Lynx rufus (bobcat): 124513048 Help Entry 124513048         CDS       T08475                                  Name (RefSeq) neurofibromin isoform X1   KO K08052   neurofibromin 1 Organism lruf  Lynx rufus (bobcat) Pathway lruf01521   EGFR tyrosine kinase inhibitor resistance lruf04010   MAPK signaling pathway lruf04014   Ras signaling pathway Brite KEGG Orthology (KO) [BR:lruf00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     124513048    04014 Ras signaling pathway     124513048  09160 Human Diseases   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     124513048 SSDB OrthologParalogGFIT Motif Pfam:  PH_NF1 RasGAP CRAL_TRIO_2 CRAL_TRIO MIF4G_like_2 Motif Other DBs NCBI-GeneID:  124513048 NCBI-ProteinID:  XP_046936714 LinkDB All DBs Position Unknown AA seq 2841 aa AA seqDB search MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL REILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGATSQMSMDHEELIRTCTPGASL RKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEAD IRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWE DTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWI NMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRL LSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNT QFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQL VEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVS LLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRL ASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAE TVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLW NMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVS FEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLN KATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERG LKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSF ISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTH WSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQI NGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVY IYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLK VFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQ FTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIA LLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAAN EPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKL ITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVAL ASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAA HLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSL PKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMR DIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESC LKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALL EQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGY RHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHR KSLLLTDISMENVPMDTYPIHHGDPSYRTLKENQPWSSPKGSEGYLAATYPAVGQTSPRA RKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYE METQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRI LYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQY QTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTP TSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTSGHCNSGRTRHGSA SQVQKQRSAGSFKRNSIKKIV NT seq 8526 nt NT seq  +upstreamnt  +downstreamnt atggccgcgcacaggccggtggaatgggtccaggccgtggtcagccgcttcgacgagcag cttccaataaaaacaggacagcagaacacacataccaaagtcagtactgaacacaacaag gaatgtcttattaatatttccaaatacaagttttctttggttatcagcggcctcaccact atcttaaagaatgttaacaatatgagaatatttggagaagctgctgaaaaaaatttgtat ctctctcagttgattatattggatacactggaaaaatgtcttgctgggcaaccaaaggac acaatgagattagatgaaacgatgctggtcaaacagttgctgccagaaatctgccatttt cttcacacctgtcgtgaaggaaaccaacatgcagctgaacttcggaattctgcatctggg gttttattttctctcagctgcaacaacttcaatgcagtgtttagtcgcatctctaccagg ttacaggaattgactgtttgttcagaagacaatgttgatgttcatgatatagaattgtta cagtatatcaatgtggattgtgcaaaattaaaacgactcctaaaggaaacagcatttaaa tttaaagccctaaagaaggttgcacagttagcagttataaatagcctggaaaaagcattt tggaactgggtagaaaactatccagatgaatttacaaagctgtaccagattccacagact gatatggctgagtgtgcagaaaaactgtttgacttggtggatggttttgctgaaagcacc aagcgtaaagcagcggtttggccactgcaaatcattctccttatcttgtgtccagaaatc attcaggatatctccaaggatgtggttgatgaaaacaacatgaataagaagttgtttctg gacagcctacggaaagcacttgccggccatggaggaagcaggcagctgacggagagtgct gcaatagcctgtgtcaaactgtgcaaagcaagtacttatatcaactgggaagacaactct gtcattttcctcctagtccagtccatggtggttgatcttaagaacctgctttttaatcca agtaagccattctcaagaggcagtcagcccgcagatgtggatctgatgattgactgcctt gtctcttgctttcgtataagccctcacaacaaccaacactttaagatctgcctggctcag aattccccttctacatttcactatgtgctggtaaattcactccatcgaatcatcaccaat tctgcgttggattggtggcctaagatcgatgctgtatattgtcactcagtcgagcttcga aacatgtttggtgaaacgcttcataaagcagtgcagggttgtggagcacacccagcaata cgaatggcaccgagtcttacatttaaagaaaaagtaacaagccttaaatttaaagaaaaa cctacagacctggagacaagaagctataagtatcttctcctgtccatggtgaaactcatt catgcggatccaaagctcttgctttgtaatccaaggaaacaggggcctgaaacccaaggc agcacagcggaattaattacagggctcgtccagctggtccctcagtcacacatgccagag atcgcacaggaggcaatggaggctctgctggttcttcatcagttagatagcattgatttg tggaatcctgatgctcctgtggaaacattttgggagattagctctcaaatgcttttttac atctgcaagaaattaactagccatcaaatgcttagtagcacagaaattctcaaatggttg cgggaaattttgatctgcaggaataaatttcttcttaaaaataagcaggcagatagaagt tcctgtcactttctcttcctttacggggtaggatgtgatgttccttcgagtggagctacc agtcagatgtccatggatcatgaagaattaatacgtacttgtacgcctggagcctctctt cggaagggaaaaggaaactcatccatggatagtgcagcagggtgcagtggcacaccgccg atatgccgacaggctcagaccaaactcgaagtggccctgtacatgtttctgtggagccct gacactgaagctgttctggttgccatgtcctgtttccgccacctctgtgaggaggcagat atccggtgtggggtggatgaagtgtcggtgcacaacttcttgcccaactataacacattc atggaatttgcctctgtcagcaatatgatgtcaacaggaagagcagcacttcagaaaaga gtgatggcactactcaggcgcatcgagcaccccactgcaggaaacacggaggcttgggaa gatacacatgcaaagtgggaacaagccacaaaactaatcctcaactatccaaaagctaaa atggaagatggccaggctgctgaaagccttcacaagaccattgttaagaggcgaatgtct catgtgagtggaggaggatccatagatttgtctgacacggactccctacaggaatggatc aacatgactggcttcctttgcgcccttgggggagtgtgcctgcagcaaagaagcaactct ggcttggcaacctatagcccccctatgggcccagtcagtgaacgcaagggttccatgatt tcggtgatgtcctcggagggaaatgcagatacacctgtcagcaaatttatggatcggctg ttatccttaatggtgtgcaaccatgagaaagtgggacttcaaatacggaccaacgttaag gatctggtgggtctagaattgagtcctgctctttatccaatgctatttaacaaattgaag aataccatcagcaagttttttgactcgcaaggacaggttttattgaccgacaccaatact cagtttgtggagcaaaccatagctataatgaagaacttactagataatcatactgaaggc agctccgaacatctggggcaagctagcattgaaacaatgatgttaaatctagtcagatat gttcgagtgcttgggaacatggtccatgcaattcaaataaaaacgaaactgtgtcagtta gtcgaggtaatgatggcaaggagagatgacctctcattttgtcaagagatgaaatttagg aataagatggtagaatacctgacagactgggtcatgggaacatcaaaccaagcagcagat gatgatgtaaaatgtcttacaagagacttggaccaggcgagcatggaagccgttgtttca ctcctggctggtcttccactgcagcctgaggaaggagatggtgtggaattgatggaagcc aagtcacagttatttctgaagtatttcacattgtttatgaaccttttgaatgactgtagt gaagttgaagatgaaaatgcacaaacaggtggcaggaaacgtggcatgtcccggaggctg gcatcactgaggcactgcacagtccttgcaatgtccaacttactcaatgctaatgtggac agtggcctcatgcactccataggtttaggttatcacaaagatcttcagacaagagctaca tttatggaagttctgacaaaaatcctccagcaaggcacagaatttgacacgcttgcagaa acggtgctggccgaccggtttgagaggctggtggagttggtcacaatgatgggagaccag ggagagctcccaatagccatggctttggccaacgtggtcccgtgttctcagtgggatgaa ctagctcgagttctagtgactctgtttgattctcggcatttgctctaccaactgctctgg aacatgttttctaaggaagtagaattggcagactccatgcagactcttttccgaggaaac agcttagccagtaaaataatgaccttctgtttcaaggtatatggtgctacctacctacaa aaactcctggatccgttattacgaatcgtgatcacatcctctgattggcaacatgttagc tttgaagtggatcctaccaggttagaacaatcagagagccttgaggaaaaccaacggaac cttctgcagatgactgaaaagttcttccatgccatcatcagttcctcctcagaattcccc cctcagcttcgaagtgtgtgccactgtttataccaggcaacttgccactccctactgaat aaagctacagtaaaagaaaaaaaggaaaacaaaaaatcagtggttagccagcgtttccct cagaacagcatcggtgcagtgggaagtgccatgttcctcagatttatcaatcctgccatt gtctcaccgtatgaagcagggattttagataaaaagccgccacctagaattgaaaggggc ttgaagttaatgtcaaagatacttcagagcattgccaatcatgttctcttcacaaaagaa gagcatatgcgaccttttaatgattttgtgaaaagcaactttgatgcagcgcggaggttt ttccttgatatagcatctgattgtcctaccagtgatgcagtaaatcatagtctctccttc atcagtgatggcaatgtgcttgcattacatcgtctactctggaacaatcaagagaaaatt ggccagtatctttccagtaacagggatcacaaagctgttggaagacgaccttttgataag atggcaacacttcttgcgtacttgggtcctccagagcacaaacctgtggccgatacacat tggtccagccttaaccttaccagttcaaagtttgaggaatttatgactaggcatcaagta catgaaaaagaagagttcaaggctttgaaaacattaagtattttctaccaagctgggact tccaaagctgggaatcctatattttattatgttgcacggaggtttaaaactggccaaatc aatggcgatttgctgatataccacgtcttgctgactttaaagccatattatgcaaagcca tatgaaattgtagtggaccttacccatactgggcctagcaatcgctttaaaacggacttt ctctccaagtggtttgttgtttttcctggctttgcttatgacaatgtctctgcagtctat atctataactgcaactcctgggtcagagagtataccaagtatcacgaacggctactgact ggcctcaaaggcagcaagaggctcattttcatcgactgtcctgggaaactggctgagcac atagagcatgaacaacagaaactgcctgctgccacactggctttagaagaggacctgaag gtattccacaatgctctcaagctagctcacaaagacaccaaggtttctattaaagttggt tctactgctgttcaagtaacctcagcagagcgaacgaaagtcctaggacagtcggtcttt ctaaatgatatctattatgcttcggaaattgaagagatctgcctggtggatgagaaccag tttaccttaaccattgcaaaccagggcacaccgctcaccttcatgcaccaggagtgcgaa gccatcgtccagtctatcattcacatccggacacgctgggagctgtcgcagcccgactcc atcccccagcacaccaagattcggccaaaagacgtccctgggacactactcaatattgca ttacttaatttaggcagttccgaccctagtttacggtcagctgcctataatcttctctgt gccttaacttgtacctttaatttaaaaatcgagggccagctactagagacgtcaggttta tgcatccctgccaacaacaccctctttattgtctctattagtaagacactggcggccaat gagccacatctcaccttagaatttttggaagagtgtatttctggatttagcaaatctagt attgaattgaaacacctttgtttggaatacatgactccatggctgtcaaacctggtccgt ttttgtaagcacaatgatgatgccaaacgacaaagagttaccgccattctcgataagctg ataacaatgaccataaatgagaaacagatgtatccatctattcaagccaaaatatggggg agccttgggcagattacagatctccttgacgttgtactagacagtttcatcaaaaccagt gcgacaggtggcttgggatcaataaaagccgaggtgatggcagatactgccgtagctttg gcttctggaaatgtgaaattggtttccagcaaggttattggaaggatgtgcaaaataatt gacaagacatgcttgtctccaactcctaccttagaacagcatctcatgtgggacgacatt gccatcctcgcacgctacatgctgatgctgtccttcaacaattcccttgacgtggcagct catctcccctacctcttccacgttgttactttcttagtagccacggggccgctctccctt agagcttccacacacggattggtcattaatatcattcactctctgtgtacttgttcacag ctgcattttagtgaagaaaccaagcaagttttgagactcagtttgacagagttctcatta cccaagttttacttgctgtttggcattagcaaagtcaagtcagctgccgtcattgccttc cgctccagttaccgggacaggtcattctctcctggctcctatgagagggagacttttgct ttgacatctttggaaacagtcacagaagctttgttggagataatggaggcatgtatgaga gatattccaacatgcaagtggctggaccagtggacggaactagctcaaagattcgcattc caatataatccatccctgcaaccgagagctcttgttgtctttggctgtattagcaagcga gtgtctcatgggcagataaagcagattatccgtattcttagcaaggcacttgagagttgc ttaaaaggacctgatacttacaacagtcaagttctgatagaagccacagtaatagcgcta accaaattacagccgctcctcaataaggactcccctctgcacaaagccctcttttgggta gctgtggctgtgctacagctcgatgaggtcaacttgtattcagcaggcaccgcccttctt gaacaaaacctgcacaccttagacagtctgcggatattcaacgacaagagtccagaggaa gtatttatggcaatccggaaccctctggaatggcactgcaagcagatggatcattttgtt ggactcaatttcaactctaactttaactttgcgctggttggacacctcttaaaagggtac aggcatccttcacctgccattgttgcaagaacggtcagaattctgcatacactactgact ctggtcaacaaacatagaaactgtgacaaatttgaggtgaacacacagagcgtggcttac ttggcagccttactcacagtgtctgaggaggttcgaagtcgctgtagcctaaaacataga aagtctcttcttcttactgatatttcaatggaaaatgttcctatggatacatatcccatc catcatggtgaccccagctataggacgctaaaggagaaccagccgtggtcatctcccaaa ggttctgaggggtaccttgcagccacctatccagccgtgggccagaccagtccccgggcc aggaagtccatgagcttggacatggggcagccttctcaggccaacacgaagaagttgctg ggaacaaggaaaagttttgatcacttgatatcagacacaaaggctcctaaaaggcaagaa atggaatcagggatcacaacaccccccaaaatgaggagagtagcagaaactgattatgaa atggaaactcagcggatttcctcatcacaacaacacccgcatttgcgtaaagtttcggtg tctgaatcaaatgttctcttggatgaagaagtacttactgatccaaagatccaagcactt cttcttaccgttctggctacgctggtaaaatataccacggatgagtttgatcagcgaatt ctttatgaatacttagcggaagccagtgttgttttccccaaggtttttccagtcgtacac aatttgttggactctaagatcaacaccctgttgtcattgtgccaagatccaaatttgtta aatccaattcatggaattgtgcagagtgtggtgtaccatgaggaatctccaccacagtac cagacatcgtacctgcaaagttttggttttaatggcttgtggcggtttgcaggacccttt tcaaagcaaacccaaatcccagactatgctgagcttattgttaagtttcttgatgccttg attgacacgtatttgcctggaattgatgaagaaaccagtgaggagtccctcctgacaccc acttctccttatcctcctgcagtgcagagccagcttagtatcactgctaaccttaacctt tctaattccatgacctcactcgcaacttcccagcattccccagggatcgacaaggagaac gttgaactctcccccacctctggccactgtaacagtggacgcactcgccatggatccgca agccaggtgcagaagcaaagaagcgctggcagtttcaaacgtaatagcattaagaagatc gtgtga

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