KEGG   Lynx rufus (bobcat): 124517731
Entry
124517731         CDS       T08475                                 
Name
(RefSeq) mitogen-activated protein kinase 3 isoform X1
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
lruf  Lynx rufus (bobcat)
Pathway
lruf01521  EGFR tyrosine kinase inhibitor resistance
lruf01522  Endocrine resistance
lruf01524  Platinum drug resistance
lruf04010  MAPK signaling pathway
lruf04012  ErbB signaling pathway
lruf04014  Ras signaling pathway
lruf04015  Rap1 signaling pathway
lruf04022  cGMP-PKG signaling pathway
lruf04024  cAMP signaling pathway
lruf04062  Chemokine signaling pathway
lruf04066  HIF-1 signaling pathway
lruf04068  FoxO signaling pathway
lruf04071  Sphingolipid signaling pathway
lruf04072  Phospholipase D signaling pathway
lruf04114  Oocyte meiosis
lruf04140  Autophagy - animal
lruf04148  Efferocytosis
lruf04150  mTOR signaling pathway
lruf04151  PI3K-Akt signaling pathway
lruf04210  Apoptosis
lruf04218  Cellular senescence
lruf04261  Adrenergic signaling in cardiomyocytes
lruf04270  Vascular smooth muscle contraction
lruf04350  TGF-beta signaling pathway
lruf04360  Axon guidance
lruf04370  VEGF signaling pathway
lruf04371  Apelin signaling pathway
lruf04380  Osteoclast differentiation
lruf04510  Focal adhesion
lruf04520  Adherens junction
lruf04540  Gap junction
lruf04550  Signaling pathways regulating pluripotency of stem cells
lruf04611  Platelet activation
lruf04613  Neutrophil extracellular trap formation
lruf04620  Toll-like receptor signaling pathway
lruf04621  NOD-like receptor signaling pathway
lruf04625  C-type lectin receptor signaling pathway
lruf04650  Natural killer cell mediated cytotoxicity
lruf04657  IL-17 signaling pathway
lruf04658  Th1 and Th2 cell differentiation
lruf04659  Th17 cell differentiation
lruf04660  T cell receptor signaling pathway
lruf04662  B cell receptor signaling pathway
lruf04664  Fc epsilon RI signaling pathway
lruf04666  Fc gamma R-mediated phagocytosis
lruf04668  TNF signaling pathway
lruf04713  Circadian entrainment
lruf04720  Long-term potentiation
lruf04722  Neurotrophin signaling pathway
lruf04723  Retrograde endocannabinoid signaling
lruf04724  Glutamatergic synapse
lruf04725  Cholinergic synapse
lruf04726  Serotonergic synapse
lruf04730  Long-term depression
lruf04810  Regulation of actin cytoskeleton
lruf04910  Insulin signaling pathway
lruf04912  GnRH signaling pathway
lruf04914  Progesterone-mediated oocyte maturation
lruf04915  Estrogen signaling pathway
lruf04916  Melanogenesis
lruf04917  Prolactin signaling pathway
lruf04919  Thyroid hormone signaling pathway
lruf04921  Oxytocin signaling pathway
lruf04926  Relaxin signaling pathway
lruf04928  Parathyroid hormone synthesis, secretion and action
lruf04929  GnRH secretion
lruf04930  Type II diabetes mellitus
lruf04933  AGE-RAGE signaling pathway in diabetic complications
lruf04934  Cushing syndrome
lruf04935  Growth hormone synthesis, secretion and action
lruf04960  Aldosterone-regulated sodium reabsorption
lruf05010  Alzheimer disease
lruf05020  Prion disease
lruf05022  Pathways of neurodegeneration - multiple diseases
lruf05034  Alcoholism
lruf05132  Salmonella infection
lruf05133  Pertussis
lruf05135  Yersinia infection
lruf05140  Leishmaniasis
lruf05142  Chagas disease
lruf05145  Toxoplasmosis
lruf05152  Tuberculosis
lruf05160  Hepatitis C
lruf05161  Hepatitis B
lruf05163  Human cytomegalovirus infection
lruf05164  Influenza A
lruf05165  Human papillomavirus infection
lruf05166  Human T-cell leukemia virus 1 infection
lruf05167  Kaposi sarcoma-associated herpesvirus infection
lruf05170  Human immunodeficiency virus 1 infection
lruf05171  Coronavirus disease - COVID-19
lruf05200  Pathways in cancer
lruf05203  Viral carcinogenesis
lruf05205  Proteoglycans in cancer
lruf05206  MicroRNAs in cancer
lruf05207  Chemical carcinogenesis - receptor activation
lruf05208  Chemical carcinogenesis - reactive oxygen species
lruf05210  Colorectal cancer
lruf05211  Renal cell carcinoma
lruf05212  Pancreatic cancer
lruf05213  Endometrial cancer
lruf05214  Glioma
lruf05215  Prostate cancer
lruf05216  Thyroid cancer
lruf05218  Melanoma
lruf05219  Bladder cancer
lruf05220  Chronic myeloid leukemia
lruf05221  Acute myeloid leukemia
lruf05223  Non-small cell lung cancer
lruf05224  Breast cancer
lruf05225  Hepatocellular carcinoma
lruf05226  Gastric cancer
lruf05230  Central carbon metabolism in cancer
lruf05231  Choline metabolism in cancer
lruf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lruf05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lruf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    124517731
   04012 ErbB signaling pathway
    124517731
   04014 Ras signaling pathway
    124517731
   04015 Rap1 signaling pathway
    124517731
   04350 TGF-beta signaling pathway
    124517731
   04370 VEGF signaling pathway
    124517731
   04371 Apelin signaling pathway
    124517731
   04668 TNF signaling pathway
    124517731
   04066 HIF-1 signaling pathway
    124517731
   04068 FoxO signaling pathway
    124517731
   04072 Phospholipase D signaling pathway
    124517731
   04071 Sphingolipid signaling pathway
    124517731
   04024 cAMP signaling pathway
    124517731
   04022 cGMP-PKG signaling pathway
    124517731
   04151 PI3K-Akt signaling pathway
    124517731
   04150 mTOR signaling pathway
    124517731
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    124517731
   04148 Efferocytosis
    124517731
  09143 Cell growth and death
   04114 Oocyte meiosis
    124517731
   04210 Apoptosis
    124517731
   04218 Cellular senescence
    124517731
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    124517731
   04520 Adherens junction
    124517731
   04540 Gap junction
    124517731
   04550 Signaling pathways regulating pluripotency of stem cells
    124517731
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    124517731
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    124517731
   04613 Neutrophil extracellular trap formation
    124517731
   04620 Toll-like receptor signaling pathway
    124517731
   04621 NOD-like receptor signaling pathway
    124517731
   04625 C-type lectin receptor signaling pathway
    124517731
   04650 Natural killer cell mediated cytotoxicity
    124517731
   04660 T cell receptor signaling pathway
    124517731
   04658 Th1 and Th2 cell differentiation
    124517731
   04659 Th17 cell differentiation
    124517731
   04657 IL-17 signaling pathway
    124517731
   04662 B cell receptor signaling pathway
    124517731
   04664 Fc epsilon RI signaling pathway
    124517731
   04666 Fc gamma R-mediated phagocytosis
    124517731
   04062 Chemokine signaling pathway
    124517731
  09152 Endocrine system
   04910 Insulin signaling pathway
    124517731
   04929 GnRH secretion
    124517731
   04912 GnRH signaling pathway
    124517731
   04915 Estrogen signaling pathway
    124517731
   04914 Progesterone-mediated oocyte maturation
    124517731
   04917 Prolactin signaling pathway
    124517731
   04921 Oxytocin signaling pathway
    124517731
   04926 Relaxin signaling pathway
    124517731
   04935 Growth hormone synthesis, secretion and action
    124517731
   04919 Thyroid hormone signaling pathway
    124517731
   04928 Parathyroid hormone synthesis, secretion and action
    124517731
   04916 Melanogenesis
    124517731
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    124517731
   04270 Vascular smooth muscle contraction
    124517731
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    124517731
  09156 Nervous system
   04724 Glutamatergic synapse
    124517731
   04725 Cholinergic synapse
    124517731
   04726 Serotonergic synapse
    124517731
   04720 Long-term potentiation
    124517731
   04730 Long-term depression
    124517731
   04723 Retrograde endocannabinoid signaling
    124517731
   04722 Neurotrophin signaling pathway
    124517731
  09158 Development and regeneration
   04360 Axon guidance
    124517731
   04380 Osteoclast differentiation
    124517731
  09159 Environmental adaptation
   04713 Circadian entrainment
    124517731
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    124517731
   05206 MicroRNAs in cancer
    124517731
   05205 Proteoglycans in cancer
    124517731
   05207 Chemical carcinogenesis - receptor activation
    124517731
   05208 Chemical carcinogenesis - reactive oxygen species
    124517731
   05203 Viral carcinogenesis
    124517731
   05230 Central carbon metabolism in cancer
    124517731
   05231 Choline metabolism in cancer
    124517731
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    124517731
  09162 Cancer: specific types
   05210 Colorectal cancer
    124517731
   05212 Pancreatic cancer
    124517731
   05225 Hepatocellular carcinoma
    124517731
   05226 Gastric cancer
    124517731
   05214 Glioma
    124517731
   05216 Thyroid cancer
    124517731
   05221 Acute myeloid leukemia
    124517731
   05220 Chronic myeloid leukemia
    124517731
   05218 Melanoma
    124517731
   05211 Renal cell carcinoma
    124517731
   05219 Bladder cancer
    124517731
   05215 Prostate cancer
    124517731
   05213 Endometrial cancer
    124517731
   05224 Breast cancer
    124517731
   05223 Non-small cell lung cancer
    124517731
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    124517731
   05170 Human immunodeficiency virus 1 infection
    124517731
   05161 Hepatitis B
    124517731
   05160 Hepatitis C
    124517731
   05171 Coronavirus disease - COVID-19
    124517731
   05164 Influenza A
    124517731
   05163 Human cytomegalovirus infection
    124517731
   05167 Kaposi sarcoma-associated herpesvirus infection
    124517731
   05165 Human papillomavirus infection
    124517731
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    124517731
   05135 Yersinia infection
    124517731
   05133 Pertussis
    124517731
   05152 Tuberculosis
    124517731
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    124517731
   05140 Leishmaniasis
    124517731
   05142 Chagas disease
    124517731
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    124517731
   05020 Prion disease
    124517731
   05022 Pathways of neurodegeneration - multiple diseases
    124517731
  09165 Substance dependence
   05034 Alcoholism
    124517731
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    124517731
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    124517731
   04933 AGE-RAGE signaling pathway in diabetic complications
    124517731
   04934 Cushing syndrome
    124517731
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    124517731
   01524 Platinum drug resistance
    124517731
   01522 Endocrine resistance
    124517731
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lruf01001]
    124517731
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:lruf03036]
    124517731
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:lruf04147]
    124517731
Enzymes [BR:lruf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     124517731
Protein kinases [BR:lruf01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   124517731
Chromosome and associated proteins [BR:lruf03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     124517731
Exosome [BR:lruf04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   124517731
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Haspin_kinase FTA2 Kdo
Other DBs
NCBI-GeneID: 124517731
NCBI-ProteinID: XP_046943159
LinkDB
Position
Unknown
AA seq 410 aa
MAAAAAQGGGGGEPGGADGVGPGVSGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
AKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEVGQPPATGLVGRWMGRRPSVP
GLSLTSLLPQPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGALEAP
NT seq 1233 nt   +upstreamnt  +downstreamnt
atggcggcggcggcggctcaggggggcgggggcggggagcccgggggagctgatggggtc
ggcccgggggtctcgggggaggtggaggtagtgaaggggcagccgttcgacgtgggcccg
cgctacacgcagctgcagtacatcggcgagggcgcgtacggcatggtcagctcagcttat
gaccacgtgcgcaagactcgcgtggccatcaagaaaatcagccccttcgagcatcagacc
tattgccagcgcacactgcgggagatccagatcttgctgcgcttccgccatgagaacgtc
attggcatccgggacattctgcgggcgcccaccctggaagccatgagggatgtctacatt
gtgcaggacctgatggagacagacctgtacaagttgctcaaaagccagcagctgagcaac
gaccacatttgctacttcctctaccagatcctgcggggcctcaagtatatccactcagcc
aacgtgctccaccgggatttaaagccctctaacctgctcatcaacaccacctgcgacctt
aagatctgtgattttggcctggcccggattgccgatcctgagcatgaccacactggcttc
ctgacagaatatgtggccacacgctggtaccgggctccagaaatcatgcttaactccaag
ggctacaccaagtccatcgacatctggtctgtgggctgcattctggctgagatgctctcc
aacaggcccatcttccctggcaagcactacctggaccagctcaaccacattctggggatc
ctgggctccccatcccaggaggacttgaattgtatcatcaacatgaaggcccgaaactac
ctacagtctctgccctccaagaccaaggtggcctgggccaagctttttcccaagtcagat
gccaaagcccttgatctgctagaccggatgttgacctttaaccccaacaaacggatcaca
gtggaggaagcactggctcacccctacctggagcagtactacgacccaacggatgaggtg
ggccagccaccagcaacagggctggtgggtagatggatgggtaggcgaccctcagtaccc
ggcctgagcctgacttctttactaccccagccagtggccgaggagcctttcaccttcgac
atggagctggatgatctacccaaggagcggctgaaggagctcatcttccaggagacagcc
cgcttccagcctggggcactggaggccccctaa

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