KEGG   Lynx rufus (bobcat): 124506951
Entry
124506951         CDS       T08475                                 
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
lruf  Lynx rufus (bobcat)
Pathway
lruf01522  Endocrine resistance
lruf04010  MAPK signaling pathway
lruf04012  ErbB signaling pathway
lruf04014  Ras signaling pathway
lruf04024  cAMP signaling pathway
lruf04068  FoxO signaling pathway
lruf04071  Sphingolipid signaling pathway
lruf04137  Mitophagy - animal
lruf04140  Autophagy - animal
lruf04141  Protein processing in endoplasmic reticulum
lruf04210  Apoptosis
lruf04215  Apoptosis - multiple species
lruf04217  Necroptosis
lruf04310  Wnt signaling pathway
lruf04380  Osteoclast differentiation
lruf04510  Focal adhesion
lruf04517  IgSF CAM signaling
lruf04530  Tight junction
lruf04620  Toll-like receptor signaling pathway
lruf04621  NOD-like receptor signaling pathway
lruf04622  RIG-I-like receptor signaling pathway
lruf04625  C-type lectin receptor signaling pathway
lruf04657  IL-17 signaling pathway
lruf04658  Th1 and Th2 cell differentiation
lruf04659  Th17 cell differentiation
lruf04660  T cell receptor signaling pathway
lruf04664  Fc epsilon RI signaling pathway
lruf04668  TNF signaling pathway
lruf04722  Neurotrophin signaling pathway
lruf04723  Retrograde endocannabinoid signaling
lruf04728  Dopaminergic synapse
lruf04750  Inflammatory mediator regulation of TRP channels
lruf04910  Insulin signaling pathway
lruf04912  GnRH signaling pathway
lruf04914  Progesterone-mediated oocyte maturation
lruf04917  Prolactin signaling pathway
lruf04920  Adipocytokine signaling pathway
lruf04926  Relaxin signaling pathway
lruf04930  Type II diabetes mellitus
lruf04931  Insulin resistance
lruf04932  Non-alcoholic fatty liver disease
lruf04933  AGE-RAGE signaling pathway in diabetic complications
lruf04935  Growth hormone synthesis, secretion and action
lruf04936  Alcoholic liver disease
lruf05010  Alzheimer disease
lruf05012  Parkinson disease
lruf05016  Huntington disease
lruf05017  Spinocerebellar ataxia
lruf05020  Prion disease
lruf05022  Pathways of neurodegeneration - multiple diseases
lruf05132  Salmonella infection
lruf05133  Pertussis
lruf05135  Yersinia infection
lruf05142  Chagas disease
lruf05145  Toxoplasmosis
lruf05152  Tuberculosis
lruf05161  Hepatitis B
lruf05162  Measles
lruf05166  Human T-cell leukemia virus 1 infection
lruf05167  Kaposi sarcoma-associated herpesvirus infection
lruf05169  Epstein-Barr virus infection
lruf05170  Human immunodeficiency virus 1 infection
lruf05171  Coronavirus disease - COVID-19
lruf05200  Pathways in cancer
lruf05208  Chemical carcinogenesis - reactive oxygen species
lruf05210  Colorectal cancer
lruf05212  Pancreatic cancer
lruf05231  Choline metabolism in cancer
lruf05415  Diabetic cardiomyopathy
lruf05417  Lipid and atherosclerosis
lruf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lruf00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    124506951
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    124506951
   04012 ErbB signaling pathway
    124506951
   04014 Ras signaling pathway
    124506951
   04310 Wnt signaling pathway
    124506951
   04668 TNF signaling pathway
    124506951
   04068 FoxO signaling pathway
    124506951
   04071 Sphingolipid signaling pathway
    124506951
   04024 cAMP signaling pathway
    124506951
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    124506951
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    124506951
   04137 Mitophagy - animal
    124506951
  09143 Cell growth and death
   04210 Apoptosis
    124506951
   04215 Apoptosis - multiple species
    124506951
   04217 Necroptosis
    124506951
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    124506951
   04530 Tight junction
    124506951
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    124506951
   04621 NOD-like receptor signaling pathway
    124506951
   04622 RIG-I-like receptor signaling pathway
    124506951
   04625 C-type lectin receptor signaling pathway
    124506951
   04660 T cell receptor signaling pathway
    124506951
   04658 Th1 and Th2 cell differentiation
    124506951
   04659 Th17 cell differentiation
    124506951
   04657 IL-17 signaling pathway
    124506951
   04664 Fc epsilon RI signaling pathway
    124506951
  09152 Endocrine system
   04910 Insulin signaling pathway
    124506951
   04920 Adipocytokine signaling pathway
    124506951
   04912 GnRH signaling pathway
    124506951
   04914 Progesterone-mediated oocyte maturation
    124506951
   04917 Prolactin signaling pathway
    124506951
   04926 Relaxin signaling pathway
    124506951
   04935 Growth hormone synthesis, secretion and action
    124506951
  09156 Nervous system
   04728 Dopaminergic synapse
    124506951
   04723 Retrograde endocannabinoid signaling
    124506951
   04722 Neurotrophin signaling pathway
    124506951
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    124506951
  09158 Development and regeneration
   04380 Osteoclast differentiation
    124506951
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    124506951
   05208 Chemical carcinogenesis - reactive oxygen species
    124506951
   05231 Choline metabolism in cancer
    124506951
  09162 Cancer: specific types
   05210 Colorectal cancer
    124506951
   05212 Pancreatic cancer
    124506951
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    124506951
   05170 Human immunodeficiency virus 1 infection
    124506951
   05161 Hepatitis B
    124506951
   05171 Coronavirus disease - COVID-19
    124506951
   05162 Measles
    124506951
   05167 Kaposi sarcoma-associated herpesvirus infection
    124506951
   05169 Epstein-Barr virus infection
    124506951
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    124506951
   05135 Yersinia infection
    124506951
   05133 Pertussis
    124506951
   05152 Tuberculosis
    124506951
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    124506951
   05142 Chagas disease
    124506951
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    124506951
   05012 Parkinson disease
    124506951
   05016 Huntington disease
    124506951
   05017 Spinocerebellar ataxia
    124506951
   05020 Prion disease
    124506951
   05022 Pathways of neurodegeneration - multiple diseases
    124506951
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    124506951
   05418 Fluid shear stress and atherosclerosis
    124506951
   05415 Diabetic cardiomyopathy
    124506951
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    124506951
   04936 Alcoholic liver disease
    124506951
   04932 Non-alcoholic fatty liver disease
    124506951
   04931 Insulin resistance
    124506951
   04933 AGE-RAGE signaling pathway in diabetic complications
    124506951
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    124506951
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lruf01001]
    124506951
Enzymes [BR:lruf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     124506951
Protein kinases [BR:lruf01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   124506951
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH DUF530
Other DBs
NCBI-GeneID: 124506951
NCBI-ProteinID: XP_046929031
LinkDB
Position
Unknown
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagattctacattt
acagttttgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctgagccggccg
tttcagaatcagactcatgctaaacgggcttacagagagctagttctaatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggaactagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcccagtaatatagtggtaaaa
tcagactgcactttgaagattcttgactttggactggccaggactgcaggaactagtttt
atgatgacgccttacgtagtgactcgctactacagagcacctgaggtcatcctagggatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgccctgaattcatgaagaaactacaaccaacagtaaggacttacgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccctgatgtacttttc
ccagctgactcggaacacaacaaacttaaagccagtcaggcaagggacttgttatccaaa
atgctggtaattgatgcatctaaaaggatctctgtagatgaagccctccagcatccatat
atcaatgtctggtatgatccttctgaagcagaagctccaccacccaagatacctgacaag
caattagatgaaagggaacatacaatagaagagtggaaagagttgatatacaaagaagtt
atggacttggaggagagaaccaagaatggagttatacgggggcagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcatcatcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctcagatacagatagcagtctggaagcatcagct
ggacctctgggctgttgtagatga

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