KEGG   Lynx rufus (bobcat): 124527077
Entry
124527077         CDS       T08475                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
lruf  Lynx rufus (bobcat)
Pathway
lruf00562  Inositol phosphate metabolism
lruf01100  Metabolic pathways
lruf01521  EGFR tyrosine kinase inhibitor resistance
lruf01522  Endocrine resistance
lruf01524  Platinum drug resistance
lruf04012  ErbB signaling pathway
lruf04014  Ras signaling pathway
lruf04015  Rap1 signaling pathway
lruf04024  cAMP signaling pathway
lruf04062  Chemokine signaling pathway
lruf04066  HIF-1 signaling pathway
lruf04068  FoxO signaling pathway
lruf04070  Phosphatidylinositol signaling system
lruf04071  Sphingolipid signaling pathway
lruf04072  Phospholipase D signaling pathway
lruf04081  Hormone signaling
lruf04140  Autophagy - animal
lruf04145  Phagocytosis
lruf04150  mTOR signaling pathway
lruf04151  PI3K-Akt signaling pathway
lruf04152  AMPK signaling pathway
lruf04210  Apoptosis
lruf04211  Longevity regulating pathway
lruf04213  Longevity regulating pathway - multiple species
lruf04218  Cellular senescence
lruf04360  Axon guidance
lruf04370  VEGF signaling pathway
lruf04380  Osteoclast differentiation
lruf04510  Focal adhesion
lruf04517  IgSF CAM signaling
lruf04518  Integrin signaling
lruf04550  Signaling pathways regulating pluripotency of stem cells
lruf04611  Platelet activation
lruf04613  Neutrophil extracellular trap formation
lruf04620  Toll-like receptor signaling pathway
lruf04625  C-type lectin receptor signaling pathway
lruf04630  JAK-STAT signaling pathway
lruf04650  Natural killer cell mediated cytotoxicity
lruf04660  T cell receptor signaling pathway
lruf04662  B cell receptor signaling pathway
lruf04664  Fc epsilon RI signaling pathway
lruf04666  Fc gamma R-mediated phagosome formation
lruf04668  TNF signaling pathway
lruf04670  Leukocyte transendothelial migration
lruf04722  Neurotrophin signaling pathway
lruf04725  Cholinergic synapse
lruf04750  Inflammatory mediator regulation of TRP channels
lruf04810  Regulation of actin cytoskeleton
lruf04910  Insulin signaling pathway
lruf04914  Progesterone-mediated oocyte maturation
lruf04915  Estrogen signaling pathway
lruf04917  Prolactin signaling pathway
lruf04919  Thyroid hormone signaling pathway
lruf04923  Regulation of lipolysis in adipocytes
lruf04926  Relaxin signaling pathway
lruf04929  GnRH secretion
lruf04930  Type II diabetes mellitus
lruf04931  Insulin resistance
lruf04932  Non-alcoholic fatty liver disease
lruf04933  AGE-RAGE signaling pathway in diabetic complications
lruf04935  Growth hormone synthesis, secretion and action
lruf04960  Aldosterone-regulated sodium reabsorption
lruf04973  Carbohydrate digestion and absorption
lruf05010  Alzheimer disease
lruf05017  Spinocerebellar ataxia
lruf05020  Prion disease
lruf05100  Bacterial invasion of epithelial cells
lruf05132  Salmonella infection
lruf05135  Yersinia infection
lruf05142  Chagas disease
lruf05146  Amoebiasis
lruf05160  Hepatitis C
lruf05161  Hepatitis B
lruf05162  Measles
lruf05163  Human cytomegalovirus infection
lruf05164  Influenza A
lruf05165  Human papillomavirus infection
lruf05166  Human T-cell leukemia virus 1 infection
lruf05167  Kaposi sarcoma-associated herpesvirus infection
lruf05168  Herpes simplex virus 1 infection
lruf05169  Epstein-Barr virus infection
lruf05170  Human immunodeficiency virus 1 infection
lruf05171  Coronavirus disease
lruf05200  Pathways in cancer
lruf05203  Viral carcinogenesis
lruf05205  Proteoglycans in cancer
lruf05206  MicroRNAs in cancer
lruf05207  Chemical carcinogenesis - receptor activation
lruf05208  Chemical carcinogenesis - reactive oxygen species
lruf05210  Colorectal cancer
lruf05211  Renal cell carcinoma
lruf05212  Pancreatic cancer
lruf05213  Endometrial cancer
lruf05214  Glioma
lruf05215  Prostate cancer
lruf05218  Melanoma
lruf05220  Chronic myeloid leukemia
lruf05221  Acute myeloid leukemia
lruf05222  Small cell lung cancer
lruf05223  Non-small cell lung cancer
lruf05224  Breast cancer
lruf05225  Hepatocellular carcinoma
lruf05226  Gastric cancer
lruf05230  Central carbon metabolism in cancer
lruf05231  Choline metabolism in cancer
lruf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lruf05415  Diabetic cardiomyopathy
lruf05417  Lipid and atherosclerosis
lruf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lruf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    124527077
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    124527077
   04014 Ras signaling pathway
    124527077
   04015 Rap1 signaling pathway
    124527077
   04370 VEGF signaling pathway
    124527077
   04630 JAK-STAT signaling pathway
    124527077
   04668 TNF signaling pathway
    124527077
   04066 HIF-1 signaling pathway
    124527077
   04068 FoxO signaling pathway
    124527077
   04070 Phosphatidylinositol signaling system
    124527077
   04072 Phospholipase D signaling pathway
    124527077
   04071 Sphingolipid signaling pathway
    124527077
   04024 cAMP signaling pathway
    124527077
   04151 PI3K-Akt signaling pathway
    124527077
   04152 AMPK signaling pathway
    124527077
   04150 mTOR signaling pathway
    124527077
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    124527077
   04517 IgSF CAM signaling
    124527077
   04518 Integrin signaling
    124527077
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    124527077
   04140 Autophagy - animal
    124527077
  09143 Cell growth and death
   04210 Apoptosis
    124527077
   04218 Cellular senescence
    124527077
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    124527077
   04550 Signaling pathways regulating pluripotency of stem cells
    124527077
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    124527077
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    124527077
   04613 Neutrophil extracellular trap formation
    124527077
   04620 Toll-like receptor signaling pathway
    124527077
   04625 C-type lectin receptor signaling pathway
    124527077
   04650 Natural killer cell mediated cytotoxicity
    124527077
   04660 T cell receptor signaling pathway
    124527077
   04662 B cell receptor signaling pathway
    124527077
   04664 Fc epsilon RI signaling pathway
    124527077
   04666 Fc gamma R-mediated phagosome formation
    124527077
   04670 Leukocyte transendothelial migration
    124527077
   04062 Chemokine signaling pathway
    124527077
  09152 Endocrine system
   04910 Insulin signaling pathway
    124527077
   04923 Regulation of lipolysis in adipocytes
    124527077
   04929 GnRH secretion
    124527077
   04915 Estrogen signaling pathway
    124527077
   04914 Progesterone-mediated oocyte maturation
    124527077
   04917 Prolactin signaling pathway
    124527077
   04926 Relaxin signaling pathway
    124527077
   04935 Growth hormone synthesis, secretion and action
    124527077
   04919 Thyroid hormone signaling pathway
    124527077
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    124527077
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    124527077
  09156 Nervous system
   04725 Cholinergic synapse
    124527077
   04722 Neurotrophin signaling pathway
    124527077
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    124527077
  09158 Development and regeneration
   04360 Axon guidance
    124527077
   04380 Osteoclast differentiation
    124527077
  09149 Aging
   04211 Longevity regulating pathway
    124527077
   04213 Longevity regulating pathway - multiple species
    124527077
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    124527077
   05206 MicroRNAs in cancer
    124527077
   05205 Proteoglycans in cancer
    124527077
   05207 Chemical carcinogenesis - receptor activation
    124527077
   05208 Chemical carcinogenesis - reactive oxygen species
    124527077
   05203 Viral carcinogenesis
    124527077
   05230 Central carbon metabolism in cancer
    124527077
   05231 Choline metabolism in cancer
    124527077
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    124527077
  09162 Cancer: specific types
   05210 Colorectal cancer
    124527077
   05212 Pancreatic cancer
    124527077
   05225 Hepatocellular carcinoma
    124527077
   05226 Gastric cancer
    124527077
   05214 Glioma
    124527077
   05221 Acute myeloid leukemia
    124527077
   05220 Chronic myeloid leukemia
    124527077
   05218 Melanoma
    124527077
   05211 Renal cell carcinoma
    124527077
   05215 Prostate cancer
    124527077
   05213 Endometrial cancer
    124527077
   05224 Breast cancer
    124527077
   05222 Small cell lung cancer
    124527077
   05223 Non-small cell lung cancer
    124527077
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    124527077
   05170 Human immunodeficiency virus 1 infection
    124527077
   05161 Hepatitis B
    124527077
   05160 Hepatitis C
    124527077
   05171 Coronavirus disease
    124527077
   05164 Influenza A
    124527077
   05162 Measles
    124527077
   05168 Herpes simplex virus 1 infection
    124527077
   05163 Human cytomegalovirus infection
    124527077
   05167 Kaposi sarcoma-associated herpesvirus infection
    124527077
   05169 Epstein-Barr virus infection
    124527077
   05165 Human papillomavirus infection
    124527077
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    124527077
   05135 Yersinia infection
    124527077
   05100 Bacterial invasion of epithelial cells
    124527077
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    124527077
   05142 Chagas disease
    124527077
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    124527077
   05017 Spinocerebellar ataxia
    124527077
   05020 Prion disease
    124527077
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    124527077
   05418 Fluid shear stress and atherosclerosis
    124527077
   05415 Diabetic cardiomyopathy
    124527077
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    124527077
   04932 Non-alcoholic fatty liver disease
    124527077
   04931 Insulin resistance
    124527077
   04933 AGE-RAGE signaling pathway in diabetic complications
    124527077
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    124527077
   01524 Platinum drug resistance
    124527077
   01522 Endocrine resistance
    124527077
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lruf04131]
    124527077
Enzymes [BR:lruf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     124527077
Membrane trafficking [BR:lruf04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    124527077
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 124527077
NCBI-ProteinID: XP_046956292
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaaatatcctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaactagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaataccagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaagtccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacatcgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtctgtg
tctcgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggcaatggag
cttctggattgtaattacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatacttaacagatgacaagctttctcagtacttaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctaaataggcaagttgaagctatggaaaagctcattaacttaactgacattctcaaa
caagaaaagaaggatgaaacacaaaaggtacagatgaaatttttagttgagcaaatgcgg
agaccagatttcatggatgctctacagggttttctgtctcctctaaatcctgcccatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgttaacactgcagatcattcgcattatg
gaaaatatctggcaaaatcaaggccttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcagatt
cagtgcaaaggtggcctgaaaggcgcactgcagttcaacagccacactctacaccagtgg
ctcaaagacaagaacaaaggcgaaatatacgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcatactgggaatcggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactatttcatatagattttggacactttttggatcat
aagaagaaaaaatttggttataaacgggaacgtgtgccgtttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaattcgaaaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
ctcttctcaatgatgcttggctctggaatgccagaactgcaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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