Labeo rohita (rohu): 127183502 Help Entry 127183502         CDS       T09007                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism lroh  Labeo rohita (rohu) Pathway lroh04020   Calcium signaling pathway lroh04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:lroh00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     127183502 (ryr3)    04020 Calcium signaling pathway     127183502 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lroh04040]     127183502 (ryr3) Ion channels [BR:lroh04040]  Voltage-gated cation channels   Ryanodine receptor    127183502 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Ago_Mid DUF2207_C Motif Other DBs NCBI-GeneID:  127183502 NCBI-ProteinID:  XP_050995538 LinkDB All DBs Position 20:complement(18925078..19030766) Genome browser AA seq 4864 aa AA seqDB search MAEGGEGEDEVQFLRTEDEVVLQCVAAIQKENRKFCLSAEGLGNRLCYLEPTSEAKYFPP DLCICNFVLEQSLSVRALQEMLAGQSGEGNPDHEQWAAQGGGHRTLLYGHAILLRHSFSG MYLTCLKTSRSLTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVS SERYLHLSISNGSIQVDASFMQTLWNVQPTCSRSNVEVGFLLGGQVFRLFHGHDESLTIP GSEQSQEQQRVVNYEAGKGGSKARSLWRLEPLRISWSGSHIRWGQPFRLRHLSTGHYLGQ TEDNGLILLDREKSDTTATSFCFRSSKEKSDSGPKRDIDGMGVAEIKYGDSVCFIMHVST GLWLSYQAPDAKSSRLGPLKRRAVLSPEGHMDDGLTLQLCQHEESRAARIIRNTTRLFTQ FIRGLDGLNGEKTTEVTLPVCAVLQALNDLIVYFQQPDSELEHEEKQRQLRSLIKRQDLF KEEGMLTLVSHCIDRLNVYNSAAEFEELAGEEAGEAWKDILNLLYELLASLIRGNRTNCT QFSRKLDWLVSKLERLESSSGILEVLHCILIESPESLNIIQKAHIKSIISLLYKHGRNHK ILDVLCSLCVCNGVAVRANQNFICDHLLPRRDLLLQTRLVNDVQSMRPNIFLGMSEGSAQ YKKWYFELIIDQVDHYVTSEPTHLRVGWATTKGYAPYPGGGEGWGGNGVGDDLYSYSFDG LHLWSGRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNVDGFFF PVVSFSAGVKVRFLLGGRHGDFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDLEGVRD LLGTTEFLSQASFIPIPVDTSQIVLPPHLENVRDKLAENIHELWGMNKIELGWMYGKVRD DNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVAQVNINAEDDLKKMKLPKN YMMANGYKPTPLDLSDVKLTPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNRRN PRLVPYALLDERTKKSNRDSLREAIRTLVGYGYFIDPPDQETAHIVEKEGIESIRLFRVE KTYAVKTGKWYFEFEALTGGDMRVGWARPGCRPDIELGLDDQSFVFDGYRGRRVHMGSHF FGRSWSKGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFEAEDGFIPVCSLGLSQ IGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPEDHPHIEVT RIDGTVDTPPCLKVTHKTYGTQTSNDDMVCCRLSMPVEFHSGPRKITDINEVIAEDQRAK KDDGGKIDYASITKYYYSVRVFAGQDPSSVWVGWVTPDYHYYSKHFSLSTVRTVTVTLGD ERGRVHESVRRSNCYMVCAGDVVSSSTGRSNTDLEIGCAIDLASGLVSFTANGRDLPTAY QVEPNTKLFPAVFVQPTSPNLFQFEFPKIPDAMPLSSAIFKSLQRNPEPQCPPRLDVQTI VSVLWSRMPNTFLSVETARVSERHGWVVQCLEPLQMMAVHIPEENRCIDIMELSENEDLR QFHYHTLKLFCALCALGNNRVAHALCSHLDQSQLLYTIDNQYLSGQLREGFYDVLISIHL ETGKEAHLMMNNEFIIPVTDETRSIRLFPDDSKRHSLPGVGLSTSITPRLNFTPPCFITP KRDQPLFSPQIPLGTLKEKAISMLTEAVQGGGAHIRDPVGGSVEYQFVPILKLIGTLLIM GAMTSEEVRTILLLIDPSVFGDGKEEEEQTAVAEQGAEKEEATSNEEKAVEAGEEESKEA KQPPKGLLEKSLPESVKRQMCELLHYFCDCELKQRIESIVAFSDDFVSKLQYNQKFRYNE LMQALNMSAAVTAKKTKEFRSPPQEQINMLLNFSAGDDCTCPEELQEELQSFHDDLRLHC GIPMEEEEEEQDTSLKGRLMSLVYKIKGRPQKTEEKPTEQEQAAPTNLKELISQTMVTWA QECKIQDAALVRSMFSLLRRQYDGVGELLRALRKSYTISAKSVGDAINLLASLGQIRSLL SVRMGEEEGQLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKNKEIAFP KMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLACPAMRGSTPLDVAASSVMDN NSLALALEEPDLEKVVTYLAGCGLQNCPMLIARGYPDIGWNPIEGERYLSFLRFAVFVNG ESVEENANVVVKLLIRRPECFGPALRGEGGQGLLAAMKEAIKISEDPALDLPNLPEGAAP IVGEDEEEEEVAHMGNSIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVPTK DLVGIISIPLKMPVVNKDGTVTEPDMNASFCPEHKAPMVLFLDRVYGIDDQSFLMHLLEV GFLPDLRASASLDSEVLRTTETALAMNRYIGSAVLPLLTRCAHLFAHTEHYATLVDSTLH TIYRLSKGRSLTKAQRDAIDECLLAICKHLRPSMLQQLLRRLVFDVPQLTEYCKMPIKLL TNHYEQNWKYYCLPTGLGSYGMASEEELHLTKKLFWGLFDALSQKKYDAELFKMAMPCLS AIAGAIPPDYVDSSPGSTLVKQASVDAQGNFDPQPINTANISLPEKLDYIASKFAEHSHE KWSSEKIALGWTAGDKVDDKAKTHPLLKPYKALSEKERETYRYPVKETLKSMLAMGWNIE RTKEGEAMFQQRETEKQRKISESSQGEFIPAPQDLENVILSRELQAMVETVAENYHNIWA KKKKKELDIKGGGSHPLLVPYDTLTAKEKYRDREKAQELFKFLQVNGYAISRGLKDMEQD SSSMEKRIAYKFLKRLLNYVDSAQEFIAHLEAMATSGKTEKSPHDQEIKFFAKVLLPLID QYFKNHCLYFLSSPNISLSSSGYASNKEKEMITSLFCKLAALVRHRISLFGSDSTTMVSC LHILSRSLDFRTVMKSGSELVKAGVRTFFENAAEDLEKTLENLKLGKLGQSRTQMKGVTQ IISYTSVALLPILTVLFQYITQHQFGAELLLDDIQLSCYRILTSLYSLGTGKNIYVEKQL PVLGECLSTLVGAMPVAFLEPHLNMHNPQSVFNTKTPRERAILSMPDTVDEMCPEMPHLD GLMKDIGDISESGARYTDMPQVIEVILPMLCNYLSYWWAKGPENSPVDANCCTTVTSEHL SLILGNILKILNNNLGIDNAPWMKRLAVYTQPIISKASPDLLRTHFLPTLEKLKKKTVKV VAEEELLRAESRADTQEAELQILDEFAVLCRDLYAFYPMLIRYVDNNRSKWLKQPDSDST ELFKMVSEIFILWCKSHNFKREEQNFVVQHEINNLAFLTGDSKTKMSKSGGQDQERRGKR RRGELYSIQTSLIVAAHKKMLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKDYLRRNL HLQEKSADPAVQWQLNLYRDVVVKSEGPPDPEHNVDRVQAISAAVYYLDQVELPLRNKKM VFQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLSGYQRLWIETEEYSFEEKLVQDLA KTPMTVVEEEEEEEAEVQPDPLHQLILHFSHNALTERSFLEEDPLYIAYADMMAKSCAEN EEEEEEEGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTGTLKL GISILNGGNVLVQQKMLDYLKDKRDAGFFKSLSGLMMSCSVLDLNAFERQNKAESLGMVT EEGSINVSERGSKVLQNDDFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIIISTV DYLLRLQESISDFYWYYSGKDIMDEAGQLNFSKALAVAKQIFNSLTEYIQGPCIGNQQSL AHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMVVMMLSLLEGNVVNGTI GKQMVDTLVESSNNVEMILKFFDMFLKLKDLTTSDNFKEYDPDFKGVISKKEFQKSMDSQ KQYTQSEIEFLLSCVEADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRL STFLDLAESVLSYFEPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQFIFD VVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDTQERPEEDEDEELHSLLEGFSEEED TSLESASAFTAACASVKKSMSNFRKMLTFKNMRKQFKKFRKLTIREMITGFFSFFWMLFT GFFKGIFGIIFGFFHIIWSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDVMEAEKN ESSELVVSADMVQMTGAAAEKLDSDMIMDLLNPAVKKEGKHGAEPGLGDVCEVLTESSTP VEKKKSQKVTTEKPESEPEKADTENQEKEDKAKEETPEEPAAAKPAPKTKRGSSKEEAPA FMASFFAGLEVYKSKMLNYLARNFYNLRLLALFVAFAINFILLFYKVTGDFDDEEEEEGS WGGEEEEGDEDDEGMEYFILQESTGYMAPTLTFLAVLHTIISLLCVVGYYCLKVPLVVFK REKEIARKLEFDGLYITEQPSDDDIKGQWDRLVIATPSFPNNYWDKFVKRKVINKYGDLY GAERIAELLGLDKSALDFDPTEEAVVKEASLLSWLSSIDTKYHIWKMGVVLTDNSYLYLI WYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTV VAFNFFRKFYNKSEDEDAPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYELYR ILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPH GFETHTLQEHNLANYLFFLMYLINKDETEYTGQESYVWKMYQERCWDFFPAGDCFRKQYE DQLG NT seq 14595 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggtggtgaaggggaagatgaggttcagttcttacgaactgaagatgaggtg gttctgcagtgtgtcgccgccattcagaaggagaaccgcaaattctgcctatcagcagag ggactcggcaaccgcctgtgttatctagagcccacatcagaggcgaagtattttcctcct gacctatgcatctgtaactttgtactggagcagtcgctctcagtgcgagctctacaggag atgctcgctgggcagagcggtgaaggaaatcctgatcatgagcaatgggcagcacaggga ggtggacatcggacactgctctacggtcacgccatcctccttaggcattccttcagtgga atgtatctgacatgcctgaagacttctaggtctctgacagacaaactgtcttttgatgtt ggccttcaagaggattcaactggggaagcttgttggtggacaattcacccagcatccaag cagaggtcagagggtgagaaggtgcgcattggagatgacctcatcttggtcagcgtgtcc tctgagagatacctgcacctatctatctctaatggaagcattcaagtggatgcttcattc atgcaaacactgtggaacgttcagcctacctgctccagaagcaacgtggaagtgggattt cttttgggtgggcaagtgtttcgcttgttccatgggcatgatgagagtctcaccatacca ggatccgagcaaagccaagagcaacagagagtggtgaactatgaggctggcaaaggaggg tccaaagccaggtctttatggagactggagcctcttcggataagctggagcgggagtcac atcagatggggtcagcctttccgcctacgccatctctctaccggtcactacctgggccag acagaggacaatggtctgatactgctggacagggagaagtctgacaccaccgcaacatcc ttctgtttccggtcaagcaaggaaaagagtgactcgggcccaaagcgtgatattgatggt atgggggtcgcagagatcaaatacggcgattcggtttgcttcatcatgcatgtgtccacg ggcctgtggttgtcctatcaggcgcctgatgccaaatcttctcgcctgggaccactgaag agaagggctgtcctgtctcccgagggccatatggatgacgggctgactctgcagctttgc cagcacgaggagtcccgggcggctcgcatcattcgcaataccacccggctcttcactcag ttcatcaggggtctggatggcttgaatggggagaagactacagaggtgacgctgcctgtg tgtgcagtgctgcaggcactcaacgacctcattgtgtacttccagcagcctgactctgag ctcgaacatgaggagaaacaaaggcagctccgatctctcatcaagcgccaggatctcttc aaagaagagggaatgctgaccctggtctcacactgcatcgatcgcctaaacgtgtacaac agtgccgctgagtttgaggagttagcaggcgaggaggctggagaggcctggaaggacatt ctcaacctcctctatgagcttctggcctctctcattcgaggcaacaggaccaactgcaca cagttctctcgcaagctggattggctagtcagcaagcttgagcgattggagtcctcatca ggcattttagaggtgcttcattgtatcctaatcgagagtccagaatctctgaacatcatc cagaaggcccacatcaaatccattatttctctgctgtacaagcatggacgcaaccacaag attctagatgttctctgttccctgtgtgtctgcaatggtgtggctgtaagagccaatcag aattttatctgtgaccacctgcttcccaggagagacctgctgctccagacacgattggtc aatgatgtccaaagtatgagacccaacatcttcctgggcatgagtgaaggctcggcacag tacaagaaatggtactttgagctgatcatcgatcaagtagaccactatgtgaccagtgag cccacccaccttcgtgttggctgggccaccaccaaaggctacgccccctatcccgggggt ggagagggttggggaggaaacggtgtcggtgacgatctttactcttacagttttgatggg cttcatctgtggtcagggcgaatcccacgggccgtggcctctattaaccagcacttgctg aattcagatgatgttgtgagttgctgtctggatctcggggcccctagcatgtctttccga attaacggtcagcccgttcaaggcatgtttgaagacttcaacgtagatggcttcttcttt cccgtcgtcagtttttcagcaggggtcaaggtccgtttcttgttgggtggtcgccatgga gactttaagttcctgcctccagcaggctacgcgccatgttacgaagccctgcttcccaaa gaaaagatgcgtgtggagcctgtgaaggagtataaaagagacctggagggagtgagagat ctgctgggcaccacagagttcctgtcccaggcttctttcattcctattcctgttgacacc agccagattgtcctgcctccacatcttgaaaatgtgcgggacaagttagctgaaaacatc catgagctctggggcatgaacaaaatagagcttggctggatgtatggcaaggtccgagat gacaacaagagacagcacccttgtcttgttgacttctctaaactgccagaaacagaaaag aattataacctgcagatgtcaactgaaactttaaagaccctacttgctttgggatgccat gttgcacaagttaatataaatgctgaagacgacctgaaaaaaatgaaactccccaagaac tacatgatggcaaatggttataaacctacaccgctggatctttctgatgtgaaactgaca cctggacaggaggttctagttgataaattggctgaaaatgctcataatgtttgggccaaa gatcgcattaaacaaggatggacctatggtattcagcaggatttgaaaaaccgtcgtaat ccacgtctggtgccatatgctttattagacgaacgcactaagaaatcaaacagagacagt cttcgagaggctatccgtactctggttggatatggatatttcatagacccacctgatcaa gagactgctcacatcgtagagaaggagggcattgaatccatccgtctcttccgtgtggag aagacctacgctgtgaagaccgggaagtggtattttgagttcgaagcgctcactggagga gacatgcgggtgggctgggcacggcctggatgcagacctgatatagaacttggactagat gaccagtccttcgtctttgatggctacaggggccgccgggttcatatgggcagtcatttc tttgggaggtcatggagtaaaggagatgtggtaggctgcatgatcaacatggaggacaaa tccatgatattcaccctgaatggagagatcttgatcaccaacaagggttctgagctctgc tttgcagactttgaagctgaagatggattcatcccagtgtgcagcctgggtctttcccaa attggccgtatgaatttaggaaaagacgctagtacttttaagtactacactatgtgtggc cttcaggaggggtttgagccctttgctgtcaacatgaatcgagaagtcaccatgtggttc agcaaacgtctgcctacgtttgttaatgtcccagaggaccacccccatattgaggttact agaatagatggaactgtggacacacctccatgtctaaaggtaacacacaagacatatggg acccagactagcaatgacgacatggtttgttgtcgtctaagcatgcctgttgagttccac tctggccctcggaagatcactgatatcaatgaggtgatcgctgaggaccaaagagctaag aaggacgatggaggcaagattgattatgccagcattacaaagtactactactctgtgaga gtgtttgctgggcaagatccatcgtccgtttgggtgggctgggtgacaccagactaccac tactacagcaaacacttcagcctcagcacagtacgcaccgtgactgtaacgctgggtgac gagcggggacgtgttcatgagagtgtgaggaggagtaattgttacatggtctgtgctggg gatgttgtcagcagctccacaggccgtagtaacactgatctggagattggctgcgccata gatctggcctcaggcctggtctcattcactgccaatggcagagatctgcctactgcatac caggttgagcctaacactaagctgttccctgctgtgtttgttcaacccacaagtcccaac ctcttccagtttgagtttccaaaaatcccagatgcaatgcccctgtcttcagccatcttt aagagcttacaaagaaacccagagccccagtgtcctcctcggctggacgtgcagacaatc gtgtccgtgttgtggagcagaatgcccaacaccttcctgtcagtggagacggctcgtgtg agtgagaggcatggctgggtggtgcagtgtctggagcccctgcagatgatggctgttcat atcccagaggagaacaggtgtattgacatcatggaactgtcagaaaacgaagatctacgg cagttccactatcacactttaaagctcttctgcgccctttgtgccctgggcaacaaccgt gttgctcacgccctctgtagccatcttgaccaatcgcagcttttgtacaccattgataat cagtacctgtctggtcagctgcgtgaaggcttttacgacgtcctcatcagcattcacctg gaaacgggcaaagaggcccatctcatgatgaacaacgagtttataatcccagtaacggac gagacgagaagcatccgcctcttccctgacgactctaagcgtcactctcttcctggtgta ggcttgagcacttcaattacccctcgtctcaacttcacccctccgtgtttcattacccct aagcgcgatcagcctctcttcagcccacagatccctctgggtaccttaaaggagaaagcc atcagcatgcttacggaggccgtgcagggcggaggcgcccacattcgagatcctgtgggt ggaagcgttgagtatcagtttgtgccgattcttaagttgattggcaccctgctgataatg ggagccatgaccagcgaggaggtgaggaccatcctgcttctcattgaccccagtgtgttt ggggacggaaaggaggaggaggagcagacagcagtggcagaacagggagccgagaaagag gaggccaccagtaatgaagagaaggctgtggaggctggggaggaggagagtaaagaggct aagcagcctcctaaaggtcttctggagaaaagcttgcctgaatcggtcaaacggcagatg tgtgagctgctgcactatttctgtgactgtgagctgaagcagcgcattgagtccatcgtg gccttctcagatgattttgtatccaaactgcaatacaatcagaaattccgctacaatgag ttgatgcaagccctcaacatgtcagctgctgtcactgccaaaaagacaaaagagttccgc tcacctcctcaagagcagataaatatgttattgaacttcagtgctggtgatgattgcacc tgccctgaggagcttcaagaggagcttcaaagcttccacgatgacctgcgactacattgt ggcatccctatggaagaggaagaggaggagcaagacacatcgcttaaaggccgcctaatg tccctggtatacaagattaaaggtcgtccacaaaaaaccgaggaaaaaccaacagagcaa gaacaggctgctcctaccaacttaaaggagctcatatctcagactatggtcacctgggct caggagtgcaagatccaagacgcggctctggtccgtagcatgttcagccttttgagaagg cagtatgatggtgtcggtgagctgctcagggccttgaggaagagctacaccatcagtgcc aagtctgtaggggacgcaatcaacctgttggcctcactgggccagattcgttcactgctt agcgtccgcatgggggaagaagagggccagcttatgatcgacggcctgggggacatcatg aacaacaaagtgttttaccagcatccaaatctgatgcgtgttcttggcatgcatgagacc gtaatggaggtcatggtcaatgtactaggaggagacaagaataaggagattgccttcccc aagatggtggccagctgttgtcgcttcctgtgctacttctgtcgcatcagccgtcagaac cagaaggctatgtttgaccacctgagctacctcctggagaacagcagtgtgggactggca tgcccagccatgagaggctccacacctttagatgtggctgcctcctctgtgatggacaat aacagtttagctctggcacttgaagaacctgatcttgagaaggtggtgacatatctggca ggctgtggcttgcagaactgcccgatgctcattgccaggggatacccagatattggctgg aacccaatagagggagaacgctatttgtctttcctacgttttgctgtctttgtcaatggt gaaagtgtcgaagagaacgctaatgtagtagtgaagcttttgatcaggcgtccggagtgc tttggacctgctctcagaggagagggagggcaaggtttactcgctgccatgaaggaagcc atcaagatctcagaagatcctgctttagacctgcctaatttacccgagggggctgcacca atcgtcggagaggatgaagaggaggaggaggtcgcccacatgggcaactctattatgtcc ttctactcagcccttattgatcttcttggccgctgtgcacctgagatgcatcttataaac aaaggcaagggtgaagcgctgcgtatccgtgccatcctccgttctttagttcccactaag gatttggtcggaattattagtattccactcaaaatgccggtcgtcaataaagatggcact gtgacagagccagatatgaatgccagcttctgtccggagcacaaagcacccatggtgctg ttcctggaccgtgtctatggtattgacgaccaaagcttcttgatgcacctgctggaggtg ggcttcctgccagacctgcgcgcatcagcctccctggactcggaggtgctcaggaccaca gagacagccctggccatgaaccgctacattggatccgcagtacttcctctgttgacccgc tgtgctcatctgttcgctcacaccgagcactacgcaacacttgttgactctacgctgcac accatctatcgcctctcaaagggccgatcactcaccaaggcccagagagatgctattgat gaatgtctactggccatctgcaagcatctgaggccatctatgctgcagcaactattgcgt cgtcttgtgtttgatgttccacagcttacagagtactgcaagatgcccattaagctgttg accaatcactatgagcagaactggaagtactactgtctgccaacaggcctgggcagctat ggaatggcatcagaggaggaactccatctcaccaagaaactcttctggggactttttgat gctctttctcaaaagaaatatgatgcagagcttttcaaaatggccatgccgtgtctgagt gccatagctggtgccataccacctgactacgtcgactccagcccaggttccacattagtt aagcaggcctctgtggatgcgcaaggcaactttgacccccagcctattaacactgctaac atctcactgcctgaaaagctagattacattgcaagcaagtttgccgagcattcccatgag aaatggtcctctgagaagattgctctcggctggactgcgggagataaagtagatgacaaa gctaaaactcatccacttctgaaaccgtacaaagcactgagtgaaaaggaaagggagacg taccgctatcctgtgaaagagactctgaagagcatgttggcaatgggatggaacattgag aggaccaaagaaggagaggctatgttccagcaacgggaaacagaaaaacagcgcaagata tcagaatcttctcagggtgagtttattccagccccacaagatttggaaaatgttattctg tcaagagaactacaggcgatggttgaaacagttgcagaaaattaccacaacatttgggca aagaagaagaaaaaggagcttgacattaaaggagggggaagtcatccattgttggtaccg tatgacacactgacggcaaaggagaagtacagagatcgagagaaggcccaggaactcttt aaattcctccaggtcaatggatatgccatcagcagaggtctgaaggacatggagcaggat tcctcttctatggaaaagcggatcgcctataagttcctcaagaggctcttgaattatgtt gattctgcacaggagtttatcgcccatcttgaggctatggctaccagtgggaagacagaa aaatctccccatgatcaagagatcaagttttttgctaaggttctgctgcccctcatagac cagtacttcaaaaaccattgtttgtacttcctgtcatcccccaacatcagcctgagcagc agtggctacgcatccaacaaagagaaggagatgatcacgagtttgttctgtaagctggca gcccttgtcagacatagaatatcactctttggaagtgactccaccaccatggtgagctgc ttgcacatcctgtcacgctcactggacttcaggactgtgatgaagtctggctcagagctg gtgaaggctggtgtcaggacgttctttgagaatgcagcggaagacctggagaagactctg gagaacttaaagctggggaagctgggtcagtcacgcacccagatgaagggcgttacacag atcatcagctacacctcagtggccctgctgcccatcttgacggttcttttccagtatatc acccaacatcagtttggagcagagctgttactggacgacatccagctgtcctgctaccgc atcctgaccagcctctactcattgggcactggcaaaaacatctatgtggaaaaacagctt ccagtgctgggtgaatgtttatctactctggttggggccatgcctgttgccttcctggaa ccccacctaaatatgcacaacccccaatctgtcttcaacaccaagacaccaagagaacga gctattttgagcatgccagacactgtggatgagatgtgtcctgagatgccccatctggac ggcctgatgaaggacatcggtgacatttctgaatccggagcacgctacacagatatgcca caggtcatcgaggtcatcctgcccatgttgtgtaactatctgtcttactggtgggcaaaa ggcccagaaaactccccagttgatgccaattgctgcacaactgtcacatctgagcatctt agcctaattctgggcaacatccttaagattctcaataacaaccttggcattgataatgcc ccatggatgaaaagactcgcagtatacacccagcctatcattagcaaggctagcccagat cttcttagaacgcacttcctgccaacgctggagaaactgaagaagaaaacagtgaaggta gtggctgaagaggagctgctgagggctgaaagcagggcagacactcaggaagctgaactg cagattctggatgagtttgctgttctctgcagggatctgtatgccttctatccaatgctc attcgttatgtggacaacaacagatccaaatggctgaagcaaccagattcagactcaact gaacttttcaaaatggtgtcagagattttcatcctttggtgtaaatctcataactttaaa agggaagagcaaaattttgtggtgcaacatgaaatcaacaacctggcgttccttactgga gacagcaagacgaagatgtcaaaatctggaggtcaggaccaagagagaagaggaaaaagg agaagaggagagttgtactccatccagacttcacttatcgtagcagctcacaagaagatg ttgcccattggtctgaacatgtgcactcctggagaccaggagctcatttcccttgctaag atccgttatagcctgaaagacacagatgacgaggttaaggattatctgaggaggaacctc catcttcaggagaagtcagcagatccagcagtgcagtggcagctgaacctctacagagat gttgtggtgaagagtgagggacctccagacccagagcataatgtggatagagttcaggcc atctctgctgctgtctactaccttgatcaggttgagctgccgctgaggaacaagaagatg gtgtttcaaaagctgctgtcaaagcaaagaaagcgtgccgtggtggcctgtttccgcatg gcaccgctttacaacttaccaaggcatcgctcaattaacctcttcctcagtggctatcag agactttggatagagacagaggagtactcctttgaggagaagctagtgcaggacctggca aaaactcccatgactgtggtagaggaagaagaggaagaagaagctgaagttcagccagat cctcttcatcagctcatcctccactttagtcataatgcactgacagagagaagtttccta gaagaggatcctctctacattgcatatgctgacatgatggcaaagagctgcgctgagaat gaggaagaagaagaagaggagggaaaagaaaaaacttttgaggaaaaagaaatggagaag cagaagattttgtaccagcaggccagacttcacgcccgaggggctgctgagatggtgcta cagatgatcagtgccagtaaaggccgacttggtcccatggtgactggcacccttaaactg ggaatttctatcctaaatggaggcaacgttcttgtccagcagaaaatgctggattatttg aaggataaacgagatgcgggcttctttaaaagtttatctggactaatgatgtcttgcagt gtgctggatttaaatgcatttgaaaggcaaaataaggcagagagtcttggaatggtgact gaagaggggtcaatcaacgtgagcgagcggggttccaaagtgctacaaaatgatgacttt acaaaggatttattcaggtttttgcaactcctatgtgaggggcacaataatgatttccaa aacttcttgcggacccaaactggaaacactactacggtcaacatcattattagcactgtg gactacctattacgtctacaggaatctataagtgatttctactggtattactctgggaaa gatatcatggatgaggctgggcaacttaacttctccaaagctttggcagtagccaaacaa atctttaactcactcactgagtacattcagggcccttgtattgggaatcagcaaagtttg gcacacagcaggttgtgggacgcagtggttgggttcctgcatgttttcgcaaacatgcaa atgaaactgtcacaggattctagtcaaatcgagttattgaaagagctgatggatttacag aaagatatggtggtcatgatgttatctcttctggagggtaatgtggtgaatggaactatc ggcaagcagatggttgacacattagtggagtcctccaacaatgtggaaatgatcctcaag ttcttcgacatgttccttaaactgaaggacctcactacatctgataactttaaggagtac gacccagatttcaaaggcgttatatccaagaaggagttccagaagtctatggatagccaa aagcaatacacacagtctgagatcgagtttctcctctcctgtgtggaggcagatgaaaat gacatgttcaactacaaggagtttgtggaacgtttccatgaaccagctaaggacattggc ttcaatgtagctgtgcttctcacgaacctatcagaacacatgcctcacgactcacgcttg tccaccttcttagacctggcagaaagcgttcttagttactttgagccatacctaggtcgt attgagatcatggggggtgccaagaggattgagagggtttactttgagatcagcgagtct agtagaacccagtgggagaaacctcaggtcaaagagtccaaacgccaattcatcttcgat gtggtcaacgaaggcggtgagagtgagaagatggagttatttgtgaacttctgtgaggac accatctttgagatgcagttggcctctcagatctctgagccagacacccaagagcgacct gaggaggacgaagacgaggagttgcacagtctgctcgaaggattctctgaggaggaagac acatctctcgagtccgcctcggccttcaccgcagcctgtgcttctgtcaagaagagcatg tctaatttccgtaaaatgctgacgtttaagaatatgagaaagcagtttaagaaattcagg aagctgactatcagggaaatgatcacagggttcttctccttcttctggatgctcttcacc gggttcttcaaaggcattttcgggatcatcttcgggttctttcatattatttggtcctcc atgtttggaggtggtcttgtggagggtgctaaaaacatgaaagtgactgatatcttgggt aacatgcctgatccaacacagttcgggatccatggtgatgtaatggaagcagaaaaaaat gaaagcagtgagttggtggtgtcggcagatatggtgcagatgaccggtgctgctgctgag aagctggattcggatatgataatggatctacttaatccagctgtgaagaaggaggggaag catggggcagaacctggtctgggtgatgtctgtgaagtcctgacagagtctagcacccca gttgagaaaaagaagagccagaaagtaacaacagagaagccagaatccgagccagagaaa gctgacactgagaatcaggagaaagaagacaaggctaaagaggaaacacccgaggaacca gcagcagcaaaaccagctccaaaaaccaaacgtggctcatcaaaggaagaagctccagca ttcatggccagcttctttgcagggcttgaagtctacaaatccaaaatgctgaactacctg gctcgcaatttctacaaccttcgtcttctggctttgtttgtggccttcgccattaacttc atcctgctcttctacaaggtgactggagatttcgacgatgaggaagaggaggaaggatcc tggggtggtgaagaggaggaaggcgatgaagatgatgaaggaatggagtacttcattctt caggagagcactggctacatggcacccacgttgacgttcttagctgtactacacacgatc atctccttactctgtgttgttggatactactgtctcaaggttcctttagtcgtgttcaag agagagaaggagattgccaggaagcttgagtttgatggtttgtatattacagagcagccg tctgacgatgacatcaaaggacagtgggatcgtttggtcattgcaactccgtccttccct aacaattactgggacaaatttgttaagaggaaggtcatcaataaatatggtgatctgtac ggggcagagcgcattgctgaactcctgggtctggacaagagcgctctggactttgatccc actgaagaggctgtggtgaaggaagcctccctgctatcctggttgagctcaattgatacc aagtaccacatctggaaaatgggtgtggtgttgacagacaattcttacctctacctgatc tggtacaccaccatgtctattctgggacattacaataacttcttctttgccgctcatttg ctggacattgccatgggctttaagaccttgaggactatcctctcttctgtgactcacaat ggcaaacagctggtgttgaccgtgggcctcctggcggttgtggtctacctatacaccgtg gtggcttttaacttcttccgcaagttctacaacaagagcgaggatgaggacgcacctgac atgaagtgtgatgatatgatgacttgctacctgttccacatgtacgtgggtgtgagagct ggcggtggtattggtgatgaaattgaggacccggccggcgacccgtatgagctctaccgc attctgtttgacatcaccttcttcttctttgtcatcgtcattctgctggccatcattcag ggtttgattattgatgccttcggtgagttgagagaccagcaggagcaggtgaaagaggac atggagacaaaatgcttcatctgtggaatcgggaatgactactttgacacaactccgcac ggctttgagacccataccttacaagagcacaatctggccaactatttattcttcctgatg tatcttatcaacaaagatgagactgaatacactggtcaggagtcgtatgtttggaagatg tatcaggagaggtgctgggatttcttccctgctggagactgcttccgaaagcaatacgag gaccagctgggctag

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