatggtttgtacatcacagaacaaccatcagaggacgacatcaaagga cagtgggacagactggtcatcaacactcaatcttttccaaataattactgggataagttt gtgaagaggaaggtgatggataaatacggagagttttacggacacgaccgaatcagcgag ctgctcgggatggacaaagctgctctggacttcagcgacgctcataagaagaggaaacct cgtagagatggctctctggctgctgtgctgaactccatcgatgtgaaatatcagatctgg aagctcggagttgttttcaccgacaactcattcctgtacctggcctggtacatgaccatg tcaatccttggtcactacaacaacttcttcttcgctgctcacctgctcgacatcgccatg ggcttcaaaacgctgaggaccatcctatcgtctgtcacacacaacggcaaacagctggtg ctgacagtgggtctgctggccgtggttgtgtatctctacactgtggtggcctttaacttc tttaggaagttctacaataaaggagaggatggcgaactgccggatatgaagtgtgacgac atgctgacatgctacatgttccacatgtatgtaggggtgagggcagggggaggaatcggg gaccagattgaggacccagcaggtgacgagtacgagatctatcgcatcatcttcgacatc accttcttcttcttcgtcatcgtcatcctgctcgccatcatccagggtctgatcatcgac gcttttggagaactccgagaccaacaggaacaagtgaaggaagacatggagactaaatgt ttcatctgtgggatagggaacgattacttcgacacagttccacacggctttgagacgcac acactgcaggagcacaacttagccaactacctattctttgtgatgtatcttatcaacaaa gatgaaacagagcacacaggacaggagtcgtatgtttggaagatgtaccaggagcgctgc tgggagttctttcctgctggtgactgtttccggaaacagtacgaggatcagctcaactga

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