Labeo rohita (rohu): 127180108 Help Entry 127180108         CDS       T09007                                  Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism lroh  Labeo rohita (rohu) Pathway lroh04020   Calcium signaling pathway lroh04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:lroh00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     127180108    04020 Calcium signaling pathway     127180108  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lroh04040]     127180108 Ion channels [BR:lroh04040]  Voltage-gated cation channels   Ryanodine receptor    127180108 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 L_lac_phage_MSP Motif Other DBs NCBI-GeneID:  127180108 NCBI-ProteinID:  XP_050990010 LinkDB All DBs Position 17:complement(531359..707647) Genome browser AA seq 4882 aa AA seqDB search MAEGGDAEDEIQFLRTDDEVVLQCVACIQKENRKFCLSAEGLGNRLCYLEPTSEAKYVPP DLCICSFVLEQSLSVRALQEMLAKTGQNNDQFIRKAAQGGGHRTLLYGHAILLRHSFSRM YLTCLKTSRSMTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSS ERYLHLSISNGSIQVDASFMQTLWNVHPTCSGSNVEEGYLLGGHVMRLFHGHDEVLTIPG SDQSEEEQRLVNYETGKAGAKARSLWRLEPLRISWCGSHIRWGQPFRLRHLTTGHYLALT EDRGVVLQDRERSDTTSTAFCFRASKEKLECSPKRDIEGMGVAEIKYGDSQCFVMHVATG LWLSYQAPDVKSARLGPLKRRVCLHSEGHMDDGLTLQRCQHEESRAARIIRNTTRLFSCF IRELDGLSAKNRSSVVLPIEEVLQTLNDLIAYFRLPDAELEHEKKQIKLRSLKNRQNLFK QEGMLSLVSSCIDRLSVYNSAAHFGECAGEEAGAAWKDILNLLYELLAALIRGNRNNCTQ FSHNLDWLVSKLERLESSSGILEVLHCILTESPEALNIIQRGHIKTIISLLYKHGRNHKI LDVLCSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIFVGVSEGSAQY RKWYFELMIDHVDHFLTGEPSHLRVGWASTKGYAPYPGGGEGWGGNGVGDDLYSYGFDGL HLWSGRIPRTVASVKQHLLASDDVVSCCMDLNAPSISFRINGQPVQGMFENFNIDGLFFP VVSFSAGVKVRFLLGGRHGDFKFLPPSGYAPCYEALLPKEKMRVEPVKEYKRDAEGVRDL LGNAHFTSQTSFIPKPVDTSQIVMPPHLEKVRDRLAENIHELWGMNKIELGWSYGKIRED NKRQHPCLVDFSKLPETERNYNLQMSTETLKTLLALGCHVVQVKVNAEEELKKLKLPKNY IMSNGYKPSPLDLSEVKLSAGQELLVDKLSENAHNVWAKDRIKQGWTYGIQQDVKSKRNP RLVPYALLDERTKKSNRDSLREAIRTLIGYGYNVEPPDQDAGHVVERLSIDKIRFFRVER TYAVKMGKWYFEFEAVTGGDMRVGWARPGCKPDVELGTDAQAYVFDGHRGHRLHMGSRLF GRCWHAGDVVGCMINLEDKSMIFTLNGEILITNKGSELCFADFDIEDGFIPVCSLGLSQV GRMNLGKDASTFKYYTMCGLQEGFEPYAVNMNREVTMWFSKRLPTFCNVPKDHHHIAVTR IDGTVDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSCFRSSAYTHVNGLCEDEPLK LKHRHPVKSTKHSDEGRRTDYSSITTYYHSVRIFAGQDPSCVWVGWVTPDYHYYSNHFSL SKNRTVTVTLGDERGRVHESVKRSNCYMVWGGDVTSAAHSSSRSNVDLEIGCLIDLATGL LTFTVNGKELPTSYQVEPSTKLFPAVFVRPTSSSLFQFELAKIKNAMPISSAIFKSEHKN PVPQCPPRLDVQTISSVLWSRMPNIFLKVETARVSERHGWMVQCVEPLQMLAVHIPEENR CVDIMELSEQEDLRTFHYHTLKLYCALCAHGNTRVAHALCSHLDQSQLLYTIDNQYLSGL LREGFYDVLISVHLETARAARRMMNNEFIIPITAETRGIRLFPDASKRHRPPGVGLSTSL KPRLHFGPPCFISTKREQHLYSPEIPLDVLKEKAISMLTEAVQGGGDHIRDPVGGSVEFQ FVPILRLIATLLTMGVLTSRDVHKILLLIEPGVFAEHSPRDATAKEGLTGAEEKAVEAGE EEARDGKALVKGLLEKKLPESVKRQMCELLHYFCDCELRHRIEAIVSFSDSFVSKLQFNQ KFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFNMGEDCPCPADIQEELYDFHG ELRLHCGIPVEEDEEDQDSSIKARLLALVYKIKGQPQKSEREPTEKEHSVPSNLKELISQ TMVSWAQETHIQDPELVRLMFSLLRRQYDSIGELLRAMRKTYTISAASVHDTIHLLASLG QIRSLLSVRMGKEEEQLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGGKS QEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAA SSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLSKGYPDIGWNPIEGERYLSFLRF AVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISENPSLDLPSA GPAHASDASTEGEEEEEVVHMGNAILSFYSALIDLLGRCAPEMHLINKGKGEALRIRAIL RSLVPTEDLVGIISIPLKMPVVNKDGSVTEPDVAASFCPDHKAPMVLFLDRVYGIEDQSF LLHLLEVGFLPDLRAAASLDTEALRTTETALAMNRYIGSAVLPLLTRCAPHFSGTEHHAA LIDSTLYTIYRLSKGCSLTKAQRDAIEECLLAICKYLRPSMLQHLLRRLVFDVPLLSEYC KMPLKLLTNHYEQNWKYYCLPSGWGSYGQASEEELLLTKKIFWGIFDSLSQKKYEQDLFK MAMPCLSAIAGALPPDYIDSTLSTTLEKQVSVDTQGNFDPRPINTANICLPEKLEYIANK YAEHSHEKWAAEKVLLGWKHGENIDEKAKTHPMLRSYKSLTEKEKEAYRWTVRESLKSML AMGWSIDRTREGESMFQQREMEKMRRISQASQGNGFNPNPLDMSSVLLSRELQSMVEVVA ENYHNIWAKKKKSDLGSRAAGGAHPLLVPYDTLTAKEKTKDRERAQDLFRFLQINGYAIS RGLKDMEQDSSSMEKRFAYRFLKKLLKYVDSAQEFIAHLEAMASSGKNDRSPHEQEIKFF AKVLLPLIDQYFKNHSMYFLSSPTKNLSSSGYASNKEKEMVTSLFCKLAALVRHRISLFG SDSTTMVSCLHILAHTLDTRTVMKSGSELVKAGLRTFFENAAEDLEKTLENLKLGKFTHS RSQMKGVSQNINYTTVALLPILTALFEHITEHQFGSDLLLDDVQVSCYRILTSLYSLGTG KNIYVERQLPALGECLATLAGAMPVAFLEPQLNTHNPCSVFNTKTSRERALVGLPESVED VCPEMPRLDGLMKDINDMSESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENRPASVCS TTVTSEHLSLILGNILKILNSNLGIDEASWMKRIAVYAQPIISKARADLLKTHFLPTLEK LKKKTVKVVAEEELLKADGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWL KEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDSKTKMAKSFLP KAGGQDQERKHKKRRGDFYSIQTSLIVAALKKMLPIGLNMCTPGDQELIMLAKTRYGLRD TDEEVKEHIRQNLHLQEKSADPAVQWQLNLYKDVMVKTEDTSDPDRSIERIQSISAAVFH LEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLTGYQRLWIEAE MYSFEEKLVQDLAKTQPKTDEEEEEITDTQPDPLHQLILHFSHNALTERSSLEEDQLYIA YADMMAKSCAENEEEDEEGKEKTFEEKEMEKQKTLYQQARLHDRGAAEMVLQMISASKGR LGSMVTFTLKLGISVLNGGNIIVQQKMLDYLKEKRDVGFFKSLSGLMQSCSVLDLNAFER QNKAEGLGMVTEEGSINVRERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRTQTGN TTTVNIIISTVDYLLRLQESISDFYWYYSGKDVMDEAGQRNFSKALAVAKQIFNSLTEYI QGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMIVMMLS LLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSENFKEHDPDRKGVIS KKEFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEEFVKRFHEPAKDIGFNVAVLLTN LSEHMPHDSRLSAFLNLAESVLNYFEPYLGRIEIMGGGKRIERVYFEISESSRTQWEKPQ VKESKRQFIFDVVNKGGESEKMELFVNFCEDTIFEMQLASLISEPDAAERQEEDDDEDDA RSLDLEEDEEDGALESSSAFALACVSMRKSLSNLRQLLTFRSMKRQYRKLRKMSVREMIR GFFFFFWMIFTGMFRFLYSLVWGFFHILWSTLFGGGLVEGAKNMKVTDILGNMPDPTQFG IHGDVLELEKLEYCDVSSVAELGRLAAGDQAEMDLMTELMNIQPRREGGKHGMEPGLGDV SEVIGVDAPSLASAVHQKKAQEAASKQAAESESKSESEKADVEDGEKKDQDKSKEETVSD SLSDEEKKPPKKRRGQRKEQAEAFMAAFLAGLDVYQTKTLNYLARNFYNLRFLALFVAFA INFILLFYKVTGEDSDDLDPWTRREEEEDEGVMEYFVLQENTGYMAPTLRFLAVMHTVIS FLCVLGYYYLKVPLVVFKREKEIARKLEFDGLYITEQPFDDDIKGQWDRLVINTPSFPNN YWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFNPTEETVIKDASLLSWLSSIDTKY HVWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGK QLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSADEDEPDMKCDDMMTCYLFHMYVGVRAGG GIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDME TKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQ ERCWDFFPAGDCFRKQYEDQLG NT seq 14649 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggcggagacgcggaggatgagattcagttcctgcgcacggacgatgaggtg gttctgcagtgtgtggcctgcattcagaaggagaaccgcaagttctgtctgagcgctgag ggtttggggaaccgcctgtgttacctggagcccacatcagaggccaagtatgttcctcca gatctgtgcatctgtagttttgtgctggagcagtcgctgtccgtgcgtgcgctgcaggag atgctcgccaaaaccggacaaaacaatgaccagttcatcagaaaggcggctcagggcgga ggacaccggacgttactgtacggccacgccattctcctcagacactccttcagcaggatg tatctgacctgtttgaagacgtcacgctccatgacggataaactgtcgtttgatgtggga cttcaggaagactcgacaggtgaggcctgctggtggaccattcatcccgcgtctaaacag agatcagagggggagaaagtgcgtatcggagatgatctcatactcgtcagcgtctcatcg gagcgatatctgcatctgtccatatccaatggcagcatccaggtggacgcgtccttcatg cagacgctgtggaacgtccatcccacctgctcagggagcaacgtggaggaaggatatctt cttggcggtcatgtgatgcgtctctttcacggacacgatgaggttctgacgatcccagga tctgatcagagtgaagaagagcagagattggtgaactatgagacgggtaaagccggagca aaagcccgatctctctggaggctggagccgttacggatcagttggtgtggcagtcacatc cgctggggtcagccgtttcgccttcgtcatctgaccaccggtcactatctagcgctgacg gaggacagaggcgtcgttctgcaggacagagagagatcagacaccacgtccacagccttc tgcttcagagcctccaaggagaagctggagtgcagtccgaagcgggacatcgaggggatg ggagtggcagagatcaaatacggagattcgcagtgtttcgtgatgcacgtggccacgggt ctgtggttgtcctatcaggcgccggacgtcaaatccgctcgactcgggccgctcaaacga cgggtgtgtcttcactcagaaggacacatggacgatggtttgacgttacagcgctgtcaa cacgaggagtctcgagccgctcgaatcatccgcaacaccacgcgactcttcagctgcttc atcagagagctggacggtttgagcgccaagaaccgctcgtctgtggttctgcccatcgag gaggttctccagacgctcaacgacctgatcgcctacttcagactgcctgacgccgagctg gagcacgagaagaaacagatcaagctgcgctccctgaagaacagacagaacctcttcaag caggaggggatgctgtctctggtgtccagctgcatcgaccgcttgagcgtttataacagc gcggctcatttcggcgagtgtgcgggcgaagaggccggagccgcgtggaaagacattctc aacctgctctacgagctgctggccgctctcatccgcgggaacaggaacaactgcacacag ttctcgcacaacctggactggctggtcagcaaactcgagagactcgagtcgtcttcaggg atcttggaggttcttcactgtattctgactgaaagtccagaagctctgaacatcatccag agaggacacatcaaaaccatcatctctctgctctacaaacacggacgcaaccacaagatc ctggacgtcctgtgctctctgtgtgtgtgtaacggagtcgctgtcagagccaatcagaac ctgatctgtgatcacctgctgcccaaacgagacctgctgctgcagacgcgactcgtcaac gacgtccagagcatgaggcccaatatcttcgtaggagtcagcgaaggctccgcccagtac aggaagtggtattttgagctgatgatcgatcatgtggatcacttcctgacgggcgagccg tcgcacctgcgggttggctgggcgtccactaaaggttacgctccctacccgggcggcgga gagggctggggcgggaacggcgtcggggacgatctctactcgtacggcttcgatggactg cacctgtggtcaggccgaatcccgaggacggtggcgtctgtgaagcagcacctgttggcg tcggatgacgtggtgagctgctgcatggatctgaacgctcccagcatctcgttcaggatc aacgggcagccggtgcagggaatgttcgagaacttcaacatcgacggcctcttcttcccc gtggtcagcttctccgccggcgtcaaggtgcgcttcctgttgggcggtcgtcacggagac ttcaagttcctgccgccgtcgggttacgcgccgtgttacgaggctctgctgcccaaagaa aagatgagggtcgaaccggtcaaagaatacaagagagacgcggaaggagtcagagattta ctgggaaacgcgcacttcacctcacagacttccttcattcccaaacctgtggacacgtct cagatcgtgatgcctcctcatctggagaaggttcgagatcgtctggcggagaacatccat gagctgtggggaatgaacaagatcgagctgggctggtcttacgggaagatcagagaggat aacaagcggcagcacccgtgtctggtggatttctccaaactgccagaaacagagaggaac tacaacctgcagatgtccaccgaaacgctcaagactctgctggcgttgggctgtcacgtg gtgcaggtcaaagtcaacgctgaagaggagctgaagaagctcaaactccccaagaattat ataatgtctaacggctataagccgtcaccgctggatctgtctgaggtcaaactgagcgcc gggcaggagctgctggtggacaaactgtcagaaaacgctcacaacgtctgggccaaagac cgcatcaaacagggctggacctacggcatccagcaggatgtgaagagcaagcgtaaccct cgtctggtgccgtatgctttactcgatgagcgcaccaagaaatcaaaccgcgacagcctg cgggaagccatacgaacgctcatcggatacgggtacaacgtcgagccgcccgaccaggac gccggtcacgtggtggagaggctgagcatcgataagatccgtttcttccgtgtggagcgc acgtacgccgtgaagatggggaagtggtattttgagtttgaggcggtgacgggtggagac atgcgggtgggctgggctcggcccggctgcaaacccgacgtggagctgggaacggacgcc caagcctacgtctttgacggccatcggggtcatcggctccacatgggcagtcgtctgttc ggccgctgctggcacgccggtgacgttgttggttgtatgatcaacttggaggacaaatcc atgatcttcaccctgaacggagaaatcctgatcactaacaagggctctgagctgtgcttc gccgactttgacatcgaagacggtttcatcccggtctgtagtttgggtctgtctcaggtg ggccgtatgaatttggggaaggacgccagcacgtttaagtactacaccatgtgcggcctg caggaggggttcgagccctacgccgtcaacatgaaccgcgaggtgaccatgtggttcagc aaacgcctgcccaccttctgcaacgtccccaaagaccaccatcacatcgcggtcacgagg atcgacgggacggtggacagtcctccgtgtctcaaagtgacccataagacgttcgggact cagaacagtaacgctgacatggtgttctgcagactcagtatgccggtggagtttcactcg tgtttcaggagcagcgcttacacgcacgtcaacggcctgtgtgaggacgagccgctcaag ctcaaacacaggcatccagtgaaatccaccaaacactcggatgaaggcagaagaacagat tacagcagcatcaccacatactatcactcggtcaggatattcgcgggtcaggacccgtcc tgcgtgtgggtcggctgggtcacccccgactaccattactatagcaaccacttcagcctc agcaagaaccgcacggtgaccgtcaccctgggagacgagcggggtcgcgtgcacgagagc gtgaagaggagtaactgttacatggtgtggggtggagacgtcaccagcgccgcacactcg tccagccgcagcaacgtggatttagagatcgggtgcctcatcgatttggccacgggtctg ttaacgttcacagtcaacggaaaagagcttcccacgtcataccaggtggagcccagcaca aaactgtttcctgctgtgtttgtgcggccgacgagctccagtctcttccagtttgaactg gctaaaatcaagaacgccatgcccatctcgtccgccatctttaagagcgaacacaagaat cccgttcctcagtgtcctccacgactggacgtccagaccattagctctgtgctttggagc cgaatgcccaacatcttcctgaaggtggagacggcccgtgtgagcgagaggcacggatgg atggtccagtgtgtggaaccgctgcagatgctggccgtgcacatcccagaggagaaccgg tgtgtggacatcatggagctgtcggagcaggaggatctgcgcacgttccactatcacacg ctgaagctgtactgcgctctgtgcgctcacgggaacacgcgtgtggctcacgccctctgc agtcacctggaccaatcgcagctgctctacaccatcgacaaccagtacctgtcgggtctg ctgcgcgagggcttctacgacgtcctcatcagcgtgcacctggagacggcccgagccgcc cgacgcatgatgaacaacgagttcatcatccccatcacggccgagacgcgcggcatccgc ctcttccccgacgcctccaaacgccaccggccaccgggcgtcgggctcagcacgtccctc aaacccagactgcacttcgggccgccctgcttcatcagcaccaaacgcgagcagcacctc tacagccccgagatcccgctggacgtgctgaaggagaaggccatcagcatgctgacggag gcggtgcagggcggaggagaccacatccgcgaccccgtcggaggaagcgtggagttccag ttcgtgcccatcctgcggctcatcgccacgctgctcaccatgggcgtcctgaccagccgc gacgtgcacaagatcctgctgctcatcgagcccggcgtgttcgccgaacacagccccaga gacgccacggccaaagaagggctgacgggagccgaggagaaggcggtggaggccggagag gaggaggcccgagacgggaaggcgctcgtcaaggggctgctggagaagaaactccccgaa tctgtcaaacgacagatgtgtgaactgctgcattatttctgtgactgtgagctgaggcat cgcatcgaggccatcgtctcgttctccgacagcttcgtttctaaactccagttcaatcag aagttccgctataacgagctgatgctggcgctcaacatgtcggccgccgtcaccgccaaa aagaccaaagagtttcgctccccgccgcaggaacagattaacatgctgctgaactttaac atgggtgaggactgtccctgtccagcagacatacaggaggagctctacgacttccacggc gagctgcgactgcactgcgggattccggtggaggaggatgaggaggatcaggactcgtct attaaagctcgtcttctggctctcgtctacaagatcaagggtcaaccgcagaaatctgag cgcgagcccaccgagaaggagcacagcgttccctcgaatctgaaggagctgatctctcag acgatggtgagctgggctcaggagacgcacatccaggacccggagctggtgcggctgatg ttcagtctgctgagacgacagtacgacagcatcggcgagctgctccgagccatgaggaag acctacaccatcagcgccgcctccgtccacgacaccatacacctgctggcgtctctgggt cagatccgctcgctgctcagcgtgcgcatggggaaagaagaggagcagctgatgatcgac ggcctcggggacatcatgaataataaggttttctaccagcatccaaacctcatgcgtgtt ctggggatgcacgagaccgtcatggaggtgatggtgaacgtcctgggaggaggaaagtct caggaaatcgcgtttcctaagatggtggccagctgctgccgcttcctgtgttacttctgt cgcatcagccgtcagaaccagaaggccatgtttgatcatctcagctacctgctggagaac agcagcgtggggttggcgtctccgtccatgagaggatccactcctctagacgtggcggct tcatcggtgatggacaacaacggtctggcgctggcgctggaggagcccgacctggacaag gttgtgacgtatctggccggctgcggtctgcagagctgtcccatgctcctgtccaaagga tatccagacatcggctggaaccccatcgagggcgagcgatacctgtccttcctgcgattc gccgtgtttgtgaacggtgagagtgtggaggagaactccagcgtggtggtgaagctcctg attcgtcggcccgagtgtttcggtcccgccctgagaggagaaggaggaaacgggctgctg gcggccatgaaggaggccatcaagatctctgagaaccccagcctggatctgcccagcgcc ggcccggctcacgcttcagacgcctccactgagggcgaggaggaagaggaagtggttcac atgggaaacgccatcctgtccttctactcggctctgatcgacctgctgggccgctgcgct ccagagatgcacctgatcaataagggtaaaggtgaagctctgaggattcgtgccatcctg cgttctctcgtccccactgaggatctggtcggtatcatcagtatccctctcaagatgccc gtcgtcaataaagacggcagcgtgacggagcctgacgtggcggccagtttctgtccggac cacaaggcgcccatggtgctgttcctggaccgcgtgtacggcatcgaggaccagagcttc ctgctgcatctgttagaggtgggcttcctgccggacctgagagccgccgcctcgctggac acggaggctttgcgcaccacagaaacggctctggctatgaacaggtacatcggttcggcc gtgctgcccctgctgacccgctgcgctccgcacttctccggcacagagcatcacgccgcg ctcatcgactccacgctctacaccatctaccgtctgtccaagggctgttcgctcaccaaa gcccagcgagacgccatcgaggagtgtctgctggccatctgcaagtatctcaggccctcc atgctccagcatctgctgcgccgactcgtgtttgacgtgccgttgttgtctgaatactgt aagatgcctctgaagctgttgacgaatcattacgagcagaactggaagtattactgcctg ccgtccggatgggggagttacggtcaggcgtctgaggaggagctgctgctcaccaagaag atcttctggggaatctttgactctctttctcagaagaagtacgagcaggatctgtttaag atggccatgccgtgtctgagtgccatcgctggagctctgccgccggactacatcgactcc acgctcagcaccacgctggagaaacaggtgtctgtggacacgcagggaaacttcgacccc agacccataaacacagccaacatctgcctgccggagaagctggagtacatcgcaaacaaa tacgctgaacattcccacgagaaatgggctgctgagaaagtgcttctgggctggaaacat ggagaaaacatcgacgagaaagccaaaactcaccccatgctgagatcatacaaatccctg acggagaaggagaaggaggcgtaccgctggacggtgcgcgagtcgttgaagagcatgcta gcgatgggctggagcatcgaccgcaccagagaaggagagagcatgtttcagcagagagag atggagaagatgcgccgcatctcacaggcctctcaggggaacggcttcaatccaaaccca ctggacatgagcagcgtccttctgtccagagaactgcagtcgatggttgaagtcgtggct gaaaactatcacaacatctgggccaagaagaagaagagcgatctgggcagcagagccgca ggaggagctcatccgctgctggtgccgtacgacacgctcacggccaaagagaagaccaaa gaccgagagcgagcgcaggatctcttccgcttcctgcagatcaacggatacgccatcagc aggggtctgaaggacatggagcaggactcgtcctccatggagaaacgcttcgcctaccgc ttcctgaagaagctgctgaagtacgtggactcggcgcaggagttcatcgctcacctcgag gcgatggcgtccagcggaaagaacgacagatcgcctcatgaacaggaaatcaagttcttt gcaaaggtgctcctccccctcattgaccagtactttaaaaaccactcgatgtacttcctg tcgtcgcccactaagaatctgagcagcagcggatacgcgtcaaacaaggagaaggagatg gtgaccagtctgttctgcaagctggccgctctggttagacacaggatctctctgtttgga agcgactccaccacgatggtcagctgtctgcacatcctcgctcacacgctggacaccagg accgtgatgaagtccggatcggagctggtcaaagcgggtttgaggacgttcttcgagaac gcggctgaagatctggagaagactctggagaacctgaagctggggaagttcacgcactcg cgcagtcagatgaagggcgtctcgcagaacatcaactacaccaccgtggctctgctgccc atcctcaccgctctcttcgagcacatcaccgaacaccagttcggctccgacctgctgctg gatgacgtgcaggtgtcgtgttatcgaatcctgaccagtttgtactcgctggggacgggg aagaacatctacgtggaaaggcagctgccggcgctgggcgagtgtttggcgactctagcc ggtgcgatgccggtggcgtttctggagccgcagctcaacacacacaacccctgctccgtg ttcaacaccaaaacgtctcgagaacgagccctggtgggtttgccggagtcggtggaggac gtgtgtcccgagatgcctcgtctggacggtctgatgaaggacatcaatgacatgtcggag tcgggcgcgcgctacacggagatgccgcacgtcatcgaggtggttctgcccatgctgtgt aactatctgtcgtactggtgggaaagaggaccggagaaccggcccgcgtccgtctgcagc accaccgtcacctccgagcacctcagcctcatcctggggaacatcctcaagatcctcaac agcaacctgggcatcgacgaggcctcctggatgaagcgcatcgcagtgtacgctcagccc atcatcagtaaggcgcgcgccgacctgctgaagacgcacttcctgcccacgctggagaag ctgaagaagaagacggtgaaggtggtggcggaggaggagcttctgaaagccgacgggaag ggcgacacccaggaggcggagcttctgatcctggatgagtttgcggtgctgtgcagagac ctgtacgccttctaccccatgctcatccgctacgtcgacaacaacaggtctcggtggctg aaggaaccggacgcggattctaatgagctcttcaggatggtggcagaaatcttcatcctg tggtgtaaatcccacaacttcaagagggaagagcagaactttgttgttcagaatgagatc aacaatctgtcgtttctcaccggcgacagtaaaaccaagatggcgaagtcattcctaccc aaggctggaggtcaggatcaggagcggaagcataagaagcggcgcggagacttttactcc atccagacgtctctgatcgtggcggcgctgaagaagatgctgcccatcggtctgaacatg tgcacgccgggagaccaggagctcatcatgctggccaagacacgatacggcctgagagac acagatgaggaggtgaaggagcacatcagacagaacctacacctgcaggagaagtctgca gatccagccgtccagtggcagctcaacctctataaggacgtgatggtgaagacggaggac acttcagatccggatcggagtatcgagagaatacagagcatctcagccgctgtcttccat ctggaacaggttgagcagccgttgcgctctaagaagtgtgtttggcagaagttgctgtct aagcagcggaagcgagccgttgtggcgtgtttcagaatggcaccgctctacaacctgccc aggcatcgctctattaacctgttcctcacgggctaccagcggctctggatagaggcagag atgtactcgtttgaggagaagctagtgcaggatttggcaaagacacagccgaaaactgat gaagaggaggaggagatcacagacactcagccggaccctcttcatcaactcatcctgcac tttagtcacaatgcgctgacagaacgcagctctctagaggaggatcagctgtacatcgca tacgcagacatgatggcaaagagttgtgctgaaaatgaggaagaggatgaggaaggaaaa gagaaaacatttgaggagaaggaaatggagaagcagaagactctgtaccagcaggcccga ctccatgacagaggagcagcagagatggtcttacagatgatcagcgctagcaaaggtcgt ttgggttcgatggtcaccttcacgctgaagctcggcatctccgttctcaacggcggaaac atcatagtccagcagaaaatgctggactatctgaaggagaagcgagacgtgggattcttt aagagtctgtcagggctgatgcagtcgtgcagtgttttggatctgaacgcgttcgagcgt cagaataaggctgagggtttggggatggtgacggaggaagggtccatcaacgtgagggag cgcggctctaaagttcttcagaatgacgagttcaccaaagatctgttcaggttcctgcaa ctcctgtgtgaaggacacaataacgacttccagaactttctcaggacgcagacgggaaac acaaccacagtcaacatcatcatcagcaccgtcgactatctgctcagactgcaggagtcc attagtgatttttactggtattactctggtaaagacgtgatggatgaagcgggtcagagg aatttctccaaagcgctcgctgtagccaaacagatcttcaactcgctcactgaatacata cagggtccgtgtatcgggaaccagcagagtttggctcacagcagactctgggacgccgtc gtcgggtttctccacgtcttcgccaacatgcagatgaagctgtcacaggactccagtcag atcgagctgctcaaggagctgatggatctgcagaaggacatgattgtcatgatgctgtcg ctgctggaaggaaacgtggtgaacgggaccatcggcaagcagatggtggacactctggtg gagtcctccagcaacgtggagatgattctcaagttcttcgacatgttcctcaagctgaaa gatctgacgacctcagagaacttcaaggagcacgaccccgaccgcaaaggcgtgatctcc aagaaagaattccagaagtccatggagaaccagaagcagtactctcagtccgagatcgag ttcctgctgtcctgcgccgaggccgacgagaacgacatgttcaactacgaagagttcgtc aagcgcttccacgaacccgccaaggacatcggcttcaacgtggcggttcttctcaccaac ctgtcggagcacatgcctcacgactctcgtctgtccgccttcctgaacctggccgagagc gttctcaactacttcgagccctacctgggccgcatcgagatcatgggcggcggcaagaga atcgagagggtttacttcgagatcagcgagtccagccgaacgcagtgggagaaaccgcag gtcaaagagtccaagcggcagttcatcttcgacgtggtcaacaaaggtggagaatctgag aagatggagctgttcgtgaacttctgcgaggacaccatcttcgagatgcagctggcgtct ctgatctccgagccggacgctgccgagagacaagaggaggacgatgacgaagacgatgct cggagcctggatctagaggaggacgaggaagacggcgcgctggagtcctcctcggcgttc gctctggcctgcgtctccatgaggaagagcctctccaacctgcggcagctgctgaccttc aggagcatgaagagacaataccgcaagctgaggaagatgagcgtccgggagatgatccga ggattcttcttcttcttctggatgatcttcaccggcatgttccgcttcctctacagcctg gtctggggcttcttccacatcctgtggtccacgctgttcggcggcggcctcgtggaagga gccaagaacatgaaggtgacggacattctgggcaacatgcccgaccccacgcagttcggg atccacggggacgtcctggagctggagaagctggagtactgcgacgtgtcgtcggtggcg gagctcggacgcttggcggcgggagatcaggccgagatggacctcatgacggagctgatg aacatccagcccaggagggaaggaggcaaacacggcatggagccgggactgggagacgtg tccgaggtgatcggagtggacgctccgtctttagccagcgccgtccatcagaagaaagct caggaagctgcgagtaaacaggcggctgaatctgagagcaaatctgagtcggagaaagcc gatgtggaggacggagagaagaaagatcaggacaagagcaaagaggagacggtttcagac tcgctgtcagacgaggagaagaagccgccgaagaagagacgcggtcagaggaaggagcag gccgaggccttcatggcggcgtttttagccggtctggacgtctatcagaccaaaaccctg aattatctggccaggaacttctacaacctgcgatttctggctctgtttgtggcgttcgcc atcaacttcatcctgctcttctacaaggtgaccggtgaggattcggatgatctggacccg tggacgcggcgcgaggaagaggaggatgaaggagtgatggagtattttgttcttcaggag aacacgggttacatggcgccgaccctgcgcttcctcgccgtcatgcacaccgtcatctcc ttcctctgtgtgctgggatactactatctgaaggtgccgctggtggtgttcaagcgtgag aaggagatcgcacggaagctggagttcgacggcctctacatcaccgagcagccgtttgat gatgatattaaaggccagtgggacagactcgtcatcaacacgccgtctttccccaacaac tactgggacaaatttgtcaaacggaaggttattaataagtacggtgatctctacggagcc gagcggatcgcggagctgctgggtttggataaaagtgctttagacttcaatcccactgag gagacggtcattaaagacgcctcgctgctgtcctggttgagctccattgacacaaagtac cacgtgtggaagatgggcgttgtgttcacagataactcatttctgtatctggtctggtac accaccatgtccattctgggacactataataatttcttcttcgctgctcatcttctggac attgccatgggcttcaaaacgctgaggaccatcctgtcctccgtcacacacaacggcaaa cagctggtgctgacggtcgggctgctcgctgtggttgtgtatctctacacggtcgtagcg ttcaacttcttccgcaagttctacaacaagagcgccgatgaggacgagcccgatatgaag tgtgatgacatgatgacgtgttatctgttccacatgtatgtgggtgtgcgtgccggcggc gggatcggtgacgagatcgaggacccggcgggcgacccgtacgagctctaccggatcctg ttcgacatcaccttcttcttcttcgtcattgtgattctgctggccatcatacaaggtttg atcattgatgcgtttggagaactgagagaccagcaggagcaggtcaaagaggacatggag accaaatgcttcatctgtggaattggaaacgactacttcgacacgacgccacacggattc gagactcacaccttacaagagcacaacctcgcaaactacctatttttcctgatgtacctg atcaacaaggatgaaaccgagcacactggtcaggagtcgtacgtgtggaagatgtaccag gagcgctgctgggatttcttcccggccggagactgtttccgtaagcagtacgaagaccag ctgggctga

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