Lynx rufus (bobcat): 124509491
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Entry
124509491 CDS
T08475
Name
(RefSeq) serine/threonine-protein kinase A-Raf
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
lruf
Lynx rufus (bobcat)
Pathway
lruf01521
EGFR tyrosine kinase inhibitor resistance
lruf01522
Endocrine resistance
lruf04010
MAPK signaling pathway
lruf04012
ErbB signaling pathway
lruf04068
FoxO signaling pathway
lruf04270
Vascular smooth muscle contraction
lruf04650
Natural killer cell mediated cytotoxicity
lruf04720
Long-term potentiation
lruf04726
Serotonergic synapse
lruf04730
Long-term depression
lruf04810
Regulation of actin cytoskeleton
lruf04910
Insulin signaling pathway
lruf04914
Progesterone-mediated oocyte maturation
lruf04928
Parathyroid hormone synthesis, secretion and action
lruf05010
Alzheimer disease
lruf05022
Pathways of neurodegeneration - multiple diseases
lruf05034
Alcoholism
lruf05160
Hepatitis C
lruf05161
Hepatitis B
lruf05200
Pathways in cancer
lruf05205
Proteoglycans in cancer
lruf05208
Chemical carcinogenesis - reactive oxygen species
lruf05210
Colorectal cancer
lruf05211
Renal cell carcinoma
lruf05212
Pancreatic cancer
lruf05213
Endometrial cancer
lruf05214
Glioma
lruf05215
Prostate cancer
lruf05218
Melanoma
lruf05219
Bladder cancer
lruf05220
Chronic myeloid leukemia
lruf05221
Acute myeloid leukemia
lruf05223
Non-small cell lung cancer
lruf05224
Breast cancer
lruf05225
Hepatocellular carcinoma
lruf05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
lruf00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
124509491
04012 ErbB signaling pathway
124509491
04068 FoxO signaling pathway
124509491
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
124509491
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
124509491
09152 Endocrine system
04910 Insulin signaling pathway
124509491
04914 Progesterone-mediated oocyte maturation
124509491
04928 Parathyroid hormone synthesis, secretion and action
124509491
09153 Circulatory system
04270 Vascular smooth muscle contraction
124509491
09156 Nervous system
04726 Serotonergic synapse
124509491
04720 Long-term potentiation
124509491
04730 Long-term depression
124509491
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
124509491
05205 Proteoglycans in cancer
124509491
05208 Chemical carcinogenesis - reactive oxygen species
124509491
09162 Cancer: specific types
05210 Colorectal cancer
124509491
05212 Pancreatic cancer
124509491
05225 Hepatocellular carcinoma
124509491
05226 Gastric cancer
124509491
05214 Glioma
124509491
05221 Acute myeloid leukemia
124509491
05220 Chronic myeloid leukemia
124509491
05218 Melanoma
124509491
05211 Renal cell carcinoma
124509491
05219 Bladder cancer
124509491
05215 Prostate cancer
124509491
05213 Endometrial cancer
124509491
05224 Breast cancer
124509491
05223 Non-small cell lung cancer
124509491
09172 Infectious disease: viral
05161 Hepatitis B
124509491
05160 Hepatitis C
124509491
09164 Neurodegenerative disease
05010 Alzheimer disease
124509491
05022 Pathways of neurodegeneration - multiple diseases
124509491
09165 Substance dependence
05034 Alcoholism
124509491
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
124509491
01522 Endocrine resistance
124509491
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
lruf01001
]
124509491
Enzymes [BR:
lruf01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
124509491
Protein kinases [BR:
lruf01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
124509491
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
Pkinase_fungal
Kdo
TUG-UBL1
UPF0767
Motif
Other DBs
NCBI-GeneID:
124509491
NCBI-ProteinID:
XP_046932105
LinkDB
All DBs
Position
Unknown
AA seq
608 aa
AA seq
DB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQVYHSVQDLSGGSRQHEAPSNRPLNEPL
TPQGPSSRTQHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSSLLQLTAQSFS
TDAAGSRGGGDGAPRGSPSPSVPSGRKSPHSKSPSEQREQRERKSLADDKKKVKNLGYRD
SGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVL
RKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMD
YLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVI
RMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNC
PKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACL
LSAARLVP
NT seq
1827 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtacggggtcttaatcaggattgctgtgtg
gtctaccggctgattgaggggcgaaagacagtcactgcctgggacacagccattgccccc
ctggatggagaggagctcatcgtagaggtccttgaagatgtgccactgaccatgcacaat
tttgtacggaagacgttcttcagcctggcattctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcactgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccgacaggtctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaggctccctcgaaccgccccctgaatgagccgcta
acccctcagggtcccagctcccgcacccagcaccgcgaccctgagcactttcccttcccc
gcccctgccaacgccccactccagcgcatccgctccacatccactcccaacgtgcacatg
gtcagcaccacggcccccatggactccagcctcctccagctcactgcccagagtttcagc
accgatgctgctggtagtagaggcggtggcgacggagccccccgggggagccccagcccc
agcgtgccctcggggaggaagtccccacattccaaatccccgtcagagcagcgtgagcag
cgggagcggaagtccttggctgatgacaagaagaaagtgaagaatctggggtaccgggac
tcgggctattactgggaggtgccgcccagcgaggtgcagctgctgaagaggatcgggacg
ggctcgtttggcaccgtgtttcgcgggcggtggcatggcgacgtggccgtgaaggtgctc
aaggtggctcaacccacagcggagcaggcgcaggccttcaagaacgagatgcaggtgctc
aggaagacacgtcatgtcaacatcttgctattcatgggcttcatgacccggccgggattt
gccatcatcacacagtggtgtgagggctccagcctgtaccaccacctacatgtggccgac
acacgcttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggac
tacctccatgccaagaacattatccaccgagatctcaagtctaacaacatcttcctacac
gaggggctcacagtgaagatcggtgactttggcctggccacggtgaagacacggtggagc
ggtgcccagcccttggaacagccctcgggctctgtgctatggatggcggctgaggtgatc
cgtatgcaggacccgaacccctacagcttccagtcggatgtctacgcctacggggttgtg
ctctatgagctcatgaccggctctctgccttacagccacattggcagccgtgaccagatt
atcttcatggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgc
cccaaggccatgcggcgcctgctgtctgactgcctcaagttccagcgagaggaacgtccc
ctcttcccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgag
cggagtgcctccgaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctc
ctcagcgcggcccgccttgtgccttag
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integrated database retrieval system