Lynx rufus (bobcat): 124526344
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Entry
124526344 CDS
T08475
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
lruf
Lynx rufus (bobcat)
Pathway
lruf00230
Purine metabolism
lruf00670
One carbon pool by folate
lruf01100
Metabolic pathways
lruf01523
Antifolate resistance
Module
lruf_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
lruf00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
124526344
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
124526344
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
124526344
Enzymes [BR:
lruf01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
124526344
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
124526344
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
124526344
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
ATP-grasp_2
CPSase_L_D2
ATP-grasp_4
ATP-grasp_3
Dala_Dala_lig_C
CbiJ
RimK
ATP-grasp_5
Motif
Other DBs
NCBI-GeneID:
124526344
NCBI-ProteinID:
XP_046955253
LinkDB
All DBs
Position
Unknown
AA seq
1009 aa
AA seq
DB search
MAARVLIIGGGGREHTLAWKLAQSNRVKHVLVAPGNAGTACLEKISNTAISISDHTALAQ
FCKDENIEFVVVGPEAPLAAGIVGNLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TARWRAFTRPEEACSFIMSADFPALVVKASGLAAGKGVIVAKSTEEACRAVQEIMQEKAY
GAAGETIVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDHGPNTGGMGAYCPAP
QVSKDLLLKIKNTVLQRTVDGMQQEGMPYTGVLYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTFDGLLHTSLPVWLENRTALTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKDGKVVTSGGRVLSVTAIQENLISALEEAKKGLAAIKFEGAIYRKD
IGSRAIAYLQQPRGLTYKESGVDIAAGNMLVKKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFKDPLLACGTDGVGTKLKIAQQCNRHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLDTTEAVVAGIARACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVIGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKFGVDLDAQTWRIPRIFSWLQQEG
HLSEEEMARTFNCGVGAVLVVSKDRTEQILRDIKQHSEEAWVIGKVVACPEGSPRVKVKH
LIETMQANGSVLENGTLKNHFSVQPKKARVAVLISGTGSNLQALIDNTREPSSCAHIVVV
ISNKAAVAGLDKAERAGIPTRVINHKLYKSRVEFDTAIDQVLEEFSTDIVCLAGFMRILS
GPFVRKWNGKMLNIHPSLLPSFKGSNAHEQVLEAGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVTTLSERVKLAEHKLFPAALQLVASGTVQLGENGKIRWVTE
NT seq
3030 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgcgtacttataattggcggtggcggaagggaacatacactggcctggaaa
cttgcacagtctaatcgtgtcaaacatgtgttggttgccccgggcaatgcaggcactgcc
tgcttggaaaagatttcaaatactgccatctcgataagtgatcacactgcccttgctcag
ttctgcaaagatgagaacattgaattcgtagttgttggaccagaggcacctctggctgct
ggaattgttgggaacctgacctctgcaggagtgcgatgctttggtcccacagcagaagca
gctcagttagagtccagcaagagatttgccaaagagtttatggaccgacacggaatcccg
accgcacggtggagagctttcaccagacctgaggaggcctgcagctttattatgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcagctgggaaaggggtgattgtt
gcaaagagcacagaagaagcctgcagggctgtacaggagatcatgcaggagaaagcttat
ggagcagctggagaaacaattgtcattgaagaacttcttgaaggagaagaggtttcttgt
ctgtgcttcactgatggcaggaccgtggcccccatgcccccagcacaagaccataaacga
ttgctggagggcgatcacggccccaacacagggggaatgggagcctattgtccggcacct
caggtttccaaggatttgctgctaaaaataaaaaatacagttcttcagaggacagtggat
ggcatgcagcaggagggtatgccatacacaggtgtcctctatgctggtataatgctgacc
aaggatggcccaaaagttctggagtttaattgccgtttcggtgatccagagtgccaagtg
atcctcccgctgcttaaaagtgatctttatgaagtgattcagtctacctttgatggcctg
ctccacacatctctgcctgtctggctggaaaaccgcaccgccctaactgtcgtgatggca
agtaagggctacccaggagattacaccaagggtgtggagataacaggctttcctgaggct
caagctttaggactggaggtgttccacgcaggcactgccctgaaagatggcaaagtggtg
actagtgggggtagagtcctttcggtaacagccatccaggaaaatctcatttcagccctt
gaagaagccaagaaaggactagctgctataaaatttgagggagccatttacaggaaggac
attggctctcgtgccatagcttacctccaacagcccaggggcctgacttacaaggaatct
ggggtagacattgcagctggaaatatgctggtcaagaaaattaaacctttagcaaaagct
acctccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcctgtggaacagatggtgtggggactaaactg
aagattgcccagcagtgtaatagacatgataccattggccaagatttggttgcaatgtgt
gtaaatgatattctggcccaaggtgcagagcccctcttcttccttgattacttttcctgt
ggaaaacttgacctcgatacaactgaagctgttgttgctggaattgccagagcctgtggg
aaagctggatgtgctctccttggaggtgaaactgcagaaatgcctgacatgtatcctcct
ggagagtatgacctggccggttttgccgtcggtgccatggagcgggatcagaaactccct
cacctggaaagaatcaccgaaggggatgttgttattggaatagcttcatctggtcttcac
agcaatggatttagccttgtgaggaaaattgtagcaaaatcttccctccagtactcctct
ccagcacctgatggctgtggtgaccagaccttaggggacttacttctgactccaacgaga
atctacagccattcgctattacctgtcctacgttcaggacatgtcaaggcctttgcccat
attactggtggaggattgctagaaaacatccccagagtccttcctgagaaatttggagtg
gatttagatgcccagacctggaggatccccaggatcttctcgtggttacagcaagaagga
cacctctctgaggaagagatggccagaacatttaactgcggggttggggccgtcctcgtg
gtgtcgaaggataggacagagcagattctgagggatatcaagcagcacagcgaagaagcc
tgggtgattggcaaggtggttgcgtgtcctgaaggttctcctcgtgtgaaagtcaagcat
ctgattgaaaccatgcaagcaaatggatcagtattggagaatggcactctgaaaaatcat
ttctctgtccaaccaaaaaaggcaagagtggctgtcttaatatctggaacaggatcaaac
ctccaagccctcatagacaatactagggagccaagtagctgtgcacacatcgttgttgtt
atctccaacaaagctgcagtggctggcttagataaagcagaaagagccggaattcccacc
agagtaatcaatcataaattatataaaagtcgtgtagaatttgacactgcaattgaccaa
gtccttgaagagttctccacagacatagtctgtcttgcaggattcatgagaattttatct
ggcccctttgtcagaaaatggaatgggaaaatgctcaacatccatccatccttgctcccg
tcttttaagggttcaaatgcacatgagcaagtcctagaagccggggtcacagtcactggg
tgtactgtgcactttgtagctgaagatgtagatgctggacagattatcttacaagaagct
gttccagtgaagaggggtgacaccgttacaactctgtctgaaagagtgaaattagcagag
cacaaactatttcccgcagccctccagctggtagccagtggaactgtacagcttggagaa
aatggcaagattcgttgggtcacagagtag
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