Labeo rohita (rohu): 127173803 Help Entry 127173803         CDS       T09007                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism lroh  Labeo rohita (rohu) Pathway lroh04020   Calcium signaling pathway lroh04260   Cardiac muscle contraction lroh04261   Adrenergic signaling in cardiomyocytes lroh04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:lroh00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     127173803 (ryr2a)    04020 Calcium signaling pathway     127173803 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     127173803 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     127173803 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lroh04040]     127173803 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:lroh04990]     127173803 (ryr2a) Ion channels [BR:lroh04040]  Voltage-gated cation channels   Ryanodine receptor    127173803 (ryr2a) Domain-containing proteins not elsewhere classified [BR:lroh04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    127173803 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  127173803 NCBI-ProteinID:  XP_050979741 LinkDB All DBs Position 12:225906..317247 Genome browser AA seq 4978 aa AA seqDB search MTDGEAEDEIQFLRTDDEVVLQCSAMVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPD LSICTFVLEQSLSVRALQEMLANTEERAEGLIDMEKWKFMMKTAQGGGHRTLLYGHAVLL RHSYSGMYLCCLSTARSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDL ILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHM DECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHVT TGKYLSMMDDQGLLLMDKEKADVKSTAFCFRSSKEKLDFGLRKEVDGMGVPDIKYGDSVC YIQHVDAGLWLTYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRS TVFLFNRFIRGLDALSKKGKTSTLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRA LKSRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGESWKSILNSLYELLAALI RGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLL DKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFL GVSEGSAQYKKWYYELIVDHVEPFVTAEATHLRVGWASTQGYAPYPGGGEGWGGNGVGDD LYSYGFDGLHLWAGCVARSVSSPNQHVLRAEDVVSCCLDLSAPSISFRINGQPVQGMFEN FNSDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPSGYAPCFEAVLPREKLRVEHSQEYK HDHGRTRDLLGPTVTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELG WTYGAVRDDNKRQHPCLVEFSRLPEQERSYNLQMSQETLKTLLALGCHVGVADERAAEKV KNLKLSAKYELSSGYKPAPMDLSHIKLASTQEAMVDKLAENAHNVWARDRIRQGWTYGIQ QVGVCDIKNKRNPRLVPYVLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARADS CNLSAERFRIFRAEKTYSVNGGKWYFELEVVTAGEMRVGWARPGCLPDLELGSDDQAFVF DGFKAQRWHQGNEHFGRSWQSGDVVGCMVDMNERTMMFTLNGEVLLDDSGSELAFKDFEV WDGFIPVCSLGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDLTMWISKRLPQ FIPVPLNHEHIEVTRIDGTVESPPCLKVTQRSFGSQNSSTDIMFYRLSMPIECSEAFLRS PGGTLAANGSFFSPKRDLEDFETVSDFEVLMKTPHSHMSSNGPDRERDEFNNHKDHNQEK PSKIKQRFLLKRMKPEMNSSNSSARLSEEVLADERDDCENLIQTSTYYYSVRIFPGQEPS SVWVGWVTSDFHQYDPAFELSKVRTVTVTLGDEKGKVHESIKRSNCYMVWGGECSIPSQG RNNNGLEIGCLVDTANGLLTFTSNGKELSTFYQVEPSTKLFPAVFAQATSPNVFQFELGR IKSVMPLSAGLFKSERKNAVPQCPPRLHVQFLTSVLWSRVPNQFLRSEVSRVSERLGWMV QSSEPLQFMTLHIPEENRSLDILELTEQRELLKFHYHTLRLYSAICALGNNRVAHALCSH VDEAQLLYAIQNKYMPGLLRTGYYDLLIDIHLSSYATARLMMNSEYIVPMTPETKSITLF PNEKKKHGLPGIGLSTSLQPRMRFSSPSFVGAVSGHHGNGAAAGGDCFQYSPEFPLETLK SRTMEMLTEAVREGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKTILQLIEP SVFSQDSGVESGGGTPETKDGCGRGRLEGGGAEEHGLRGKMPKEGLLQMKLPEPVKLQMC HLLQYLCDCQVRHRIEAVVAFSDDFVANLQENQRFRYNEVMQALNMSAALTARKTKEFRS PPQEQINMLLNFKDEKQDCPCPEDIREQLLDFHEDLMTHCGIETDDDKSGDGDSDFTIRG RLMSLVEKVTYLKKKMTDIPKKKKSKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVL LHRQYDGIGGQVRALPKTYTINAVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIHGLS DIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRIS RQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQ YLAGCGLQSCVMLMSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRR PECFGPALRGEGGNGLLAAMEEAIKISEDPSRDGPSPTTEESRTLNDIMEEEEDDTIHMG NAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLVGVISIPFLMPTL AKDGSVIEPDMSAGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTA ALSATDMALALNRYLCTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQ RDAIEECLLAVCGKLRPSMMQHLLRRLVFDVPVLNEHTKMPLKLLTNHYERCWKYYCLSG GWGSFGAALDEELHLSRKLFWGIFDALARKKYDVELFKLALPCLSAVGGALPPDYMESNY MAMMEKQSSMDAEGNFNPQPADTGSVVVPEKLDHFVNKYAEYSHEKWSMDKFAVGWVHGE QMCESSRVHPLLKPYKCLSEKDKEVYRWPIRESLKTMLSWGWSIERMRESDASTLHNRTR RISLSSQRSIEGAHGFSPRPVDMSNVTLSRDLHAMAELLAENYHNIWAQKKKLELESKGG GSHPLLVPYDTLTAKEKSKDREKAQDILKFFQINGYSVSRAMKEQDLDTPSIEKRFAYTF LQQLITYVDEAHEHMLEYDAGVRPKGDKIPHEQQVKFFGKVVLPLVDQYFKNHRLYFLST AVRPISSGGHASNKEKEMVTSLFCKLAVLVRHRISLFGNDATSIVNCLHILGQTLDARTV MKTGQDSVKAALRAFFDNAAEDLEKTMENLRQGQFTHTRSQPKGVTQIINYTTVALLPVL SSLFEHIGQNLFGEDLILDDVQVSCYRILNSLYSLGTSKSIYVERQRPALGECLAAFSGA FPVAFLEPSLNRHNTYSIYNCKSSRERAALGLPAQVDEVCALVPSLERALEEIMELAESG MRYTQMPHVMEVLLPMLCSYMSHWWEHGPESNPERAESCCTSLTSEHMNTLLGNILKIIY NNLGIDEGAWMKRLAVFSQPIIGKAKSQLLKTHFLPLMEKLKKKAATVLQDEEHMKAEGR GEMSESELLILDEFTILVRDLYAFYPLLIRFVDYNRAKWLKEPNTEAEELFRMVAEVFIF WAKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKGAVSDQERKKMKKRGDRYSLQTSL IVAALKRLLPVGLNICAPGDQELIGLAKSRFTQKDTEDEVRETIRNNLHLQGKLEDPAIR WQMALYKDMPNRSEDTSDPEKTVYRVLNIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGGEEPSEEDE MTKHIDPLHQLIQLFSRTALTEKCKLEEDNLYMAYADIMAKSCHDEEEEDEEEVKSFEEK EMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKM LDYLKDKRDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQ DDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWY YSGKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVF AHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVE MILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAE TDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLQTFLELAESVLNYFQP YLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVN FCEDTIFEMQLAAQMSDAGERSASKEDSEREKPEEESPEMGFFSVTTVRTALFALRYNVM LLMKVLSMKSLKKQVKKAKKMTVKDLVTTLVSFYWSVLLGLLHFAFSVARGFFRIIYNSF LGGGLVEGAKTMKVSELLANMPDPTQDEVRGETEEGEKKPADKTSPEEDLADLTVATDDT DLLSDIFGLDLKREGGQYKLMPHNPNASLTDLLNTPVPPPPTPSPELRRRHQTKGSSSSA DNSEVVEETKSVPEKAEGENGEKAQKKKEEAVKRKVRQHYEPDLQESAFWKKIIAYQRKL LNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSAVTEGKEVLFSSSSDTSVRWDPLGG SGARPVTVHFVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARK LEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISEL LGMDKAALDFSDAHEKKKPKRDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMSMS ILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFF RKFYNKSEDGESPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDIT FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHT LQEHNLANYLFFFMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14937 nt NT seq  +upstreamnt  +downstreamnt atgacggacggcgaagccgaagatgagatccagttcttacggaccgatgatgaggtggtc ctccagtgctccgccatggtccataaggagcagcagaagctctgtctggcggccgagggc ttcgggaacagactctgtttcctcgagtccacgtccaactcaaagaacgttcctccagat ctgtccatatgcacgtttgtgctggagcagtcgctgtctgtgcgagcgctgcaggagatg ctggccaacacagaggagcgagcggaagggctcatagacatggagaaatggaaattcatg atgaagacggcgcagggcggaggtcaccggacgctgctctacggtcacgcggtcttactg agacactcctacagcggcatgtatctgtgctgtctctctacggctcgctcatccaccgac aagttggcatttgacgtggggcttcaggaagacacgacaggtgaggcgtgttggtggacc atccacccggcgtccaagcagaggtcagagggtgagaaggtgcgagtgggtgatgatctc atcctggtcagcgtgtcgtctgaacgatacctgcacttgtcgtatggtaatggaagtttg cacgtggacgcggctttccagcagacgctgtggagcgtggctccgatctgctccggcagt gaagtggctcagggctttctgattggtggagatgttctgcggctgctgcacggtcacatg gacgagtgtttgaccgtcccgtcaggagaacacggagaggaacagcgcaggacggtccat tatgagggtggagccgtgtccatccacgccagatccctctggaggctcgagacgcttcga gtcgcgtggagcggcagtcacatccgctggggtcagccgtttcggttgcgtcacgtgacc accggaaagtatctcagcatgatggacgatcaagggctcctgctaatggacaaggagaaa gcggacgtcaaatcgacagccttctgcttccgttcctcaaaagagaagctggactttggc ctgaggaaggaggtggacgggatgggcgtcccggacatcaaatacggcgactcggtctgt tacatccagcatgtggacgcggggctctggctcacgtaccagtcggtggacgccaagtgt gcgcgaatgggcggagttcagaggaaggccatcatgcatcatgagggtcacatggatgat ggtttgacactctcgcggtcacaacacgaggagtcgcgcaccgcacgagtcatacgcagc acggttttcctcttcaaccgcttcatcaggggtttagacgctctgagtaagaagggaaag acgtccaccctcgatctgcccatcgaatcggtcagcctgagtctacaggatctgatcgga tacttccagccgcccgacgagcacctggagcacgaggacaaacagaaccgcctgcgagcg ctcaagagcagacagaacctcttccaggaggagggaatgatcaacctggtgctggagtgt atcgatcgtctgcatgtgtacagcagtgcggctcattttgcagacgtggccggtaaagag gcaggagaatcctggaagtccatcctgaactccctgtacgagctcctggctgctctgatc aggggaaacaggaagaattgtgctcagttttctggctctctggattggctgatcagtcgt ctggagaggttggaagcgtcgtccgggattctggaggttctgcactgtgttctggtggag agtccagaagctctgaacatcattaaagagggacacatcaaatccatcatctcactgctg gacaaacacggacgcaaccacaaggtgctggatgttctgtgttctctgtgcgtgtgtcac ggcgtggccgttcgctccaatcagcacctgatctgtgataacctgctgcccggcagagac ctgctgctgcagacgcgactcgtcaatcacgtcagcagcatgaggcccaacatcttcctg ggtgtgagtgaaggctctgcccagtacaagaagtggtattatgagctgatcgtggaccat gtggagccattcgtaacagccgaagccactcatctgcgggtgggctgggcgtccacccag ggctacgcgccgtatccgggcggaggagagggctggggtgggaacggcgtcggggacgac ctgtactcgtatggctttgatggactgcacctgtgggcaggttgtgtggcacgttcggtc agctcacccaatcagcacgtgctgcgggccgaggacgtggtcagctgctgtctggatctc agcgctcccagcatctccttccgtatcaacggccagccggtccagggaatgtttgagaac ttcaactcagacggactcttcttccccgtcgtgtccttctccgccggagtcaaagtgcgc ttcctgttgggcggtcgtcatggagagttcaagttcctgcccccatccggttacgctcca tgttttgaggccgttttaccacgtgagaagctgcgagtggagcacagtcaggagtacaaa catgatcacgggagaacacgcgacctcctgggacccacagtcacactgtcacaggcggcc ttcacaccaacacctgtggacaccagtcagattgtgttgccgccacatcttgagcggatc cgggagaaactggcagaaaacatccatgagctgtgggtgatgaacaagattgagctggga tggacttacggagcggtgagagatgataataaacggcagcacccgtgtctggtggagttc tccagacttcctgaacaagagcgcagctacaacctacagatgtctcaggagacccttaag actcttctggcgttgggctgtcatgttggagtggcggacgaacgggcggcagagaaagta aaaaatctgaagctttcagcaaaatacgagctgtccagcgggtataaaccggcccctatg gacctgagccacatcaaactggcgtctacccaggaggccatggtggacaagctggcagag aatgctcacaacgtctgggcccgagatcgcatacggcagggctggacctacggcatccag caggtcggtgtgtgtgacatcaagaacaagagaaaccctcgtctggttccttacgtcctt ctggatgagagaaccaagaaatcaaacaaagacagtctgcgagaagccgtgcgaacgctg ctgggatacggatacaacctggaggccccggatcaagaccacgcagctcgagcagactcg tgtaatctctctgccgagcgcttccggatattcagagcggagaagacatacagcgtgaac ggagggaagtggtactttgagctggaggtggtaacggcgggggagatgcgtgtgggctgg gcgagacctggctgtctgccggacctagagctgggctcagacgatcaggccttcgtcttt gatggatttaaggctcagcgctggcatcaggggaacgagcacttcggccgctcctggcag tctggagacgtggtgggctgcatggtggacatgaacgaacgcaccatgatgttcacgctc aacggagaggtgctactcgacgactccggctctgaactcgcattcaaagacttcgaagtt tgggatggtttcatcccggtctgcagtctgggcgtgtgtcaggtgggtcgtatgaacttt gggaaggatgtgagcacgctgaagtacttcaccatctgcggcctgcaggagggctacgag cccttcgccgtcaacatgaaccgtgatctgaccatgtggatcagcaaacggctgcctcag tttatcccagtcccgctcaaccacgagcacatcgaggtcacgcggatcgacgggacggtg gagagcccgccgtgcttaaaggtcacccagaggtcgttcggctcacagaacagtagcaca gacattatgttctatcgcctcagcatgcccatcgagtgctcggaggcgttcctgcgctcg cccggcgggacgctagcggccaacgggagtttcttctctcccaaaagagatctggaggat ttcgagacagtgtcggactttgaggtcctcatgaagacaccacacagtcacatgagctcg aacggacccgacagggagcgagatgaattcaacaaccacaaagatcataatcaggagaag ccctcgaaaatcaaacagaggttcttgctgaaaagaatgaagcccgaaatgaacagcagt aactccagcgctcgtctgtcagaggaggttttggctgatgagagagacgattgtgagaat ctcatacagacatcaacgtattattactcggtgaggatcttccccgggcaggagccatcc agcgtttgggtcggctgggtgacgtcagactttcatcagtacgaccctgcctttgagctc agcaaggtgcgaaccgtcaccgttaccctgggagacgagaagggcaaagttcacgagagc atcaagcgcagtaactgttacatggtgtggggcggcgagtgcagcattcccagtcagggc cgcaacaataacgggctggagatcggatgtttggtagacacagccaacggcctcctcaca ttcacctccaacggcaaagagctcagcaccttctaccaggtggagcccagtactaaactt ttccctgcagtgtttgcgcaggcaaccagtccaaacgtcttccagttcgaactgggacgc atcaagagcgtcatgccgctgtctgcgggtctgtttaaaagcgagcggaagaacgcggtt cctcagtgtccgccgcggttacacgtgcagttcctcacatctgtgttatggagccgtgta cccaatcagttcctgaggtcagaggtcagcagggtcagtgagagactgggctggatggtg cagagttcagagccactgcagttcatgacgctccacatacctgaggagaacaggtctctg gatatcctggagctgacggagcagagagagctgctgaagttccactaccacacgctgcgc ttgtattcggccatctgcgcgctggggaacaaccgcgtggctcacgcgctctgcagtcac gtggacgaggcgcagctcctctacgccatccagaacaagtacatgccgggcctgctgcgc accggatactacgacctgctgatcgacatccacctgagcagctacgccacggcgcgcctc atgatgaactccgagtacatcgtccccatgacgcccgagaccaagagcatcacgctcttc cccaacgagaagaagaagcacggcctgccggggatcggcctgagcacctcgctgcagccg cgcatgcgcttctcctcgcccagcttcgtgggcgccgtcagcgggcaccacggtaacggc gcggccgccgggggcgactgtttccagtacagtcccgagtttccgctggagacgctgaag agccgcacgatggagatgctgacggaggcggtgcgggagggcagcttacacgtgcgcgac cccgtcggcggcagcaccgagttcctgttcgtcccgctcattaaactcttctacacgctc ctcatcatgggcatcttccacaacggagacctgaagaccatcctgcagctgatcgagccc agcgtcttttcgcaggactccggcgtggagagcggaggcgggacgccggaaacgaaggac ggttgtgggcggggacgactggaagggggcggagctgaggagcacggcctgagaggaaag atgcccaaagaaggacttctacagatgaagcttcctgaacccgtcaaactccagatgtgt catctgctgcagtacctgtgcgactgtcaggtgcgtcaccgtatcgaggctgtggtcgcg ttctctgatgactttgtggcaaatctgcaggagaaccagcgtttccgctataatgaagtc atgcaagcgctgaacatgtccgccgctctgacggcacgcaaaaccaaagagttccgctct cctccgcaggaacagatcaacatgctgctgaattttaaggatgagaagcaggactgtccg tgtccggaggacatccgtgaacagctgctagacttccatgaagatctgatgacacactgt ggcattgagacggatgatgataaatcaggcgatggagacagtgatttcaccatcaggggg cgtctgatgtctctggtggagaaggtgacctacctgaagaagaaaatgactgatatacca aagaagaagaaatcaaagaaacccagcaccttacagcagctgatctcggagacgatggtg cgctgggctcaggagtcggtcatcgaggatcccgagctggtgcgggccatgttcgtgttg ctccaccggcagtacgacggcatcggcggacaggtgcgagcgctgcccaagacctacacc atcaacgccgtctcggtggaggacaccatcaacctgctggcgtctctgggtcagatccgc tctctgctcagcgtcaggatgggccgcgaggaggagaagctcatgattcatgggctcagt gacatcatgaataacaaggtgttctaccagcatccgaacctgatgagagcgctcggcatg cacgagaccgtcatggaggtgatggtgaacgtcctgggaggaggagagtccaaggaaatc acctttcctaagatggtggccaactgctgccggttcctgtgctacttctgtcgcatcagc cgtcagaatcagaaggccatgtttgatcatctcagctaccttctggagaacagcagcgtg ggtctcgcgtctccgtccatgcgaggttccactcctctggatgtggccgccgcgtctgtg atggataataatgaactggctctggcgctgagagagccggacctcgagaaggtggtccag tatctggcgggctgtggcctccagagctgcgtgatgctgatgtctaaaggatatcctgac atcggctggaacccggttgagggtgaacggtacctggacttcctccggtttgcggtcttc tgtaacggtgagagcgtggaggagaacgctaacgtggtggtgcggctcctgattcgccgg cccgagtgttttggccccgccctgcgtggagagggcgggaacgggctgctggcggcgatg gaggaagccataaagatctcagaagatcccagcagagacggaccgtcacccaccacagag gagagcaggacacttaatgacatcatggaggaagaggaagacgacaccattcacatggga aacgccatcatgacgttctacgccgctctgatcgatctgttgggccgctgcgctccagag atgcacctgatccacgcggggaagggagaggccatccgtatccgagccatcctgcgctcg ctcattcccattgaggatctggtgggagtgatcagcatcccgttcctgatgcccacgctg gccaaagacggttctgtgatcgagccggacatgtcggcgggattctgtcccgatcacaaa gcggccatggttctgttcctggaccgggtttacggcatcgaggaccagaacttcctcctg cacctgctggaagtgggctttcttcctgacctcagagcagccgcctcattggacacggcg gctctgagcgccacagacatggcgttggccctgaaccggtacctgtgcacggccgtcctg ccgctgctcactaaatgcgctccgctgtttgccgggacggagccgttcgcgtctctcatc gactctctgctgcacaccgtctacagactgtcgaaaggctgctgtctcaccaaagcgcag agagacgccatcgaggagtgtctgctggccgtgtgcggtaaactgcgcccctcgatgatg cagcatctgttgaggcgtctggtgtttgatgttcctgtgctcaacgaacacactaaaatg cctctgaagctcctgaccaatcactacgagcgctgctggaagtactactgtctgtccgga ggatggggaagcttcggcgccgcgttggacgaggaactgcatttgtccagaaagcttttc tggggaatctttgatgctctggccagaaagaaatatgacgtggagctgtttaagttggca ctgccgtgtctgagcgcggtgggtggagctttacctccagattatatggagtcaaactac atggccatgatggagaaacagtcgtcaatggacgctgagggaaacttcaacccgcagccc gccgacaccggcagtgttgttgttcctgagaaactcgatcatttcgtcaataaatatgca gaatactcccatgaaaaatggtccatggataagtttgccgtcggctgggttcatggagag cagatgtgtgaatcatccagagttcatccgctgctcaaaccctacaaatgtctgtctgag aaggataaggaggtttaccgctggccaatcagagagagtctgaagacgatgctgtcgtgg ggctggagcatcgagcggatgagagagagcgacgcatctacgttacacaaccgcacgcgc cggatctctctgtccagtcagcgctccatagagggcgctcacggtttcagcccgcggccc gtcgacatgagcaacgtgacgctgtccagagacctgcatgcgatggcggagctgctggcc gagaactatcacaacatttgggctcagaagaaaaaactggagctggaatccaaaggagga ggaagtcatccattactggttccttatgacactttaactgccaaagagaaatccaaagac cgagagaaagcacaagacatcctcaagttctttcagatcaacggatacagcgtctcaagg gctatgaaagaacaggatctggacacgccgtccatagagaaacgcttcgcctacacgttt ctgcagcagctgatcacgtatgtggatgaagctcatgaacacatgctggagtacgatgct ggagttcgaccgaaaggagacaaaattcctcacgagcaacaggtcaaattcttcgggaag gttgtgcttccgctggtggaccagtacttcaaaaaccatcggctctacttcctgtccacc gccgttcgaccgatcagcagcggcggccacgcctccaataaagagaaggagatggtgacc agcctgttctgcaaactagccgttctggtgcggcaccggatctccctgttcgggaatgat gccacgtctattgtaaactgcctgcacatcctgggacagacactggacgccaggactgtg atgaaaaccggtcaggactctgtcaaagcggctctgagggcgttctttgataacgcagca gaagatctggagaagacgatggagaacctgcggcagggtcagttcacgcacacgcggtcg cagcccaaaggagtcacacagatcataaactacaccaccgtcgctctgctgcccgtcctc tcatcgctgttcgagcacatcggacagaacctgttcggagaggatctcatactggatgat gtccaggtttcctgttatcggattctgaacagtttgtactcacttggaaccagtaaaagt atttatgttgagaggcagcgtccggctctcggcgagtgtctggccgcgttttcgggtgca tttcctgtggccttcctggagcccagtctgaacagacacaacacatactccatatacaac tgcaaaagctcccgagaacgagcagcgctgggtctccccgctcaggtggacgaggtgtgc gcgctggtgccgtctctggagcgagcgctggaggagatcatggagctggccgaatcgggc atgcgttacacacagatgcctcacgtgatggaggtgctgctgcccatgctgtgcagttac atgtctcactggtgggaacacggacccgagagcaacccggagcgtgccgagagctgctgc acctcgctgacctccgaacacatgaacacgctgctgggaaacatcctcaagatcatctac aacaacctgggcatcgacgagggagcctggatgaagagactcgcagtgttttctcagccc atcatcggtaaagccaagtctcagctgctgaagactcacttcctgccgctgatggagaag ctgaagaagaaggcggcgacggtcctgcaggatgaggaacacatgaaggcggagggccgg ggcgagatgtccgagtctgagctcctcatcctggacgagttcaccatcctggtgcgagac ctgtacgccttctacccgctgctcatacgcttcgtcgactacaacagagcaaagtggctg aaggaaccgaacactgaggcagaggaattattccgtatggtggctgaagtctttatattc tgggccaaatcacacaactttaaaagagaagagcaaaactttgtggttcagaatgaaatc aacaacatgtccttcctcataactgataccaaatccaagatgtctaagggagccgtatca gaccaggagaggaagaagatgaagaaacgcggtgaccgatattccctccagacgtcgcta atcgtcgccgctctcaagcgtttacttcctgtggggctgaacatctgcgcgccgggagac caggagctgatcggacttgccaagagccgtttcacacagaaagacactgaggacgaggtg cgagagaccatacggaacaacctccacctgcagggaaagctggaggatcctgcaatccgc tggcagatggcgctgtataaagacatgcccaaccgcagcgaggacacgtctgatcccgag aagaccgtctacagagtgctgaacatcgcacacgtgctcttccacctcgatcaggtggaa catcctcagcgcagtaaaaaggccgtgtggcacaagcttctttccaaacagagaaagaga gccgtagtggcctgtttcaggatggcgccgctttacaacctgcccaggcaccgagccgtg aacctgttcctccagggttatgagaaatcctggattgagacagaagagcattattttgag gacaagctgattgaggatttggccaaaccaggtggagaggagccgtcggaggaggacgag atgaccaaacacatcgacccgctacaccagctcatacagctgttcagcagaaccgcgctg actgagaaatgtaaactcgaggaggacaatctctacatggcgtacgctgatatcatggcc aagagctgtcatgatgaagaggaggaggatgaagaggaggtcaagagttttgaggagaag gagatggagaagcagaagctgctgtatcagcaggcccgactgcacgaccgcggcgcggct gagatggtgctgcagaccatcagcgccagtaaaggagagatggggccgatggtggcgtct acactgaagctgggcatcgccatactcaacggaggaaactcaaccgttcagcagaaaatg ctggactacctgaaagacaaacgggacgtgggttttttccagagtctggcgggactgatg cagtcgtgcagtgttctggatctcaacgccttcgagaggcagaataaagccgagggactc gggatggtgacggaggaaggatcagtcatcactcatgagcgtggtgaaaaggtcatgcaa gatgacgaattcacctgtgacctcttccgcttcctgcagctgctctgtgagggacacaat tcagactttcagaactacctgagaacacagacaggaaacaacacgacggtcaacatcatc atctccaccgtggattatctgctcagagtccaggagtccatcagtgatttctactggtac tactccgggaaagacgtcatcgatgaacaaggccagcgcaatttctccaaagcaatcaat gtagccaaacaagtcttcaacactctcacagagtacattcagggcccttgtacggggaat cagcagagtctggctcacagccgcctgtgggacgcagttgttggtttcttgcacgttttt gcacatatgcagatgaagctgtctcaggattcaagccaaatcgagctgctgaaggagctt atggatcttcagaaggatatggtcgtgatgcttctgtccatgctggaaggaaatgttgtg aatggcaccattggaaagcagatggtggacatgctggtggagtcctcgaacaacgtggag atgattctgaagttctttgacatgttcctcaaactgaaagatctgacatcgtcagacacc ttcaaagagtacgaccccgacggcaaaggcgtcatctccaagagggacttccacaaggcc atggagagccataaacactacacccaatccgagacagagttcctgctctcctgcgcggaa accgacgaaaacgagctcctggactacgaagagttcgtcgaacgcttccacgagccggcc aaggacatcggcttcaacgtggccgtccttctgaccaacctgtcggagcacatgccccac gactcgcgcctccagaccttcctggagctggccgagagcgtgctgaactacttccagccg tacctgggccgcatcgagatcatgggcagcgccaagcgcatcgagcgcgtgtacttcgag atcagcgagtcgagccgcacgcagtgggagaagccgcaggtcaaggagtccaagcggcag ttcatcttcgacgtggtgaacgaaggcggcgagaaggagaaaatggagctcttcgtcaac ttctgcgaagacaccatctttgagatgcagctggcggcgcagatgtccgacgccggcgag cgctcggctagcaaagaggacagcgagagagagaaacccgaggaggagagtcccgagatg ggcttcttctccgtcaccaccgtacggacggccctgttcgccttacgatacaacgtcatg ctcctaatgaaggtgctgtccatgaagagcctcaagaagcaggtgaagaaagccaagaag atgacggtgaaggacctggtgaccacgctggtgtccttctactggagcgtcctgctggga ctcctgcacttcgccttcagcgtcgctcgaggattcttccggatcatttacaacagcttt ctcggaggcggtctggtggagggcgccaagaccatgaaggtgtcggagctcctggccaac atgcccgacccgacgcaggacgaggtgagaggagagaccgaggagggcgagaagaaaccc gccgacaaaacctcgcccgaggaagacctggccgatctgacggtggccacggacgacacc gacctcctgtccgatatattcggtttggatctgaagagagaaggcggccagtacaaactg atgcctcacaatccgaacgccagcctcacggatctgctcaacacgcccgtcccgcctccg cccacaccctcaccggagctccgcagacgacaccagacgaagggctcttcatcctcagca gacaacagtgaagttgtggaggaaaccaaatcagtgcctgagaaagcagaaggggaaaat ggagagaaagcacagaagaagaaggaggaagcggtcaagaggaaggtcagacagcactac gagcctgatctgcaggagtcggccttctggaagaagatcatcgcttaccaacgcaagctg ctgaattattttgcacgaaatttctacaacatgagaatgttggctttgtttgtggccttt gcaatcaacttcattctgctgttttacaaggtgtccacgtcctcggccgtcaccgagggg aaggaggtgctgttcagctcgtcctcagacaccagcgtgcggtgggatcctctgggcggc tccggcgctcgtcccgtcactgtgcacttcgtgctggaggagagcagcggctacatggag cccacgctgaggatcttagccatcctgcacaccgtcatctccttcttctgcatcatcggc tactactgcttaaaggttcctctggtgattttcaagcgtgagaaggaagtggccagaaag ctggagtttgacggtctgtacatcactgaacagccgtcggaggacgatattaaaggccag tgggatcggctggtcatcaacacacagtccttcccaaacaattactgggataaatttgtg aagaggaaggtgatggataagtatggagagttttacggacatgatcggatcagtgagctg ctcgggatggataaagctgcgctggacttcagtgacgcccatgagaaaaagaaaccaaag agagacagttcactggccgcagtactgaactccatcgatgtgaagtatcagatatggaag ctgggcgtcgtcttcactgataactcgttcctgtatctggcctggtacatgagcatgtcc atcctcggccactacaacaacttcttctttgccgcccacctgctggacatcgccatgggc ttcaagacgctcaggaccatcctgtcctccgtcacacacaacggcaaacagctggtcctg actgtcggtctgctggcggttgtggtgtatctctacactgtggtggctttcaacttcttc cgtaagttctacaataagagtgaagatggagaatcaccagacatgaagtgtgacgacatg ctaacgtgctatatgttccacatgtacgttggcgttcgtgccggcggcggcatcggtgat cagatcgaagatccggccggtgacgagtacgagatctatcgcatcatctttgacatcacc ttcttcttcttcgtcattgtcatcctcctggccatcattcagggtctgatcatcgatgcg tttggtgagttgagagaccagcaggagcaggtgaaagaggacatggagacgaagtgcttc atctgtgggattggaaacgactacttcgacacggttcctcacggcttcgagacgcacacg ctgcaggaacacaacctggccaactatctatttttcttcatgtatctcatcaacaaggat gaaacagagcacacaggccaggagtcgtacgtttggaaaatgtaccaggaacgttgctgg gagttcttccccgctggcgactgtttccggaaacaatacgaggaccagctcaactaa

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