KEGG   Lynx rufus (bobcat): 124512209
Entry
124512209         CDS       T08475                                 
Name
(RefSeq) son of sevenless homolog 2 isoform X1
  KO
K03099  son of sevenless
Organism
lruf  Lynx rufus (bobcat)
Pathway
lruf01521  EGFR tyrosine kinase inhibitor resistance
lruf01522  Endocrine resistance
lruf04010  MAPK signaling pathway
lruf04012  ErbB signaling pathway
lruf04014  Ras signaling pathway
lruf04062  Chemokine signaling pathway
lruf04068  FoxO signaling pathway
lruf04072  Phospholipase D signaling pathway
lruf04150  mTOR signaling pathway
lruf04151  PI3K-Akt signaling pathway
lruf04510  Focal adhesion
lruf04540  Gap junction
lruf04630  JAK-STAT signaling pathway
lruf04650  Natural killer cell mediated cytotoxicity
lruf04660  T cell receptor signaling pathway
lruf04662  B cell receptor signaling pathway
lruf04664  Fc epsilon RI signaling pathway
lruf04714  Thermogenesis
lruf04722  Neurotrophin signaling pathway
lruf04810  Regulation of actin cytoskeleton
lruf04910  Insulin signaling pathway
lruf04912  GnRH signaling pathway
lruf04915  Estrogen signaling pathway
lruf04917  Prolactin signaling pathway
lruf04926  Relaxin signaling pathway
lruf04935  Growth hormone synthesis, secretion and action
lruf05034  Alcoholism
lruf05160  Hepatitis C
lruf05161  Hepatitis B
lruf05163  Human cytomegalovirus infection
lruf05165  Human papillomavirus infection
lruf05200  Pathways in cancer
lruf05205  Proteoglycans in cancer
lruf05206  MicroRNAs in cancer
lruf05207  Chemical carcinogenesis - receptor activation
lruf05208  Chemical carcinogenesis - reactive oxygen species
lruf05210  Colorectal cancer
lruf05211  Renal cell carcinoma
lruf05213  Endometrial cancer
lruf05214  Glioma
lruf05215  Prostate cancer
lruf05220  Chronic myeloid leukemia
lruf05221  Acute myeloid leukemia
lruf05223  Non-small cell lung cancer
lruf05224  Breast cancer
lruf05225  Hepatocellular carcinoma
lruf05226  Gastric cancer
lruf05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:lruf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    124512209
   04012 ErbB signaling pathway
    124512209
   04014 Ras signaling pathway
    124512209
   04630 JAK-STAT signaling pathway
    124512209
   04068 FoxO signaling pathway
    124512209
   04072 Phospholipase D signaling pathway
    124512209
   04151 PI3K-Akt signaling pathway
    124512209
   04150 mTOR signaling pathway
    124512209
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    124512209
   04540 Gap junction
    124512209
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    124512209
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    124512209
   04660 T cell receptor signaling pathway
    124512209
   04662 B cell receptor signaling pathway
    124512209
   04664 Fc epsilon RI signaling pathway
    124512209
   04062 Chemokine signaling pathway
    124512209
  09152 Endocrine system
   04910 Insulin signaling pathway
    124512209
   04912 GnRH signaling pathway
    124512209
   04915 Estrogen signaling pathway
    124512209
   04917 Prolactin signaling pathway
    124512209
   04926 Relaxin signaling pathway
    124512209
   04935 Growth hormone synthesis, secretion and action
    124512209
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    124512209
  09159 Environmental adaptation
   04714 Thermogenesis
    124512209
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    124512209
   05206 MicroRNAs in cancer
    124512209
   05205 Proteoglycans in cancer
    124512209
   05207 Chemical carcinogenesis - receptor activation
    124512209
   05208 Chemical carcinogenesis - reactive oxygen species
    124512209
   05231 Choline metabolism in cancer
    124512209
  09162 Cancer: specific types
   05210 Colorectal cancer
    124512209
   05225 Hepatocellular carcinoma
    124512209
   05226 Gastric cancer
    124512209
   05214 Glioma
    124512209
   05221 Acute myeloid leukemia
    124512209
   05220 Chronic myeloid leukemia
    124512209
   05211 Renal cell carcinoma
    124512209
   05215 Prostate cancer
    124512209
   05213 Endometrial cancer
    124512209
   05224 Breast cancer
    124512209
   05223 Non-small cell lung cancer
    124512209
  09172 Infectious disease: viral
   05161 Hepatitis B
    124512209
   05160 Hepatitis C
    124512209
   05163 Human cytomegalovirus infection
    124512209
   05165 Human papillomavirus infection
    124512209
  09165 Substance dependence
   05034 Alcoholism
    124512209
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    124512209
   01522 Endocrine resistance
    124512209
SSDB
Motif
Pfam: RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH RHG20_PH PH_19 PH_10 IQ_SEC7_PH PH_13
Other DBs
NCBI-GeneID: 124512209
NCBI-ProteinID: XP_046935658
LinkDB
Position
Unknown
AA seq 1332 aa
MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPNLSANEESLYYIEELIFQLLNKLC
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI
ERIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
LSPKFNEHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA
CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPICPFYNRHLRSKHLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPG
YSSAEYRLKEKFVMRKIQICDKEDTCECKHAFEIVSKDENSIIFAAKSAEEKNNWMAALI
SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLA
VEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR
GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPI
EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILD
EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR
KVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCK
QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPYKISFSRIAETDLESTV
SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLN
EEPLIPPPLPPRKKFDHDASNSKGNTKSDDDPPAIPPRQPPPPKVKPRVPAPTGAFDGPL
HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDPEWLRDVSTCPNSPN
TPPSTPSPRVPRRCYALSSSHNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPSY
RLPLLENAETPQ
NT seq 3999 nt   +upstreamnt  +downstreamnt
atgcagcaggcgccgcagccgtacgagttcttcagcgaagagaacagtccgaaatggcgg
ggactgctcgtctcggccctgcggaaggttcaggagcaagtacatcccaatctctcagct
aatgaagagtctctctattatattgaagagctgatttttcagctgcttaataaattatgc
atggctcagccaaggactgttcaagatgtagaggaacgtgttcagaagacctttcctcat
ccaattgacaagtgggctattgctgatgcacaatctgccatagaaaaacgaaaacgaaga
aatcctctcttactgcctgtggacaaaatccatccttcattgaaggaggttttagggtac
aaagtggactatcatgtatccctgtatattgtggctgtactagagtatatctcagctgat
attttgaagttggctggtaattatgtttttaatatccgacattatgaaatatctcagcag
gacattaaagtgtcaatgtgtgcagataaggttttgatggacatgtttgatcaggatgac
ataggtttggtttctctctgtgaagatgaaccgagttcttcaggtgaattaaactactat
gaccttgtcagaactgaaattgcagaagaaaggcagtatctacgggaattaaatatgatt
ataaaagtgtttcgagaagctttcctttctgacaggaagctatttaaaccttctgatatt
gaaaggattttcagtaacatttcagatatacatgaattgaccgtgaaacttctaggtctt
attgaagacacagttgaaatgactgatgaaagcagccctcatccattagctggcagctgt
tttgaagatttggcagaagagcaagcatttgatccttatgaaacattatcacaggatatt
ctgtctccaaaatttaatgaacatttcagtaagttgatggccagacctgcagtggctcta
cactttcagtccattgctgatggttttaaagaggcagttcgttatgtccttccacgcctt
atgctggtgcctgtatatcattgttggcactattttgaattattaaagcaattgaaagca
tgtagtgaagagcaggaagacagagaatgtttgaaccaagctattactgctcttatgaat
ctccaaggtagtatggaccgaatatacaagcagtattcacctagacgccgacctggggat
cctatttgccctttttataatcgtcacttaagaagcaagcatctggctattaaaaaaatg
aatgaaattcagaaaaacatagatggatgggaaggcaaagatattggacagtgttgtaat
gaattcattatggaaggtccattgacacgaattggtgctaaacatgaacggcatattttc
ctctttgatggcttaatgattagctgtaagcccaatcatagccagtcacgccttccaggt
tacagtagtgcagaatacagattaaaagaaaaatttgtcatgaggaaaatacaaatatgt
gataaagaagatacctgtgagtgtaaacatgcttttgaaatagtatccaaagatgaaaac
agcataatatttgctgctaagtctgctgaagagaaaaataattggatggccgcacttatt
tctcttcactatcgtagtacactagatcgaatgctagattcagtgttattgaaagaagaa
aatgagcagccattgagattaccaagccctgaagtgtatcgttttgtggtaaaagactct
gaggaaaacattgtttttgaagacaacttgcaaagtagaagtggaattcccatcattaaa
ggaggaactgtggtgaaattaattgaaaggttaacatatcatatgtatgcagatcccaat
tttgtccgtacttttcttactacataccgttcattttgtaaaccacaggaattactaagc
ttactgattgaacgatttgaaattccagagccagaacctactgaagcagataaattggca
gtagagaaaggcgaacagccaatcagtgcagaccttaaaaggtttcgcaaggaatatgtc
caaccagtacaacttaggatcttaaatgtgtttcggcactgggttgaacatcatttttat
gactttgaaagagatttggagttgcttgagagactagaatccttcatttcaagtgtaaga
gggaaagctatgaagaagtgggtagagtcaattgctaagatcatcaagaggaagaaacaa
gctcaggcaaatggaataagccataatattacctttgagagtccacctccaccaattgaa
tggcatattagcagaccaggacagtttgaaacatttgatcttatgacacttcatccaata
gaaattgcacgtcagctgacacttttggaatctgatctctacaggaaagtccagccttct
gaacttgtagggagtgtgtggaccaaagaagataaagaaataaattctccaaatttatta
aaaatgattcgccataccacaaatctcaccctctggtttgaaaagtgcattgtggaagca
gaaaattttgaggaacgggtggcagtactaagtagaattatagaaattctgcaagttttt
caagatttgaataatttcaatggtgtattggagatagtcagtgcagtaaattcagtgtca
gtgtacagactagaccatacttttgaggcattgcaggaaagaaaaaggagaattttggat
gaagctgtggaattaagtcaagatcactttaaaaaatacctagtaaaacttaagtcaatc
aatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaaaactgaagaa
gggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaagaggagg
aaagtagctgaaattactggagaaattcagcagtatcagaatcaaccttactgtttacgg
atagaaccagaaatgaggagattctttgaaaaccttaaccccatgggaagtgcttctgaa
aaggagtttacagattatttgttcaataagtcactagaaattgaaccccgaaactgcaaa
cagccacctcgatttcctaggaaatcaactttctctttaaaatctcctggaataaggcct
aatacaggccgacatggctctacctcaggcactttacgaggtcatccaacaccattagaa
agagaaccatataagataagctttagtcggattgctgaaactgatcttgaatcaactgtg
tcagcaccaacctctccaaatacgccatctactccaccggtatctgcttcttcagacctt
agtgtgtttttagatgtggatctcaacagttcctgtggcagcaatagcatctttgctcca
gtcctcttgccacattcaaagtctttcttcagttcatgtggtagtttacataaactaaat
gaagagccactgattcctcctccacttcctcctcgaaaaaagtttgatcatgatgcttca
aattccaagggaaatacgaaatctgatgatgacccccctgctattccaccaagacaacct
cctcctccaaaggtaaaacccagagttcctgctcctactggtgcatttgacgggcctctg
catagtccacctccaccaccgccgagagatcctcttcctgatacccctccaccagttccc
cttcggcctccagaacactttataaactgtccatttaatcttcagccacctccactagga
catcttcacagagatccagagtggctcagagacgttagtacctgtccaaattcaccaaat
actcctcctagcacaccctctccaagagtaccacgtcgatgctatgcgctcagttccagt
cacaataaccttgctcatcctcaagctccccctgttccaccaaggcagaattcaagccct
cacctaccaaaactgccaccaaagacttataaacgggagctttcacaccccccatcgtac
agactgcctttgctagaaaatgcagaaactcctcaatga

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